Genetic variants of eNOS gene may modify the susceptibility to idiopathic male infertility

References

• Amir I, Sheikh N, Najafi R, et al. (2011). The correlation between total antioxidant capacity and nitric oxide concentration in seminal plasma with sperm DNA damage. Iran J Reprod Med 9(suppl 1):18
   Google Scholar
• Bianco B, Ghirelli-Filho M, Cavalheiro CM, et al. (2013). Variants in endothelial nitric oxide synthase (eNOS) gene in idiopathic infertile Brazilian men. Gene 519:13–17
   PubMed Web of Science ®Google Scholar
• Buldreghini E, Mahfouz RZ, Vignini A, et al. (2010). Single nucleotide polymorphism (SNP) of the endothelial nitric oxide synthase (eNOS) gene (Glu298Asp variant) in infertile men with asthenozoospermia. J Androl 31:482–8
   PubMedGoogle Scholar
• Egger M, Davey Smith G, Schneider M, Minder C. (1997). Bias in meta-analysis detected by a simple, graphical test. Br Med J 315:629–34
   PubMed Web of Science ®Google Scholar
• Erkan E, Toktas G, Unluer E, et al. (2012). Expression of NOS isoforms in internal spermatic veins of infertile men with varicocele. Syst Biol Reprod Med 58:268–73
   PubMed Web of Science ®Google Scholar
• Foghi K, Novin MG, Jabbari ZM, et al. (2011). Immuno-histochemical localization of endothelial nitric oxide synthase in testicular cells of men with non-obstructive azoospermia. Iran J Reprod Med 9:277–80
   Google Scholar
• Fujisawa M, Yamanaka K, Tanaka H, et al. (2001). Expression of endothelial nitric oxide synthase in the Sertoli cells of men with infertility of various causes. BJU Int 87:85–8
   Google Scholar
• Gharagozloo P, Aitken RJ. (2011). The role of sperm oxidative stress in male infertility and the significance of oral antioxidant therapy. Hum Reprod 26:1628–40
   PubMed Web of Science ®Google Scholar
• Hao Y, Montiel R, Huang Y. (2010). Endothelial nitric oxide synthase (eNOS) 894 G > T polymorphism is associated with breast cancer risk: a meta-analysis. Breast Cancer Res Treat 124:809–13
   Google Scholar
• He Y, Fan Z, Zhang J, et al. (2011). Polymorphisms of eNOS gene are associated with diabetic nephropathy: a meta-analys. Mutagenesis 26:339–49
   Google Scholar
• Higgins JP, Thompson SG, Deeks JJ, Altman DG. (2003). Measuring inconsistency in meta-analyses. Br Med J 327:557–60
   PubMed Web of Science ®Google Scholar
• Ishikawa T, Kondo Y, Goda K, Fujisawa M. (2005). Overexpression of endothelial nitric oxide synthase in transgenic mice accelerates testicular germ cell apoptosis induced by experimental cryptorchidism. J Androl 26:281–8
   Google Scholar
• Kasahara E, Sato EF, Miyoshi M, et al. (2002). Role of oxidative stress in germ cell apoptosis induced by di(2-ethylhexyl)phthalate. Biochem J 365:849–56
   PubMed Web of Science ®Google Scholar
• Kaur P, Bansal MP. (2003). Effect of oxidative stress on the spermatogenic process and hsp70 expressions in mice testis. Indian J Biochem Biophys 40:246–51
   Google Scholar
• Lee NP, Cheng CY. (2008). Nitric oxide and cyclic nucleotides: their roles in junction dynamics and spermatogenesis. Oxid Med Cell Longev 1:25–32
   PubMed Web of Science ®Google Scholar
• Leeson CP, Hingorani AD, Mullen MJ, et al. (2002). Glu298Asp endothelial nitric oxide synthase gene polymorphism interacts with environmental and dietary factors to influence endothelial function. Circ Res 90:1153–8
   PubMed Web of Science ®Google Scholar
• Lewis SE, Donnelly ET, Sterling ES, et al. (1996). Nitric oxide synthase and nitrite production in human spermatozoa: evidence that endogenous nitric oxide is beneficial to sperm motility. Mol Hum Reprod 2:873–8
   PubMed Web of Science ®Google Scholar
• Miyamoto Y, Saito Y, Nakayama M, et al. (2000). Replication protein A1 reduces transcription of the endothelial nitric oxide synthase gene containing a -786T-C mutation associated with coronary spastic angina. Hum Mol Genet 9:2629–37
   PubMed Web of Science ®Google Scholar
• Nachtigall RD. (2006). International disparities in access to infertility services. Fertil Steril 85:871–5
   PubMed Web of Science ®Google Scholar
• Nakayama M, Yasue H, Yoshimura M, et al. (1999). T-786–>C mutation in the 5′-flanking region of the endothelial nitric oxide synthase gene is associated with coronary spasm. Circulation 99:2864–70
   PubMed Web of Science ®Google Scholar
• Nuti F, Krausz C. (2008). Gene polymorphisms/mutations relevant to abnormal spermatogenesis. Reprod Biomed Online 16:504–13
   PubMed Web of Science ®Google Scholar
• O’Bryan MK, Zini A, Cheng CY, Schlegel PN. (1998). Human sperm endothelial nitric oxide synthase expression: correlation with sperm motility. Fertil Steril 70:1143–7
   PubMed Web of Science ®Google Scholar
• O’Flynn O’Brien KL, Varghese AC, Agarwal A. (2010). The genetic causes of male factor infertility: a review. Fertil Steril 93:1–12
   PubMed Web of Science ®Google Scholar
• Pasqualotto FF, Sharma RK, Nelson DR, et al. (2000). Relationship between oxidative stress, semen characteristics, and clinical diagnosis in men undergoing infertility investigation. Fertil Steril 73:459–64
   PubMed Web of Science ®Google Scholar
• Rodriguez S, Gaunt TR, Day IN. (2009). Hardy--Weinberg equilibrium testing of biological ascertainment for mendelian randomization studies. Am J Epidemiol 169:505–14
   PubMed Web of Science ®Google Scholar
• Rosselli M, Dubey RK, Imthurn B, et al. (1995). Effects of nitric oxide on human spermatozoa: evidence that nitric oxide decreases sperm motility and induces sperm toxicity. Hum Reprod 10:1786–90
   PubMed Web of Science ®Google Scholar
• Rosselli M, Keller PJ, Dubey RK. (1998). Role of nitric oxide in the biology, physiology and pathophysiology of reproduction. Hum Reprod Update 4:3–24
   PubMed Web of Science ®Google Scholar
• Safarinejad MR, Shafiei N, Safarinejad S. (2010). The role of endothelial nitric oxide synthase (eNOS) T-786C, G894T, and 4a/b gene polymorphisms in the risk of idiopathic male infertility. Mol Reprod Dev 77:720–7
   PubMed Web of Science ®Google Scholar
• Simoni M, Bakker E, Krausz C. (2004). EAA/EMQN best practice guidelines for molecular diagnosis of y-chromosomal microdeletions. Int J Androl 27:240–9
   PubMed Web of Science ®Google Scholar
• Sinici I, Atalar E, Kepez A, et al. (2010). Intron 4 VNTR polymorphism of eNOS gene is protective for cardiac syndrome X. J Investig Med 58:23–7
   Google Scholar
• Stephens M, Donnelly P. (2003). A comparison of Bayesian methods for haplotype reconstruction from population genotype data. Am J Hum Genet 73:1162–9
   PubMed Web of Science ®Google Scholar
• Thannickal VJ, Fanburg BL. (2000). Reactive oxygen species in cell signaling. Am J Physiol Lung Cell Mol Physiol 279:L1005–28
   PubMed Web of Science ®Google Scholar
• Tsukada T, Yokoyama K, Arai T, et al. (1998). Evidence of association of the ecNOS gene polymorphism with plasma NO metabolite levels in humans. Biochem Biophys Res Commun 245:190–3
   PubMed Web of Science ®Google Scholar
• Vandenbroucke JP, von Elm E, Altman DG, et al. (2007). Strengthening the reporting of observational studies in epidemiology (STROBE): explanation and elaboration. Epidemiology 18:805–35
   PubMed Web of Science ®Google Scholar
• Wang J, Dudley D, Wang XL. (2002). Haplotype-specific effects on endothelial NO synthase promoter efficiency: modifiable by cigarette smoking. Arterioscler Thromb Vasc Biol 22:e1–4
   PubMed Web of Science ®Google Scholar
• Wang X, Sharma RK, Sikka SC, et al. (2003). Oxidative stress is associated with increased apoptosis leading to spermatozoa DNA damage in patients with male factor infertility. Fertil Steril 80:531–5
   PubMed Web of Science ®Google Scholar
• Wang XL, Mahaney MC, Sim AS, et al. (1997). Genetic contribution of the endothelial constitutive nitric oxide synthase gene to plasma nitric oxide levels. Arterioscler Thromb Vasc Biol 17:3147–53
   PubMed Web of Science ®Google Scholar
• Wink DA, Miranda KM, Espey MG, et al. (2001). Mechanism of antioxidant effects of nitric oxide. Antioxid Redox Signal 3:201–13
   Google Scholar
• World Health Organization. (1999). WHO Laboratory Manual for the Examination of Human Semen and Sperm-cervical Mucus Interaction, 4th ed. Cambridge, UK: Cambridge University Press
   Google Scholar
• World Health Organization. (2010). WHO laboratory manual for the examination and processing of human semen, 5th ed. Geneva, Switzerland: World Health Organization
   Google Scholar
• Yun YJ, Park JH, Song SH, Lee S. (2008). The association of 4a4b polymorphism of endothelial nitric oxide synthase (eNOS) gene with the sperm morphology in Korean infertile men. Fertil Steril 90:1126–31
   PubMed Web of Science ®Google Scholar
• Zini A, Abitbol J, Girardi SK, et al. (1998). Germ cell apoptosis and endothelial nitric oxide synthase (eNOS) expression following ischemia-reperfusion injury to testis. Arch Androl 41:57–65
   PubMed Web of Science ®Google Scholar
• Zini A, O’Bryan MK, Magid MS, Schlegel PN. (1996). Immunohistochemical localization of endothelial nitric oxide synthase in human testis, epididymis, and vas deferens suggests a possible role for nitric oxide in spermatogenesis, sperm maturation, and programmed cell death. Biol Reprod 55:935–41
   PubMed Web of Science ®Google Scholar
• Zhang K, Bai P, Shi S, et al. (2012). The G894T polymorphism on endothelial nitric oxide synthase gene is associated with increased coronary heart disease among Asia population: evidence from a Meta-analysis. Thromb Res 130:192–7
   Google Scholar