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Original Article

Brain-derived HIV-1 tat sequences from AIDS patients with dementia show increased molecular heterogeneity

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Pages 387-393 | Received 09 Jan 1998, Accepted 28 Apr 1998, Published online: 05 Aug 2009

Reference

  • Adamson D. C., Wildemann B., Sasaki M., Glass J. D., Mcarthur J. C., Christov V. I., Dawson T. M., Dawson V. L. Immunologic NO synthase: Elevation in severe AIDS dementia and induction by HIV-1 gp41. Science 1996; 274: 1917–1921
  • Chen P., Mayne M., Power C., Nath A. The Tat protein of HIV-1 induces tumor necrosis factor-a production: implications for HTV-1 associated neurological diseases. J Biol Chem 1997; 272: 22385–22388
  • Corboy J. R., Buzy J. M., Zink M. C., Clements J. E. Expression directed from HIV long terminal repeats in the central nervous system of transgenic mice. Science 1992; 258: 1804–1807
  • Chao L. Sex in RNA viruses The Evolutionary Biology of Viruses, S. Morse. Raven Press, New York NY 1994
  • Dreyer E. B., Kaiser P. K., Offerman J. T., Lipton S.A. HIV-1 coat protein neurotoxicity prevented by calcium channel antagonists. Science 1990; 248: 364–367
  • Gartner S., Mcdonald R. A., Hunter E. A., Bouwman F., Liu Y., Popovic M. Gp120 sequence variation in brain and in T-lymphocyte human immunodeficiency virus type 1 primary isolates. J Hum Virol 1997; 1: 3–18
  • Gaynor R. B. Regulation of HIV-1 gene expression by the transactivator protein tat. Curr Topic Microbiol Immunol 1995; 191: 52–77
  • Glass J. D., Fedor H., Wesselingh S. L., Mcarthur J. C. Immunocytochemical quantitation of human immunodeficiency virus in the brain: correlations with dementia. Ann Neurol 1995; 38: 755–762
  • Green W. C. The molecular biology of human immunodeficiency virus type 1 infection. New Eng J Med 1991; 324: 308–337
  • Hasenkrug K. J., Robertson S. J., Portis J., Machete F., Niche J., Chesebro B. Two separate envelope regions influence induction of brain disease by a polytxopic murine retrovirus (FMCF98). J Virol 1996; 70: 4825–4828
  • Hughes E. S., Bell J. S., Simmonds P. Investigation of the dynamics of the spread of human immunodeficiency virus to brain and other tissues by evolutionary analysis of sequences from the p17gagand env genes. J Virol 1997; 71: 1272–1280
  • Kim T., Mudry R. A., Rexrode C. A., Pathak V. K. Retroviral mutation rates and A-to-G hypermutations during different stages of retroviral infection. J Virol 1996; 70: 7594–7602
  • Kumar S., Tamura K., Nei M. MEGA: molecular evolutionary genetics analysis, version 1.01. Pennsylvania State University, University Park, PA 16802 1993
  • Li W-H. Molecular evolution. Sinauer Associates, Sunderland MA 1997
  • Lipton S. A., Gendelman H. E. Dementia associated with the acquired immunodeficiency syndrome. New Eng J Med 1995; 332: 934–940
  • Ma M., Geiger J. D., Nath A. Molecular determinants for cellular uptake of tat protein of human immunodeficiency virus type 1 in brain cells. J Virol 1997; 71: 2495–2499
  • Magnuson DSK, Knudsen B. E., Geiger J. D., Brownstone R. M., Nath A. Human immunodeficiency virus type 1 tat activates non-N-Methyl-D-Aspartate excitatory amino acid receptors and causes neurotoxicity. Ann Neurol 1995; 37: 373–380
  • Mankowski J. L., Flahery M. T., Spelman J. P., Hauer D. A., Didier P. J., Martin Adee A., Murphey-Corb M., Kirstein L. M., Munoz A., Clements J. E., Zink M. C. Pathogenesis of simian immunodeficiency virus encephalitis: viral determinants of neurovirulence. J Virol 1997; 71: 6055–6060
  • Mayne M., Bratanich A. C., Chen P., Rana F., Nath A., Power C. HIV-1 Tat molecular diversity and induction of TNF-α: implications for HIV-induced neurological disease. Neuroimmunomodulation 1998, (In press)
  • Moyle G. J. Use of viral resistance patterns to antiretroviral drugs in optimising selection of drug combinations and sequences. Drugs 1996; 52: 168–185
  • Myers G., Wain-Hobson S., Korber B., Smith R. F. Human Retroviruses and AIDS. A compilation and analysis of nucleic acid and amino acid sequences. Theoretical biology and biophysics group T-10. Los Alamos, NM 1995
  • Nath A., Psooy K., Martin C., Knudsen B., Magnuson D. S., Haughey N., Geiger J. D. Identification of a human immunodeficiency virus type 1 Tat epitope that is neuroexcitatory and neurotoxic. J Virol 1996; 70: 1475–1480
  • Power C., Mcarthur J. C., Johnson R. T., Griffin D. E., Glass J. D., Perryman S., Chesebro B. Demented and non-demented patients with AIDS differ in brain-derived human immunodeficiency virus type 1 envelope sequences. J Virol 1994; 68: 4643–4649
  • Power C., Mcarthur J. C., Johnson R. T., Griffin D. E., Glass J. D., Dewey R., Chesebro B. Distinct HIV-1 env sequences are associated with neurotropism and neurovirulence. Curr Top Microbiol Immunol 1995; 202: 97–104
  • Price R. W., Brew B. J. The AIDS dementia complex. J Infect Dis 1988; 158: 1079–1083
  • Renjifo B., Borrero I., Essex M. Tax mutation associated with tropical spastic paraparesis/human T-cell leukemia virus type I-associated myelopathy. J Virol 1995; 69: 2611–2616
  • Sei S., Saito K., Stewart S. K., Crowley J. S., Brouwers P., Kleiner D. E., Katz D. A., Pizzo P. A., Heyes M. P. Increased human immunodeficiency virus type 1 (HIV-1) DNA content and quinolinic acid concentration in brain tissues from patients with HIV-encephalopathy. J Infect Dis 1995; 172: 638–647
  • Sharpless N. E., Wa O. B., Verdin E., Kufta C. V., Chen I.S.Y, Dubois Dalcq M. Human immunodeficiency virus type 1 tropism for brain microglial cells is determined by a region of the env glycoprotein that also controls macrophage tropism. J Virol 1992; 66: 2588–2593
  • Takahashi K., Wesselingh S. L., Griffin D. E., Mcarthur J. C., Johnson R. T., Glass J. D. Localization of HIV-1 in human brain using polymerase chain reaction/In situ hybridization and immunocytochemistry. Ann Neurol 1996; 39: 705–711
  • Tyor W. R., Glass J. D., Griffin J. W., Becker S., Mcarthur J. C., Bezman L., Griffin D. E. Cytokine expression in the brain during the acquired immunodeficiency syndrome. Ann Neurol 1992; 31: 349–360
  • Van Hemert F. J., Berkout B. The tendency of lentiviral open reading frames to become A-rich: constraints imposed by viral genome organization and cellular tRNA availability. J Mol Evol 1995; 41: 132–140
  • Ward A. C. Neurovirulence of influenza A virus. J Neuro Virol 1996; 2: 139–151
  • Wesselingh S. L., Power C., Glass J. D., Tyor W. R., Mcarthur J. C., Farber J. M., Griffin J. W., Griffin D. E. Intracerebral cytokine messenger RNA expression in acquired immunodeficiency syndrome dementia. Ann Neurol 1993; 33: 576–582
  • Wiley C. A., Schrier R. D., Nelson J. A., Lampert P. W., Old-Stone M. B. Cellular localization of human immunodeficiency virus infection within the brains of acquired immune deficiency syndrome patients. Proc Natl Acad Sci USA 1986; 83: 7089–7093
  • Wong J. K., Ignacio C. C., Torriani F., Havlir D., Fitch N.J.S, Richman D. D. In vivo compartmentalization of human immunodeficiency virus: evidence from examination of pol sequences from autopsy tissues. J Virol 1997; 71: 2059–2071

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