Interactions between macrophages and brain microvascular endothelial cells: role in pathogenesis of HIV-1 infection and blood-brain barrier function

References

• Arthur FW, Shivers RR, Bowman PD. Astrocyte-mediated induction of tight junctions in brain capillary endothelium: an efficient in vitro model. Dev Brain Res 1987; 36: 155–159
   Google Scholar
• Balis FM, Pizzo PA, Butler KM, Hawkins ME, Brouwers P, Husson RN, Jacobsen F, Blaney SM, Gress J, Jarosinski P, Poplack DG. Clinical pharmacology of 2′,3′-dideoxyinosine in human immunodeficiency virus-infected children. J Infect Dis 1992; 165: 99–104
   PubMed Web of Science ®Google Scholar
• Betz AL, Goldstein GW. Polarity of the blood-brain barrier: neutral amino acid transport into isolated brain capillaries. Science 1987; 202: 225–227
   Google Scholar
• Boven LA, Gomes L, Hery C, Gray F, Verhoef J, Portegies P, Tardieu M, Nottet H SLM. Increased peroxynitrite activity in AIDS Dementia Complex: implications for the neuropathogenesis of HIV-1 infection. J Immunol 1999a; 162: 4319–4327
   PubMedGoogle Scholar
• Boven LA, Middel J, Portegies P, Verhoef J, Jansen GH, Nottet H SLM. Overexpression of NGF and bFGF in AIDS dementia complex. J Neuroimmunol 1999b; 97: 154–162
   Google Scholar
• Breitner J CS, Welsh KA, Helms MJ, Gaskell PC, Gau BA, Roses AD, Pericak-Vance MA, Saunders AM. Delayed onset of Alzheimer's disease with nonsteroidal anti-inflammatory and histamine H2 blocking drugs. Nrurobiol Aging 1995; 16: 523–530
   PubMed Web of Science ®Google Scholar
• Breitner J CS. The role of anti-inflammatory drugs in the prevention and treatment of Alzheimer's disease. Annu Rev Med 1996; 47: 401–411
   PubMed Web of Science ®Google Scholar
• Buhl R, Jaffe H, Holroyd K, Borok Z, Roum JH, Mastrangeli A, Wells FB, Kirby M, Saltini C, Crystal RG. Activation of alveolar macrophages in asymptomatic HIV-infected individuals. J Immunol 1993; 150: 1019–1028
   Google Scholar
• Bukrinsky MI, Nottet H SLM, Schmidtmayerova H, Dubrovsky L, Flanagan CR, Mullins ME, Lipton SA, Gendelman HE. Regulation of nitric oxide synthase activity in human immunodeficiency virus type 1 (HIV-1)-infected monocytes: implications for HIV-associated neurological disease. J Exp Med 1995; 181: 735–745
   PubMed Web of Science ®Google Scholar
• Butler KM, Husson RN, Balis FM, Brouwers P, Eddy J, El-Amin D, Gress J, Hawkins M, Jarosinsky P, Moss H, Poplack D, Santacroce S, Venzon D, Winer L, Wolters P, Pizzo PA. Dideoxyinosine in children with symptomatic human immunodeficiency virus infection. N Engl J Med 1991; 324: 137–144
   PubMed Web of Science ®Google Scholar
• Chakrabarti L, Hurtrel M, Maire M-A, Vazeux R, Dormont D, Motgnier L, Hurtrel B. Early viral replication in the brain of SIV-infected rhesus monkeys. Am J Pathol 1991; 139: 1273–1280
   PubMedGoogle Scholar
• Conant K, Garzino-Demo A, Nath A, Mc Arthur JC, Halliday W, Power C, Gallo RC, Major EO. Induction of monocyte chemoattractant protein-1 in HIV-1 tat-stimulated astrocytes and elevation in AIDS dementia. Proc Natl Acad Sci USA 1998; 95: 3117–3121
   PubMed Web of Science ®Google Scholar
• Dhawan S, Toro LA, Jones E, Meltzer MS. Interactions between HIV-infected monocytes and the extracellular matrix: HIV-infected monocytes secrete neutral metalloproteases that degrade basement membrane protein matrices. J Leukoc Biol 1992; 52: 244–248
   PubMed Web of Science ®Google Scholar
• Dhawan S, Weeks BS, Soderland C, Schnaper HW, Toro LA, Asthana SP, Hewlett IK, Stetler-Stevenson WG, Yamada SS, Yamada KM, Melzer MS. HIV-1 infection alters monocyte interactions with human microvascular endothelial cells. J Immunol 1995; 154: 422–432
   PubMed Web of Science ®Google Scholar
• Davis LE, Hjelle BL, Miller VE, Palmer DL, Llewellyn AL, Merlin TL, Young SA, Mills RG, Wachsman W, Wiley CA. Early viral brain invasion in iatrogenic human immunodeficiencv virus infection. Neurology 1992; 42: 1736–1739
   PubMed Web of Science ®Google Scholar
• DeBault LE, Cancilla PA. γ-glutamyl transpeptidase in isolated brain endothelial cells: Induction by glial cells in vitro. Science 1980; 207: 653–655
   PubMed Web of Science ®Google Scholar
• Gendelman HE, Orenstein JM, Baca LM, Weiser B, Burger H, Kalter DC, Meltzer MS. The macrophage in the persistence and pathogenesis of HIV-1 infection. AIDS 1989; 3: 475–495
   PubMed Web of Science ®Google Scholar
• Gendelman HE, Zeng J, Coulter CL, Ghorpade A, Che M, Thylin M, Rubocki R, Persidsky Y, Hahn F, Reinhard J, Swindells S. Suppression of inflammatory neurotoxins by highly active antiretroviral therapy in human immunodeficiency virus-associated dementia. J Inf Dis 1998; 178: 1000–1007
   PubMed Web of Science ®Google Scholar
• Gilles PN, Lathey JL, Spector SA. Replication of macrophage-tropic and T-cell-tropic strains of human immunodeficiency virus type 1 is augmented by macrophage-endothelial contact. J Virol 1995; 69: 2133–2139
   Google Scholar
• Goldstein GW, Betz AL. Recent advances in understanding brain capillary function. Ann Neurol 1983; 14: 389–395
   PubMedGoogle Scholar
• Goudsmit J, DeWolf F, Paul DA, Epstein LG, Lange J MA, Krone W JA, Speelman H, Wolters EC, van der Noordaa J, Oleske JM, van der Helm HJ, Coutinho RA. Expression of human immunodeficiency virus antigen (HIV-Ag) in serum and cerebrospinal fluid during acute and chronic infection. Lancet 1986; 2: 177–180
   PubMed Web of Science ®Google Scholar
• Hickey WF, Vass K, Lassman H. Bone marrow derived elements in the central nervous system: an immunohistochemical and ultrastructural survey of rat chimera. J Neuropathol Exp Neurol 1992; 51: 246–256
   Google Scholar
• Ho DD, Rota TR, Schooly RT, Kaplan JC, Allan JD, Groopman JE, Resnick L, Felsenstein D, Andrews CA, Hirsch MS. Isolation of HTLV-III from cerebrospinal fluid and neural tissue of patients with neurological syndromes related to the acquired immunodeficiency syndrome. N Engl J Med 1985; 313: 1493–1497
   PubMed Web of Science ®Google Scholar
• Hofman FM, Wright AD, Dohadwala MM, Wong-Staal F, Walker SM. Exogenous Tat protein activates human endothelial cells. Blood 1993; 92: 2774–2780
   Google Scholar
• Hollander H, Stringari S. Human immunodeficiency virus-associated meningitis: Clinical course and correlations. Am J Med 1987; 83: 813–816
   Google Scholar
• Janzer RC, Raff MC. Astrocytes induce blood-brain barrier properties in endothelial cells. Nature 1987; 325: 253–258
   PubMed Web of Science ®Google Scholar
• Kiebburtz K and the Dana Consortium on the Therapy of HIV Dementia and Related Cognitive Disorders. Safety and tolerability of the antioxidant OPC-14117 in HIV-associated cognitive impairment. Neurology 1997; 49: 142–146
   Google Scholar
• Kim JS, Chopp M, Gautain SC. High dose methylprednisolone therapy reduces expression of JE/MCP-1 MRNA and macrophage accumulation in the ischemic rat brain. J Neurol Sci 1995; 128: 28–35
   PubMed Web of Science ®Google Scholar
• Kim RB, Fromm MF, Wandel C, Leake B, Wood A JJ, Rodem DM, Wilkinson GR. The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors. J Clin Invest 1998; 101: 289–294
   PubMed Web of Science ®Google Scholar
• Koenig S, Gendelman HE, Orenstein JM, Dal Canto MC, Pezeshkpour GH, Yungbluth M, Janotta F, Aksamit A, Martin MA, Fauci AS. Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy. Science 1986; 233: 1089–1093
   PubMed Web of Science ®Google Scholar
• Korber B TM, Kunstman KJ, Patterson BK, Furtado M, Mc Evilly MM, Levy R, Wolinsky SM. Genetic differences between blood- and brain-derived viral sequences from human immunodeficiency virus type 1-infected patients: Evidence of conserved elements in the V3 region of the envelope protein of brain-derived sequences. J Virol 1994; 68: 7467–7481
   PubMed Web of Science ®Google Scholar
• Lafrenie RM, Wahl LM, Epsteain JS, Hewlett IK, Yamada KM, Dhawan S. HIV-1 tat modulates monocyte function and alters their interactions with microvessel endothelial cells: A mechanism of HIV pathogenesis. J Immunol 1996; 156: 1638–1645
   PubMed Web of Science ®Google Scholar
• Lahdevirta J, Maury C PJ, Teppo AM, Repo H. Elevated levels of circulating eachectin/tumor necrosis factor in patients with acquired immunodeficiency syndrome. Am J Med 1988; 85: 289–291
   PubMed Web of Science ®Google Scholar
• Lawson LJ, Perry VH, Gordon S. Turnover of resident microglia in the normal adult mouse brain. Neuroscience 1992; 48: 405–415
   PubMed Web of Science ®Google Scholar
• Lee CG, Gottesman MM, Cardarelli CO, Ramachandra M, Jeang K, Ambudkar SV, Pastan I, Dey S. HIV-1 protease inhibitors are substrates for the MDR1 multidrug transporter. Biochemistry 1998; 37: 3594–3601
   PubMed Web of Science ®Google Scholar
• Li H, Newcombe J, Groome NP, Cuzner ML. Characterization and distribution of phagocytic macrophages in multiple sclerosis plaques. Neuropathol Appl Neurobiol 1993; 19: 214–223
   Google Scholar
• Limoges J, Persidsky Y, Bock P, Gendelman HE. Dexamethasone therapy worsens the neuropathology of human immunodeficiency virus type 1 encephalitis in SCID mice. J Inf Bis 1997; 175: 1368–1381
   Google Scholar
• Ling EA, Wong WC. The origin and nature of ramified and amoeboid microglia: a historical review and current concepts. Glia 1993; 7: 9–18
   PubMed Web of Science ®Google Scholar
• Masliah E, Achim CL, De Ge N., Teresa R, Terry RD, Wiley CA. Spectrum of human immunodeficiency virus-associated neocortical damage. Ann Neurol 1992; 32: 321–329
   PubMed Web of Science ®Google Scholar
• Masliah E, Heaton RK, Marcotte TD, Ellis RJ, Wiley CA, Mallory M, Achim CL, Mc Cutchan JA, Nelson JA, Atkinson JH, Grant I, the HNCR Group. Dendritic injury is a pathological substrate for human immunodeficiency virus-related cognitive disorders. Ann Neurol 1997; 42: 963–972
   PubMed Web of Science ®Google Scholar
• Mc Geer PL, Itagaki S, Boyes BE, Mc Geer EG. Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains. Neurology 1988a; 38: 1285–1291
   Google Scholar
• Mc Geer PL, Itagaki S, Mc Geer EG. Expression of the histocompatibility glycoprotein HLA-DR in neurological disease. Acta Neuropathol Berl 1988b; 76: 550–557
   Google Scholar
• Moses AV, Bloom FE, Pauza CD, Nelson JA. HIV infection of human brain capillary endothelial cells occurs via a CD4/galactosylceramide-independent mechanism. Proc Natl Acad Sci USA 1993; 90: 10474–10478
   PubMed Web of Science ®Google Scholar
• Muhleisen H, Gehrmann J, Meyermann R. Reactive microglia in Creutzfeldt-Jakob disease. Neuropathol App. Neurobiol 1995; 21: 505–517
   PubMedGoogle Scholar
• Nedergaard M. Direct signaling from astrocytes to neurons in cultures of mammalian brain cells. Science 1994; 263: 1768–1771
   PubMed Web of Science ®Google Scholar
• Norenberg MD. Astrocyte responses to CNS injury. J Neuropathol Exp Neurol 1994; 53: 213–220
   PubMed Web of Science ®Google Scholar
• Nottet H SLM, Bär DR, van Hassel H, Verhoef J, Boven LA. Cellular aspects of HIV-1 infection of macrophages leading to neuronal injury in in-vitro models for HIV-1 encephalitis. J Leukoc Biol 1997; 62: 107–116
   Google Scholar
• Nottet H SLM, Dhawan S. HIV-1 entry into brain: mechanisms for the infiltration of HIV-1 infected macrophages across the blood-brain barrier. The Neurology of AIDS, HE Gendelman, SA Lipton, LG Epstein, S Swindells. Chapman & Hall, New York 1998; 49–60
   Google Scholar
• Nottet H SLM, Gendelman HE. Unravelling the neuroimmune mechanisms for the HIV-1-associated cognitive/motor complex. Immunol Today 1995a; 16: 441–448
   PubMedGoogle Scholar
• Nottet H SLM, Jett M, Flanagan CR, Zhai Q-H, Persidsky Y, Rizzino A, Bernton EW, Genis P, Baldwin T, Schwartz J, La Benz C, Gendelman HE. A regulatory role for astrocytes in HIV-1 encephalitis: an overexpression of eicosanoids, platelet-activating factor, and tumor necrosis factor-α by activated HIV-1-infected monocytes is attenuated by primary human astrocytes. J Immunol 1995b; 154: 3567–3581
   PubMed Web of Science ®Google Scholar
• Nottet H SLM, Persidsky Y, Sasseville VG, Nakuna AN, Bock P, Zhai Q-H, Sharer LR, Mc Comb RD, Swindels S, Soderland C, Gendelman HE. Mechanisms for the transendothelial migration of HIV-1-infected monocytes into brain. J Immunol 1996; 156: 1284–1295
   PubMed Web of Science ®Google Scholar
• Pardridge WM. Brain metabolism: A perspective from the blood-brain barrier. Physiol Rev 1983; 63: 1481–1535
   PubMed Web of Science ®Google Scholar
• Pardridge WM, Eisenberg J, Yang J. Human blood-brain barrier insulin receptor. J Neurochem 1985; 44: 1771–1778
   PubMed Web of Science ®Google Scholar
• Parpura V, Basarsky TA, Liu F, Jeftinija K, Jeftinija S, Haydon PG. Glutamate-mediated astrocyte-neuron signalling. Nature 1994; 369: 744–747
   PubMed Web of Science ®Google Scholar
• Perno CF, Cooney DA, Gao WY, Hao Z, Johns DG, Foli A, Hartman NR, Calio R, Broder S, Yarchoan R. Effects of bone marrow stimulatory cytokines on human immunodeficiency virus replication and the antiviral activity of dideoxynucleosides in cultures of monocyte/macrophages. Blood 1992; 80: 995–1003
   PubMed Web of Science ®Google Scholar
• Perry VH, Anthony DC, Bolton SJ, Brown HC. The blood-brain barrier and the inflammatory response. Mol Med Today 1997; 3: 335–341
   PubMedGoogle Scholar
• Persidsky Y, Stins M, Way D, Witte MH, Weinand M, Kim KS, Bock P, Gendelman HE, Fiala M. A model for monocyte migration through the blood-brain barrier during HIV-1 encephalitis. J Immunol 1997; 158: 3499–3510
   PubMed Web of Science ®Google Scholar
• Poland SD, Rice G PA, Dekaban GA. HIV-1 infection of human brain-derived microvascular endothelial cells in vitro. J Acquir Immune Defic Syndr Hum Retrov 1995; 8: 437–445
   PubMedGoogle Scholar
• Portegies P, Enting RH, de Jong MD, Danner SA, Reiss P, Goudsmit J, Lange JM. AIDS dementia complex and didanosine. Lancet 1994; 344: 759
   PubMedGoogle Scholar
• Pulliam L, Gascon R, Stubblebine M, Mc Guire D, Mc Grath MS. Unique monocyte subset in patients with AIDS dementia. Lancet 1997; 349: 692–695
   PubMed Web of Science ®Google Scholar
• Quagliarello VJ, Wispelwey B, Long WJ, Jr, Scheld WM. Recombinant human interleukin-1 induces meningitis and blood-brain barrier injury in the rat. Characterization and comparison with tumor necrosis factor. J Clin Invest 1991; 87: 1360–1366
   PubMed Web of Science ®Google Scholar
• Rogers J, Kirby LC, Hempelman SR, Berry DL, Mc Geer PL, Kazniak AW, Zalinsky J, Cofield M, Mansukhani L, Willson P, Kogan F. Clinical trial of indomethacin in Alzheimer's disease. Neurology 1993; 43: 1609–1611
   PubMed Web of Science ®Google Scholar
• Sanders VJ, Pittman CA, White MG, Wang G, Wiley CA, Achim CL. Chemokines and receptors in HIV encephalitis. AIDS 1998; 12: 1021–1026
   PubMed Web of Science ®Google Scholar
• Sato K, Kuratsu J, Takeshima H, Yoshimura T, Ushio Y. Expression of monocyte chemoattractant protein-1 in meningioma. J Neurosurg 1995; 82: 874–878
   PubMedGoogle Scholar
• Schmidtmayerova H, Nottet H SLM, Nuovo G, Raabe T, Flanagan CR, Dubrovsky L, Gendelman HE, Cerami A, Bukrinsky MB, Sherry B. HIV-1 infection alters chemokine ji peptide expression in human monocytes: implications for recruitment of leukocytes into brain and lymph nodes. Proc Natl Acad Sci USA 1996; 93: 700–704
   PubMed Web of Science ®Google Scholar
• Seilhean D, Duyckaerts C, Vazeux R, Bolgert F, Brunet P, Katlama C, Gentilini M, Hauw JJ. HIV-1 associated cognitive/motor complex: absence of neuronal loss in the cerebral neocortex. Neurology 1993; 43: 1492–1499
   Google Scholar
• Sharer LR, Michaels J, Murphey-Corb M, Hu F-S, Kuebler DJ, Martin LN, Baskin GB. Serial pathogenesis study of SIV brain infection. J Med Primatol 1991; 20: 211–217
   Google Scholar
• Sharpless NE, O'Brien WA, Verdin E, Kufta CV, Chen I SY, Dubois-Dalcq M. Human immunodeficiency virus type 1 tropism for brain microglial cells is determined by a region of the env glycoprotein that controls macrophage tropism. J Virol 1992; 66: 2588–2593
   Google Scholar
• Sidtis JJ, Gatsonis C, Price RW, Singer EJ, Collier AC, Richman DD, Hirsch MS, Schaerf FW, Fischl MA, Kieburtz K, Simpson D, Koch MA, Feinberg J, Dafni Y. Zidovudine treatment of the AIDS dementia complex: results of a placebo-controlled trial, AIDS Clinical Trials Group. Ann Neurol 1993; 33: 343–349
   PubMed Web of Science ®Google Scholar
• Smits HA, van Muiswinkel FL, de Vos NM, Nottet H SLM. The amyloid-β (l-42)-induced respiratory burst of primary human macrophages is enhanced in the presence of amyloid-β (25–35). Alzheimer's disease and related disorders: etiology, pathogenesis and therapeutics, K Iqbal, DF Swaab, B Winblad, HM Wis-Niewski. John Wiley & Sons, England 1999; 457–461
   Google Scholar
• Soontornniyomkij V, Wang G, Pittman CA, Wiley CA, Achim CL. Expression of brain-derived neurotrophic factor protein in activated microglia of HIV-1 encephalitis. Neuropathol Appl Neurobiol 1998; 24: 453–460
   Google Scholar
• Sporer B, Paul R, Koedel U, Grimm R, Wick M, Goebel FD, Pfister H. Presence of matrix metallopro-teinase-9 activity in the cerebrospinal fluid of human immunodeficiency virus-infected patients. J Inf Dis 1998; 178: 854–857
   PubMed Web of Science ®Google Scholar
• Stewart PA, Wiley MJ. Developing nervous system induced formation of blood-brain barrier characteristics invading endothelial cells: A study using quail-chick transplantation chimeras. Dev Biol 1981; 84: 183–192
   PubMed Web of Science ®Google Scholar
• Takeshima H, Kuratsu J, Takeya M, Yoshimura T, Ushio Y. Expression and localization of messenger RNA and protein for monocyte chemoattractant protein-1 in human maliganant alioma. J Neurosurg 1994; 80: 1056–1062
   Google Scholar
• Van Muiswinkel FL, Raupp S FA, de Vos NM, Smits HA, Verhoef J, Eikelenboom P, Nottet H SLM. The amino-terminus of the amyloid-β peptide is critical for cellular binding and consequent activation of the respiratory burst of human macrophages. J Neuroim-munol 1999; 96: 121–130
   PubMed Web of Science ®Google Scholar
• Varki A. Selectin ligands. Proc Natl Acad Sci USA 1994; 91: 7390–7397
   PubMed Web of Science ®Google Scholar
• Vazeux R, Brousse N, Jarry A, Henin D, Marche C, Vedrenne C, Mikol J, Wolff M, Michon C, Rozenbaum W, Bureau JF, Montagnier L, Brahic M. AIDS subacute encephalitis. Identification of HIV-infected cells. Am J Pathol 1987; 126: 403–410
   PubMed Web of Science ®Google Scholar
• Wahl SM, Allen JB, McCartney-Francis N, Morganti-Kossmann MC, Kossmann T, Ellingsworth L, Mai UE, Mergenhagen SE, Orenstein JM. Macrophage-and astrocyte-derived transforming growth factor-β as a mediator of central nervous system dysfunction in acquired immune deficiency syndrome. J Exp Med 1991; 173: 981–991
   PubMedGoogle Scholar
• Wei X, Ghosh SK, Taylor ME, Johnson VA, Emini EA, Deutsch P, Lifson JD, Bonhoeffer S, Nowak MA, Hahn BH, Saag MS, Shaw GM. Viral dynamics in human immunodeficiency virus type 1 infection. Nature 1995; 373: 117–122
   PubMed Web of Science ®Google Scholar
• Weiss JM, Downie SA, Lyman WD, Berman JW. Astrocyte-derived monocyte-chemoattractant protein-1 directs the transmigration of leukocytes across a model of the human blood-brain barrier. J Immunol 1998; 161: 6896–6903
   PubMed Web of Science ®Google Scholar
• Wiley CA, Schrier RD, Nelson JA, Lampert PW, Oldstone MB. Cellular localization of human immunodeficiency virus infection within the brains of acquired immune deficiency syndrome patients. Proc. Natl Acad Sci USA 1986; 83: 7089–7093
   PubMed Web of Science ®Google Scholar
• Zhu T, Mo H, Wang N, Nam DS, Cao Y, Koup RA, Ho DD. Genotypic and phenotypc characterisation of HIV-1 in patients with primary infection. Science 1993; 261: 1179–1181
   PubMed Web of Science ®Google Scholar