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Original Article

HIV infection of choroid plexus in AIDS and asymptomatic HIV-infected patients suggests that the choroid plexus may be a reservoir of productive infection

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Pages 670-677 | Received 31 Mar 1999, Accepted 11 Jun 1999, Published online: 10 Jul 2009

References

  • An SF, Scaravilli F. Early HIV-1 infection of the central nervous system. Review Archives de Anatomie et de Cytologie Path 1997; 45: 94–105
  • Bagasra O, Lavi E, Bobroski L, Khalili K, Pestaner JP, Tawadros R, Pomerantz RJ. Cellular reservoirs of HIV-1 in the central nervous system of infected individuals: identification by the combination of in situ polymerase chain reaction and immunohisto-chemistry. AIDS 1996; 10: 573–585
  • Baskin GB, Murphey-Corb M, Roberts ED, Didier PJ, Martin LN. Correlates of SIV encephalitis in rhesus monkeys. J Med Primatol 1992; 21: 59–63
  • Bell JE, Busuttil A, Ironside JW, Rebus S, Donaldson YK, Simmonds Peuther JR. Human immunodeficiency virus and the brain: investigation of virus load and neuropathologic changes in pre-AIDS subjects. J Infect Dis 1993; 168: 818–824
  • Bertrand E, Cunningham MP, Geigy R. Comparative studies of American and African trypanosomiasis. World Health Organization Technical Report. WHO, Geneva 1969; 28–30
  • Budka H, Wiley CA, Kleihues P, Artigas J, Asbury AK, Cho ES, Cornblath DR, Dal Canto MC, DeGirolami U, Dickson D, Epstein LG, Esiri MM, Giangaspero F, Gosztonyi G, Gray F, Griffin JW, Henin D, Iwasaaki Y, Janssen RS, Johnson RT, Lantos PL, Lyman WD, Mc Arthur JC, Nagashima K, Peress N, Petito CK, Price RW, Rhodes RH, Rosenblum M, Said G, Scaravilli F, Sharer LR, Vinters HV. HIV-associated disease of the nervous system: review of nomenclature and proposal for neuropathology-based terminology. Brain Pathol 1991; 1: 143–152
  • Chakrabarti L, Hurtrel M, Maire MA, Vazeux R, Dormont D, Montagnier L, Hurtrel B. Early viral replication in the brain of SIV-infected rhesus monkeys. Am J Pathol 1991; 139: 1273–1280
  • Chen YH, Dietrich MP. A common immunological epitope existing between HIV-1 gp41 and human interferon-alpha and beta. Immunobio 1998; 198: 333–342
  • Chiodi F, Keys B, Albert J, Hagberg L, Lundeberg J, Uhlen M, Fenyo EM, Norkrans G. Human immunodeficiency virus type 1 is present in the cerebrospinal fluid of a majority of infected individuals. J Clin Microbiol 1992; 7: 1768–1771
  • Connor RI, Sheridan KE, Ceradini D, Choe S, Landau NR. Change in co-receptor uses correlates with disease progression in HIV-1-infected individuals. J Exp Med 1997; 185: 621–628
  • DiStefano M, Gray F, Leitner T, Chiodi F. Analysis of env V3 sequences from HIV-1 infected brain indicates restrained virus expression throughout the disease. J Virol 1996; 49: 41–48
  • Dominguez V, Gevorkian G, Govezensky T, Rodriguez H, Viveros M, Coch G, Macotela Y, Masso F, Pacheco M, Estrada JL, Lavalle C, Larralde C. Antigenic homology of HIV-1 gp41 and human platelet glycoprotein GPIIIa (integrin beta3). AIDS Hum Retroviral 1998; 17: 385–390
  • Edinger AL, Mankowski JL, Doranz BJ, Margulies BJ, Lee B, Rucker J, Sharron M, Hoffman TL, Berson JF, Zink MC, Hirsch VM, Clements JE, Doms RW. CD4-independent, CCR5-dependent infection of brain capillary endothelial cells by a neurovirulent simian immunodeficiency virus strain. Proc Natl Acad Sci USA 1997; 94: 14742–14747
  • Falangola MF, Castro-Filha BG, Petito CK. Immune complex deposition in the choroid plexus of AIDS patients. Ann Neurol 1994; 36: 437–440
  • Falangola MF, Hanly A, Galvao-Castro B, Petito CK. HIV infection of human choroid plexus: a possible mechanism of viral entry into the CNS. J Neuropathol Exp Neurol 1995; 54: 497–503
  • Falangola MF, Petito CK. Choroid plexus infection in cerebral toxoplasmosis in AIDS patients. Neurology 1993; 43: 2035–2040
  • Flaherty MT, Hauer DA, Mankowski JL, Zink MC, Clements JE. Molecular and biological characterization of a neurovirulent molecular clone of simian immunodeficiency virus. J Virol 1997; 71: 5790–5798
  • Gabuzda DH, Ho DD, de la Monte SM, Hirsch MS, Rota TR, Sobel RA. Immunohistochemical identification of HTLV III antigen in brains of patients with AIDS. Ann Neurol 1986; 20: 289–295
  • Gilles PN, Lathey JL, Spector SA. Replication of macrophage-tropic and T-cell-tropic strains of human immunodeficiency virus type 1 is augmented by macrophage-endothelial cell contact. J Virol 1995; 69: 2133–2139
  • Goudsmit J, de Wolf F, Paul DA, Epstein LG, Lange JM, Krone WJ, Speelman H, Wolters EC, Van der Noordaa J, Oleske JM. Expression of human immunodeficiency virus antigen (HIV-Ag) in serum and cerebrospinal fluid during acute and chronic infection. Lancet 1986; 2: 177–180
  • Gray F, Lescs M-C, Keohane C, Paraire F, Marc B, Durigon MB, Gherardi R. Early brain changes in HIV infection: neuropathological study of 11 HIV seropositive, non-AIDS cases. J Neuropathol Exo Neurol 1992; 51: 177–185
  • Gyorkey F, Melnick JL, Gyorkey P. Human immunodeficiency virus in brain biopsies of patients with AIDS. J Infect Dis 1987; 155: 870–876
  • Hanly A, Petito CK. HLA-DR-positive dendritic cells of the normal human choroid plexus: a potential reservoir of HIV in the central nervous system. Hum Pathol 1998; 29: 88–93
  • Harouse JM, Wrobleska Z, Laughlin MA, Hickey WF, Schonwetter BS, Gonzalez-Scarano F. Human choroid plexus cells can be latently infected with human immunodeficiency virus. Neurology 1989; 25: 406–411
  • Hickey WF, Hsu BL, Kimura H. T-cell entry into the rat central nervous system. J Neurosci Res 1991; 28: 354–260
  • Ho DD, Rota TR, Shooley RT, Kaplan JC, Allan JD, Groopman JE, Resnick L, Felgenstein D, Andrews CA, Hirsch MS. Isolation of HTLV-III from cerebrospinal fluid and neural tissues of patients with neurologic syndromes related to the acquired immunodeficiency syndrome. N Engl J Med 1985; 313: 1493–1497
  • Kibayashi K, Mastri AR, Hirsch CS. Neuropathology of human immunodeficiency virus infection at different disease stages. Human Path 1996; 27: 637–642
  • Lackner AA, Smith MO, Munn RL, Martfeld DJ, Gardner MB, Marx PA, Dandekar S. Localization of simian immunodeficiency virus in the central nervous system of rhesus monkeys. Am J Pathol 1991; 139: 609–621
  • Lu Z, Berson JF, Chen Y, Turner JD, Zhang T, Sharron M, Jenks MH, Wang Z, Kim J, Rucker J, Hoxie JA, Peiper SC, Doms RW. Evolution of HIV-1 coreceptor usage through interactions with distinct CCR5 and CXCR4 domains. Proc Natl Acad Sci USA 1997; 94: 6426–6431
  • Mankowski JL, Spelman JP, Ressetar HG, Strandberg JD, Laterra J, Carter DL, Clements JE, Zink MC. Neurovirulent simian immunodeficiency virus replicates productively in endothelial cells of the central nervous system in vivo and in vitro. J Virol 1994; 68: 8202–8208
  • Matyszak MK, Lawason LJ, Perry VA, Gordon S. Stromal macrophages of the choroid plexus situated at an interface between the brain and peripheral immune system constitutively express major histocompatibility class II antigens. J Neuroimmunol 1992; 40: 173–12
  • Maxwell WL, Hardy IG, Watt C, Mc Gadey J, Graham DI, Adams JH, Gennarelli TA. Changes in the choroid plexus, responses by intrinsic epiplexus cells and recruitment from monocytes after experimental head acceleration injury in the non-human primate. Acta Neuropathol 1992; 84: 78–84
  • Mc Arthur JC, Cohen BA, Farzedegan H, Cornblath DR, Seines OA, Ostrow D, Johnson RT, Phair J, Polk BF. Cerebrospinal fluid abnormalities in homosexual men with and without neuropsychiatric findings. Ann Neurol 1998; 23: S34–S37, (suppl)
  • Moses AV, Bloom FE, Pauza CD, Nelson JA. Human immunodeficiency virus infection of human brain capillary endothelial cells occurs via a CD4/galactosylceramide-independent mechanism. Proc Natl Acad Sci 1993; 90: 10474–10478
  • Netsky MG, Shuangshoti S. The choroid plexus in health and disease. University Press of Virginia, Charlottesville, VA 1975
  • Parmentier HK, van Wichen DF, Meyling FH, Goudsmit J, Schuurman HJ. Epitopes of human immunodeficiency virus regulatory proteins tat, nef and rev are expressed in normal human tissue. Airier. J Path 1992; 141: 1209–1216
  • Petito CK, Cho E-S, Lemann W, Navia BA, Price RW. Neuropathology of acquired immunodeficiency syndrome (AIDS): An autopsy review. J Neuropathol Exp Neurol 1986; 45: 635–646
  • Petito CK, Chen H, Torres-Munoz J, Wood C. Sequences analysis of V3 region of HIV env gene suggests that choroid plexus virus originates from systemic as well as from brain sources. Neuroviro 1998; 4: 362A
  • Petito CK, Chen H, Hanna C, Wood C. Choroid plexus harbors HIV in AIDS and in asymptomatic HIV-infected patients: a molecular and immunohisto-chemical study. J Neuropath Exp Neurol 1999; 58: 527A
  • Poland SD, Rice G PA, Dekaban GA. HIV-1 infection of human brain-derived microvascular endothelial cells in vitro. J Acq Immune Def Synd Hum Retrovirol 1995; 8: 437–445
  • Post MJ, Sheldon JJ, Hensley GT, Soila K, Tobias J, Curan J, Querar R, Moskowitz L. Central nervous system disease in acquired immunodeficiency syndrome: prospective correlation using CT, MR imaging and pathologic studies. Radiology 1986; 158: 141–148
  • Queiroz AC, Cendon-Filha SP. O envolviment do plexo coroide e ependima na tuberculose. Sua importancia na disseminacao da doenca no sitema nervoso central. Arq Neuro Psquiatr 1991; 49: 52–56
  • Queiroz AC, Martinez A MB. Micoses do sistema nervoso central- Dados anatomo patogicos da criptococose e aspergiloses cerebrais. Arq Neuro Psquiatr 1979; 35: 329–339
  • Resnick L, Berger JR, Shapshak P, Toutellotte WE. Early penetration of the blood-brain barrier by HIV. Neurology 1988; 38: 9–14
  • Serot JM, Foliguet B, Bene MC, Favre GC. Ultrastructual and immunohistochemical evidence for dendritic-like cells within human choroid plexus epithelium. Neuroreport 1997; 8: 1995–1998
  • Sharer LR. Pathology of HIV-1 infection of the central nervous system. A review. J Neuropath Exp Neurol 1992; 51: 3–11
  • Sharma DP, Zink MC, Anderson M, Adams R, Clements JE, Joag SV, Narayan O. Derivation of neurotropic simian immunodeficiency virus from exclusively lymphocytotropic parenteral virus: Pathogenesis of infection in macaques. J Virol 1992; 66: 3550–3556
  • Sinclair W, Gray F, Ciardi A, Scaravelli F. Immunohistochemical changes and PCR detection of HIV provirus DNA in brains of asymptomatic HIV-positive patients. J Neuropathol Exp Neurol 1994; 53: 43–50
  • Smith MO, Heyes MP, Lackner AT. Early intrathecal events in rhesus macaques infected with pathogenic and nonpathogenic molecular clones of simian immunodeficiency virus. Lab Invest 1995; 72: 547–558
  • Speck RF, Wehrly K, Piatt EJ, Atchison RE, Charo IF, Kabat D, Chesebro B, Goldsmith MA. Selective employment of chemokine receptors as human immunodeficiency virus type 1 coreceptors determined by individual amino acids within the envelope V3 loop. J Virol 1997; 71: 7136–7139
  • Spehar T, Strand M. Molecular mimicry between HIV-1 gp41 and an astrocyte isoform of alpha-actinin. Neurovirol 1995; 1: 381–390
  • Stout JC, Reynolds RJ, Terrv JL, Archibold SL, Abramson I, Wolfson T, Mc Cutchan AJ, Wallace R, Mark WR, Atkinson HJ. GrantI and the HIV Neurobehavioral Research Center groupProgressive cerebral volume loss in human immunodeficiency virus infection. Arch Neurol 1998; 55: 161–168
  • Strelow LI, Watry DD, Fox HS, Nelson JA. Efficient infection of brain microvascular endothelial cells by an in vivo-selected neuroinvasive SIVmac variant. J Neuro Virol 1998; 4: 269–280
  • Tacchetti C, Favre A, Moresco L, Meszaros P, Luzzi P, Truini M, Rizzo F, Grossi CE, Ciccone E. HIV is trapped and masked in the cytoplasm of lymph node follicular dendritic cells. Amer J Path 1997; 150: 533–542
  • Tennyson VM, Pappas GD. The fine structure of the choroid plexus: adult and developmental stages. Prog Brain Res 1968; 29: 63–85
  • Tracey I, Lane J, Chang I, Bavia B, Lackner A, Gonzalez RG. aH Magnetic resonance spectroscopy reveals neuronal injury in a simian immunodeficiency virus macaque model. J Acq Immune Deficiency Syn Hum Retrovirol 1997; 15: 21–27
  • Wiley CA, Schrier RB, Nelson JA, Lampert PW, Oldstone M BA. Cellular localization of human immunodeficiency virus infection within the brains of acquired immune deficiency syndrome patients. Proc Natl Acad Sci 1986; 93: 7089–7093

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