Prevalence, incidence and risk factors of testosterone deficiency in a population-based cohort of men: results from the study of health in Pomerania

References

• HaringR, VolzkeH, FelixSB, SchipfS, DorrM, RosskopfD, NauckM, SchoflC, WallaschofskiH. Prediction of metabolic syndrome by low serum testosterone levels in men: results from the study of health in Pomerania. Diabetes. 2009;58:2027–2031.
   PubMed Web of Science ®Google Scholar
• KupelianV, PageST, AraujoAB, TravisonTG, BremnerWJ, McKinlayJB. Low sex hormone-binding globulin, total testosterone, and symptomatic androgen deficiency are associated with development of the metabolic syndrome in nonobese men. The Journal of clinical endocrinology and metabolism. 2006;91:843–850.
   PubMed Web of Science ®Google Scholar
• YeapBB, HydeZ, AlmeidaOP, NormanPE, ChubbSA, JamrozikK, FlickerL, HankeyGJ. Lower testosterone levels predict incident stroke and transient ischemic attack in older men. The Journal of clinical endocrinology and metabolism. 2009;94:2353–2359.
   PubMed Web of Science ®Google Scholar
• SvartbergJ, von MuhlenD, MathiesenE, JoakimsenO, BonaaKH, Stensland-BuggeE. Low testosterone levels are associated with carotid atherosclerosis in men. J Intern Med. 2006;259:576–582.
   PubMed Web of Science ®Google Scholar
• VikanT, JohnsenSH, SchirmerH, NjolstadI, SvartbergJ. Endogenous testosterone and the prospective association with carotid atherosclerosis in men: the Tromso study. European journal of epidemiology. 2009;24:289–295.
   PubMed Web of Science ®Google Scholar
• FarrellJB, DeshmukhA, BaghaieAA. Low testosterone and the association with type 2 diabetes. The Diabetes educator. 2008;34:799–806.
   Google Scholar
• HallSA, AraujoAB, EscheGR, WilliamsRE, ClarkRV, TravisonTG, McKinlayJB. Treatment of symptomatic androgen deficiency: results from the Boston Area Community Health Survey. Archives of internal medicine. 2008;168:1070–1076.
   PubMed Web of Science ®Google Scholar
• AraujoAB, O'DonnellAB, BrambillaDJ, SimpsonWB, LongcopeC, MatsumotoAM, McKinlayJB. Prevalence and incidence of androgen deficiency in middle-aged and older men: estimates from the Massachusetts Male Aging Study. The Journal of clinical endocrinology and metabolism. 2004;89:5920–5926.
   PubMed Web of Science ®Google Scholar
• ShoresMM, MatsumotoAM, SloanKL, KivlahanDR. Low serum testosterone and mortality in male veterans. Archives of internal medicine. 2006;166:1660–1665.
   PubMed Web of Science ®Google Scholar
• YeapBB, AlmeidaOP, HydeZ, NormanPE, ChubbSA, JamrozikK, HankeyGJ, FlickerL. Healthier lifestyle predicts higher circulating testosterone in older men: the Health In Men Study. Clin Endocrinol (Oxf). 2009;70:455–463.
   PubMed Web of Science ®Google Scholar
• WangC, NieschlagE, SwerdloffRS, BehreH, HellstromWJ, GoorenLJ, KaufmanJM, LegrosJJ, LunenfeldB, MoralesA, MorleyJE, SchulmanC, ThompsonIM, WeidnerW, WuFC. ISA, ISSAM, EAU, EAA and ASA recommendations: investigation, treatment and monitoring of late-onset hypogonadism in males. Aging Male. 2009;12:5–12.
   PubMed Web of Science ®Google Scholar
• NieschlagE, BehreH, NieschlagS. Andrology: Male Reproductive Health and Dysfunction. 3rd ed., Berlin: Springer; 2009.
   Google Scholar
• AraujoAB, EscheGR, KupelianV, O'DonnellAB, TravisonTG, WilliamsRE, ClarkRV, McKinlayJB. Prevalence of symptomatic androgen deficiency in men. The Journal of clinical endocrinology and metabolism. 2007;92:4241–4247.
   PubMed Web of Science ®Google Scholar
• LiuCC, WuWJ, LeeYC, WangCJ, KeHL, LiWM, HsiaoHL, YehHC, LiCC, ChouYH, HuangCH, HuangSP. The prevalence of and risk factors for androgen deficiency in aging Taiwanese men. J Sex Med. 2009;6:936–946.
   PubMed Web of Science ®Google Scholar
• MorleyJE, KaiserFE, PerryHM, 3rd, PatrickP, MorleyPM, StauberPM, VellasB, BaumgartnerRN, GarryPJ. Longitudinal changes in testosterone, luteinizing hormone, and follicle-stimulating hormone in healthy older men. Metabolism: clinical and experimental. 1997;46:410–413.
   PubMed Web of Science ®Google Scholar
• WongSY, ChanDC, HongA, WooJ. Prevalence of and risk factors for androgen deficiency in middle-aged men in Hong Kong. Metabolism: clinical and experimental. 2006;55:1488–1494.
   PubMed Web of Science ®Google Scholar
• SchneiderHJ, SieversC, KlotscheJ, BohlerS, PittrowD, LehnertH, WittchenHU, StallaGK. Prevalence of low male testosterone levels in primary care in Germany: cross-sectional results from the DETECT study. Clin Endocrinol (Oxf). 2009;70:446–454.
   PubMed Web of Science ®Google Scholar
• FeldmanHA, LongcopeC, DerbyCA, JohannesCB, AraujoAB, CovielloAD, BremnerWJ, McKinlayJB. Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts male aging study. The Journal of clinical endocrinology and metabolism. 2002;87:589–598.
   PubMed Web of Science ®Google Scholar
• GrayA, FeldmanHA, McKinlayJB, LongcopeC. Age, disease, and changing sex hormone levels in middle-aged men: results of the Massachusetts Male Aging Study. The Journal of clinical endocrinology and metabolism. 1991;73:1016–1025.
   PubMed Web of Science ®Google Scholar
• HarmanSM, MetterEJ, TobinJD, PearsonJ, BlackmanMR. Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging. The Journal of clinical endocrinology and metabolism. 2001;86:724–731.
   PubMed Web of Science ®Google Scholar
• SvartbergJ, MidtbyM, BonaaKH, SundsfjordJ, JoakimsenRM, JordeR. The associations of age, lifestyle factors and chronic disease with testosterone in men: the Tromso Study. European journal of endocrinology / European Federation of Endocrine Societies. 2003;149:145–152.
   PubMed Web of Science ®Google Scholar
• AnderssonAM, JensenTK, JuulA, PetersenJH, JorgensenT, SkakkebaekNE. Secular decline in male testosterone and sex hormone binding globulin serum levels in Danish population surveys. The Journal of clinical endocrinology and metabolism. 2007;92:4696–4705.
   PubMed Web of Science ®Google Scholar
• TravisonTG, AraujoAB, O'DonnellAB, KupelianV, McKinlayJB. A population-level decline in serum testosterone levels in American men. The Journal of clinical endocrinology and metabolism. 2007;92:196–202.
   PubMed Web of Science ®Google Scholar
• SnyderPJ. Decreasing testosterone with increasing age: more factors, more questions. The Journal of clinical endocrinology and metabolism. 2008;93:2477–2478.
   Google Scholar
• TravisonTG, AraujoAB, KupelianV, O'DonnellAB, McKinlayJB. The relative contributions of aging, health, and lifestyle factors to serum testosterone decline in men. The Journal of clinical endocrinology and metabolism. 2007;92:549–555.
   PubMed Web of Science ®Google Scholar
• VolzkeH, AlteD, SchmidtCO, RadkeD, LorbeerR, FriedrichN, AumannN, LauK, PiontekM, BornG, et alCohort Profile: The Study of Health in Pomerania. International journal of epidemiology.
   Google Scholar
• KawachiI, KennedyBP. The relationship of income inequality to mortality: does the choice of indicator matter?Social science & medicine (1982). 1997;45:1121–1127.
   PubMed Web of Science ®Google Scholar
• AlteD, LuedemannJ, RoseHJ, JohnU. Laboratory markers carbohydrate-deficient transferrin, gamma-glutamyltransferase, and mean corpuscular volume are not useful as screening tools for high-risk drinking in the general population: results from the Study of Health in Pomerania (SHIP). Alcoholism, clinical and experimental research. 2004;28:931–940.
   Google Scholar
• WinklerG, DoringA. Validation of a short qualitative food frequency list used in several German large scale surveys. Zeitschrift fur Ernahrungswissenschaft. 1998;37:234–241.
   PubMedGoogle Scholar
• WHO. Measuring obesity - classification and description of anthropometric data. Report on a WHO consultation of the epidemiology of obesity. Warsaw, 21–23 October1987.
   Google Scholar
• Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation. 2002;106:3143–3421.
   PubMed Web of Science ®Google Scholar
• HaringR, WallaschofskiH, NauckM, DorrM, BaumeisterSE, VolzkeH. Ultrasonographic hepatic steatosis increases prediction of mortality risk from elevated serum gamma-glutamyl transpeptidase levels. Hepatology. 2009;50:1403–1411.
   PubMed Web of Science ®Google Scholar
• PocockSJ, McCormackV, GueyffierF, BoutitieF, FagardRH, BoisselJP. A score for predicting risk of death from cardiovascular disease in adults with raised blood pressure, based on individual patient data from randomised controlled trials. BMJ. 2001;323:75–81.
   PubMed Web of Science ®Google Scholar
• GrollDL, ToT, BombardierC, WrightJG. The development of a comorbidity index with physical function as the outcome. Journal of clinical epidemiology. 2005;58:595–602.
   PubMed Web of Science ®Google Scholar
• TravisonTG, AraujoAB, HallSA, McKinlayJB. Temporal trends in testosterone levels and treatment in older men. Current opinion in endocrinology, diabetes, and obesity. 2009;16:211–217.
   Google Scholar
• SchatzlG, MadersbacherS, TemmlC, Krenn-SchinkelK, NaderA, SregiG, LapinA, HermannM, BergerP, MarbergerM. Serum androgen levels in men: impact of health status and age. Urology. 2003;61:629–633.
   PubMed Web of Science ®Google Scholar
• LapauwB, GoemaereS, ZmierczakH, Van PottelberghI, MahmoudA, TaesY, De BacquerD, VansteelandtS, KaufmanJM. The decline of serum testosterone levels in community-dwelling men over 70 years of age: descriptive data and predictors of longitudinal changes. European journal of endocrinology / European Federation of Endocrine Societies. 2008;159:459–468.
   PubMed Web of Science ®Google Scholar
• WuFC, TajarA, PyeSR, SilmanAJ, FinnJD, O'NeillTW, BartfaiG, CasanuevaF, FortiG, GiwercmanA, et alHypothalamic-pituitary-testicular axis disruptions in older men are differentially linked to age and modifiable risk factors: the European Male Aging Study. The Journal of clinical endocrinology and metabolism. 2008;93:2737–2745.
   PubMed Web of Science ®Google Scholar
• LaaksonenDE, NiskanenL, PunnonenK, NyyssonenK, TuomainenTP, ValkonenVP, SalonenJT. The metabolic syndrome and smoking in relation to hypogonadism in middle-aged men: a prospective cohort study. The Journal of clinical endocrinology and metabolism. 2005;90:712–719.
   PubMed Web of Science ®Google Scholar
• MullerM, den TonkelaarI, ThijssenJH, GrobbeeDE, van der SchouwYT. Endogenous sex hormones in men aged 40–80 years. European journal of endocrinology / European Federation of Endocrine Societies. 2003;149:583–589.
   PubMed Web of Science ®Google Scholar
• SvartbergJ, von MuhlenD, SundsfjordJ, JordeR. Waist circumference and testosterone levels in community dwelling men. The Tromso study. European journal of epidemiology. 2004;19:657–663.
   PubMed Web of Science ®Google Scholar
• MohrBA, BhasinS, LinkCL, O'DonnellAB, McKinlayJB. The effect of changes in adiposity on testosterone levels in older men: longitudinal results from the Massachusetts Male Aging Study. European journal of endocrinology / European Federation of Endocrine Societies. 2006;155:443–452.
   PubMed Web of Science ®Google Scholar
• Barrett-ConnorE, KhawKT, YenSS. Endogenous sex hormone levels in older adult men with diabetes mellitus. American journal of epidemiology. 1990;132:895–901.
   PubMed Web of Science ®Google Scholar
• SparkRF. Testosterone, diabetes mellitus, and the metabolic syndrome. Current urology reports. 2007;8:467–471.
   PubMedGoogle Scholar
• LaaksonenDE, NiskanenL, PunnonenK, NyyssonenK, TuomainenTP, ValkonenVP, SalonenR, SalonenJT. Testosterone and sex hormone-binding globulin predict the metabolic syndrome and diabetes in middle-aged men. Diabetes Care. 2004;27:1036–1041.
   PubMed Web of Science ®Google Scholar
• HakimianP, BluteM, Jr., KashanianJ, ChanS, SilverD, ShabsighR. Metabolic and cardiovascular effects of androgen deprivation therapy. BJU international. 2008;102:1509–1514.
   PubMed Web of Science ®Google Scholar
• KaragiannisA, HarsoulisF. Gonadal dysfunction in systemic diseases. European journal of endocrinology / European Federation of Endocrine Societies. 2005;152:501–513.
   PubMed Web of Science ®Google Scholar
• WangC, NieschlagE, SwerdloffR, BehreHM, HellstromWJ, GoorenLJ, KaufmanJM, LegrosJJ, LunenfeldB, MoralesA, et alInvestigation, treatment, and monitoring of late-onset hypogonadism in males: ISA, ISSAM, EAU, EAA, and ASA recommendations. J Androl. 2009;30:1–9.
   PubMedGoogle Scholar
• LiuPY, DeathAK, HandelsmanDJ. Androgens and cardiovascular disease. Endocrine reviews. 2003;24:313–340.
   PubMed Web of Science ®Google Scholar
• FriedrichN, VolzkeH, RosskopfD, StevelingA, KrebsA, NauckM, WallaschofskiH. Reference ranges for serum dehydroepiandrosterone sulfate and testosterone in adult men. J Androl. 2008;29:610–617.
   Google Scholar
• WangTJ. New cardiovascular risk factors exist, but are they clinically useful?European heart journal. 2008;29:441–444.
   PubMed Web of Science ®Google Scholar