Exposure to caspofungin activates Cap and Hog pathways in Candida albicans

References

• Wisplinghoff H, Bischoff T, Tallent SM, . Nosocomial bloodstream infections in US hospitals: Analysis of 24,179 cases from a prospective nationwide surveillance study. Clin Infect Dis 2004; 39: 309–317.
   PubMed Web of Science ®Google Scholar
• Deresinski S, Stevens DA. Caspofungin. Clin Infect Dis 2003; 36: 1445–1457.
   PubMed Web of Science ®Google Scholar
• Maertens J, Raad I, Petrikkos G, . Efficacy and safety of caspofungin for treatment of invasive aspergillosis in patients refractory to or intolerant of conventional antifungal therapy. Clin Infect Dis 2004; 39: 1563–1571.
   PubMed Web of Science ®Google Scholar
• Sarria JC, Bradley JC, Habash R, . Candida glabrata endophthalmitis treated successfully with caspofungin. Clin Infect Dis 2005; 40: e46–8.
   Web of Science ®Google Scholar
• Soustre J, Rodier MH, Imbert-Bouyer S, . Caspofungin modulates in vitro adherence of Candida albicans to plastic coated with extracellular matrix proteins. J Antimicrob Chemother 2004; 53: 522–525.
   PubMedGoogle Scholar
• Betts R, Glasmacher A, Maertens J, . Effcacy of caspofungin against Candida or invasive Aspergillus infections in neutropenic patients. Cancer 2006; 106: 466–473.
   PubMed Web of Science ®Google Scholar
• Rajendram R, Alp NJ, Mitchell AR, . Candida prosthetic valve endocarditis cured by caspofungin therapy without valve replacement. Clin Infect Dis 2005; 40: e72–4.
   PubMed Web of Science ®Google Scholar
• Walsh TJ, Teppler H, Donowitz GR, . Caspofungin versus liposomal amphotericin B for empirical antifungal therapy in patients with persistent fever and neutropenia. N Engl J Med 2004; 351: 1391–1402.
   PubMed Web of Science ®Google Scholar
• Abruzzo GK, Gill CJ, Flattery AM, . Effcacy of the echinocandin caspofungin against disseminated aspergillosis and candidiasis in cyclophosphamide-induced immunosuppressed mice. Antimicrob Agents Chemother 2000; 44: 2310–2318.
   PubMed Web of Science ®Google Scholar
• Bachmann SP, Patterson TF, López-Ribot JL. In vitro activity of caspofungin (MK-0991) against Candida albicans clinical isolates displaying different mechanisms of azole resistance. J Clin Microbiol 2002; 40: 2228–2230.
   PubMed Web of Science ®Google Scholar
• Petraitiene R, Petraitis V, Groll AH, . Antifungal effcacy of caspofungin (MK-0991) in experimental pulmonary aspergillosis in persistently neutropenic rabbits: pharmacokinetics, drug disposition, and relationship to galactomannan antigenemia. Antimicrob Agents Chemother 2002; 46: 12–23.
   PubMed Web of Science ®Google Scholar
• Denning DW. Echinocandin antifungal drugs. Lancet 2003; 362: 1142–1151.
   PubMed Web of Science ®Google Scholar
• Busch SJ, Sassone-Corsi P. Dimers, leucine zippers and DNA-binding domains. Trends Genet 1990; 6: 36–40.
   PubMed Web of Science ®Google Scholar
• Zhang X, De Micheli M, Coleman ST, Sanglard D, Moye-Rowley WS. Analysis of the oxidative stress regulation of the Candida albi-cans transcription factor, Cap1p. Mol Microbiol 2000; 36: 618–629.
   PubMedGoogle Scholar
• Wang Y, Cao YY, Jia XM, . Cap1p is involved in multiple pathways of oxidative stress response in Candida albicans. Free Radic Biol Med 2006; 40: 1201–1209.
   PubMed Web of Science ®Google Scholar
• Alonso-Monge R, Navarro-García F, Román E, . The Hog1 mitogen-activated protein kinase is essential in the oxidative stress response and chlamydospore formation in Candida albicans. Eukaryot Cell 2003; 2: 351–361.
   PubMed Web of Science ®Google Scholar
• Brewster JL, de Valoir T, Dwyer ND, Winter E, Gustin MC. An osmosensing transduction pathway in yeast. Science 1993; 259: 1760–1763.
   PubMed Web of Science ®Google Scholar
• Saito H, Tatebayashi K. Regulation of the osmoregulatory HOG MAPK cascade in yeast. J Biochem 2004; 136: 267–272.
   PubMed Web of Science ®Google Scholar
• Hohmann S. Osmotic stress signaling and osmoadaptation in yeasts. Microbiol Mol Biol Rev 2002; 66: 300–372.
   PubMed Web of Science ®Google Scholar
• Foster JG, Hess JL. Responses of superoxide dismutase and glutathi-one reductase activity in cotton leaf tissue to an atmosphere enriched in oxygen. Plant Physiol 1980; 66: 482–487.
   PubMed Web of Science ®Google Scholar
• Larsen B, White S. Antifungal effect of hydrogen peroxide on catalase-producing strains of Candida spp. Infect Dis Obst Gynecol 1995; 3: 73–78.
   Google Scholar
• Alarco AM, Raymond M. The bZip Transcription Factor Cap1p is involved in multidrug resistance and oxidative stress response in Candida albicans. J Bacteriol 1999; 181: 700–708.
   PubMed Web of Science ®Google Scholar
• Enjalbert B, Smith DA, Cornell MJ, . Role of the Hog1 stress-activated protein kinase in the global transcriptional response to stress in the fungal pathogen Candida albicans. Mol Biol Cell 2006; 17: 1018–1032.
   PubMed Web of Science ®Google Scholar
• Ikner A, Shiozaki K. Yeast signaling pathways in the oxidative stress response. Mutat Res 2005; 569: 13–27.
   PubMed Web of Science ®Google Scholar
• Lee J, Spector D, Godon C, Labarre J, Toledano MB. A new anti-oxidant with alkyl hydroperoxide defense properties in yeast. J Biol Chem 1999; 274: 4537–4544.
   Google Scholar
• Schüller C, Brewster JL, Alexander MR, Gustin MC, Ruis H. The HOG pathway controls osmotic regulation of transcription via the stress response element (STRE) of the Saccharomyces cerevisiae CTT1 gene. EMBO J 1994; 13: 4382–4389.
   PubMed Web of Science ®Google Scholar
• Rep M, Krantz M, Thevelein JM, Hohmann S. The transcriptional response of Saccharomyces cerevisiae to osmotic shock. Hot1p and Msn2p/Msn4p are required for the induction of subsets of high osmolarity glycerol pathway-dependent genes. J Biol Chem 2000; 275: 8290–8300.
   PubMed Web of Science ®Google Scholar
• Rep M, Proft M, Remize F, . The Saccharomyces cerevisiae Sko1p transcription factor mediates HOG pathway-dependent osmotic regulation of a set of genes encoding enzymes implicated in protection from oxidative damage. Mol Microbiol 2001; 40: 1067–1083.
   PubMed Web of Science ®Google Scholar
• Wymann M, von Tscharner V, Deranleau D, Baggiolini M. Chemiluminescence detection of H2O2 produced by human neutrophils during the respiratory burst. Anal Biochem 1987; 165: 371–378.
   PubMed Web of Science ®Google Scholar
• Wheeler RT, Fink GR. A drug-sensitive genetic network masks fungi from the immune system. PLoS Pathog 2006; 2: e35. DOI: 10.1371/ journal.ppat.0020035.
   PubMed Web of Science ®Google Scholar