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Review Article

Nutrient sensing G protein-coupled receptors: interesting targets for antifungals?

Pages 671-680 | Received 23 Jul 2008, Accepted 26 Dec 2008, Published online: 04 Nov 2009

References

  • Lagerström MC, Schiöth HB. Structural diversity of G protein-coupled receptors and significance for drug discovery. Nat Rev Drug Discov 2008; 7: 339–357.
  • Chung S, Funakoshi T, Civelli O. Orphan GPCR research. Br J Pharmacol 2008; 153: S339–S346.
  • Brown AJ, Dyos SL, Whiteway MS, . Functional coupling of mammalian receptors to the yeast mating pathway using novel yeast/mammalian G protein alpha-subunit chimeras. Yeast 2000; 16: 11–22.
  • Minic J, Sautel M, Salesse R, Pajot-Augy E. Yeast system as a screening tool for pharmacological assessment of G protein-coupled receptors. Curr Med Chem 2005; 12: 961–969.
  • Ladds G, Goddard A, Davey J. Functional analysis of heterologous GPCR signalling pathways in yeast. Trends Biotechnol 2005; 23: 367–373.
  • Cismowski MJ, Takesono A, Ma C, Lanier SM, Duzic E. Identification of modulators of mammalian G-protein signaling by functional screens in the yeast Saccharomyces cerevisiae. Methods Enzymol 2002; 344: 153–168.
  • Szekeres PG. Functional assays for identifying ligands at orphan G protein-coupled receptors. Receptors Channels 2002; 8: 297–308.
  • Ladds G, Davis K, Hillhouse EW, Davey J. Modified yeast cells to investigate the coupling of G protein-coupled receptors to specific G proteins. Mol Microbiol 2003; 47: 781–792.
  • Szekeres G, Muir I, Spinage D, . Neuromedin U is a potent agonist at the orphan G protein-coupled receptor FM3. J Biol Chem 2000; 275: 20247–20250.
  • Phleger KD, Eidne KA. Illuminating insights into protein-protein interactions using bioluminescence resonance energy transfer (BRET). Nat Methods 2006; 3: 165–174.
  • Jockers R, Maurice P, Boutin JA, Delagrange P. Melatonin receptors, heterodimerization, signal transduction and binding sites: what's new?. Br J Pharmacol 2008; 154: 1182–1195.
  • Levoye A, Dam J, Ayoub MA, Guillaume J-L, Jockers R. Do orphan G-protein-coupled receptors have ligand-independent functions? New insights from receptor heterodimers. EMBO Rep 2006; 7: 1094–1098.
  • Versele M, Lemaire K, Thevelein JM. Sex and sugar in yeast: two distinct GPCR systems. EMBO Rep. 2001; 2: 574–579.
  • Dohlman HG, Thorner J, Caron MG, Lefkowitz RJ. Model systems for the study of seven-transmembrane-segment receptors. Annu Rev Biochem 1991; 60: 653–688.
  • Lengeler KB, Davidson RC, D'Souza C, . Signal transduction cascades regulating fungal development and virulence. Microbiol Mol Biol Rev 2000; 64: 746–785.
  • Bölker M. Sex and crime: heterotrimeric G proteins in fungal mating and pathogenesis. Fungal Gen Biol 1998; 25: 143–156.
  • Borges-Walmsley MI, Walmsley AR. cAMP signalling in pathogenic fungi: control of dimorphic switching and pathogenicity. Trends Microbiol 2000; 8: 133–141.
  • Kraakman L, Lemaire K, Ma P, . A Saccharomyces cerevisiae G-protein coupled receptor, Gpr1, is specifically required for glucose activation of the cAMP pathway during the transition to growth on glucose. Mol Microbiol 1999; 32: 1002–1012.
  • Maidan MM, De Rop L, Serneels J, . The G protein-coupled receptor Gpr1 and the Gα protein Gpa2 act through the cAMP-PKA pathway to induce morphogenesis in Candida albicans. Mol Biol Cell 2005; 16: 1971–1986.
  • Xue C, Bahn YS, Cox GM, Heitman J. G protein-coupled receptor Gpr4 senses amino acids and activates the cAMP-PKA pathway in Cryptococcus neoformans. Mol Biol Cell 2006; 17: 667–679.
  • Li L, Borkovich KA. GPR-4 is a predicted G protein-coupled receptor required for carbon source-dependent asexual growth and development in Neurospora crassa. Eukaryot Cell 2006; 5: 1287–1300.
  • Kulkarni RD, Thon MR, Pan H, Dean RA. Novel G protein-coupled receptor-like proteins in the plant pathogenic fungus Magnaporthe grisea. Genome Biology 2005; 6: R24.
  • Graul CR, Sadée W. Evolutionary relationships among G protein-coupled receptors using a clustered database approach. AAPS Pharmasci 2001; 3: 1–23.
  • Altschul SF, Madden TL, Schäffer AA, . Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucl Acids Res 1997; 25: 3389–3402.
  • Thompson DJ, Gibson TJ, Plewniak F, Jeanmougin F, Higgins DG. The ClustalX windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. Nucl Acids Res 1997; 24: 4876–4882.
  • Xue Y, Batlle M, Hirsch JP. GPR1 encodes a putative G protein-coupled receptor that associates with the Gpa2p G subunit and functions in a Ras-independent pathway. EMBO J 1998; 17: 1996–2007.
  • Versele M, de Winde JH, Thevelein JM. A novel regulator of G-protein signalling in yeast, Rgs2, downregulates glucose-activation of the cAMP pathway through direct inhibition of Gpa2. EMBO J 1999; 18: 5577–5591.
  • Thevelein JM, de Winde JH. Novel sensing mechanisms and targets for the cAMP-protein kinase A pathway in the yeast Saccharomyces cerevisiae. Mol Microbiol 1999; 32: 1002–1012.
  • Lemaire K, Van De Velde S, Van Dijck P, Thevelein JM. Nutrients as ligand for the G protein coupled receptor Gpr1 in the yeast Saccharomyces cerevisiae. Mol Cell 2004; 16: 293–299.
  • Harashima T, Heitman J. The Galpha protein Gpa2 controls yeast differentiation by interacting with Kelch repeat proteins that mimic G beta subunits. Mol Cell 2002; 10: 163–173.
  • Battle M, Lu A, Green D, Xue Y, Hirsch JP. Krh1p and Krh2p act downstream of the Gpa2p Galpha subunit to negatively regulate haploid invasive growth. J Cell Sci 2003; 116: 701–711.
  • Peeters T, Louwet W, Gelade R, . Kelch-repeat proteins interacting with the Galpha protein Gpa2 bypass adenylate cyclase for direct regulation of protein kinase A in yeast. Proc Natl Acad Sci USA 2006; 103: 13034–13039.
  • Peeters T, Versele M, Thevelein JM. Directly from Galpha to protein kinase A: the kelch repeat protein bypass of adenylate cyclase. Trends Biochem Sci 2007; 32: 547–554.
  • Niranjan T, Guo X, Victor J, Lu A, Hirsch JP. Kelch repeat protein interacts with the yeast Galpha subunit Gpa2p at a site that couples receptor binding to guanine nucleotide exchange. J Biol Chem 2007; 282: 24231–24238.
  • Harashima T, Anderson S, Yates JRr, Heitman J. The Kelch proteins Gpb1 and Gpb2 inhibit Ras activity via association with the yeast RasGAP neurofibromin homologs Ira1 and Ira2. Mol Cell 2006; 22: 819–830.
  • Zeller CE, Parnell SC, Dohlman HG. The RACK1 ortholog Asc1 functions as a G-protein beta subunit coupled to glucose responsiveness in yeast. J Biol Chem 2007; 282: 25168–25176.
  • Hoffman CS. Propping up our knowledge of G protein signaling pathways: diverse functions of putative noncanonical Gbeta subunits in fungi. Sci STKE 2007; 370: pe3.
  • Lorenz MC, Pan X, Harashima T, . The G protein-coupled receptor Gpr1 is a nutrient sensor that regulates pseudohyphal differentiation in Saccharomyces cerevisiae. Genetics 2000; 154: 609–622.
  • Ansari K, Martin S, Farkasovsky M, Ehbrecht I-M, Küntzel. Phospholipase C binds tot the receptor-like GPR1 protein and controls pseudohyphal differentiation in Saccharomyces cerevisiae. J Biol Chem 1999; 274: 30052–30058.
  • Tamaki H, Miwa T, Shinozaki M, . GPR1 regulates filamentous growth through FLO11 in yeast Saccharomyces cerevisiae. Biochem Biophys Res Commun 2000; 267: 164–168.
  • Lorenz MC, Heitman J. Yeast pseudohyphal growth is regulated by GPA2, a G protein α homolog. EMBO J 1997; 16: 7008–7018.
  • Van de Velde S, Thevelein JM. cAMP-PKA and Snf1 signaling mechanisms underlie the superior potency of sucrose for induction of filamentation in yeast. Eukaryot Cell 2007; 7: 286–293.
  • Hoffman CS, Winston F. Isolation and characterization of mutants constitutive for expression of the fbp1 gene of Schizosaccharomyces pombe. Genetics 1990; 124: 807–816.
  • Welton RM, Hoffman CS. Glucose monitoring in fission yeast via the Gpa2 Galpha, the git5 Gbeta and the git3 putative glucose receptor. Genetics 2000; 156: 513–521.
  • Hoffman CS, Winston F. Glucose repression of transcription of hte Schizosaccharomyces pombe fbp1 gene occurs by a cAMP signaling pathway. Genes Dev 1991; 5: 561–571.
  • Alaamery MA, Hoffman CS. Schizosaccharomyces pombe Hsp90/Git10 is requred for glucose/cAMP signaling. Genetics 2008; 178: 1927–1936.
  • Feng Q, Summers E, Guo B, Fink GR. Ras signaling is required for serum-induced hyphal differentiation in Candida albicans. J Bacteriol 1999; 181: 6339–6346.
  • Rocha CRC, Schröppel K, Harcus D, . Signalling through adenylyl cyclase is essential for hyphal growth and virulence in the pathogenic fungus Candida albicans. Mol Biol Cell 2001; 12: 3631–3643.
  • Miwa T, Takagi Y, Shinozaki M, . Gpr1, a putative G-protein-coupled receptor, regulates morphogenesis and hypha formation in the pathogenic fungus Candida albicans. Eukaryotic Cell 2004; 3: 919–931.
  • Biswas S, Van Dijck P, Datta A. Environmental sensing and signal transduction pathways regulating morphopathogenic determinants. Microbiol Mol Biol Rev 2007; 71: 348–376.
  • Maidan MM, Thevelein JM, Van Dijck P. Carbon source induced yeast-to-hypha transition in Candida albicans is dependent on the presence of amino acids and on the G protein coupled receptor Gpr1. Biochem Soc Trans 2005; 33: 291–293.
  • Bennett RJ, Johnson AD. The role of nutrient regulation and the Gpa2 protein in the mating pheromone response of C. albicans. Mol Microbiol 2006; 62: 100–119.
  • Alspaugh JA, Perfect JR, Heitman J. Cryptococcus neoformans mating and virulence are regulated by the G-protein α subunit GPA1 and cAMP. Genes Dev 1997; 11: 3206–3217.
  • Han K-H, Seo J-A, Yu J-H. A putative G protein-coupled receptor negatively controls sexual development in Aspergillus nidulans. Mol Microbiol 2004; 51: 1333–1345.
  • Klein PS, Sun TJ, Saxe CLr, . A chemoattractant receptor controls development in Dictyostelium discoideum. Science 1988; 241: 1467–1472.
  • Lafon A, Seo JA, Han KH, Yu JH, d'Enfert C. The heterotrimeric G-protein GanB (alpha)-SfaD(beta)GpgA(gamma) is a carbon source sensor involved in early cAMP-dependent germination in Aspergillus nidulans. Genetics 2005; 171: 71–80.
  • Ponting CP, Mott R, Bork P, Copley RR. Novel protein domains and repeats in Drosophila melanogaster: insights into structure, function, and evolution. Genome Res 2001; 11: 1996–2008.
  • Hardwick KG, Pelham RB. ERS1 a seven transmembrane domain protein from Saccharomyces cerevisiae. Nucl Acids Res 1990; 18: 2177–
  • Anderson jB, Sirjusingh C, Parsons AB, . Mode of selection and experimental evolution of antifungal drug resistance in Saccharomyces cerevisiae. Genetics 2003; 163: 1287–1298.
  • Reinders J, Zahedi RP, Pfanner N, Meisinger C, Sickmann A. Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 2006; 5: 1543–1554.
  • Chung K-S, Won M, Lee S-B, . Isolation of a novel gene from Schizosaccharomyces pombe: stm1+ encoding a seven-transmembrane loop protein that may couple with the heterotrimeric Ga2 protein, Gpa2. J Biol Chem 2001; 276: 40190–40201.
  • Bolker M. Ustilago maydis: a valuable model system for the study of fungal dimorphism and virulence. Microbiology 2001; 147: 1395–1401.
  • Town M, Jean G, Cherqui S, . A novel gene encoding an integral membrane protein is mutated in nephropathic cystinosis. Nat Genet 1998; 18: 319–324.
  • Kalatzis V, Cherqui S, Antignac C, Gasnier B. Cystinosin, the protein defective in cystinosis, is a H(+)-driven lysosomal cystine transporter. EMBO J 2001; 20: 5940–5949.
  • Lemaire K, . Gpr1, a G-protein coupled receptor involved in glucose-sensing in Saccharomyces cerevisiae, Leuven: K. U. Leuven, 2000.
  • Chung KS, Won M, Lee JJ, . Yeast-based screening to identify modulators of G-protein signalling using uncontrolled cell division cycle by overexpression of Stm1. J Biotechnol 2007; 129: 547–554.
  • Maidan MM, De Rop L, Relloso M, . Combined inactivation of the Candida albicans GPR1 and TPS2 genes results in a-virulence in a mouse model for systemic infection. Infect Immun 2008; 76: 1686–1694.
  • Van Dijck P, De Rop L, Szlufcik K, Van Ael E, Thevelein JM. Disruption of the Candida albicans TPS2 gene encoding trehalose-6-phosphate phosphatase decreases infectivity without affecting hypha formation. Infect Immun 2002; 70: 1772–1782.
  • Oppenheim FG, Yang YC, Diamond RD, . The primary structure and functional characterization of the neutral histidine-rich polypeptide from human parotid secretion. J Biol Chem 1986; 261: 1177–1182.
  • Pollock JJ, Denepitiya L, MacKay BJ, Iacono VJ. Fungistatic and fungicidal activity of human parotid salivary histidine-rich polypeptides on Candida albicans. Infect Immun 1984; 44: 702–707.
  • Helmerhorst EJ, Reijnders IM, Van't Hof W, . Amphotericin B- and fluconazole-resistant Candida spp., Aspergillus fumigatus, and other newly emerging pathogenic fungi are susceptible to basic antifungal peptides. Antimicrob Agents Chemother 1999; 43: 702–704.
  • Vylkova S, Jang WS, Li W, Nayyar N, Edgerton M. Histatin 5 initiates osmotic stress response in Candida albicans via activation of the Hog1 MAP kinase pathway. Eukaryot Cell 2007; 6: 1876–1888.
  • De Smet K, Contreras R, Van Dijck P, inventors. Use of histatin and GPR1 inhibitors as antifungal agent. Patent application number: EP06116702. 2006.
  • Dietrich FS, Voegeli S, Brachat S, . The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome. Science 2004; 304: 304–307.
  • Cliften P, Sudarsanam P, Desikan A, . Finding functional features in Saccharomyces genomes by phylogenetic footprinting. Science 2003; 301: 71–76.

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