Exposure to host or fungal PGE₂ abrogates protection following immunization with Candida-pulsed dendritic cells

References

• Soll DR, Galask R, Schmid J, . Genetic dissimilarity of commensal strains of Candida spp. carried in different anatomical locations of the same healthy women. J Clin Microbiol 1991; 29: 1702–17010.
   PubMed Web of Science ®Google Scholar
• Kleinegger CL, Lockhart SR, Vargas K, Soll DR. Frequency, intensity, species, and strains of oral Candida vary as a function of host age. J Clin Microbiol 1996; 34: 2246–2254.
   PubMed Web of Science ®Google Scholar
• Edmond MB, Wallace SE, McClish DK, . Nosocomial bloodstream infections in United States hospitals: a three-year analysis. Clin Infect Dis 1999; 29: 239–244.
   PubMed Web of Science ®Google Scholar
• Noverr MC, Toews GB, Huffnagle GB. Production of prostaglandins and leukotrienes by pathogenic fungi. Inf Immun 2002; 70: 400–402.
   PubMed Web of Science ®Google Scholar
• Noverr MC, Phare SM, Toews GB, Coffey MJ, Huffnagle GB. Pathogenic yeasts Cryptococcus neoformans and Candida albicans produce immunomodulatory prostaglandins. Infect Immun 2001; 69: 2957–2963.
   PubMed Web of Science ®Google Scholar
• Deva R, Shankaranarayanan P, Ciccoli R, Nigam S. Candida albicans induces selectively transcriptional activation of cyclooxygenase-2 in HeLa cells: pivotal roles of Toll-like receptors, p38 mitogen-activated protein kinase, and NF-kappa B. J Immunol 2003; 171: 3047–3055.
   PubMedGoogle Scholar
• Kalo-Klein A, Witkin S. Prostaglandin E2 enhances and gamma Interferon inhibits germ tube formation in Candida albicans. Infect Immun 1990; 58: 260–262.
   PubMed Web of Science ®Google Scholar
• Noverr MC, Huffnagle GB. Regulation of Candida albicans morphogenesis by fatty acid metabolites. Infect Immun 2004; 72: 6206–6210.
   PubMed Web of Science ®Google Scholar
• Saville SP, Lazzell AL, Monteagudo C, Lopez-Ribot JL. Engineered control of cell morphology in vivo reveals distinct roles for yeast and filamentous forms of Candida albicans during infection. Eukaryotic cell 2003; 2: 1053–1060.
   PubMed Web of Science ®Google Scholar
• Alem MA, Douglas LJ. Prostaglandin production during growth of Candida albicans biofilms. J Med Microbiol 2005; 54: 1001–1005.
   PubMed Web of Science ®Google Scholar
• Erb-Downward JR, Noverr MC. Characterization of prostaglandin E2 production by Candida albicans. Infect Immun 2007; 75: 3498–3505.
   PubMed Web of Science ®Google Scholar
• d'Ostiani CF, Del Sero G, Bacci A, . Dendritic cells discriminate between yeasts and hyphae of the fungus Candida albicans. Implications for initiation of T helper cell immunity in vitro and in vivo. J Exp Med 2000; 191: 1661–1674.
   PubMed Web of Science ®Google Scholar
• Romagnoli G, Nisini R, Chiani P, . The interaction of human dendritic cells with yeast and germ-tube forms of Candida albicans leads to efficient fungal processing, dendritic cell maturation, and acquisition of a Th1 response-promoting function. J Leukoc Biol 2004; 75: 117–126.
   PubMed Web of Science ®Google Scholar
• Torosantucci A, Romagnoli G, Chiani P, . Candida albicans yeast and germ tube forms interfere differently with human monocyte differentiation into dendritic cells: a novel dimorphism-dependent mechanism to escape the host's immune response. Infect Immun 2004; 72: 833–843.
   Google Scholar
• Netea MG, Van Der Graaf CA, Vonk AG, . The role of toll-like receptor (TLR) 2 and TLR4 in the host defense against disseminated candidiasis. J Infect Dis 2002; 185: 1483–1489.
   PubMed Web of Science ®Google Scholar
• van der Graaf CA, Netea MG, Verschueren I, van der Meer JW, Kullberg BJ. Differential cytokine production and Toll-like receptor signaling pathways by Candida albicans blastoconidia and hyphae. Infect Immun 2005; 73: 7458–7464.
   PubMed Web of Science ®Google Scholar
• Blasi E, Mucci A, Neglia R, . Biological importance of the two Toll-like receptors, TLR2 and TLR4, in macrophage response to infection with Candida albicans. FEMS Immunol Med Microbiol 2005; 44: 69–79.
   PubMedGoogle Scholar
• Li X, Qin J. Modulation of Toll-interleukin 1 receptor mediated signaling. J Mol Med 2005; 83: 258–266.
   PubMed Web of Science ®Google Scholar
• Villamon E, Roig P, Gil ML, Gozalbo D. Toll-like receptor 2 mediates prostaglandin E(2) production in murine peritoneal macrophages and splenocytes in response to Candida albicans. Res Microbiol 2005; 156: 115–118.
   PubMed Web of Science ®Google Scholar
• Kalinski P, Hilkens CM, Snijders A, Snijdewint FG, Kapsenberg ML. IL-12-deficient dendritic cells, generated in the presence of prostaglandin E2, promote type 2 cytokine production in maturing human naive T helper cells. J Immunol 1997; 159: 28–35.
   PubMed Web of Science ®Google Scholar
• Harizi H, Juzan M, Pitard V, Moreau JF, Gualde N. Cyclooxygenase-2-issued prostaglandin e(2) enhances the production of endogenous IL-10, which down-regulates dendritic cell functions. J Immunol 2002; 168: 2255–2263.
   PubMed Web of Science ®Google Scholar
• Fabricius D, Neubauer M, Mandel B, . Prostaglandin E2 inhibits IFN-alpha secretion and Th1 costimulation by human plasmacytoid dendritic cells via E-prostanoid 2 and E-prostanoid 4 receptor engagement. J Immunol; 184: 677–684.
   PubMedGoogle Scholar
• Pulendran B, Palucka K, Banchereau J. Sensing pathogens and tuning immune responses. Science 2001; 293: 253–256.
   PubMed Web of Science ®Google Scholar
• Harizi H, Gualde N. Dendritic cells produce eicosanoids, which modulate generation and functions of antigen-presenting cells. Prostaglandins Leukot Essent Fatty Acids 2002; 66: 459–466.
   PubMed Web of Science ®Google Scholar
• Jozefowski S, Bobek M, Marcinkiewicz J. Exogenous but not endogenous prostanoids regulate cytokine secretion from murine bone marrow dendritic cells: EP2, DP, and IP but not EP1, EP3, and FP prostanoid receptors are involved. Int Immunopharmacol 2003; 3: 865–878.
   PubMedGoogle Scholar
• Louie A, Baltch AL, Smith RP, . Tumor necrosis factor alpha has a protective role in a murine model of systemic candidiasis. Infect Immun 1994; 62: 2761–2772.
   PubMed Web of Science ®Google Scholar
• Fonzi WA, Irwin MY. Isogenic strain construction and gene mapping in Candida albicans. Genetics 1993; 134: 717–728.
   PubMed Web of Science ®Google Scholar
• Angelov GS, Tomkowiak M, Marcais A, Leverrier Y, Marvel J. Flt3 ligand-generated murine plasmacytoid and conventional dendritic cells differ in their capacity to prime naive CD8 T cells and to generate memory cells in vivo. J Immunol 2005; 175: 189–195.
   PubMedGoogle Scholar
• Lu L, McCaslin D, Starzl TE, Thomson AW. Bone marrow-derived dendritic cell progenitors (NLDC 145+, MHC class II+, B7-1dim, B7-2-) induce alloantigen-specific hyporesponsiveness in murine T lymphocytes. Transplantation 1995; 60: 1539–1545.
   PubMed Web of Science ®Google Scholar
• Brawand P, Fitzpatrick DR, Greenfield BW, . Murine plasmacytoid pre-dendritic cells generated from Flt3 ligand-supplemented bone marrow cultures are immature APCs. J Immunol 2002; 169: 6711–6719.
   PubMed Web of Science ®Google Scholar
• Zelante T, De Luca A, Bonifazi P, . IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance. Eur J Immunol 2007; 37: 2695–2706.
   PubMed Web of Science ®Google Scholar
• Romani L, Puccetti P. Protective tolerance to fungi: the role of IL-10 and tryptophan catabolism. Trends Microbiol 2006; 14: 183–189.
   PubMed Web of Science ®Google Scholar
• Brasel K, De Smedt T, Smith JL, Maliszewski CR. Generation of murine dendritic cells from flt3-ligand-supplemented bone marrow cultures. Blood 2000; 96: 3029–3039.
   PubMed Web of Science ®Google Scholar
• Gilliet M, Liu YJ. Human plasmacytoid-derived dendritic cells and the induction of T-regulatory cells. Hum Immunol 2002; 63: 1149–1155.
   PubMed Web of Science ®Google Scholar
• Annunziato F, Cosmi L, Liotta F, Maggi E, Romagnani S. The phenotype of human Th17 cells and their precursors, the cytokines that mediate their differentiation and the role of Th17 cells in inflammation. Int Immunol 2008; 20: 1361–1368.
   PubMed Web of Science ®Google Scholar
• MacCallum DM, Castillo L, Brown AJ, Gow NA, Odds FC. Early-expressed chemokines predict kidney immunopathology in experimental disseminated Candida albicans infections. PLoS One 2009; 4: e6420.
   PubMed Web of Science ®Google Scholar
• Spellberg B, Johnston D, Phan QT, Edwards JE Jr, French SW, Ibrahim AS, Filler SG. Parenchymal organ, but not splenic, immunity correlates with host survival during systemic candidiasis. Infect Immun 2003; 71: 5756–64.
   PubMedGoogle Scholar
• Hanekom WA, Mendillo M, Manca C, . Mycobacterium tuberculosis inhibits maturation of human monocyte-derived dendritic cells in vitro. J Infect Dis 2003; 188: 257–266.
   Google Scholar
• van der Pouw Kraan TC, Boeije LC, Smeenk RJ, Wijdenes J, Aarden LA. Prostaglandin-E2 is a potent inhibitor of human interleukin 12 production. J Exp Med 1995; 181: 775–779.
   PubMed Web of Science ®Google Scholar
• Filler SG, Ibe BO, Ibrahim AS, . Mechanisms by which Candida albicans induces endothelial cell prostaglandin synthesis. Infect Immun 1994; 62: 1064–1069.
   PubMed Web of Science ®Google Scholar
• Witkin SS, Hirsch J, Ledger WJ. A macrophage defect in women with recurrent Candida vaginitis and its reversal in vitro by prostaglandin inhibitors. Am J Obstet Gynecol 1986; 155: 790–795.
   PubMed Web of Science ®Google Scholar
• Gantner BN, Simmons RM, Underhill DM. Dectin-1 mediates macrophage recognition of Candida albicans yeast but not filaments. EMBO J 2005; 24: 1277–1286.
   PubMed Web of Science ®Google Scholar
• Ferwerda B, Ferwerda G, Plantinga TS, . Human dectin-1 deficiency and mucocutaneous fungal infections. N Engl J Med 2009; 361: 1760–1767.
   PubMed Web of Science ®Google Scholar
• Lee HS, Lee CS, Yang CJ, Su SL, Salter DM. Candida albicans induces cyclo-oxygenase 2 expression and prostaglandin E2 production in synovial fibroblasts through an extracellular-regulated kinase ½ dependent pathway. Arthritis Res Ther 2009; 11: R48.
   Google Scholar
• Adt I, Toubas D, Pinon JM, Manfait M, Sockalingum GD. FTIR spectroscopy as a potential tool to analyse structural modifications during morphogenesis of Candida albicans. Arch Microbiol 2006; 185: 277–285.
   PubMedGoogle Scholar
• Shibata N, Suzuki A, Kobayashi H, Okawa Y. Chemical structure of the cell-wall mannan of Candida albicans serotype A and its difference in yeast and hyphal forms. Biochem J 2007; 404: 365–372.
   PubMed Web of Science ®Google Scholar
• Martinez-Gomariz M, Perumal P, Mekala S, . Proteomic analysis of cytoplasmic and surface proteins from yeast cells, hyphae, and biofilms of Candida albicans. Proteomics 2009; 9: 2230–2252.
   PubMedGoogle Scholar
• Kalo-Klein A, Witkin SS. Prostaglandin E2 enhances and gamma interferon inhibits germ tube formation in Candida albicans. Infect Immun 1990; 58: 260–262.
   PubMed Web of Science ®Google Scholar
• Funk CD. Prostaglandins and leukotrienes: advances in eicosanoid biology. Science 2001; 294: 1871–1875.
   PubMed Web of Science ®Google Scholar
• Veldhoen M, Hocking RJ, Atkins CJ, Locksley RM, Stockinger B. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 2006; 24: 179–189.
   PubMed Web of Science ®Google Scholar
• Conti HR, Shen F, Nayyar N, . Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis. J Exp Med 2009; 206: 299–311.
   PubMed Web of Science ®Google Scholar
• Huang W, Na L, Fidel PL, Schwarzenberger P. Requirement of interleukin-17A for systemic anti-Candida albicans host defense in mice. J Infect Dis 2004; 190: 624–631.
   PubMed Web of Science ®Google Scholar
• Alem MA, Douglas LJ. Effects of aspirin and other nonsteroidal anti-inflammatory drugs on biofilms and planktonic cells of Candida albicans. Antimicrob Agents Chemother 2004; 48: 41–47.
   PubMed Web of Science ®Google Scholar
• Pfaller MA, Diekema DJ. Epidemiology of invasive candidiasis: a persistent public health problem. Clin Microbiol Rev 2007; 20: 133–163.
   PubMed Web of Science ®Google Scholar