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Research Article

Genotypic heterogeneity and molecular basis of 5-flucytosine resistance among Candida dubliniensis isolates recovered from clinical specimens in Kuwait

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Pages 244-251 | Received 21 Mar 2011, Accepted 11 Jun 2011, Published online: 06 Sep 2011

References

  • Sullivan DJ, Moran GP, Pinjon E, . Comparison of the epidemiology, drug resistance mechanisms, and virulence of Candida dubliniensis and Candida albicans. FEMS Yeast Res 2004; 4: 369–376.
  • Loreto ES, Scheid LA, Nogueira CW, . Candida dubliniensis: epidemiology and phenotypic methods for identification. Mycopathologia 2010; 169: 431–443.
  • Stokes C, Moran GP, Spiering MJ, . Lower filamentation rates of Candida dubliniensis contribute to its lower virulence in comparison with Candida albicans. Fungal Genet Biol 2007; 44: 920–931.
  • Vilela MM, Kamei K, Sano A, . Pathogenicity and virulence of Candida dubliniensis: comparison with C. albicans. Med Mycol 2002; 40: 249–257.
  • Sullivan DJ, Westerneng TJ, Haynes KA, Bennett DE, Coleman DC. Candida dubliniensis sp. nov.: phenotypic and molecular characterization of a novel species associated with oral candidosis in HIV-infected individuals. Microbiology 1995; 141: 1507–1521.
  • Coleman DC, Sullivan DJ, Bennett DE, . Candidiasis: the emergence of a novel species, Candida dubliniensis. AIDS 1997; 11: 557–567.
  • Polacheck I, Strahilevitz J, Sullivan D, . Recovery of Candida dubliniensis from non-human immunodeficiency virus-infected patients in Israel. J Clin Microbiol 2000; 38: 170–174.
  • Meis JF, Ruhnke M, De Pauw BE, . Candida dubliniensis candidemia in patients with chemotherapy-induced neutropenia and bone marrow transplantation. Emerg Infect Dis 1999; 5: 150–153.
  • Sebti A, Kiehn TE, Perlin D, . Candida dubliniensis at a cancer center. Clin Infect Dis 2001; 32: 1034–1038.
  • Carr MJ, Clarke S, O'Connell F, . First reported case of endocarditis caused by Candida dubliniensis. J Clin Microbiol 2005; 43: 3023–3026.
  • Jabra-Rizk MA, Johnson JK, Forrest G, . Prevalence of Candida dubliniensis fungemia at a large teaching hospital. Clin Infect Dis 2005; 41: 1064–1067.
  • Odds FC, Hanson MF, Davidson AD, . One year prospective survey of Candida bloodstream infections in Scotland. J Med Microbiol 2007; 56: 1066–1075.
  • Baradkar VP, Mathur M, Kumar S. Neonatal septicaemia in a premature infant due to Candida dubliniensis. Ind J Med Microbiol 2008; 26: 382–385.
  • van Hal SJ, Stark D, Harkness J, Marriott D. Candida dubliniensis meningitis as delayed sequela of treated C. dubliniensis fungemia. Emerg Infect Dis 2008; 14: 327–329.
  • Chen SC, Marriott D, Playford EG, . Australian candidaemia study. Candidaemia with uncommon Candida species: predisposing factors, outcome, antifungal susceptibility, and implications for management. Clin Microbiol Infect 2009; 15: 662–669.
  • Wellinghausen N, Moerick A, Bundschuh S, . Multifocal osteomyelitis caused by Candida dubliniensis. J Med Microbiol 2009; 56: 386–390.
  • Fernandez A, Jewtuchowicz VM, Malzone MC, . Phenotypic and genotypic characterization of Candida dubliniensis isolate in a patient with disseminated candidiasis. Mycoses 2011; 54:e602–605.
  • Joly S, Pujol C, Rysz M, Vargas K, Soll DR. Development and characterization of complex DNA fingerprinting probes for the infectious yeast Candida dubliniensis. J Clin Microbiol 1999; 37: 1035–1044.
  • Gee SF, Joly S, Soll DR, . Identification of four distinct genotypes of Candida dubliniensis and detection of microevolution in vitro and in vivo. J Clin Microbiol 2002; 40: 556–574.
  • Al Mosaid A, Sullivan DJ, Polacheck I, . Novel 5-flucytosine-resistant clade of Candida dubliniensis from Saudi Arabia and Egypt identified by Cd25 fingerprinting. J Clin Microbiol 2005; 43: 4026–4036.
  • McManus BA, Coleman DC, Moran G, . Multilocus sequence typing reveals that the population structure of Candida dubliniensis is significantly less divergent than that of Candida albicans. J Clin Microbiol 2008; 46: 652–664.
  • Fleischhacker M, Prasligh J, Moran G, Ruhnke M. Longitudinal genotyping of Candida dubliniensis isolates reveals strain maintenance, microevolution, and the emergence of itraconazole resistance. J Clin Microbiol 2010; 48: 1643–1650.
  • Ahmad S, Khan Z, Mokaddas E, Khan ZU. Isolation and molecular identification of Candida dubliniensis from non-human immunodeficiency virus-infected patients in Kuwait. J Med Microbiol 2004; 56: 633–637.
  • Ahmad S, Mokaddas E, Al-Sweih N, Khan ZU. Phenotypic and molecular characterization of Candida dubliniensis isolates from clinical specimens in Kuwait. Med Princ Pract 2005; 14 (Suppl. 1): 77–83.
  • McManus BA, Moran G, Higgins JA, Sullivan DJ, Coleman DC. A Ser29Leu substitution in the cytosine deaminase Fca1p is responsible for clade-specific flucytosine resistance in Candida dubliniensis. Antimicrob Agents Chemother 2009; 53: 4678–4685.
  • Khan ZU, Ahmad S, Mokaddas E, Chandy R. Simplified sunflower (Helianthus annuus) seed agar for differentiation of Candida dubliniensis from Candida albicans. Clin Microbiol Infect 2004; 10: 590–592.
  • Clinical Laboratory Standards Institute (formerly National Committee for Clinical Laboratory Standards). Reference Method for Broth Microdilution Antifungal Susceptibility Testing of Yeast. 2nd. Approved Standard M27-A2. Wayne, PA: National Committee for Clinical Laboratory Standards, 2002.
  • Al-Sweih N, Ahmad S, Khan ZU, Khan S, Chandy R. Prevalence of Candida dubliniensis among germ tube-positive Candida isolates in a maternity hospital in Kuwait. Mycoses 2005; 48: 347–351.
  • Khan ZU, Ahmad S, Mokaddas E, . Actinomucor elegans var. kuwaitiensis isolated from the wound of a diabetic patient. Antonie van Leeuwenhoek 2008; 94: 343–352.
  • Fotedar R, Al Hedaithy SS. Prevalence of Candida dubliniensis among germ tube-positive yeasts recovered from the respiratory specimens in HIV-negative patients. Mycoses 2004; 47: 150–155.
  • Khlif M, Sellami H, Sellami A, . Candida dubliniensis: first identification in Sfax hospital, Tunisia. Mycoses 2008; 52: 171–175.
  • McCullough MJ, Hepworth G, Gordon I, Clemons KV, Stevens DA. Molecular epidemiology of global Candida dubliniensis isolates utilizing genome-wide, co-dominant, PCR-based markers for strain delineation. Med Mycol 2009; 47: 789–795.

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