Blastomyces dermatitidis septins CDC3, CDC10, and CDC12 impact the morphology of yeast and hyphae, but are not required for the phase transition

References

• Gauthier GM, Klein BS. Insights into fungal morphogenesis and immune evasion. Microbe 2008; 3: 416–423.
   PubMedGoogle Scholar
• Wheat LJ, Slama TG, Eitzen HE, . A large urban outbreak of histoplasmosis: clinical features. Ann Intern Med 1981; 94: 331–337.
   PubMed Web of Science ®Google Scholar
• Schneider E, Hajjeh RA, Spiegel RA, . A coccidioidomycosis outbreak following the Northridge, Calif, earthquake. JAMA 1997; 277: 904–908.
   PubMed Web of Science ®Google Scholar
• Klein BS, Tebbets B. Dimorphism and virulence in fungi. Curr Opin Microbiol 2007; 10: 314–319.
   PubMed Web of Science ®Google Scholar
• Gauthier GM, Safdar N, Klein BS, Andes DR. Blastomycosis in solid organ transplant recipients. Transpl Infect Dis 2007; 9: 310–317.
   PubMed Web of Science ®Google Scholar
• Nemecek JC, Wuthrich M, Klein BS. Global control of dimorphism and virulence in fungi. Science 2006; 312: 583–588.
   PubMed Web of Science ®Google Scholar
• Gauthier GM, Sullivan TD, Gallardo SS, . SREB, a GATA transcription factor that directs disparate fates in Blastomyces dermatitidis including morphogenesis and siderophore biosynthesis. PLoS Pathog 2010; 6: e1000846.
   PubMed Web of Science ®Google Scholar
• Nguyen VQ, Sil A. Temperature-induced switch to the pathogenic yeast form of Histoplasma capsulatum requires Ryp1, a conserved transcriptional regulator. Proc Natl Acad Sci USA 2008; 105: 4880–4885.
   PubMed Web of Science ®Google Scholar
• Webster RH, Sil A. Conserved factors Ryp2 and Ryp3 control cell morphology and infectious spore formation in the fungal pathogen Histoplasma capsulatum. Proc Natl Acad Sci USA 2008; 105: 14573–14578.
   PubMed Web of Science ®Google Scholar
• Todd RB, Greenhalgh JR, Hynes MJ, Andrianopoulos A. TupA, the Penicillium marneffei Tup1 homologue, represses both yeast and spore development. Mol Microbiol 2003; 48: 85–94.
   PubMed Web of Science ®Google Scholar
• Longtine MS, Bi E. Regulation of septin organization and function in yeast. Trends Cell Biol 2003; 13: 403–409
   PubMed Web of Science ®Google Scholar
• Krajaejun T, Gauthier GM, Rappleye CA, Sullivan TD, Klein BS. Development and application of a green fluorescent protein sentinel system for identification of RNA interference in Blastomyces dermatitidis illuminates the role of septin in morphogenesis and sporulation. Eukaryot Cell 2007; 6: 1299–1309.
   PubMedGoogle Scholar
• Juvvadi PR, Fortwendel JR, Rogg LE, Steinbach WJ. Differential localization of septins during growth of the human fungal pathogen Aspergillus fumigatus reveal novel functions. Biochem Biophys Res Commum 2011; 415: 238–243.
   Google Scholar
• Hartwell LH. Genetic control of the cell division cycle in yeast IV. Genes controlling bud emergence and cytokinesis. Exp Cell Res 1971; 69: 245–276.
   Web of Science ®Google Scholar
• Alverez-Tabares I, Perez-Martin J. Septins from the phytopathogenic fungus Ustilago maydis are required for proper morphogenesis but dispensable for virulence. PLoS One 2010; 5: e12933.
   Web of Science ®Google Scholar
• Kozubowski L, Heitman J. Septins enforce morphogenetic events during sexual reproduction and contribute to virulence of Cryptococcus neoformans.Mol Microbiol 2010; 75: 658–675.
   Google Scholar
• Warenda AJ, Konopka JB. Septin function in Candida albicans morphogenesis. Mol Biol Cell 2002; 13: 2732–2746.
   PubMed Web of Science ®Google Scholar
• McVeigh I, Morton K. Nutritional studies of Histoplasma capsulatum. Mycopath Mycol Appl 1965; 25: 294–308.
   PubMedGoogle Scholar
• Worsham PL, Goldman WE. Quantitative plating of Histoplasma capsulatum without addition of conditioned medium or siderophores. J Med Vet Mycol 1988; 26: 137–143.
   PubMedGoogle Scholar
• Sullivan TD, Rooney PJ, Klein BS. Agrobacterium tumefaciens integrates transfer DNA into a single chromosomal site of dimorphic fungi and yields homokaryotic progeny from multinucleate yeast. Eukaryot Cell 2002; 1: 895–905.
   PubMedGoogle Scholar
• McDonough ES, Wisniewski TR, Penn LA, Chan DM, McNamara WI. Preliminary studies on conidial liberation of Blastomyces dermatitidis and Histoplasma capsulatum. Sabouraudia 1976; 14: 199–204.
   PubMedGoogle Scholar
• Metzenberg RL. Bird medium: an alternative to Vogel medium. Fung Gen Newslet 2004; 51: 19–20.
   Google Scholar
• Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCt method. Methods 2001; 24: 402–408.
   Google Scholar
• Pan F, Malmberg RL, Momany M. Analysis of septins across kingdoms reveals orthology and new motifs. BMC Evol Biol 2007; 7: 103.
   PubMed Web of Science ®Google Scholar
• Mino M, Tanaka K, Kamei T, . Shs1p: a novel member of septin that interacts with Spa2p, involved with polarized growth in Saccharomyces cerevisiae. Biochem Biophys Res Commun 1998; 251: 732–736.
   PubMed Web of Science ®Google Scholar
• Ozsarac N, Bhattacharyya M, Dawes IA, Clancy MJ. The SPR3 gene encodes a sporulation-specific homologue of the yeast CDC3/10/11/12 family of bud neck microfilaments and is regulated by ABFI. Gene 1995; 164: 157–162.
   PubMed Web of Science ®Google Scholar
• De Virgilio C, Demarini DJ, Pringle JR. SPR28, a sixth member of the septin gene family in Saccharomyces cerevisiae that is expressed specifically in sporulating cells. Microbiology 1996; 142: 2897–2905.
   PubMedGoogle Scholar
• Versele M, Gullbrand B, Shulewitz MJ, . Protein–protein interactions governing septin heteropentamer assembly and septin filament organization in Saccharomyces cerevisiae. Mol Biol Cell 2004; 15: 4568–4583.
   PubMed Web of Science ®Google Scholar
• Casamayor A, Synder M. Molecular dissection of a yeast septin: distinct domains are required for septin interaction, localization and function. Mol Cel Biol 2003; 23: 2767–2777.
   Web of Science ®Google Scholar
• Momany M, Pan F, Malmberg RL. Evolution and conserved domains of the septins. In: Hall PA, Russell SHE, Pringle JR, (eds.). The Septins. 1st edn. New York: Wiley-Blackwell, 2008:35–45.
   Google Scholar
• Wolf E, Kim PS, Berger B. Multicoil: a program for predicting two- and three-stranded coiled coils. Protein Sci 1997; 6: 1179–1189.
   PubMed Web of Science ®Google Scholar
• Boyce KJ, Chang H, D’Souza CA, Kronstad JW. An Ustilago maydis septin is required for filamentous growth in culture and for full symptom development on Maize. Euk Cell 2005; 4: 2044–2056.
   PubMedGoogle Scholar
• Nguyen TQ, Sawa H, Okano H, White JG. The C. elegans septin genes, unc-59 and unc-61, are required for normal postembryonic cytokineses and morphogenesis, but have no essential function in embryogenesis. J Cell Sci 2000; 113; 3825–3837.
   PubMed Web of Science ®Google Scholar
• Adam JC, Pringle JR, Peifer M. Evidence of functional differentiation among Drosophila septins in cytokinesis and cellularization. Mol Biol Cell 2000; 11: 3123–3135.
   PubMed Web of Science ®Google Scholar
• Nakahira M, Macedo JN, Seraphim TV, . A draft of the human septin interactome. PLoS One 2010; 5: e13799.
   Web of Science ®Google Scholar
• Momany M, Zhao J, Lindsey R, Westfall PJ. Characterization of the Aspergillus nidulans septin (asp) gene family. Genetics 2001; 157: 969–977.
   PubMed Web of Science ®Google Scholar
• An H, Morrell JL, Jennings JL, Link AJ, Gould KL. Requirements of fission yeast septins for complex formation, localization, and function. Mol Biol Cell 2004; 15: 5551–5564.
   PubMed Web of Science ®Google Scholar
• Farkasovsky M, Herter P, Beater V. Wittinghofer. Nucleotide binding and filament assembly of recombinant yeast septin complexes. Biol Chem 2005; 386: 643–656.
   PubMed Web of Science ®Google Scholar
• Roncero C, Sanchez Y. Cell separation and the maintenance of the cell integrity during cytokinesis in yeast: the assembly of septum. Yeast 2010; 27: 521–530.
   PubMed Web of Science ®Google Scholar
• Warenda AJ, Kauffman S, Sherrill TP, Becker JM, Konopka JB. Candida albicans septin mutants are defective for invasive growth and virulence. Infect Immun 2003; 71: 4045–4051.
   PubMed Web of Science ®Google Scholar
• Momany M, Hamer JE. The Aspergillus nidulans septin encoding gene, aspB, is essential for growth. Fungal Genetic Biol 1997; 21: 92–100.
   PubMed Web of Science ®Google Scholar