95
Views
0
CrossRef citations to date
0
Altmetric
Research Article

Mechanism of activity and toxicity of Nystatin-Intralipid

, , , &
Pages 422-431 | Received 28 Jun 2012, Accepted 16 Sep 2012, Published online: 23 Oct 2012

References

  • Pound MW, Townsend ML, Dimondi V, Wilson D, Drew RH. Overview of treatment options for invasive fungal infections. Med Mycol 2011; 49: 561–580.
  • Shadkhan Y, Segal E, Bor A, et al. The use of commercially available lipid emulsions for the preparation of amphotericin B-lipid admixtures. J Antimicrob Chemother 1997; 39: 655–658.
  • Shadkchan Y, Segal E. Antifungal activity of amphotericin B-lipid admixtures in experimental systemic candidosis in naive mice. J Antimicrob Chemother 1999; 44: 787–790.
  • Shadkchan Y, Segal E. Treatment of experimental candidosis with amphotericin B-Intralipid admixtures in immunocompromised mice. J Antimicrob Chemother 2001; 48: 245–251.
  • Shadkchan Y, Zaslavsky Z, Segal E. Pharmacokinetics of amphotericin B in serum and tissues in mice treated with amphotericin B-Intralipid. Med Mycol 2003; 41: 15–19.
  • Shadkchan Y, Keisari Y, Segal E. Cytokines in mice treated with amphotericin B-intralipid. Med Mycol 2004; 42: 123–128.
  • Sionov E, Segal E. Treatment of murine systemic aspergillosis with polyene-intralipid admixtures. Med Mycol 2004; 42: 73–80.
  • Ng AW, Wasan KM, Lopez-Berestein G. Development of liposomal polyene antibiotics: an historical perspective. J Pharm Pharm Sci 2003; 6: 67–83.
  • Semis R, Polacheck I, Segal E. Nystatin-intralipid preparation: characterization and in vitroactivity against yeasts and molds. Mycopathologia 2010; 169: 333–341.
  • Collins-Gold LC, Lyons RT, Bartholow LC. Parenteral emulsions for drug delivery. Adv Drug Del Rev 1990; 5: 189–208.
  • Hippalgaonkar K, Majumdar S, Kansara V. Injectable lipid emulsions – advancements, opportunities and challenges. AAPS Pharm Sci Tech 2010; 11: 1526–1540.
  • Washington C, Lance M, Davis SS. Toxicity of amphotericin B emulsion formulations. J Antimicrob Chemother 1993; 31: 806–808.
  • Semis R, Mendlovic S, Polacheck I, et al. Activity of an intralipid formulation of nystatin in murine systemic candidiasis. Int J Antimicrob Agents 2011; 38: 336–340.
  • Altboum Z, Gottlieb S, Lebens GA, et al. Isolation of the Candida albicanshistidinol dehydrogenase (HIS4) gene and characterization of a histidine auxotroph. J Bacteriol 1990; 172: 3898–3904.
  • Klepser ME, Ernst EJ, Lewis RE, et al. Influence of test conditions on antifungal time-kill curve results: Proposal for standardized methods. Antimicrob Agents Chemother 1998; 42: 1207–1212.
  • Sionov E, Roth D, Sandovsky-Losica H, et al. Antifungal effect and possible mode of activity of a compound from the marine sponge Dysidea herbacea. J Infect 2005; 50: 453–460.
  • Segal E, Trygerman O, Gov Y, et al. Adhesion of Candida albicansto epithelial cells: effect of antimycotics. J Mycol Med 1997; 7: 71–76.
  • Polacheck I, Levi M, Guizie M, et al. Mode of action of the antimycotic agent D2 isolated from alfalfa roots. Zbl Bact 1991; 275: 504–512
  • Kotler-Brajtburg J, Price HD, Medoff G, et al. Molecular basis for the selective toxicity of amphotericin B for yeast and filipin for animal cells. Antimicrob Agents Chemother 1974; 5: 377–382.
  • Clinical and Laboratory Standards Institute. Reference method for Broth Dilution Antifungal Susceptibility Testing of Yeasts. Approved standard, Document M27-A3, 3rd ed. Wayne, PA: Clinical and Laboratory Standards Institute, 2008.
  • Brown PS, Wang E, Aroeti B, et al. Definition of distinct compartments in polarized Madin-Darby canine kidney (MDCK) cells for membrane-volume sorting, polarized sorting and apical recycling. Traffic 2000; 1: 124–140.
  • Coligan JE, Bierer B, Margulies DH, Shevach EM, Strober W, Coico R, eds. Current protocols in immunology 1997; supp.21, A.3B. 1–A.3B.2. http://onlinelibrary.wiley.com/doi/10.1002/0471142735.ima03bs21/pdf (12 August 2012, date last accessed).
  • Wang E, Brown PS, Aroeti B, et al. Apical and basolateral endocytic pathways of MDCK cells meet in acidic common endosomes distinct from a nearly-neutral apical recycling endosome. Traffic 2000; 1: 480–493.
  • Sheff DR, Daro EA, Hull M, et al. The receptor recycling pathway contains two distinct populations of early endosomes with different sorting functions. J Cell Biol 1999; 145: 123–139.
  • Apodaca G, Katz LA, Mostov KE. Receptor-mediated transcytosis of IgA in MDCK cells is via apical recycling endosomes. J Cell Biol 1994; 125: 67–86.
  • Brajtburg J, Bolard J. Carrier effects on biological activity of amphotericin B. Clin Microbiol Rev 1996; 9: 512–531.
  • Chen WC, Chou DL, Feingold DS. Dissociation between ion permeability and the lethal action of polyene antibiotics on Candida albicans. Antimicrob Agents Chemother 1978; 13: 914–917.
  • Silva L, Coutinho A, Fedorov A, et al. Competitive binding of cholesterol and ergosterol to the polyene antibiotic nystatin. A fluorescence study. Biophys J. 2006; 90: 3625–9631.
  • te Welscher YM, ten Napel HH, Balagué MM, et al. Natamycin blocks fungal growth by binding specifically to ergosterol without permeabilizing the membrane. J Biol Chem 2008; 283: 6393–6401.
  • Bolard J, Legrand P, Heitz F, et al. One-sided action of amphotericin B on cholesterol-containing membranes is determined by its self- association in the medium. Biochemistry 1991; 30: 5707–5715.
  • Huang W, Zhang Z, Han X, et al. Ion channel behavior of amphotericin B in sterol-free and cholesterol- or ergosterol-containing supported phosphatidylcholine bilayer model membranes investigated by electrochemistry and spectroscopy. Biophys J 2002; 83: 3245–3255.
  • Neumann A, Baginski M, Czub J. How do sterols determine the antifungal activity of amphotericin B? Free energy of binding between the drug and its membrane targets. J Am Chem Soc 2010; 132: 18266–18272.
  • Vertut-Doï A, Ohnishi SI, Bolard J. The endocytic process in CHO cells, a toxic pathway of the polyene antibiotic amphotericin B. Antimicrob Agents Chemother 1994; 38: 2373–2379.
  • Kagan S, Ickowicz D, Shmuel M, et al. Toxicity mechanisms of amphotericin B and its neutralization by conjugation with arabinogalactan. Antimicrob Agents Chemother 2012 Aug 20. (Epub ahead of print).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.