Galectin-3 plays an important role in protection against disseminated candidiasis

References

• Edmond MB, Wallace SE, McClish DK, Pfaller MA, Jones RN, Wenzel RP. Nosocomial bloodstream infections in United States hospitals: a three-year analysis. Clin Infect Dis 1999; 29: 239–244.
   PubMed Web of Science ®Google Scholar
• Pfaller MA, Diekema DJ. Epidemiology of invasive candidiasis: a persistent public health problem. Clin Microbiol Rev 2007; 20: 133–163.
   PubMed Web of Science ®Google Scholar
• Blyth CC, Chen SC, Slavin MA, et al. Not just little adults: candidemia epidemiology, molecular characterization, and antifungal susceptibility in neonatal and pediatric patients. Pediatrics 2009; 123: 1360–1368.
   PubMed Web of Science ®Google Scholar
• Bassetti M, Mikulska M, Viscoli C. Bench-to-bedside review: therapeutic management of invasive candidiasis in the intensive care unit. Crit Care 2010; 14: 244.
   PubMed Web of Science ®Google Scholar
• Falagas ME, Roussos N, Vardakas KZ. Relative frequency of albicans and the various non-albicans Candida spp. among candidemia isolates from inpatients in various parts of the world: a systematic review. Int J Infect Dis 2010; 14: e954–966.
   Google Scholar
• Spiliopoulou A, Dimitriou G, Jelastopulu E, Giannakopoulos I, Anastassiou ED, Christofidou M. Neonatal intensive care unit candidemia: epidemiology, risk factors, outcome, and critical review of published case series. Mycopathologia 2012; 173: 219–228.
   PubMedGoogle Scholar
• Bassetti M, Taramasso L, Nicco E, Molinari MP, Mussap M, Viscoli C. Epidemiology, species distribution, antifungal susceptibility and outcome of nosocomial candidemia in a tertiary care hospital in Italy. PLoS One 2011; 6: e24198.
   PubMed Web of Science ®Google Scholar
• Arendrup M, Horn T, Frimodt-Moller N. In vivo pathogenicity of eight medically relevant Candida species in an animal model. Infection 2002; 30: 286–291.
   PubMed Web of Science ®Google Scholar
• Ortega M, Marco F, Soriano A, et al. Candida species bloodstream infection: epidemiology and outcome in a single institution from 1991 to 2008. J Hosp Infect 2011; 77: 157–161.
   PubMed Web of Science ®Google Scholar
• Arendrup MC, Sulim S, Holm A, et al. Diagnostic issues, clinical characteristics, and outcomes for patients with fungemia. J Clin Microbiol 2011; 49: 3300–3308.
   PubMed Web of Science ®Google Scholar
• Pappas PG, Rex JH, Lee J, et al. A prospective observational study of candidemia: epidemiology, therapy, and influences on mortality in hospitalized adult and pediatric patients. Clin Infect Dis 2003; 37: 634–643.
   PubMed Web of Science ®Google Scholar
• Mellado E, Cuenca-Estrella M, Regadera J, Gonzalez M, Diaz-Guerra TM, Rodriguez-Tudela JL. Sustained gastrointestinal colonization and systemic dissemination by Candida albicans, Candida tropicalis and Candida parapsilosis in adult mice. Diagn Microbiol Infect Dis 2000; 38: 21–28.
   PubMed Web of Science ®Google Scholar
• Benjamin DK Jr, Stoll BJ, Fanaroff AA, et al. Neonatal candidiasis among extremely low birth weight infants: risk factors, mortality rates, and neurodevelopmental outcomes at 18 to 22 months. Pediatrics 2006; 117: 84–92.
   PubMed Web of Science ®Google Scholar
• Cheng SC, Joosten LA, Kullberg BJ, Netea MG. Interplay between Candida albicans and the mammalian innate host defense. Infect Immun 2012; 80: 1304–1313.
   PubMed Web of Science ®Google Scholar
• Netea MG, Brown GD, Kullberg BJ, Gow NA. An integrated model of the recognition of Candida albicans by the innate immune system. Nat Rev Microbiol 2008; 6: 67–78.
   PubMed Web of Science ®Google Scholar
• Fradin C, Poulain D, Jouault T. beta-1,2-linked oligomannosides from Candida albicans bind to a 32-kilodalton macrophage membrane protein homologous to the mammalian lectin galectin-3. Infect Immun 2000; 68: 4391–4398.
   PubMedGoogle Scholar
• Kohatsu L, Hsu DK, Jegalian AG, Liu FT, Baum LG. Galectin-3 induces death of Candida species expressing specific beta-1,2-linked mannans. J Immunol 2006; 177: 4718–4726.
   PubMed Web of Science ®Google Scholar
• Jouault T, El Abed-El Behi M, Martinez-Esparza M, et al. Specific recognition of Candida albicans by macrophages requires galectin-3 to discriminate Saccharomyces cerevisiae and needs association with TLR2 for signaling. J Immunol 2006; 177: 4679–4687.
   PubMed Web of Science ®Google Scholar
• Esteban A, Popp MW, Vyas VK, Strijbis K, Ploegh HL, Fink GR. Fungal recognition is mediated by the association of dectin-1 and galectin-3 in macrophages. Proc Natl Acad Sci USA 2011; 108: 14270–14275.
   PubMed Web of Science ®Google Scholar
• Henderson NC, Sethi T. The regulation of inflammation by galectin-3. Immunol Rev 2009; 230: 160–171.
   PubMed Web of Science ®Google Scholar
• Sato S, St-Pierre C, Bhaumik P, Nieminen J. Galectins in innate immunity: dual functions of host soluble beta-galactoside-binding lectins as damage-associated molecular patterns (DAMPs) and as receptors for pathogen-associated molecular patterns (PAMPs). Immunol Rev 2009; 230: 172–187.
   PubMed Web of Science ®Google Scholar
• Hughes RC. Secretion of the galectin family of mammalian carbohydrate-binding proteins. Biochim Biophys Acta 1999; 1473: 172–185.
   PubMed Web of Science ®Google Scholar
• Bernardes ES, Silva NM, Ruas LP, et al. Toxoplasma gondii infection reveals a novel regulatory role for galectin-3 in the interface of innate and adaptive immunity. Am J Pathol 2006; 168: 1910–1920.
   Google Scholar
• Ferraz LC, Bernardes ES, Oliveira AF, et al. Lack of galectin-3 alters the balance of innate immune cytokines and confers resistance to Rhodococcus equi infection. Eur J Immunol 2008; 38: 2762–2775.
   PubMed Web of Science ®Google Scholar
• Farnworth SL, Henderson NC, Mackinnon AC, et al. Galectin-3 reduces the severity of pneumococcal pneumonia by augmenting neutrophil function. Am J Pathol 2008; 172: 395–405.
   PubMed Web of Science ®Google Scholar
• Nieminen J, St-Pierre C, Bhaumik P, Poirier F, Sato S. Role of galectin-3 in leukocyte recruitment in a murine model of lung infection by Streptococcus pneumoniae. J Immunol 2008; 180: 2466–2473.
   PubMed Web of Science ®Google Scholar
• Ruas LP, Bernardes ES, Fermino ML, et al. Lack of galectin-3 drives response to Paracoccidioides brasiliensis toward a Th2-biased immunity. PLoS One 2009; 4: e4519.
   PubMed Web of Science ®Google Scholar
• Netea MG, van de Veerdonk F, Verschueren I, van der Meer JW, Kullberg BJ. Role of TLR1 and TLR6 in the host defense against disseminated candidiasis. FEMS Immunol Med Microbiol 2008; 52: 118–123.
   PubMed Web of Science ®Google Scholar
• Murciano C, Villamon E, Gozalbo D, Roig P, O’Connor JE, Gil ML. Toll-like receptor 4 defective mice carrying point or null mutations do not show increased susceptibility to Candida albicans in a model of hematogenously disseminated infection. Med Mycol 2006; 44: 149–157.
   PubMed Web of Science ®Google Scholar
• Netea MG, Van Der Graaf CA, Vonk AG, Verschueren I, Van Der Meer JW, Kullberg BJ. The role of toll-like receptor (TLR) 2 and TLR4 in the host defense against disseminated candidiasis. J Infect Dis 2002; 185: 1483–1489.
   PubMed Web of Science ®Google Scholar
• Netea MG, Sutmuller R, Hermann C, et al. Toll-like receptor 2 suppresses immunity against Candida albicans through induction of IL-10 and regulatory T cells. J Immunol 2004; 172: 3712–3718.
   PubMed Web of Science ®Google Scholar
• Bellocchio S, Montagnoli C, Bozza S, et al. The contribution of the Toll-like/IL-1 receptor superfamily to innate and adaptive immunity to fungal pathogens in vivo. J Immunol 2004; 172: 3059–3069.
   PubMed Web of Science ®Google Scholar
• Li X, Utomo A, Cullere X, et al. The beta-Glucan receptor Dectin-1 activates the Integrin Mac-1 in neutrophils via vav protein signaling to promote Candida albicans clearance. Cell Host Microbe 2011; 10: 603–615.
   PubMed Web of Science ®Google Scholar
• van de Veerdonk FL, Netea MG, Jansen TJ, et al. Redundant role of TLR9 for anti-Candida host defense. Immunobiology 2008; 213: 613–620.
   Google Scholar
• Villamon E, Gozalbo D, Roig P, O’Connor JE, Fradelizi D, Gil ML. Toll-like receptor-2 is essential in murine defenses against Candida albicans infections. Microbes Infect 2004; 6: 1–7.
   PubMed Web of Science ®Google Scholar
• Saijo S, Fujikado N, Furuta T, et al. Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans. Nat Immunol 2007; 8: 39–46.
   PubMed Web of Science ®Google Scholar
• Taylor PR, Tsoni SV, Willment JA, et al. Dectin-1 is required for beta-glucan recognition and control of fungal infection. Nat Immunol 2007; 8: 31–38.
   PubMed Web of Science ®Google Scholar
• Saijo S, Ikeda S, Yamabe K, et al. Dectin-2 recognition of alpha- mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans. Immunity 2010; 32: 681–691.
   PubMed Web of Science ®Google Scholar
• Benjamin DK Jr, Stoll BJ, Gantz MG, et al. Neonatal candidiasis: epidemiology, risk factors, and clinical judgment. Pediatrics 2010; 126: e865–873.
   PubMed Web of Science ®Google Scholar
• Vankrunkelsven A, De Ceulaer K, Hsu D, Liu FT, De Baetselier P, Stijlemans B. Lack of galectin-3 alleviates trypanosomiasis-associated anemia of inflammation. Immunobiology 2010; 215: 833–841.
   PubMedGoogle Scholar
• Li Y, Komai-Koma M, Gilchrist DS, et al. Galectin-3 is a negative regulator of lipopolysaccharide-mediated inflammation. J Immunol 2008; 181: 2781–2789.
   PubMed Web of Science ®Google Scholar
• Alves CM, Silva DA, Azzolini AE, et al. Galectin-3 plays a modulatory role in the life span and activation of murine neutrophils during early Toxoplasma gondii infection. Immunobiology 2010; 215: 475–485.
   PubMed Web of Science ®Google Scholar
• Karlsson A, Christenson K, Matlak M, et al. Galectin-3 functions as an opsonin and enhances the macrophage clearance of apoptotic neutrophils. Glycobiology 2009; 19: 16–20.
   PubMed Web of Science ®Google Scholar
• Fermino ML, Polli CD, Toledo KA, et al. LPS-induced galectin-3 oligomerization results in enhancement of neutrophil activation. PLoS One 2011; 6: e26004.
   PubMed Web of Science ®Google Scholar
• Fernandez GC, Ilarregui JM, Rubel CJ, et al. Galectin-3 and soluble fibrinogen act in concert to modulate neutrophil activation and survival: involvement of alternative MAPK pathways. Glycobiology 2005; 15: 519–527.
   PubMed Web of Science ®Google Scholar
• Sato S, Ouellet N, Pelletier I, Simard M, Rancourt A, Bergeron MG. Role of galectin-3 as an adhesion molecule for neutrophil extravasation during streptococcal pneumonia. J Immunol 2002; 168: 1813–1822.
   Web of Science ®Google Scholar
• Acosta-Rodriguez EV, Montes CL, Motran CC, et al. Galectin-3 mediates IL-4-induced survival and differentiation of B cells: functional cross-talk and implications during Trypanosoma cruzi infection. J Immunol 2004; 172: 493–502.
   PubMedGoogle Scholar
• Fowler M, Thomas RJ, Atherton J, Roberts IS, High NJ. Galectin-3 binds to Helicobacter pylori O-antigen: it is upregulated and rapidly secreted by gastric epithelial cells in response to H. pylori adhesion. Cell Microbiol 2006; 8: 44–54.
   Google Scholar
• Sato S, Hughes RC. Regulation of secretion and surface expression of Mac-2, a galactoside-binding protein of macrophages. J Biol Chem 1994; 269: 4424–4430.
   PubMed Web of Science ®Google Scholar
• Demmert M, Faust K, Bohlmann MK, et al. Galectin-3 in cord blood of term and preterm infants. Clin Exp Immunol 2012; 167: 246–251.
   PubMedGoogle Scholar
• Tsai NY, Laforce-Nesbitt SS, Tucker R, Bliss JM. A murine model for disseminated candidiasis in neonates. Pediatr Res 2011; 69: 189–193.
   PubMedGoogle Scholar
• Trofa D, Soghier L, Long C, Nosanchuk JD, Gacser A, Goldman DL. A rat model of neonatal candidiasis demonstrates the importance of lipases as virulence factors for Candida albicans and Candida parapsilosis. Mycopathologia 2011; 172: 169–178.
   PubMed Web of Science ®Google Scholar