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Original Article

Comparison of the efficacy and endometrial safety of two estradiol valerate/dienogest combinations and Kliogest® for continuous combined hormone replacement therapy in postmenopausal women

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Pages 109-118 | Received 01 Feb 2000, Accepted 16 May 2000, Published online: 05 Aug 2009

References

  • Tang M S, Jacobs D, Stern Y, et al. Effect of oestrogen during menopause on risk and age of onset of Alzheimer's disease. Lancet 1996; 348: 429–32
  • Gambrell RD, Jr. Prevention of endometrial cancer with progestogens. Maturitas 1988; 8: 159–68
  • Hammond C B, Jelovsek F R, Lee K L, Creasman W T, Parker R T. Effects of long-term estrogen replacement therapy. II Neoplasia. Am J Obstet Gynecol 1979; 133: 537–47
  • Persson I, Adami H-O, Bergkvist L, et al. Risk of endometrial cancer after treatment with oestrogens alone or in conjunction with progestogens: results of a prospective study. Br Med J 1989; 298: 147–51
  • Whitehead M I, Townsend P T, Pryse-Davies J, Ryder T A, King R JB. Effects of estrogens and progestins on the biochemistry and morphology of the postmenopausal endometrium. N Engl J Med 1981; 305: 1599–605
  • Whitehead M I, Fraser D. The effects of estrogens and progestogens on the endometrium: a modern approach to treatment. Obstet Gynecol Clin North Am 1987; 14: 299–319
  • Henderson B E, Paganini-Hill A, Ross R K. Estrogen replacement therapy and protection from acute myocardial infarction. Am J Obstet Gynecol 1988; 159: 312–17
  • Bolaji I I, Grimes H, Mortimer G, Tallon D F, Fottrel P F, Eamon M O. Low-dose progesterone therapy in oestrogenised postmenopausal women: effects of plasma lipids, lipoproteins and liver function parameters. Eur J Obstet Gynecol 1993; 48: 61–8
  • Hulley S, Grady D, Bush T, et al. Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. J Am Med Assoc 1998; 280: 605–13
  • Mattsson L-Å, Cullberg G, Samsioe G. Evaluation of a continuous oestrogen-progestogen regimen for climacteric complaints. Maturitas 1982; 4: 95–102
  • Obel E B, Munk-Jensen N, Svenstrup B, et al. A two-year double-blind controlled study of the clinical effect of combined and sequential postmenopausal replacement therapy and steroid metabolism during treatment. Maturitas 1993; 16: 13–21
  • Staland B. Continuous treatment with natural oestrogens and progestogens. A method to avoid endometrial stimulation. Maturitas 1981; 3: 145–56
  • Christiansen C, Riis B J. Five years with continuous combined oestrogen/progestogen therapy. Effects of calcium metabolism, lipoproteins, and bleeding pattern. Br J Obstet Gynaecol 1990; 97: 1087–92
  • Hassager C, Christiansen C. Blood pressure during oestrogen/progestogen substitution therapy in healthy post-menopausal women. Maturitas 1988; 9: 315–23
  • Campagnoli C, Biglia N, Lanza M G, Lesca L, Peris C, Sismondi P. Androgenic progestogens oppose the decrease of insulin-like growth factor I serum level induced by conjugated estrogens in postmenopausal women. Preliminary report. Maturitas 1994; 19: 25–31
  • Cullen K J, Allison A, Martire I, Ellis M, Singer C. Insulin-like growth factor expression in breast cancer epithelium and stroma. Breast Cancer Res Treat 1992; 22: 21–9
  • Jordan V C, Fritz N F, Tormey D C. Long-term adjuvant therapy with tamoxifen: effects on sex hormone binding globulin and antithrombin III. Cancer Res 1987; 47: 4517–19
  • Staffa J A, Newschaffer C J, Jones J K, Miller V. Progestins and breast cancer: an epidemiologic review. Fertil Steril 1992; 57: 473–91
  • Byrjalsen I, Thormann L, Meinecke B, Riis B J, Christiansen C. Serum placental protein 14 (PP14) reflects endometrial status during hormone replacement therapy. Hum Reprod 1992; 7: 1042–7
  • Stanczyk F Z. Introduction: structure-function relationships, metabolism, pharmacokinetics and potency of progestins. Drugs Today 1996; 32(Suppl H)1–14
  • Müller A, Mück A O, Gräser T, Mellinger U, Oettel M, Lippert T H. The influence of a continuous-combined HRT regimen with estradiol valerate and dienogest on bleeding pattern and endometrium of postmenopausal women. J Menopause 1998; 5: 17–22
  • Gräser T, Oettel M. Organ targeting with the oral progestin dienogest. Drugs Today 1996; 32(Suppl H)43–55
  • Oettel M, Carol W, Elger W, et al. A 19-norprogestin without a 17α-ethinyl group. II. Dienogest from a pharmacodynamic point of view. Drugs Today 1995; 31: 517–36
  • Katsuki Y, Shibutani Y, Aoki D, Nozawa S. Dienogest, a novel synthetic steroid, overcomes hormone-dependent cancer in a different manner than progestins. Cancer 1997; 79: 169–76
  • Udoff L, Langenberg P, Adashi E Y. Combined continuous hormone replacement therapy: a critical review. Obstet Gynecol 1995; 86: 306–16
  • Kupperman H S, Blatt M HG, Wiesbader H, Filler W. Comparative clinical evaluation of estrogenic preparations by the menopausal and amenorrheal indices. J Clin Endocrinol 1953; 13: 688–703
  • Marslew U, Riis B, Christiansen C. Progestogens: therapeutic and adverse effects in early postmenopausal women. Maturitas 1991; 13: 7–16
  • Committee for Proprietary Medicinal Products. Points to Consider on Hormone Replacement Therapy. CPMP/EWP/021/97. CPMP, London 1997
  • Whitehead M I, Hillard T C, Crook D. The role and use of progestogens. Obstet Gynecol 1990; 75: 59S–76S
  • Kuhnz W, Hcuner A, Hümpel M, Seifert W, Michaelis K. In vivo conversion of norethisterone and norethisterone acetate to ethinyl estradiol in postmenopausal women. Contraception 1997; 56: 379–85

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