585
Views
48
CrossRef citations to date
0
Altmetric
Review

Therapeutic options for postmenopausal female sexual dysfunction

, , , , , , , , , , , , & show all
Pages 103-120 | Received 05 Dec 2008, Accepted 23 Oct 2009, Published online: 03 Dec 2009

References

  • Graziottin A. The biological basis of female sexuality. Int J Clin Pharm 1998;13(Suppl 6):S15–S22
  • Castelo-Branco C, Cancelo MJ, Chedraui P. Female sexual dysfunction in postmenopausal women. Expert Opin Ther Patents 2007;17:639–647
  • Basson R. Female sexual response: the role of drugs in the management of sexual dysfunction. Obstet Gynecol 2001;98:350–353
  • Rosen RC, Taylor JF, Leiblum SR, Bachmann GA. Prevalence of sexual dysfunction in women: results of a survey study of 329 women in an outpatient gynecological clinic. J Sex Marital Ther 1993;19:171–188
  • Dennerstein L, Randolph J, Taffe J, Dudley E, Burger H. Hormones, mood, sexuality, and the menopausal transition. Fertil Steril 2002;77(Suppl 4):S42–S48
  • Graziottin A, Leiblum SR. Biological and psychosocial pathophysiology of female sexual dysfunction during the menopausal transition. J Sex Med 2005;2(Suppl 3):133–145
  • Hayes R, Dennerstein L. The impact of aging on sexual function and sexual dysfunction in women: a review of population-based studies. J Sex Med 2005;2:317–330
  • Bruce D, Rymer J. Symptoms of the menopause. Best Pract Res Clin Obstet Gynaecol 2009;23:25–32
  • Dennerstein L, Goldstein I. Postmenopausal female sexual dysfunction: at a crossroads. J Sex Med 2005;2(Suppl 3):116–117
  • McCoy NL, Davidson JM. A longitudinal study of the effects of menopause on sexuality. Maturitas 1985;7:203–210
  • Sherwin BB. Changes in sexual behavior as a function of plasma sex steroid levels in post-menopausal women. Maturitas 1985;7:225–233
  • Warnock JK, Clayton A, Croft H, Segraves R, Biggs FC. Comparison of androgens in women with hypoactive sexual desire disorder: those on combined oral contraceptives (COCs) vs. those not on COCs. J Sex Med 2006;3:878–882
  • Davison SL, Bell R, Donath S, Montalto JG, Davis SR. Androgen levels in adult females: changes with age, menopause, and oophorectomy. J Clin Endocrinol Metab 2005;90:3847–3853
  • Basson R, Althof S, Davis S, et al Summary of the recommendations on sexual dysfunctions in women. J Sex Med 2004;1:24–34
  • Hatzichristou D, Rosen RC, Broderick G, et al Clinical evaluation and management strategy for sexual dysfunction in men and women. J Sex Med 2004;1:49–57
  • Nappi R, Salonia A, Traish AM, et al Clinical biologic pathophysiologies of women's sexual dysfunction. J Sex Med 2005;2:4–25
  • Palacios S, Castaño R, Grazziotin A. Epidemiology of female sexual dysfunction. Maturitas 2009;69:119–123
  • Raina R, Pahlajani G, Khan S, Gupta S, Agarwal A, Zippe CD. Female sexual dysfunction: classification, pathophysiology, and management. Fertil Steril 2007;88:1273–1284
  • Diagnostic and Statistical Manual of Mental Disorders-IV-TR. Washington, DC: American Psychiatric Association, 2003.
  • World Health Organization International Statistical Classifications of Diseases and Related Health Problems (ICD-10). Geneva: World Health Organization, 1992
  • Basson R. Women's sexual function and dysfunction: current uncertainties, future directions. Int J Impot Res 2008;20:466–478
  • Basson R, Berman J, Burnett A, et al Report of the International Consensus Development conference on female sexual dysfunction: definitions and classifications. J Urol 2000;163:888–893
  • Laumann EO, Paik A, Rosen RC. Sexual dysfunction in the United States: prevalence and predictors. JAMA 1999;281:537–544
  • Hayes RD, Bennet CM, Fairley CK, Dennerstein L. What can prevalence studies tell us about female sexual difficulty and dysfunction. J Sex Med 2006;3:589–595
  • Lindau ST, Schumm LP, Laumann EO, Levinson W, O'Muircheartaigh CA, Waite LJ. A study of sexuality and health among older adults in the United States. N Engl J Med 2007;357:762–774
  • Dennerstein L, Koochaki P, Barton I, Graziottin A. Hypoactive sexual desire disorder in menopausal women: a survey of Western European women. J Sex Med 2006;3:212–222
  • Leiblum SR, Koochaki PE, Rodenberg CA, Barton IP, Rosen RC. Hypoactive sexual desire disorder in postmenopausal women: US results from the Women's International Study of Health and Sexuality (WISHes). Menopause 2006;13:46–56
  • Graziottin A. Prevalence and evaluation of sexual health problems – HSDD in Europe. J Sex Med 2007;4(Suppl 3):211–219
  • Dennerstein L, Lehert P, Koochaki P, Graziottin A, Leiblum S, Alexander JA. A symptomatic approach to understanding women's health experiences: a cross-cultural comparison of women aged 20 to 70 years. Menopause 2007;14:1–9
  • West SL, D'Aloisio AA, Agans RP, Kalsbeek WD, Borisov NN, Thorp JM. Prevalence of low sexual desire and hypoactive sexual desire disorder in a nationally representative sample of US women. Arch Intern Med 2008;168:1441–1449
  • Heiman J, Piccolo L, Piccolo J. Becoming Orgasmic: A Sexual Growth Program for Women. Paramus: Prentice Hall PTR, 1976
  • Davis SR, Guay AT, Shifren JL, Mazer NA. Endocrine aspects of female sexual dysfunction. J Sex Med 2004;1:82–6
  • Davis SR, van der Mooren MJ, van Lunsen RHW, et al Efficacy and safety of a testosterone patch for the treatment of hypoactive sexual desire disorder in surgically menopausal women: a randomized, placebo-controlled trial. Menopause 2006;13:387–96
  • Shifren JL. The role of androgens in female sexual dysfunction. Mayo Clin Proc 2004;79:S19–S24
  • Traish A, Kim NN. Measurement of circulating levels of total and free testosterone. In Goldstein I, Meston C, Davis S, eds. Women's Sexual Function and Dysfunction: Study, Diagnosis, and Treatment. New York: Taylor and Francis, 2005:416
  • Sherwin BB. The impact of different doses of estrogen and progestin on mood and sexual behavior in postmenopausal women. J Clin Endocrinol Metab 1991;72:336–343
  • Wiklund I, Karlberg J, Mattsson LA. Quality of life of postmenopausal women on a regimen of transdermal estradiol therapy: a double-blind placebo-controlled study. Am J Obstet Gynecol 1993;168:824–830
  • Nathorst-Boos J, Wiklund I, Mattsson LA, Sandin K, von Schoultz B. Is sexual life influenced by transdermal estrogen therapy? A double blind placebo controlled study in postmenopausal women. Acta Obstet Gynecol Scand 1993;72:656–660
  • Nappi RE, Polatti F. The use of estrogen therapy in women's sexual functioning (CME). J Sex Med 2009;6:603–616
  • Panksepp J. Seeking systems and anticipatory states of the nervous system. In Panksepp J, ed. Affective Neuroscience: the Foundations of Human and Animal Emotions. New York: Oxford University Press, 1998:144–163
  • Studd JWW, Collins WP, Chakravarti S, Newton JR, Oram D, Parsons A. Oestradiol and testosterone implants in the treatment of psychosexual problems of postmenopausal women. Br J Obstet Gynecol 1977;84:314–315
  • Cardozo L, Gibb DM, Tuck SM, Thom MH, Studd JW, Cooper DJ. The effects of subcutaneous hormone implants during climacteric. Maturitas 1984;3:177–184
  • Dow MG, Hart DM, Forrest CA. Hormonal treatments of sexual unresponsiveness in postmenopausal women: a comparative study. Br J Obstet Gynaecol 1983;90:361–366
  • Burger HG, Hailes J, Nelson J, Menelaus M. Effect of combined implants of oestradiol and testosterone on libido in postmenopausal women. Br Med J 1987;294:936–937
  • Davis SR, McCloud P, Strauss BJ, Burger H. Testosterone enhances oestradiol's effects on postmenopausal bone density and sexuality. Maturitas 1995;21:227–236
  • Bagatell CJ, Bremner WJ. Androgens in men – uses and abuses. N Engl J Med 1996;334:707–714
  • Sarrel P, Dobay B, Wiita B. Estrogen and estrogen-androgen replacement in postmenopausal women dissatisfied with estrogen-only therapy. Sexual behavior and neuroendocrine responses. J Reprod Med 1998;43:847–856
  • Lobo RA, Rosen RC, Yang H-M, Block B, Van Der Hoop RG. Comparative effects of oral esterified oestrogens with and without methyl testosterone on endocrine profiles and dimensions of sexual function in postmenopausal women with hypoactive sexual desire. Fertil Steril 2003;79:1341–1352
  • Floter A, Nathorst-Boos J, Carlstrom K, von Schoultz B. Addition of testosterone to oestrogen replacement therapy in oophorectomized women: effects on sexuality and well-being. Climacteric 2002;5:357–365
  • Blümel JE, Del Pino M, Aprikian D, Vallejo S, Sarrá S, Castelo-Branco C. Effect of androgens combined with hormone therapy on quality of life in post-menopausal women with sexual dysfunction. Gynecol Endocrinol 2008;24:691–695
  • Sherwin BB, Gelfand MM, Brender W. Androgen enhances sexual motivation in females: a prospective, crossover study of sex steroid administration in surgical menopause. Psychosom Med 1985;47:339–351
  • Nathorst-Boos J, Floter A, Jarkander-Rolff M, Carlstrom K, von Schoultz B. Treatment with percutanous testosterone gel in postmenopausal women with decreased libido – effects on sexuality and psychological general well-being. Maturitas 2006;53:11–18
  • Somboonporn W, Davis S, Seif MW, Bell R. Testosterone for peri- and postmenopausal women. Cochrane Database Syst Rev 2005;(4): CD004509. DOI: 10.1002/14651858.CD004509.pub2
  • Buster JE, Kingsberg SA, Aguirre O, et al Testosterone patch for low sexual desire in surgically menopausal women: a randomized trial. Obstet Gynecol 2005;105:944–952
  • Simon J, Braunstein G, Nachtigall L, et al Testosterone patch increases sexual activity and desire in surgically menopausal women with hypoactive sexual desire disorder. J Clin Endocrinol Metab 2005;90:5226–5233
  • Shifren JL, Davis SR, Moreau M, et al Testosterone patch for the treatment of hypoactive sexual desire disorder in naturally menopausal women: results from the INTIMATE NM1 Study. Menopause 2006;13:770–779
  • Davis SR, Moreau M, Kroll R, et al Testosterone for low libido in postmenopausal women not taking estrogen. N Engl J Med 2008;359:2005–2017
  • Arlt W. Dehydroepiandrosterone replacement in women with adrenal insufficiency. N Engl J Med 1999;341:1013–1020
  • Lovas K, Gebre-Medhin G, Trovik TS, et al Replacement of dehydroepiandrosterone in adrenal failure: no benefit for subjective health status and sexuality in a 9-month, randomized, parallel group clinical trial. J Clin Endocrinol Metab 2003;88:1112–1118
  • Hunt PJ, Gurnell EM, Huppert FA, et al Improvement in mood and fatigue after dehydroepiandrosterone replacement in Addison's disease in a randomized, double blind trial. J Clin Endocrinol Metab 2000;85:4650–4656
  • Morales AJ, Nolan JJ, Nelson JC, Yen SS. Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age. J Clin Endocrinol Metab 1994;78:1360–1367
  • Castelo-Branco C, Vicente JJ, Figueras F, et al Comparative effects of estrogens plus androgens and tibolone on bone, lipid pattern and sexuality in postmenopausal women. Maturitas 2000;34:161–168
  • Laan E, van Lunsen RH, Everaerd W. The effects of tibolone on vaginal blood flow, sexual desire and arousability in postmenopausal women. Climacteric 2001;4:28–41
  • Nathorst-Boos J, Hammar M. Effect on sexual life – a comparison between tibolone and a continuous estradiol-norethisterone acetate regimen. Maturitas 1997;26:15–20
  • Basson R, McInnes R, Smith MD, Hodgson G, Koppiker N. Efficacy and safety of sildenafil citrate in women with sexual dysfunction associated with female sexual arousal disorder. J Womens Health Gend Based Med 2002;11:367–377
  • Kaplan SA, Reis RB, Kohn IJ, et al Safety and efficacy of sildenafil in postmenopausal women with sexual dysfunction. Urology 1999;53:481–486
  • Berman JR, Berman LA, Lin H, et al Effect of sildenafil on subjective and physiologic parameters of the female sexual response in women with sexual arousal disorder. J Sex Marital Ther 2001;27:411–420
  • Caruso S, Intelisano G, Lupo L, Agnello C. Premenopausal women affected by sexual arousal disorder treated with sildenafil: a double-blind, cross-over, placebo-controlled study. Br J Obstet Gynaecol 2001;108:623–628
  • Rosen RC, Phillips NA, Gendrano NC III, Ferguson DM. Oral phentolamine and female sexual arousal disorder: a pilot study. J Sex Marital Ther 1999;25:137–144
  • Billups KL, Berman L, Berman J, Metz ME, Glennon ME, Goldstein I. A new non-pharmacological vacuum therapy for female sexual dysfunction. J Sex Marital Ther 2001;27:435–441
  • Wilson SK, Delk JR, Billups KL. Treating symptoms of female sexual arousal disorder with the Eros-Clitoral Therapy Device. J Gend Specif Med 2001;4:54–58

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.