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Original Article

Long-term endometrial and breast safety of a specific, standardized soy extract

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Pages 368-375 | Received 28 Sep 2009, Accepted 18 Jan 2010, Published online: 10 Apr 2010

References

  • Tinelli A, Vergara D, Martignago R, Leo G, Malvasi A, Tinelli R. Hormonal carcinogenesis and socio-biological development factors in endometrial cancer: a clinical review. Acta Obstet Gynecol Scand 2008;87:1101–13
  • Allen NE, Key TJ, Dossus L, et al Endogenous sex hormones and endometrial cancer risk in women in the European Prospective Investigation into Cancer and Nutrition (EPIC). Endocr Relat Cancer 2008;15:485–97
  • Crady O, Gebretsadik T, Ernster K, Petitti V. Hormonal replacement therapy and endometrial cancer risk: a meta-analysis. Obstet Gynecol 1995;85:304–13
  • Personn I, Adami HO, Bergkvist L, et al Risk of endometrial cancer after treatment with estrogens alone or in conjunction with progestogens: results of a prospective study. Br Med J 1989;298:147–51
  • Chlebowski RT, Hendrix SL, Langer RD, et al WHI Investigators. Influence of estrogen plus progestin on breast cancer and mammography in healthy postmenopausal women: the Women's Health Initiative randomized trial. JAMA 2003;289:3243–53
  • Beral V; Million Women Study Collaborators. Breast cancer and hormone-replacement therapy in the Million Women Study. Lancet 2003;362:419–27
  • Fournier A, Berrino F, Riboli E, Avenel V, Clavel-Chapelon F. Breast cancer risk in relation to different types of hormone replacement therapy in the E3N-EPIC cohort. Int J Cancer 2005;114:448–54
  • Espié M, Daures JP, Chevallier T, Mares P, Micheletti MC, De Reilhac P. Breast cancer incidence and hormone replacement therapy: results from the MISSION study, prospective phase. Gynecol Endocrinol 2007;23:391–7
  • Kuiper GG, Carlsson B, Grandien K, et al Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. Endocrinology 1997;138:863–70
  • Wasburn S, Burke GL, Morgan T, Anthony M. Effect of soy protein supplementation on serum lipoproteins, blood pressure, and menopausal symptoms in perimenopausal women. Menopause 1999;6:7–13
  • Brzezinski A, Adlercreutz H, Shaoul R, et al Short-term effects of phytoestrogen-rich diet on postmenopausal women. Menopause 1997;4:89–94
  • Albertazzi P, Pansini F, Bonaccorsi G, Zanotti L, Forini E, De Aloysio D. The effect of dietary soy supplementation on hot flushes. Obstet Gynecol 1998;91:6–11
  • Drapier-Faure E, Chantre P, Mares P. Effects of a standardized soy extract on hot flushes: a multicentre, double-blind, randomized, placebo-controlled study Menopause 2002;9:329–34
  • Scambia G, Mango D, Signorile P, et al Clinical effects of a standardized soy extract in postmenopausal women: a pilot study. Menopause 2000;7:105–11
  • North American Menopause Society. Treatment of menopause-associated vasomotor symptoms: position statement of The North American Menopause Society. Menopause 2004;11:11–33
  • Breinholt V, Hossaini A, Svendsen GW, Brouwer C, Nielsen E. Estrogenic activity of flavonoids in mice: the importance of estrogen receptor distribution metabolism and bioavailabilty. Food Chem Toxicol 2000;38:555–64
  • Santell R, Chang Y, Nair M, Helferich W. Dietary genistein exerts estrogenic effects upon the uterus, mammary gland and the hypothalamic/pituitary axis in rats. J Nutr 1997;127:263–9
  • Foth D, Cline JM. Effects of mammalian and plant estrogens on mammary glands and uteri of macaques Am J Clin Nutr 1998;68(Suppl):1413–17S
  • Hale GE, Hughes CL, Robboy SJ, Agarwal SK, Bievre M. A double-blind randomized study on the effects of red clover isoflavones on the endometrium. Menopause 2001;8:338–46
  • Unfer V, Casini ML, Castabile L, Mignosa M, Gerli S, Di Renzo GC. Endometrial effects of long-term treatment with phytoestrogens: a randomized, double-blind, placebo-controlled study. Fertil Steril 2004;82:145–48
  • Rose DP, Boyar AP, Wynder EL. International comparisons of mortality rates for cancer of the breast, ovary, prostate, and colon, and per capita food consumption. Cancer 1986;58:2363–71
  • Wu AH, Ziegler RG, Nomura AM, et al Soy intake and risk of breast cancer in Asians and Asian Americans. Am J Clin Nutr 1998;68(6):1437–43S
  • Lee HP, Gourley L, Duffy SW, Estéve J, Lee J, Day NE. Dietary effects on breast-cancer risk in Singapore. Lancet 1991;337:1197–200
  • Boyd NF, Byng JW, Jong RA, et al Quantitative classification of mammographic densities and breast cancer risk: results from the Canadian National Breast Screening Study. J Natl Cancer Inst 1995;87:670–5
  • Palacios S, Pornel B, Bergeron C, et al Endometrial safety assessment of a specific and standardized soy extract according to international guidelines. Menopause 2007;14:1006–11
  • Balk JL, Whiteside DA, Naus G, De Ferrari E, Roberts JM. A pilot study of effects of phytoestrogens supplementation on post menopausal endometrium. J Soc Gynecol Invest 2002;9:238–42
  • Perrotti M, Fabio E, Modena AB, Rinaldi M, Omodu U, Vignano P. Effects of soy-derived isoflavones on hot flushes, endometrial thickness, and the pulsatility index of the uterine and cerebral arteries. Fertil Steril 2003;79:1112–17
  • Sammartino A, Di Carlo C, Mandato VD, Bifulco G, Di Stefano M, Nappi C. Effects of genistein on the endometrium: ultrasonographic evaluation. Gynecol Endocrinol 2003;17:45–9
  • EMEA Committee for Proprietary Medicinal Products. Human Medicines Evaluation Unit. Points to consider on hormone replacement therapy. 19 November 1997.
  • Langer RD, Landgren BM, Rymer J, Helmond FA; OPAL Investigators. Effects of tibolone and continuous combined conjugated equine estrogen/medroxyprogesterone acetate on the endometrium and vaginal bleeding: results of the OPAL study. Am J Obstet Gynecol 2006;195:1320–7
  • Gredmark T, Kvint S, Havel G, Mattsson L. Histopathological findings in women with post menopausal bleeding. Br J Obstet Gynecol 1995;102:133–6
  • Ginsbourg J, Prelevic GM. Cause of vaginal bleeding in post menopausal women taking tibolone. Maturitas 1996;24:107–10
  • Presta M. Sex hormones modulate the synthesis of basic fibroblast growth factor in human endometrial adenocarcinoma cells: implications for the neovascularization of normal and neoplastic endometrium. J Cell Physiol 1988;137:593–7
  • Torry DS, Holt VJ, Keenan JA, Harris G, Caudle MR, Torry RJ. Vascular endothelial growth factor expression in cycling human endometrium. Fertil Steril 1996;66:72–80
  • Pornel B, Lemaur Gh, Rovenne S, et al Breast density and cancer risk: latest news in breast safety of soy isoflavones. Climacteric 2008;11(Suppl 2):302
  • Maskarinec G, Takata Y, Franke AA, Williams AE, Murphy SP. A 2-year soy intervention in premenopausal women does not change mammographic densities. J Nutr 2004;134:3089–94

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