Strontium ranelate effect in postmenopausal women with different clinical levels of osteoarthritis

References

• Carbone LD, Nevitt MC, Wildy K, et al The relationship of antiresorptive drug use to structural findings and symptoms of knee osteoarthritis. Arthritis Rheum 2004;50:3516–3525
   PubMed Web of Science ®Google Scholar
• Felson DT, Neogi T. Osteoarthritis: is it a disease of cartilage or of bone? Arthritis Rheum 2004;50:341–344
   PubMed Web of Science ®Google Scholar
• Felson DT, Nevitt MC. The effects of estrogen on osteoarthritis. Curr Opin Rheumatol 1998;10:269–272
   PubMedGoogle Scholar
• Hayami T, Pickarski M, Wesolowski GA, et al The role of subchondral bone remodeling in osteoarthritis: reduction of cartilage degeneration and prevention of osteophyte formation by alendronate in the rat anterior cruciate ligament transection model. Arthritis Rheum 2004;50:1193–1206
   PubMed Web of Science ®Google Scholar
• Hayami T, Pickarski M, Zhuo Y, Wesolowski GA, Rodan GA, Duong LT. Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis. Bone 2006;38:234–243
   PubMed Web of Science ®Google Scholar
• Karsdal MA, Leeming DJ, Dam EB, et al Should subchondral bone turnover be targeted when treating osteoarthritis? Osteoarthritis Cartilage 2008;16:638–646
   PubMed Web of Science ®Google Scholar
• Reginster JY, Seeman E, De Vernejoul MC, et al Strontium ranelate reduces the risk of nonvertebral fractures in post-menopausal women with osteoporosis: TROPOS study. J Clin Endoc Metab 2005;90:2816–2822
   PubMed Web of Science ®Google Scholar
• Reijman M, Hazes JM, Bierma-Zeinstra SM, et al A new marker for osteoarthritis: cross-sectional and longitudinal approach. Arthritis Rheum 2004;50:2471–2478
   PubMed Web of Science ®Google Scholar
• Bagger YZ, Tanko LB, Alexandersen P, et al Oral salmon calcitonin induced suppression of urinary collagen type II degradation in postmenopausal women: A new potential treatment of osteoarthritis. Bone 2005;37:425–430
   PubMed Web of Science ®Google Scholar
• Meulenbelt I, Kloppenburg M, Kroon HM, et al Urinary CTX-II levels are associated with radiographic subtypes of osteoarthritis in hip, knee, hand, and facet joints in subject with familial osteoarthritis at multiple sites: the GARP study. Ann Rheum Dis 2006;65:360–365
   PubMed Web of Science ®Google Scholar
• Alexandersen P, Karsdal MA, Qvist P, Reginster JY, Christiansen C. Strontium ranelate reduces the urinary level of cartilage degradation biomarker CTX-II in postmenopausal women. Bone 2007;40:218–222
   PubMed Web of Science ®Google Scholar
• Christgau S, Garnero P, Fledelius C, et al Collagen type II C-telopeptide fragments as an index of cartilage degradation. Bone 2001;29:209–215
   PubMed Web of Science ®Google Scholar
• Hunter DJ, Spector TD. The role of bone metabolism in osteoarthritis. Curr Rheumatol Rep 2003;5:15–19
   PubMedGoogle Scholar
• Mansell JP, Bailey AJ. Abnormal cancellous bone collagen metabolism in osteoarthritis. J Clin Invest 1998;101:1596–1603
   PubMed Web of Science ®Google Scholar
• Mansell JP, Collins C, Bailey AJ. Bone, not cartilage, should be the major focus in osteoarthritis. Nat Clin Pract Rheumatol 2007;3:306–307
   PubMedGoogle Scholar
• Bailey AJ, Mansell JP, Sims TJ, Banse X. Biochemical and mechanical properties of subchondral bone in osteoarthritis. Biorheology 2004;41:349–358
   PubMed Web of Science ®Google Scholar
• Garnero P, Peterfy C, Zaim S, Schoenharting M. Bone marrow abnormalities on magnetic resonance imaging are associated with type II collagen degradation in knee osteoarthritis: a three-month longitudinal study. Arthritis Rheum 2005;52:2822–2829
   PubMed Web of Science ®Google Scholar
• Schaller S, Henriksen K, Hoegh-Andersen P, et al In vitro, ex vivo, and in vivo methodological approaches for studying therapeutic targets of osteoporosis and degenerative joint diseases: how biomarkers can assist? Assay Drug Dev Technol 2005;3:553–580
   PubMed Web of Science ®Google Scholar
• Bauer DC, Hunter DJ, Abramson SB, et al Classification of osteoarthritis biomarkers: a proposed approach. Osteoarthritis Cartilage 2006;14:723–727
   PubMed Web of Science ®Google Scholar
• Caporali R, Cimmino MA, Sarzi-Puttini P, et al Comorbid conditions in the AMICA study patients: effects on the quality of life and drug prescriptions by general practitioners and specialists. Semin Arthritis Rheum 2005;35(1 Suppl 1):31–37
   PubMed Web of Science ®Google Scholar
• Arden NK, Nevitt MC, Lane NE, et al Osteoarthritis and risk of falls, rates of bone loss, and osteoporotic fractures. Study of Osteoporotic Fractures Research Group. Arthritis Rheum 1999;42:1378–1385
   PubMed Web of Science ®Google Scholar
• Dequeker J, Dieppe PA. Disorders of bone cartilage and connective tissue. In Klippel JH, Dieppe PA, eds. Rheumatology, 2nd edn. London: Mosby, 1998
   Google Scholar
• Tanko LB, Bagger YZ, Alexandersen P, et al Safety and efficacy of a novel salmon calcitonin (sCT) technology-based oral formulation in healthy postmenopausal women: acute and 3-month effects on biomarkers of bone turnover. J Bone Miner Res 2004;19:1531–1538
   PubMed Web of Science ®Google Scholar
• Mouritzen U, Christgau S, Lehmann HJ, Tanko LB, Christiansen C. Cartilage turnover assessed with a newly developed assay measuring collagen type II degradation products: influence of age, sex, menopause, hormone replacement therapy, and body mass index. Ann Rheum Dis 2003;62:332–336
   PubMed Web of Science ®Google Scholar
• Spector TD, Conaghan PG, Buckland-Wright JC, et al Effect of risedronate on joint structure and symptoms of knee osteoarthritis: results of the BRISK randomized, controlled trial [ISRCTN01928173]. Arthritis Res Ther 2005;7:R625–R633
   PubMed Web of Science ®Google Scholar
• Karsdal MA, Tanko LB, Riis BJ, et al Calcitonin is involved in cartilage homeostasis: is calcitonin a treatment for OA? Osteoarthritis Cartilage 2006;14:617–624
   PubMed Web of Science ®Google Scholar
• Ham KD, Loeser RF, Lindgren BR, Carlson CS. Effects of long-term estrogen replacement therapy on osteoarthritis severity in cynomolgus monkeys. Arthritis Rheum 2002;46:1956–1964
   PubMed Web of Science ®Google Scholar
• Ham KD, Carlson CS. Effects of estrogen replacement therapy on bone turnover in subchondral bone and epiphyseal metaphyseal cancellous bone of ovariectomized cynomolgus monkeys. J Bone Miner Res 2004;19:823–829
   PubMed Web of Science ®Google Scholar
• Bettica P, Cline G, Hart DJ, Meyer J, Spector TD. Evidence for increased bone resorption in patients with progressive knee osteoarthritis: longitudinal results from the Chingford study. Arthritis Rheum 2002;46:3178–3184
   PubMed Web of Science ®Google Scholar
• Karsdal MA, Byrjalsen I, Leeming DJ, Christiansen C. Tibolone inhibits bone resorption without secondary positive effects on cartilage degradation. BMC Musculoskelet Disord 2008;9:153
   PubMedGoogle Scholar
• Svensson O, Hjerpe A, Reinholt FP, Wikstrom B, Engfeldt B. The effect of strontium and manganese on freshly isolated chondrocytes. Acta Pathol Microbiol Immunol Scand 1985;93:115–120
   Google Scholar
• Henrotin Y, Labasse A, Zheng SX, et al Strontium ranelate increases cartilage matrix formation. J Bone Miner Res 2001;16:299–308
   PubMed Web of Science ®Google Scholar