Isoflavones: effects on bone health

References

• Castelo-Branco C, Palacios S, Calaf J, Vázquez F, Lanchares JL. Available medical choices for the management of menopause. Maturitas 2005;52(Suppl 1):S61–70
   PubMedGoogle Scholar
• Messina M. A brief historical overview of the past two decades of soy and isoflavone research. J Nutr 2010;140:1350–4S
   PubMed Web of Science ®Google Scholar
• Shukla SK, Gupta S, Ojha SK, Sharma SB. Cardiovascular friendly natural products: a promising approach in the management of CVD. Nat Prod Res 2010;24:873–98
   PubMed Web of Science ®Google Scholar
• Ishimi Y. Soybean isoflavones in bone health. Forum Nutr 2009;61:104–16
   Google Scholar
• Kuiper GG, Carlsson B, Grandien K, et al. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. Endocrinology 1997;138:863–70
   PubMed Web of Science ®Google Scholar
• Anderson JJ, Anthony M, Messina M, Garne SC. Effects of phyto-oestrogens on tissues. Nutr Res Rev 1999;12:75–116
   PubMed Web of Science ®Google Scholar
• Blair HC, Jordan SE, Peterson TG, Barnes S. Variable effects of tyrosine kinase inhibitors on avian osteoclastic activity and reduction of bone loss in ovariectomized rats. J Cell Biochem 1996;61:629–37
   PubMed Web of Science ®Google Scholar
• Marini H, Minutoli L, Polito F, et al. OPG and sRANKL serum concentrations in osteopenic, postmenopausal women after 2-year genistein administration. J Bone Miner Res 2008;23:715–20
   PubMed Web of Science ®Google Scholar
• Breslau NA, Brinkley L, Hill KD, Pak CY. Relationship of animal protein-rich diet to kidney stone formation and calcium metabolism. J Clin Endocrinol Metab 1988;66:140–6
   PubMed Web of Science ®Google Scholar
• Sugimoto E, Yamaguchi M. Stimulatory effect of daidzein in osteoblastic MC3T3-E1 cells. Biochem Pharmacol 2000;59:471–5
   PubMed Web of Science ®Google Scholar
• Williams JP, Jordan SE, Barnes S, Blair HC. Tyrosine kinase inhibitor effects on avian osteoclastic acid transport. Am J Clin Nutr 1998;68:1369–74S
   Google Scholar
• Omi N, Aoi S, Murata K, Ezawa I. Evaluation of the effect of soybean milk and soybean milk peptides on bone metabolism in the rat model with ovariectomized osteoporosis. J Nutr Sci Vitaminol (Tokyo) 1994;40:201–11
   PubMed Web of Science ®Google Scholar
• Arjmandi BH, Alekel L, Hollis BW, et al. Dietary soybean protein prevents bone loss in an ovariectomized rat model of osteoporosis. J Nutr 1996;126:161–7
   PubMed Web of Science ®Google Scholar
• Arjmandi BH, Birnbaum R, Goyal NV, et al. Bone-sparing effect of soy protein in ovarian hormone-deficient rats is related to its isoflavone content. Am J Clin Nutr 1998;68:1364–8S
   PubMed Web of Science ®Google Scholar
• Arjmandi BH, Getlinger MJ, Goyal NV, et al. Role of soy protein with normal or reduced isoflavone content in reversing bone loss induced by ovarian hormone deficiency in rats. Am J Clin Nutr 1998;68:1358–63S
   PubMed Web of Science ®Google Scholar
• Ishimi Y, Miyaura C, Ohmura M, et al. Selective effects of genistein, a soybean isoflavone, on B-lymphopoiesis and bone loss caused by estrogen deficiency. Endocrinology 1999;140:1893–900
   PubMed Web of Science ®Google Scholar
• Fanti P, Monier-Faugere MC, Geng Z, et al. The phytoestrogen genistein reduces bone loss in short-term ovariectomized rats. Osteoporosis Int 1998;8:274–81
   PubMed Web of Science ®Google Scholar
• Picherit C, Bennetau-Pelissero C, Chanteranne B, et al. Soybean isoflavones dose-dependently reduce bone turnover but do not reverse established osteopenia in adult ovariectomized rats. J Nutr 2001;131:723–8
   PubMed Web of Science ®Google Scholar
• Kaludjerovic J, Ward WE. Neonatal exposure to daidzein, genistein, or the combination modulates bone development in female CD-1 mice. J Nutr 2009;139:467–73
   PubMed Web of Science ®Google Scholar
• Dai R, Ma Y, Sheng Z, et al. Effects of genistein on vertebral trabecular bone microstructure, bone mineral density, microcracks, osteocyte density, and bone strength in ovariectomized rats. J Bone Miner Metab 2008;26:342–9
   PubMed Web of Science ®Google Scholar
• Lees CJ, Kaplan JR, Chen H, Jerome CP, Register TC, Franke AA. Bone mass and soy isoflavones in socially housed, premenopausal macaques. Am J Clin Nutr 2007;86:245–50
   PubMed Web of Science ®Google Scholar
• Register TC, Jayo MJ, Anthony MSJ. Soy phytoestrogens do not prevent bone loss in postmenopausal monkeys. Clin Endocrinol Metab 2003;88:4362–70
   Google Scholar
• Lees CJ, Ginn TA. Soy protein isolate diet does not prevent increased cortical bone turnover in ovariectomized macaques. Calcif Tissue Int 1998;62:557–8
   PubMed Web of Science ®Google Scholar
• Horiuchi T, Onouchi T, Takahashi M, Ito H, Orimo H. Effect of soy protein on bone metabolism in postmenopausal women. Osteoporosis 2000;11:721–4
   PubMed Web of Science ®Google Scholar
• Mei J, Yeung SSC, Kung AWC. High dietary phytoestrogen intake is associated with higher bone mineral density in postmenopausal but not premenopausal women. J Clin Endocrinol Metab 2001;86:5217–21
   PubMed Web of Science ®Google Scholar
• Somekawa Y, Chiguchi M, Ishibashi T, Aso T. Soy intake related to menopausal symptoms, serum lipids, and bone mineral density in postmenopausal Japanese women. Obstet Gynecol 2001;97:109–15
   PubMed Web of Science ®Google Scholar
• Fukui Y, Miura A, Nara Y, Uesugi T, Yamori H, Yamori Y. Relationship between urinary isoflavones and bone metabolism in postmenopausal Japanese women. J Nutr 2000;130:686S
   Google Scholar
• Rice MM, LaCroix AZ, Lampe JW, et al. Soy consumption and bone mineral density in older Japanese American women in King County, Washington. J Nutr 2000;130:685S
   Google Scholar
• Guthrie JR, Ball M, Murkies A, Dennerstein L. Dietary phytoestrogen intake in mid-life Australian-born women. Climacteric 2000;3:254–61
   PubMedGoogle Scholar
• Scheiber M, Liu J, Subbiah M, Rebar R, Setchell KDR. Dietary soy supplementation reduces LDL oxidation and bone turnover in healthy post-menopausal women. Menopause 2001;8:384–92
   PubMed Web of Science ®Google Scholar
• Song YS, Paik HY. Soybean intake and bone mineral density change in Korean college women. Epidemiological observations. J Nutr 2002;132:616S.
   Web of Science ®Google Scholar
• Di Leo C, Tarolo GL, Bestetti A, et al. Osteoporosis and phytoestrogens: an assessment of bone mineral density via quantitative peripheral computed tomography in milk-egg-vegetarian women in the premenopause. Radiol Med (Torino) 2000;99:250–7
   PubMedGoogle Scholar
• Anderson JJ, Chen X, Boass A, et al. Soy isoflavones: no effects on bone mineral content and bone mineral density in healthy, menstruating young adult women after one year. J Am Coll Nutr 2002;21:388–93
   PubMed Web of Science ®Google Scholar
• Brink E, Coxam V, Robins S, Wahala K, Cassidy A, Branca F; PHYTOS Investigators. Long-term consumption of isoflavone-enriched foods does not affect bone mineral density, bone metabolism, or hormonal status in early postmenopausal women: a randomized, double-blind, placebo controlled study. Am J Clin Nutr 2008;87:761–70
   PubMed Web of Science ®Google Scholar
• Kenny AM, Mangano KM, Abourizk RH, et al. Soy proteins and isoflavones affect bone mineral density in older women: a randomized controlled trial. Am J Clin Nutr 2009;90:234–42
   PubMed Web of Science ®Google Scholar
• Potter SM, Baum JA, Teng H, et al. Soy protein and isoflavones: their effects on blood lipids and bone density in postmenopausal women. Am J Clin Nutr 1998;68:1375–9S
   PubMed Web of Science ®Google Scholar
• Alekel DL, Germain AS, Peterson CT, et al. Isoflavone-rich soy protein isolate attenuates bone loss in the lumbar spine of perimenopausal women. Am J Clin Nutr 2000;72:844–52
   PubMed Web of Science ®Google Scholar
• Wu J, Oka J, Ezaki J, et al. Possible role of equol status in the effects of isoflavone on bone and fat mass in postmenopausal Japanese women: a double-blind, randomized, controlled trial. Menopause 2007;14:866–74
   PubMed Web of Science ®Google Scholar
• Ma DF, Qin LQ, Wang PY, Katoh R. Soy isoflavone intake increases bone mineral density in the spine of menopausal women: meta-analysis of randomized controlled trials. Clin Nutr 2008;27:57–64
   PubMed Web of Science ®Google Scholar
• Arjmandi BH, Lucas EA, Khalil DA, et al. One year soy protein supplementation has positive effects on bone formation markers but not bone density in postmenopausal women. Nutr J 2005;4:8.
   PubMed Web of Science ®Google Scholar
• Harkness LS, Fiedler K, Sehgal AR, Oravec D, Lermer E. Decreased bone resorption with soy isoflavones supplementation in postmenopausal women. J Womens Health 2004;13:1000–7
   PubMed Web of Science ®Google Scholar
• Kreijkamp-Kaspers S, Kok L, Grobbee DE, et al. Effect of soy protein containing isoflavones on cognitive function, bone mineral density, and plasma lipids in postmenopausal women: a randomized controlled trial. JAMA 2004;292:65–74
   PubMed Web of Science ®Google Scholar
• Lydeking-Olsen E, Beck-Jensen JE, Setchell KD, Holm-Jensen T. Soymilk or progesterone for prevention of bone loss: a 2 year randomized, placebo-controlled trial. Eur J Nutr 2004;43:246–57
   PubMed Web of Science ®Google Scholar
• Uesugi T, Toda T, Okuhira T Chen JT. Evidence of estrogenic effect by the three-month-intervention of isoflavone on vaginal maturation and bone metabolism in early postmenopausal women. Endocr J 2003;50:613–19
   PubMed Web of Science ®Google Scholar
• Yi YB, Shu YX. Soy isoflavone intake attenuated bone loss in postmenopausal women. Acta Nutr SINICA 2004;26:49–53
   Google Scholar
• Gao YP, Li RH, Guo SZ. The effect of soy isoflavone on bone metabolism in postmenopausal women. J Shanxi Med Univ 2006;37:633–5
   Google Scholar
• Liu J, Ho SC, Su YX, Chen WQ, Zhang CX, Chen YM. Effect of long-term intervention of soy isoflavones on bone mineral density in women: a meta-analysis of randomized controlled trials. Bone 2009;44:948–53
   PubMed Web of Science ®Google Scholar
• Ma DF, Qin LQ, Wang PY, Katoh R. Soy isoflavone intake inhibits bone resorption and stimulates bone formation in menopausal women: meta-analysis of randomized controlled trials. Eur J Clin Nutr 2008;62:155–61
   PubMed Web of Science ®Google Scholar
• Wu J, Oka J, Higuchi M, et al. Cooperative effects of isoflavones and exercise on bone and lipid metabolism in postmenopausal Japanese women: a randomized placebo-controlled trial. Metabolism 2006;55:423–33
   PubMed Web of Science ®Google Scholar
• Zhang X, Shu XO, Li H, et al. Prospective cohort study of soy food consumption and risk of bone fracture among postmenopausal women. Arch Intern Med 2005;165:1890–5
   PubMed Web of Science ®Google Scholar