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Review Article

Understanding weight gain at menopause

, , , , , , & show all
Pages 419-429 | Received 12 Jun 2012, Accepted 25 Jun 2012, Published online: 15 Sep 2012

References

  • Nappi RE, Kokot-Kierepa M. Vaginal Health: Insights, Views & Attitudes (VIVA) – results from an international survey. Climacteric 2012;15:36–44
  • World Health Organization. Obesity and overweight. Fact sheet N° 311, May 2012. Available from: http://www.who.int/mediacentre/factsheets/fs311/en/
  • Pajunen P, Kotronen A, Korpi-Hyovalti E, . Metabolically healthy and unhealthy obesity phenotypes in the general population: the FIN-D2D Survey. BMC Public Health 2011;11:754
  • Hankinson AL, Daviglus ML, Van Horn L, . Diet composition and activity level of at risk and metabolically healthy obese American adults. Obesity 2012 Apr 19. Epub ahead of print
  • Wee C, Davis R, Hamel M. Comparing the SF-12 and SF-36 health status questionnaires in patients with and without obesity. Health Qual Life Outcomes 2008;6:11–15
  • Wadden TA, Phelan S. Assessment of quality of life in obese individuals. Obes Res 2002;10(Suppl 1):50–7S
  • Fjeldstad C, Fjeldstad AS, Acree LS, Nickel KJ, Gardner AW. The influence of obesity on falls and quality of life. Dyn Med 2008;7:4
  • Sternfeld B, Wang H, Quesenberry OP, . Physical activity and changes in weight and waist circumference in midlife women: findings from the Study of Women's Health across the Nation. Am J Epidemiol 2004;160:912–22
  • Guthrie JR, Dennerstein L, Dudley EC. Weight gain and the menopause: a 5-year prospective study. Climacteric 1999;2: 205–11
  • Wing PR, Matthews KA, Kuller LH, . Weight gain at the time of the menopause. Arch Intern Med 1991;15:97–102
  • Poehlman E, Toth MJ, Gardner A. Changes in energy balance and body composition at menopause: a controlled longitudinal study. Ann Intern Med 1995;123:673–8
  • Dugan SA, Everson-Rose SA, Karavolos K, . Physical activity and reduced intra-abdominal fat in midlife African-American and white women. Obesity 2010;18:1260–5
  • Brown WJ, Williams L, Ford JH, Ball K, Dobson AJ. Identifying the energy gap: magnitude and determinants of 5-year weight gain in midage women. Obes Res 2005;13:1431–41
  • Sutton-Tyrrell K, Zhao X, Santoro N, . Reproductive hormones and obesity: 9 years of observation from the Study of Women's Health Across the Nation (SWAN). Am J Epidemiol 2010;171:1203–13
  • Matthews KA, Abrams B, Crawford S, . Body mass index in midlife women: relative influence of menopause, hormone use, and ethnicity. Int J Obes Relat Metab Disord 2001;25:863–73
  • Sternfeld B, Bhat AK, Wang H, . Menopause, physical activity and body composition/fat distribution in midlife women. Med Sci Sports Exerc 2005;37:1195–202
  • Rogers NH, Perfield JW 2nd, Strissel KJ, Obin MS, Greenberg AS. Reduced energy expenditure and increased inflammation are early events in the development of ovariectomy-induced obesity. Endocrinology 2009;150:2161–8
  • Stubbins RE, Najjar K, Holcomb VB, Hong J, Nunez NP. Oestrogen alters adipocyte biology and protects female mice from adipocyte inflammation and insulin resistance. Diabetes Obes Metab 2012;14:58–66
  • Misso M, Murata Y, Boon W, Jones M, Britt K, Simpson E. Cellular and molecular characterization of the adipose phenotype of the aromatase-deficient mouse. Endocrinology 2003; 144:1474–80
  • Jones ME, Thorburn AW, Britt KL, . Aromatase-deficient (ArKO) mice accumulate excess adipose tissue. J Steroid Biochem Molec Biol 2001;79:3–9
  • Brown LM, Clegg DJ. Central effects of estradiol in the regulation of food intake, body weight, and adiposity. J Steroid Biochem Molec Biol 2010;122:65–73
  • Flegal KM, Carroll MD, Ogden CL, Curtin LR. Prevalence and trends in obesity among US adults, 1999–2008. JAMA 2010;303:235–41
  • Toth MJ, Tchernof A, Sites CK, Poehlman ET. Effect of menopausal status on body composition and abdominal fat distribution. Int J Obes Relat Metab Disord 2000;24:226–31
  • Toth MJ, Tchernof A, Sites CK, Poehlman ET. Menopause- related changes in body fat distribution. Ann N Y Acad Sci 2000;904:502–6
  • Wietlisbach V, Marques-Vidal P, Kuulasmaa K, Karvanen J, Paccaud F. The relation of body mass index and abdominal adiposity with dyslipidemia in 27 general populations of the WHO MONICA Project. Nutr Metab Cardiovasc Dis 2011 Dec 30. Epub ahead of print
  • Janssen I, Powell LH, Kazlauskaite R, Dugan SA. Testosterone and visceral fat in midlife women: the Study of Women’s Health Across the Nation (SWAN) fat patterning study. Obesity 2010;18:604–10
  • Wajchenberg BL. Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. Endocr Rev 2000;21:697–738
  • Misso ML, Jang C, Adams J, . Differential expression of factors involved in fat metabolism with age and the menopause transition. Maturitas 2005;51:299–306
  • Lee CG, Carr MC, Murdoch SJ, . Adipokines, inflammation, and visceral adiposity across the menopausal transition: a prospective study. J Clin Endocrinol Metab 2009;94:1104–10
  • Jayagopal V, Kilpatrick ES, Jennings PE, Holding S, Hepburn DA, Atkin SL. The biological variation of sex hormone-binding globulin in type 2 diabetes: implications for sex hormone- binding globulin as a surrogate marker of insulin resistance. Diabetes Care 2004;27:278–80
  • Thadhani R, Wolf M, Hsu-Blatman K, Sandler L, Nathan D, Ecker JL. First-trimester sex hormone binding globulin and subsequent gestational diabetes mellitus. Am J Obstet Gynecol 2003;189:171–6
  • Goodman-Gruen D, Barrett-Connor E. Sex hormone-binding globulin and glucose tolerance in postmenopausal women. The Rancho Bernardo Study. Diabetes Care 1997;20:645–9
  • Perry JR, Weedon MN, Langenberg C, . Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes. Hum Mol Genet 2009;19:535–44
  • Ding EL, Song Y, Manson JE, . Sex hormone-binding globulin and risk of type 2 diabetes in women and men. N Engl J Med 2009;361:1152–63
  • Peter A, Kantartzis K, Machann J, . Relationships of circulating sex hormone-binding globulin with metabolic traits in humans. Diabetes 2010;59:3167–73
  • Jorde R, Waterloo K, Storhaug H, Nyrnes A, Sundsfjord J, Jenssen TG. Neuropsychological function and symptoms in subjects with subclinical hypothyroidism and the effect of thyroxine treatment. J Clin Endocrinol Metab 2006;91:145–53
  • Wildman RP, Wang D, Fernandez I, . Associations of testosterone and sex hormone binding globulin with adipose tissue hormones in midlife women. Obesity 2012 Apr 30. Epub ahead of print
  • Davis SR, Robinson PJ, Moufarege A, Bell RJ. The contribution of SHBG to the variation in HOMA-IR is not dependent on endogenous oestrogen or androgen levels in postmenopausal women. Clin Endocrinol 2011 Nov 22. Epub ahead of print
  • Janssen I, Powell LH, Crawford S, Lasley B, Sutton-Tyrrell K. Menopause and the metabolic syndrome: the Study of Women’s Health Across the Nation. Arch Intern Med 2008;168:1568–75
  • Abdulnour J, Doucet E, Brochu M, . The effect of the menopausal transition on body composition and cardiometabolic risk factors: a Montreal-Ottawa New Emerging Team group study. Menopause 2012;19:760–7
  • Ho SC, Wu S, Chan SG, Sham A. Menopausal transition and changes of body composition: a prospective study in Chinese perimenopausal women. Int J Obes 2010;34:1265–74
  • Sowers M, Zheng H, Tomey K, . Changes in body composition in women over 6 years at midlife: ovarian and chronological aging. J Clin Endocrinol Metab 2007;92:895–901
  • Khoo CM, Sairazi, Tasum N, . Ethnicity modifies the relationships of insulin resistance, inflammation and adiponectin with obesity in a multiethnic Asian population. Diabetes Care 2011;34:1120–6
  • Gill J, Bhopal R, Douglas A, . Sitting time and waist circumference are associated with glycemia in UK South Asians: data from 1228 adults screened for the PODOSA trial. Diabetes Care 2011;34:1214–18
  • Michalakis K, Coppack SW. Primary ovarian insufficiency: relation to changes in body composition and adiposity. Maturitas 2012;71:320–5
  • Ostberg JE, Thomas EL, Hamilton G, Attar MJ, Bell JD, Conway GS. Excess visceral and hepatic adipose tissue in Turner syndrome determined by magnetic resonance imaging: estrogen deficiency associated with hepatic adipose content. J Clin Endocrinol Metab 2005;90:2631–5
  • Bakalov VK, Cooley MM, Quon MJ, . Impaired insulin secretion in the Turner metabolic syndrome. J Clin Endocrinol Metab 2004;89:3516–20
  • Hajian-Tilaki KO, Heidari B. Prevalence of obesity, central obesity and the associated factors in urban population aged 20–70 years, in the north of Iran: a population-based study and regression approach. Obes Rev 2007;8:3–10
  • Huffman JE, Sabol C, Fried B. Infectivity, growth, survival, and pathogenicity of Zygocotyle lunata (Trematoda) in experimental rodent hosts. J Parasitol 1991;77:280–4
  • Fonken LK, Workman JL, Walton JC, . Light at night increases body mass by shifting the time of food intake. Proc Natl Acad Sci USA 2010;107:18664–9
  • Bezerra IN, Curioni C, Sichieri R. Association between eating out of home and body weight. Nutr Rev 2012;70:65–79
  • Mesas AE, Munoz-Pareja M, Lopez-Garcia E, Rodriguez- Artalejo F. Selected eating behaviours and excess body weight: a systematic review. Obes Rev 2012;13:106–35
  • American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. Washington DC: American Psychiatric Press, 1994
  • Sutin AR, Zonderman AB. Depressive symptoms are associated with weight gain among women. Psychol Med 2012 Apr 5. Epub ahead of print
  • de Wit L, Luppino F, van Straten A, Penninx B, Zitman F, Cuijpers P. Depression and obesity: a meta-analysis of community-based studies. Psychiatry Res 2010;178:230–5
  • Pan A, Lucas M, Sun Q, . Bidirectional association between depression and type 2 diabetes mellitus in women. Arch Intern Med 2010;170:1884–91
  • Freeman EW. Associations of depression with the transition to menopause. Menopause 2010;17:823–7
  • Llaneza P, García-Portilla MP, Llaneza-Suárez D, Armott B, Pérez-López FR. Depressive disorders and the menopause transition. Maturitas 2012;71:120–30
  • Fernández-Alonso AM, Trabalón-Pastor M, Vara C, Chedraui P, Pérez-López FR; for The MenopAuse RIsk Assessment (MARIA) Research Group. Life satisfaction, loneliness and related factors during female midlife. Maturitas 2012;72:88–92
  • Raeder MB, Ferno J, Vik-Mo AO, Steen VM. SREBP activation by antipsychotic- and antidepressant-drugs in cultured human liver cells: relevance for metabolic side-effects? Mol Cell Biochem 2006;289:167–73
  • Demark-Wahnefried W, Peterson BL, . Changes in weight, body composition, and factors influencing energy balance among premenopausal breast cancer patients receiving adju-vant chemotherapy. J Clin Oncol 2001;19:2381–9
  • Goodwin PJ, Ennis M, Pritchard KI, . Adjuvant treatment and onset of menopause predict weight gain after breast cancer diagnosis. J Clin Oncol 1999;17:120–9
  • Gordon AM, Hurwitz S, Shapiro CL, LeBoff MS. Premature ovarian failure and body composition changes with adjuvant chemotherapy for breast cancer. Menopause 2011;18:1244–8
  • Aydin ZD. Determinants of age at natural menopause in the Isparta Menopause and Health Study: premenopausal body mass index gain rate and episodic weight loss. Menopause 2010;17:494–505
  • Morris DH, Jones ME, Schoemaker MJ, McFadden E, Ashworth A, Swerdlow AJ. Body mass index, exercise, and other lifestyle factors in relation to age at natural menopause: analyses from the Breakthrough Generations Study. Am J Epidemiol 2012;175:998–1005
  • Akahoshi M, Soda M, Nakashima E, . The effects of body mass index on age at menopause. Int J Obes Relat Metab Disord 2002;26:961–8
  • Sammel MD, Freeman EW, Liu Z, Lin H, Guo W. Factors that influence entry into stages of the menopausal transition. Menopause 2009;16:1218–27
  • Sowers MR, Randolph JF, Zheng H, . Genetic polymorphisms and obesity influence estradiol decline during the menopause. Clin Endocrinol (Oxf) 2011;74:618–23
  • Fernández-Alonso AM, Cuadros JL, Chedraui P, Mendoza M, Cuadros AM, Pérez-López FR. Obesity is related to increased menopausal symptoms among Spanish women. Menopause Int 2010;16:105–10
  • Chedraui P, Hidalgo L, Chavez D, Morocho N, Alvarado M, Huc A. Menopausal symptoms and associated risk factors among postmenopausal women screened for the metabolic syndrome. Arch Gynecol Obstet 2007;275:161–8
  • Thurston RC, Sowers MR, Sternfeld B, . Gains in body fat and vasomotor symptom reporting over the menopausal transition: the Study of Women’s Health across the Nation. Am J Epidemiol 2009;170:766–74
  • Sowers MR, Zheng H, Jannausch ML, . Amount of bone loss in relation to time around the final menstrual period and follicle-stimulating hormone staging of the transmenopause. J Clin Endocrinol Metab 2010;95:2155–62
  • van der Voort DJ, Geusens PP, Dinant GJ. Risk factors for osteoporosis related to their outcome: fractures. Osteoporos Int 2001;12:630–8
  • Compston JE, Watts NB, Chapurlat R, . ; Glow Investigators. Obesity is not protective against fracture in postmenopausal women: GLOW. Am J Med 2011;124:1043–50
  • Shah MB. Obesity and sexuality in women. Obstet Gynecol Clin North Am 2009;36:347–60, ix
  • Jones GL, Sutton A. Quality of life in obese postmenopausal women. Menopause Int 2008;14:26–32
  • Nappi RE, Verde JB, Polatti F, Genazzani AR, Zara C. Self-reported sexual symptoms in women attending menopause clinics. Gynecol Obstet Invest 2002;53:181–7
  • Pace G, Silvestri V, Guala L, Vicentini C. Body mass index, urinary incontinence, and female sexual dysfunction: how they affect female postmenopausal health. Menopause 2009;16:1188–92
  • Llaneza P, Iñarrea J, Gonzalez C, Alonso A, Arnott I, Ferrer- Barriendos J. Differences in health-related quality of life in a sample of obese and non-obese menopausal Spanish women. Maturitas 2007;58:387–94
  • Llaneza P, Gonzalez C, Fernandez-Inarrea J, Alonso A, Arnott I, Ferrer-Barriendos J. Insulin resistance and health-related quality of life in postmenopausal women. Fertil Steril 2009;91(Suppl):1370–3
  • Martelli V, Valisella S, Moscatiello S, . Prevalence of sexual dysfunction among postmenopausal women with and without metabolic syndrome. J Sex Med 2012;9:434–41
  • Miner M, Esposito K, Guay A, Montorsi P, Goldstein I. Cardiometabolic risk and female sexual health: the Princeton III summary. J Sex Med 2012;9:641–51
  • Huang AJ, Subak LL, Wing R, . An intensive behavioral weight loss intervention and hot flushes in women. Arch Intern Med 2010;170:1161–7
  • Imayama I, Alfano CM, Kong A, . Dietary weight loss and exercise interventions effects on quality of life in overweight/obese postmenopausal women: a randomized controlled trial. Int J Behav Nutr Phys Act 2011;8:118
  • Rippe JM, Price JM, Hess SA, . Improved psychological well-being, quality of life, and health practices in moderately overweight women participating in a 12-week structured weight loss program. Obes Res 1998;6:208–18
  • García González F, Ferrer García JC, Baixauli Rubio A, . [An ambulatory physical exercise program improves in the short term weight and quality of life of obese post-menopausal women]. Med Clin (Barc) 2009;133:533–8
  • Norman RJ, Flight IH, Rees MC. Oestrogen and progesterone hormone replacement therapy for peri-menopausal and post-menopausal women: weight and body fat distribution. Cochrane Database Syst Rev 2000;(2):CD001018
  • Yuksel H, Odabasi AR, Demircan S, . Effects of oral continuous 17beta-estradiol plus norethisterone acetate replacement therapy on abdominal subcutaneous fat, serum leptin levels and body composition. Gynecol Endocrinol 2006;22: 381–7
  • Davis SR, Walker KZ, Strauss BJ. Effects of estradiol with and without testosterone on body composition and relationships with lipids in post-menopausal women. Menopause 2000;7: 395–401
  • Chen Z, Bassford T, Green SB, . Postmenopausal hormone therapy and body composition – a substudy of the estrogen plus progestin trial of the Women’s Health Initiative. Am J Clin Nutr 2005;82:651–6
  • Sorensen MB, Rosenfalck AM, Hojgaard L, Ottesen B. Obesity and sarcopenia after menopause are reversed by sex hormone replacement therapy. Obes Res 2001;9:622–6
  • Sites CK, L’Hommedieu GD, Toth MJ, Brochu M, Cooper BC, Fairhurst PA. The effect of hormone replacement therapy on body composition, body fat distribution, and insulin sensitivity in menopausal women: a randomized, double-blind, placebo-controlled trial. J Clin Endocrinol Metab 2005;90:2701–7
  • dos Reis CM, de Melo NR, Meirelles ES, Vezozzo DP, Halpern A. Body composition, visceral fat distribution and fat oxidation in postmenopausal women using oral or transdermal oestrogen. Maturitas 2003;46:59–68
  • O’Sullivan AJ, Crampton LJ, Freund J, Ho KKY. The route of estrogen replacement therapy confer divergent effects on substrate oxidation and body composition in postmenopausal women. J Clin Invest 1998;102:1035–40
  • Weissberger AJ, Ho KK, Lazarus L. Contrasting effects of oral and transdermal routes of estrogen replacement therapy on 24-hour growth hormone (GH) secretion, insulin-like growth factor I, and GH-binding protein in postmenopausal women. J Clin Endocrinol Metab 1991;72:374–81
  • Sonnet E, Lacut K, Roudaut N, Mottier D, Kerlan V, Oger E. Effects of the route of oestrogen administration on IGF-1 and IGFBP-3 in healthy postmenopausal women: results from a randomized placebo-controlled study. Clin Endocrinol (Oxf) 2007;66:626–31
  • Helle SI, Omsjo IH, Hughes SC, . Effects of oral and transdermal oestrogen replacement therapy on plasma levels of insulin-like growth factors and IGF binding proteins 1 and 3: a cross-over study. Clin Endocrinol (Oxf) 1996;45:727–32
  • Cano A, Castelo-Branco C, Tarin JJ. Effect of menopause and different combined estradiol-progestin regimens on basal and growth hormone-releasing hormone-stimulated serum growth hormone, insulin-like growth factor-1, insulin-like growth factor binding protein (IGFBP)-1, and IGFBP-3 levels. Fertil Steril 1999;71:261–7
  • Kelly JJ, Rajkovic IA, O’Sullivan AJ, Sernia C, Ho KK. Effects of different oral oestrogen formulations on insulin-like growth factor-I, growth hormone and growth hormone binding protein in post-menopausal women. Clin Endocrinol 1993;39: 561–7
  • Birzniece V, Meinhardt UJ, Gibney J, . Differential effects of raloxifene and estrogen on body composition in growth hormone-replaced hypopituitary women. J Clin Endocrinol Metab 2012;97:1005–12
  • Bonds DE, Lasser N, Qi L, . The effect of conjugated equine oestrogen on diabetes incidence: the Women’s Health Initiative randomised trial. Diabetologia 2006;49:459–68
  • Institute of Medicine. Dietary Reference Intake for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids (macronutrients). Washington DC: National Academies Press, 2002
  • Ross R, Dagnone D, Jones PJ, . Reduction in obesity and related comorbid conditions after diet-induced weight loss or exercise-induced weight loss in men. A randomized, controlled trial. Ann Intern Med 2000;133:92–103
  • Douketis JD, Macie C, Thabane L, Williamson DF. Systematic review of long-term weight loss studies in obese adults: clinical significance and applicability to clinical practice. Int J Obes 2005;29:1153–67
  • Freedman MR, King J, Kennedy E. Popular diets: a scientific review. Obes Rev 2001;9(Suppl 1):1–40S
  • Sacks FM, Bray GA, Carey VJ, . Comparison of weight-loss diets with different compositions of fat, protein, and carbohydrates. N Engl J Med 2009;360:859–73
  • National Institute for Health and Clinical Excellence. Clinical guideline CG43. Obesity: The prevention, identification, assessment and management of overweight and obesity in adults and children. London, 2006. http://guidance.nice.org.uk/CG43/NICEGuidance/pdf/English
  • Ioannides-Demos LL, Piccenna L, McNeil JJ. Pharmacotherapies for obesity: past, current, and future therapies. J Obes 2011;2011:179674
  • Chan CC, Koo MW, Ng EH, Tang OS, Yeung WS, Ho PC. Effects of Chinese green tea on weight, and hormonal and biochemical profiles in obese patients with polycystic ovary syndrome – a randomized placebo-controlled trial. J Soc Gynecol Invest 2006;13:63–8
  • Bray GA, Greenway FL. Current and potential drugs for treatment of obesity. Endocr Rev 1999;20:805–75
  • Knowler WC, Barrett-Connor E, Fowler SE, . Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 2002;346:393–403
  • Picot J, Jones J, Colquitt JL, . The clinical effectiveness and cost effectiveness of bariatric surgery for obesity: a systematic review and economic evaluation. Health Technol Assess 2009; 13:1–190,  215–357, iii–iv
  • Moliver N, Mika E, Chartrand M, Burrus S, Haussmann R, Khalsa S. Increased Hatha yoga experience predicts lower body mass index and reduced medication use in women over 45 years. Int J Yoga 2011;4:77–86
  • Cohen BE, Chang AA, Grady D, Kanaya AM. Restorative yoga in adults with metabolic syndrome: a randomized, controlled pilot trial. Metab Syndr Relat Disord 2008;6:223–9
  • Littman AJ, Bertram LC, Ceballos R, . Randomized controlled pilot trial of yoga in overweight and obese breast cancer survivors: effects on quality of life and anthropometric measures. Support Care Cancer 2012;20:267–77
  • Lee JA, Kim JW, Kim DY. Effects of yoga exercise on serum adiponectin and metabolic syndrome factors in obese postmenopausal women. Menopause 2012;19:296–301
  • Hu WL, Chang CH, Hung YC. Clinical observations on laser acupuncture in simple obesity therapy. Am J Chin Med 2010; 38:861–7
  • Sui Y, Zhao HL, Wong VC, . A systematic review on use of Chinese medicine and acupuncture for treatment of obesity. Obes Rev 2012;13:409–30
  • Lambrinoudaki I, Brincat M, Erel CT, . EMAS Position Statement: managing obese postmenopausal women. Maturitas 2010;66:323–6

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