1,172
Views
77
CrossRef citations to date
0
Altmetric
REVIEW

Non-hormonal topical treatment of vulvovaginal atrophy: an up-to-date overview

&
Pages 305-312 | Received 18 Jul 2012, Accepted 27 Nov 2012, Published online: 08 Jan 2013

References

  • Al-Baghdadi O, Ewies AAA. Topical estrogen therapy in the management of postmenopausal vaginal atrophy: an up-to-date overview. Climacteric 2009;12:91–105
  • Cobleigh MA, Berris RF, Bush T, et al. Estrogen replacement therapy in breast cancer survivors. A time for change. Breast Cancer Committees of the Eastern Cooperative Oncology Group. JAMA 1994;272:540–5
  • Hill K. The demography of menopause. Maturitas 1996;23: 113–27
  • Calleja-Agius J, Brincat MP. Urogenital atrophy. Climacteric 2009;12:279–85
  • Sturdee DW, Panay N. Recommendations for the management of postmenopausal vaginal atrophy. Climacteric 2010;13: 509–22
  • Pastore LM, Carter RA, Hulka BS, Wells E. Self-reported urogenital symptoms in postmenopausal women: Women's Health Initiative. Maturitas 2004;49:292–303
  • Stenberg A, Heimer G, Ulmsten U, Cnattingius S. Prevalence of genitourinary and other climacteric symptoms in 61-year-old women. Maturitas 1996;24:31–6
  • Ganz PA, Greendale GA, Petersen L, et al. Managing menopausal symptoms in breast cancer survivors: results of a randomized controlled trial. J Natl Cancer Inst 2000;92:1054–64
  • Morales L, Neven P, Timmerman D, et al. Acute effects of tamoxifen and third-generation aromatase inhibitors on menopausal symptoms of breast cancer patients. Anticancer Drugs 2004;15:753–60
  • Cardozo L, Bachmann G, McClish D, Fonda D, Birgerson L. Meta-analysis of estrogen therapy in the management of urogenital atrophy in postmenopausal women: second report of the Hormones and Urogenital Therapy Committee. Obstet Gynecol 1998;92:722–7
  • Levine KB, Williams RE, Hartmann KE. Vulvovaginal atrophy is strongly associated with female sexual dysfunction among sexually active postmenopausal women. Menopause 2008; 15:661–6
  • Dennerstein L, Dudley EC, Hopper JL, Guthrie JR, Burger HG. A prospective population-based study of menopausal symptoms. Obstet Gynecol 2000;96:351–8
  • Nappi RE, Kokot-Kierepa M. Vaginal Health: Insights, Views & Attitudes (VIVA): results from an international survey. Climacteric 2012;15:36–44
  • Nappi RE, Kokot-Kierepa M. Women's voices in the menopause: results from an international survey on vaginal atrophy. Maturitas 2010;67:233–8
  • Barlow DH, Samsioe G, van Geelen JM. A study of European womens’ experience of the problems of urogenital ageing and its management. Maturitas 1997;27:239–47
  • Iosif CS, Bekassy Z. Prevalence of genito-urinary symptoms in the late menopause. Acta Obstet Gynecol Scand 1984;63: 257–60
  • van Geelen JM, van de Weijer PH, Arnolds HT. Urogenital symptoms and resulting discomfort in non-institutionalized Dutch women aged 50–75 years. Int Urogynecol J Pelvic Floor Dysfunct 2000;11:9–14
  • Kalogeraki A, Tamiolakis D, Tzardi M, et al. Cigarette smoking as a risk factor for intraepithelial lesion of the cervix uteri. In Vivo 1996;10:613–16
  • Derzko C, Elliott S, Lam W. Management of sexual dysfunction in postmenopausal breast cancer patients taking adjuvant aromatase inhibitor therapy. Curr Oncol 2007;14: S20–40
  • Couzi RJ, Helzlsouer KJ, Fetting JH. Prevalence of menopausal symptoms among women with a history of breast cancer and attitudes toward estrogen replacement therapy. J Clin Oncol 1995;13:2737–44
  • Dew JE, Wren BG, Eden JA. A cohort study of topical vaginal estrogen therapy in women previously treated for breast cancer. Climacteric 2003;6:45–52
  • Vassilopoulou-Sellin R, Theriault R, Klein MJ. Estrogen replacement therapy in women with prior diagnosis and treatment for breast cancer. Gynecol Oncol 1997;65:89–93
  • Loprinzi CL, Abu-Ghazaleh S, Sloan JA, et al. Phase III randomized double-blind study to evaluate the efficacy of a polycarbophil-based vaginal moisturizer in women with breast cancer. J Clin Oncol 1997;15:969–73
  • SOGC clinical practice guidelines. The detection and management of vaginal atrophy. Number145, May 2004. Int J Gynaecol Obstet 2005;88:222–8
  • Nachtigall LE. Comparative study: Replens versus local estrogen in menopausal women. Fertil Steril 1994;61:178–80
  • Gelfand MM, Wendman E. Treating Vaginal dryness in breast cancer patients: results of applying a polycarbophil moisturizing gel. J Women's Health 1994;3:427–34
  • Hubbard GB, Carey KD, Levine H, Bachmann GA. Evaluation of a vaginal moisturizer in baboons with decreasing ovarian function. Lab Anim Sci 1997;47:36–9
  • Bygdemann M, Swahn ML. Replens versus dienoestrol cream in the symptomatic treatment of vaginal atrophy in postmenopausal women. Maturitas 1996;23:259–63
  • van der Laak JAWM, de Bie LMT, de Leeuw H, de Wilde PCM, Hanselaar AGJM. The effect of Replens on vaginal cytology in the treatment of postmenopausal atrophy: cytomorphology versus computerised cytometry. J Clin Pathol 2002;55:446–51
  • Parsons A, Merritt D, Rosen A, et al. Effect of raloxifene on the response to conjugated estrogen vaginal cream or nonhormonal moisturizers in postmenopausal vaginal atrophy. Obstet Gynecol 2003;101:346–52
  • Caswell M, Kane M. Comparison of the moisturization efficacy of two vaginal moisturizers: Pectin versus polycarbophil technologies. J Cosmet Sci 2002;53:81–7
  • EMERITA: Retrieved at http://www.emerita.com/. Accessed July 10, 2012
  • Tan O, Bradshaw K, Carr BR. Management of vulvovaginal atrophy-related sexual dysfunction in postmenopausal women: an up-to-date review. Menopause 2012;19:109–17
  • RepHresh. Retrieved at: http://www.rephresh.co.uk/. Accessed July 10, 2012
  • Organic Personal Lubricants. Retrieved at: www.yesyesyes.org/. Accessed June 25, 2012
  • Hyalo GYN. Retrieved at: http://www.hyalogyn.com/. Accessed June 25, 2012
  • Hyalofemme®. Retrieved at: http://www.hyalofemme.co.uk/. Accessed July 11, 2012
  • Ekin M, Yaşar L, Savan K, et al. The comparison of hyaluronic acid vaginal tablets with estradiol vaginal tablets in the treatment of atrophic vaginitis: a randomized controlled trial. Arch Gynecol Obstet 2011;283:539–43
  • Le Donne M, Caruso C, Mancuso A, et al. The effect of vaginally administered genistein in comparison with hyaluronic acid on atrophic epithelium in postmenopause. Arch Gynecol Obstet 2011;283:1319–23
  • Morali G, Polatti F, Metelitsa EN, et al. Open, non-controlled clinical studies to assess the efficacy and safety of a medical device in form of gel topically and intravaginally used in postmenopausal women with genital atrophy. Arzneimittelforschung 2006; 56:230–8
  • Prescription drug database and drug prescribing guide | MIMS online. Retrieved at: http://www.mims.co.uk/. Accessed July 16, 2012
  • Adriaens E, Remon JP. Mucosal irritation potential of personal lubricants relates to product osmolality as detected by the slug mucosal irritation assay. Sex Transm Dis 2008;35: 512–16
  • K-Y Jelly. Wikipedia. Retrieved at: http://en.wikipedia.org/wiki/K-Y_Jelly. Accessed June 25, 2012
  • BNF.org. Retrieved at: http://www.bnf.org/. Accessed July 16, 2012
  • SYLK. Retrieved at: http://www.sylk.co.uk/. Accessed June 25, 2012
  • AquaGel. Retrieved at http://www.wms.co.uk/. Accessed July 11, 2012
  • Boots Health and Beauty, Pharmacy. and Prescriptions, UK Chemist - Boots. Retrieved at: http://www.boots.com/. Accessed June 25, 2012
  • RxList – The Internet Drug Index for prescription drugs, medications and pill identifier. Retrieved at: http://www.rxlist.com/script/main/hp.asp. Accessed July 16, 2012
  • Astroglide. Retrieved at: http://en.wikipedia.org/wiki/Astroglide. Accessed June 25, 2012
  • Slippery Stuff Gel. Retrieved at: http://www.wallace-ofarrell.com/. Accessed June 25, 2012
  • Castelo-Branco C, Rostro F. Treatment of atrophic vaginitis. Therapy 2007;4:349–53
  • Bachmann GA, Nevadunsky NS. Diagnosis and treatment of atrophic vaginitis. Am Fam Physician 2000;61:3090–6
  • Leiblum S, Bachmann G, Kemmann E, Colburn D, Swartzman L. Vaginal atrophy in the postmenopausal woman: the importance of sexual activity and hormones. JAMA 1983;249: 2195–8

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.