Estrogens and the cardiovascular system: role of estradiol metabolites in hormone replacement therapy

References

• Kannel B. W., Hjortland M. C., McNamara P. M., et al. Menopause and risk of cardiovascular disease. The Framingham Study. Ann Intern Med 1976; 85: 447–52
   PubMed Web of Science ®Google Scholar
• Lippert T. H., Mueck A. O., Ginsburg J. Sex Steroids and the Cardiovascular System. Parthenon Publishing, London 1997
   Google Scholar
• Hoffmann A. R., Paul S. M., Axelrod J. Estrogen-2 hydroxylase in the rat: distribution and response to hormonal manipulation. Biochetn Pharmacol. 1980; 29: 83–7
   PubMed Web of Science ®Google Scholar
• Van Orden D. E., Clancey C. J., Van Orden C. L., et al. Synthesis of catechol estrone by porcine uterine arteries. Presented at theEndocrine Society. 1983, abstr 30
   Google Scholar
• Van Orden D. E., Ford S. P., Farley D. B., et al. Induction of uterine arterial vasodilation by estradiol and catechol estradiols. Proc Soc Gynecol Invest. 1983, 30:abstr58
   Google Scholar
• Ford S. P., Van Orden D. E., Farley C. B. Effect of cycloheximide on catechol estrogen induced uterine hyperemia. Profi Soc Gynecol Invest 1986; 33, abstr 378
   Google Scholar
• Stice S. L., Ford S. P., Rosazza J. P., et al. Role of 4-hydroxylated estradiol in reducing Ca2+uptake of uterine arterial smooth muscle cells through potential-sensitive channels. Biol Reprod 1987; 36: 361–8
   PubMed Web of Science ®Google Scholar
• Stice S. L., Ford S. P., Rosazza J. P., et al. Interaction of 4-hydroxylated estradiol and potential-sensitive Ca2+channels in altering uterine blood flow during the estrous cycle and early pregnancy in gilts. Biol Reprod 1987; 36: 369–75
   PubMed Web of Science ®Google Scholar
• Heinle H., Orth N., Neeser E., . Effects of 17β-estradiol and its catechol metabolites on the contractility of human uterine artery: in vitro experiments. Sex Steroids and the Cardiovascular System, T.H. Lippert, A.O. Mueck, J. Ginsburg, et al. Parthenon Publishing, London 1997; 75–83
   Google Scholar
• Orth N., Neeser E., Seeger H., et al. Calcium antagonistic effect of estrogen and estrogen metabolites in smooth muscle: evidence from contraction measurements and intracellular calcium imageing. Pflügers Arch Eur J Physiol 1998; 435(Suppl)R204
   Google Scholar
• Ross R. The pathogenesis of atherosclerosis - an update. N. Engl J Med 1986; 314: 488–500
   PubMed Web of Science ®Google Scholar
• Fotsis T., Zhang Y., Pepper M. S., et al. The endogenous oestrogen metabolite 2-methoxyoestradiol inhibits angiogenesis and suppresses tumour growth. Nature (London) 1994; 368: 237–9
   PubMed Web of Science ®Google Scholar
• Nishigaki I., Sasaguri Y., Yagi K. Antiproliferative effect of 2-methoxyestradiol on cultured smooth muscle cells from rabbit aorta. Atherosclerosis. 1995; 113: 167–70
   PubMed Web of Science ®Google Scholar
• Seeger H., Mueck A. O., Lippert T. H. The antiproliferative effect of 17β-estradiol metabolites on human coronary artery smooth muscle cells. MedSci Res. 1998; 26: 481–2
   Google Scholar
• Bradlow H. L., Telang N. T., Sepkovic D. W., et al. 2-Hydroxyestrone: the ‘good’ estrogen. J Endocrinol 1996; 150: S259–65
   PubMed Web of Science ®Google Scholar
• Oettel M., Dören M., Hübler D., et al. Freie Radikale und Sexualhormone. J Menopause 1995; 3: 21–8
   Google Scholar
• Sack M. N., Rader D. J., Cannon R. O. Oestrogen and inhibition of oxidation of low-density lipoproteins in postmenopausal women. Lancet. 1994; 343: 269–70
   PubMed Web of Science ®Google Scholar
• Bush T. L., Barrett-Connor E., Cowan L. D., et al. Cardiovascular mortality and noncontraceptive use of estrogen in women: results from the Lipid Research Clinics Program Follow-up Study. Circulation 1987; 75: 1102–9
   PubMed Web of Science ®Google Scholar
• Gordon S., Cantrall E. W., Cekleniak W. P., et al. Steroid and lipid metabolism. The hypocholest-eremic effect of estrogen metabolites. Steroids 1964; 4: 267–71
   Web of Science ®Google Scholar
• Kono S., Higa H., Sunagawa H. Effects of catecholestrogen 2-monomethyl ether on serum cholesterol and lipoprotein levels. Asia-Oceania J Obstet Gynaecol. 1988; 14: 399–403
   PubMedGoogle Scholar
• Liu D. F., Bachmann K. A. An investigation of the relationship between estrogen, estrogen metabolites and blood cholesterol levels in ovari-ectomized rats. J Pharmacol Exp Ther 1998; 286: 561–8
   PubMed Web of Science ®Google Scholar
• Taniguchi S., Yanase T., Kobayashi K., et al. Catechol estrogens are more potent antioxidants than estrogens for the Cu2+-catalyzed oxidation of low or high density lipoprotein: antioxidative effects of steroids on lipoproteins. Endocr J 1994; 41: 605–11
   PubMed Web of Science ®Google Scholar
• Lacorte M., Leal A. M., Liza M., et al. Protective effect of estrogens and catecholestrogens against peroxidative membrane damage. in vitro. Lip is 1995; 30: 141–6
   PubMed Web of Science ®Google Scholar
• Esterbauer H., Striegl G., Puhl H, et al. Continuous monitoring ofin vitrooxidation of human low density lipoprotein. Free Rad Res Comm 1989; 6: 67–75
   PubMed Web of Science ®Google Scholar
• Seeger H., Mueck A. O., Lippert T. H. Effect of estradiol metabolites on the susceptibility of low density lipoprotein to oxidation. Life Sci. 1997; 61: 865–8
   PubMed Web of Science ®Google Scholar
• Seeger H., Mueck A. O., Lippert T. H. The inhibitory effect of endogenous estrogen metabolites on Climacteric copper-mediatedin vitrooxidation of LDL. Int] Clin Pharmacol Ther. 1998; 36: 383–5
   PubMedGoogle Scholar
• Fishman J., Martucci C. Dissociation of biological activities in metabolites of estradiol. Estrogens in the Environment, J.A. McLachlan. Elsevier, North Holland 1980; 131–45
   Google Scholar
• Zumoff B., Fishman J, Cassouto J., et al. Influence of age and sex on normal estradiol metabolism. J Clin Endocrinol 1968; 28: 937–41
   PubMed Web of Science ®Google Scholar
• Zumoff B., Fishman J., Cassouto J., et al. Estradiol transformation in men with breast cancer. J Clin Endocrinol 1966; 26: 960–7
   Web of Science ®Google Scholar
• Habenicht U. F. Estrogens for men: good or bad news. Aging Male. 1998; 1: 73–9
   Google Scholar
• Friedl K. E., Hannan C. J., Jines R. E., et al. High density lipoprotein-cholesterol is not decreased if an aromatizable androgen is administered. Metabolism 1590; 39: 69–74
   Google Scholar
• Bradlow H. L., Michnovicz J. J., Wong GYC, et al. Long-term responses of women to indole-3-carbinol or a high fiber diet. Cancer Prevent Biomark Epidemiol 1994; 3: 591–5
   PubMed Web of Science ®Google Scholar
• Zhu B. T., Conney A. H. Functional role of estrogen metabolism in target cells: review and perspectives. Carcinogenesis. 1998; 19: 1–27
   PubMed Web of Science ®Google Scholar