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Original Article

Herba Cistanche extract enhances mitochondrial glutathione status and respiration in rat hearts, with possible induction of uncoupling proteins

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Pages 512-517 | Received 26 Nov 2008, Accepted 05 Mar 2009, Published online: 28 Apr 2010

References

  • Ataka K, Chen D, Levitsky S, Jimenez E, Feinberg H (1992): Effect of aging on intracellular Ca2+, pHi, and contractility during ischemia and reperfusion. Circulation 86: II371–II376.
  • Bento LM, Fagian MM, Vercesi AE, Gontijo JA (2007): Effects of NH4Cl-induced systemic metabolic acidosis on kidney mitochondrial coupling and calcium transport in rats. Nephrol Dial Transplant 22: 2817–2823.
  • Bonavita F, Stefanelli C, Giordano E, Columbaro M, Facchini A, Bonafe F, Caldarera CM, Guarnieri C (2003): H9c2 cardiac myoblasts undergo apoptosis in a model of ischemia consisting of serum deprivation and hypoxia: inhibition by PMA. FEBS Lett 536: 85–91.
  • Chen P (1998): Tonic Herbs. Advanced TCM Series. Beijing, Science Press, pp. 233–320.
  • Chiu PY, Ko KM (2003): Time-dependent enhancement in mitochondrial glutathione status and ATP generation capacity by schisandrin B treatment decreases the susceptibility of rat hearts to ischemia-reperfusion injury. Biofactors 19: 43–51.
  • Chiu PY, Luk KF, Leung HY, Ng KM, Ko KM (2008): Schisandrin B stereoisomers protect against hypoxia/reoxygenation-induced apoptosis and inhibit associated changes in Ca2+-induced mitochondrial permeability transition and mitochondrial membrane potential in H9c2 cardiomyocytes. Life Sci 82: 1092–1101.
  • Echtay KS, Roussel D, St Pierre J, Jekabsons MB, Cadenas S, Stuart JA, Harper JA, Roebuck SJ, Morrison A, Pickering S, Clapham JC, Brand MD (2002): Superoxide activates mitochondrial uncoupling proteins. Nature 415: 96–99.
  • Evans WH (1992): Isolation and characterization of membranes and cell organelles. In: Rickwood D, ed., Preparative Centrifugation. A Practical Approach. New York, Oxford University Press, pp. 233–270.
  • Garvey WT (2003): The role of uncoupling protein 3 in human physiology. J Clin Invest 111: 438–441.
  • Griffith OW (1980): Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. Anal Biochem 106: 207–212.
  • Grover GJ, Dzwonczyk S, Sleph PG (1990): Ruthenium red improves postischemic contractile function in isolated rat hearts. J Cardiovasc Pharmacol 16: 783–789.
  • Hoerter J, Gonzalez-Barroso MD, Couplan E, Mateo P, Gelly C, Cassard-Doulcier AM, Diolez P, Bouillaud F (2004): Mitochondrial uncoupling protein 1 expressed in the heart of transgenic mice protects against ischemic-reperfusion damage. Circulation 110: 528–533.
  • Javadov S, Huang C, Kirshenbaum L, Karmazyn M (2005): NHE-1 inhibition improves impaired mitochondrial permeability transition and respiratory function during postinfarction remodelling in the rat. J Mol Cell Cardiol 38: 135–143.
  • Kuwabara M, Takenaka H, Maruyama H, Onitsuka T, Hamada M (1997): Effect of prolonged hypothermic ischemia and reperfusion on oxygen consumption and total mechanical energy in rat myocardium: participation of mitochondrial oxidative phosphorylation. Transplantation 64: 577–583.
  • Lemasters JJ, Nieminen AL, Qian T, Trost LC, Elmore SP, Nishimura Y, Crowe RA, Cascio WE, Bradham CA, Brenner DA, Herman B (1998): The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy. Biochim Biophys Acta 1366: 177–196.
  • Leung HY (2006): Effect of Herba Cistanche on mitochondrial ATP generation: a pharmacological basis of “Yang-invigoration”. MPhil Thesis, Hong Kong University of Science and Technology, pp. 67–69.
  • Leung HY, Ko KM (2008): Herba Cistanche extract enhances mitochondrial ATP generation in rat hearts and H9C2 cells. Pharma Biol 46: 418–424.
  • Menze MA, Hutchinson K, Laborde SM, Hand SC (2005): Mitochondrial permeability transition in the crustacean Artemia franciscana: absence of a calcium-regulated pore in the face of profound calcium storage. Am J Physiol Regul Integr Comp Physiol 289: R68–R76.
  • Redegeld FA, Moison RM, Koster AS, Noordhoek J (1992): Depletion of ATP but not of GSH affects viability of rat hepatocytes. Eur J Pharmacol 228: 229–236.
  • Teshima Y, Akao M, Jones SP, Marban E (2003): Uncoupling protein-2 overexpression inhibits mitochondrial death pathway in cardiomyocytes. Circ Res 93: 192–200.
  • Yim TK, Ko KM (2002): Antioxidant and immunomodulatory activities of Chinese tonifying herbs. Pharm Biol 40: 329–335.

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