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Original Article

Enhanced production of silymarin by Ag+ elicitor in cell suspension cultures of Silybum marianum

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Pages 708-715 | Received 19 Nov 2008, Accepted 30 Apr 2009, Published online: 06 May 2010

References

  • Cacho M, Moran M, Corchete P, Fernandez-Tarrago J (1999): Influence of medium composition on the accumulation of flavonolignans in cultured cells of Silybum marianum (L.) Gaertn. Plant Sci 144: 63–68.
  • Hasanloo T, Khavari Nejad RA, Majidi E (2007a): Evaluation of phenotypic coefficient and flavonolignan content in dried fruits of cultivated and endemic Silybum marianum (L.) Gaertn. J Med Plants 22: 77–90.
  • Hasanloo T, Khavari Nejad RA, Majidi E, Shams-Ardakani MR (2005a): Analysis of flavonolignans in dried fruits of Silybum marianum (L.) Gaertn from Iran. Pak J Biol Sci 8: 1778–1782.
  • Hasanloo T, Khavari Nejad RA, Majidi E, Ziai SA, Shams-Ardakani MR (2005b): Determination of flavonolignan of dried fruits of Silybum marianum L. Gaertn collected from different areas of Iran by spectrophotometer, TLC and HPLC. J Med Plants 4: 25–32.
  • Hasanloo T, Khavari Nejad RA, Majidi E (2007b): Media optimization for flavonolignans accumulation and growth index of callus culture of Silybum marianum (L.) Gaertn. J. Plant Res 1: 7–12.
  • Hasanloo T, Khavari Nejad RA, Majidi E, Shams-Ardakani MR (2008): Flavonolignan production in cell suspension culture of Silybum marianum (L.) Gaertn. Pharm Biol 46: 1–6.
  • Katiyar SK (2002): Treatment of silymarin, a plant flavonoid, prevents ultraviolet light-induced immune suppression and oxidative stress in mouse skin. Int J Oncol 21: 1213–1222.
  • Kvasnicka F, Biba B, Sevcik R, Voldrich M, Kratka J (2003): Analysis of the active components of silymarin. J Chromatogr A 990: 239–245.
  • Murashige T, Skoog F (1962): A revised medium for rapid growth and bioassays with tobacco tissue cultures. Physiol Plant 15: 473–497.
  • Namdeo AG (2007): Plant cell elicitation for production of secondary metabolites: A review. Pharmacog Rev 1: 69–79.
  • Neil SJ, Lenton JR, Wibberely MS (1994): Differential effects of elicitors on secondary metabolism in hairy root cultures of tobacco (Nicotiana tabacum). Biochem Soc Trans 22: 383–388.
  • Pan Z, Wang H, Zhong J (2000): Scale up study on suspension cultures of Taxus chinensis cells for production of taxane diterepene. Enzyme Microb Technol 27: 714–723.
  • Rahnama H, Hasanloo T, Shams, MR, Sepehrifar R (2008): Silymarin production in hairy root culture of Silybum marianum (L.) Gaertn. Iran J Biotechnol 6: 113–118.
  • Rajendran L, Suvarnalatha G, Ravishankar GA, Venkataraman LV (1994): Enhancement of anthocyanin production in callus cultures of Daucus carota L., under the influence of fungal elicitors. Appl Microbial Biotechnol 42: 227–231.
  • Sanchez-Sampedro MA, Fernandez-Tarago J, Corchete P (2005a): Yeast extract and methyl jasmonate induced silymarin production in cell culture of Silybum marianum L. Gaerth. J Biotechnol 119: 60–69.
  • Sanchez-Sampedro MA, Fernandez-Tarago J, Corchete P (2007): Silymarin synthesis and degradation by peroxidases of cell suspension cultures of Silybum marianum. J Plant Physiol 164: 669–674.
  • Sanchez-Sampedro MA, Fernandez-Tarrago J, Corchete P (2005b): Enhanced silymarin accumulation is related to calcium deprivation in cell suspension cultures of Silybum marianum L. Gaertn. Plant Physiol 162: 1177–1182.
  • Shams-Ardakani MR, Hemmati S, Mohagheghzadeh A (2005): Effect of elicitors on the enhancement of podophylotoxin biosynthesis in suspension cultures of Linum album. Daru 13: 56–60.
  • Thoma I, Loeffler C, Sinha AK, Gupta M, Krischke M, Steffan B, Roitsch T, Mueller MJ (2003): Cyclopentenone isoprostanes induced by reactive oxygen species trigger defense gene activation and phytoalexin accumulation in plants. Plant J 34: 363–375.
  • Tumova L, Gallova K, Rimakova J (2001): Silybum marianum. In vitro. Ceska Slov Farm 53: 135–140.
  • Van Erp NPH, Baker S, Zhao M, Rudek MA, Guchelaar HJ, Nortier JWR, Sparreboom A, Gelderblom H (2005): Effect of milk thistle (Silybum marianum) on the pharmacokinetics of irinotecan. Clin Cancer Res 11: 7800–7806.
  • Vasconsuelo A, Boland R (2007): Molecular aspects of the early stages of elicitation of secondary metabolites in plants. Plant Sci 172: 861–875.
  • Veladimir K, Walterova D (2005): Silybin and silymarin new effects and applications. Biomed Papers 149: 29–41.
  • Walker TS, Pal Bais H, Vivanco JM (2002): Jasmonic acid-induced hypericin production in cell suspension cultures of Hypericum perforatum L. (St. John’s wort). Phytochemistry 60: 289–293.
  • Xu C, Zho B, Ou Y, Wang X, Yung X, Wang Y (2007): Elicitor-enhanced syringin production in suspension cultures of Sussurea medusa. World J Microbiol Biotechnol 23: 965–970.
  • Zhang CZ, Wu JY (2003): Ethylene inhibitors enhance elicitor-induced paclitaxel production in suspension cultures of Taxus spp. cells. Enzyme Microb Technol 32: 71–77.
  • Zhao J, Davis LC, Verpoorte R (2005): Elicitor signal transduction leading to production of plant secondary metabolites. Biotechnol Adv 23: 283–333.
  • Zhao J, Hu Q, Zhu WH (2001): Enhanced catharanthine production in Catharanthus roseus cell cultures by combined elicitor treatment in shake flasks and bioreactors. Enzyme Microb Technol 28: 673–681.

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