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Research Article

Anti-inflammatory activity of Alchornea triplinervia ethyl acetate fraction: Inhibition of H2O2, NO and TNF-α

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Pages 1320-1327 | Received 20 Aug 2009, Accepted 03 Mar 2010, Published online: 14 Sep 2010

References

  • Abad MJ, Bermejo P, Alvarez M, Guerra JA, Silvan AM, Villar AM (2004): Flavonoids and a sesquiterpene lactone from Tanacetum microphyllum inhibit anti-inflammatory mediators in LPS-stimulated mouse peritoneal macrophages. Planta Med 70: 34–38.
  • Achike FI, Kwan CY (2003): Nitric oxide, human diseases and the herbal products that affect the nitric oxide signaling pathway. Clin Exp Pharmacol Physiol 30: 605–615.
  • Alvarez E, Leiro J, Orallo F (2002): Effect of (-)-epigallocatechin-3-gallate on respiratory burst of rat macrophages. Int Immunopharmacol 2: 849–855.
  • Ayisi NK, Nyadedzor C (2003): Comparative in vitro effects of AZT and extracts of Ocimum gratissimum, Ficus polita, Clausena anisata, Alchornea cordifolia, and Elaeophorbia drupifera against HIV-1 and HIV-2 infections. Antiviral Res 58: 25–33.
  • Barroso GM (1984): Sistemática de Angiospermas do Brasil. Viçosa, Brazil, UFV Imprensa Universitária.
  • Beckman JS, Koppenol WH (1996): Nitric oxide, superoxide, and peroxynitrite: The good, the bad, and ugly. Am J Physiol 271: C1424–1437.
  • Benencia F, Courrèges MC, Coulombié FC (1999): Trichilia glabra: Effect on the phagocytic activity and respiratory burst response of peritoneal macrophages. Immunopharmacol 41: 45–53.
  • Braca A, Mendez J, Menichini F, Morelli I (2002): Constituents of Alchornea triplinervia (Euphorbiaceae). Biochem Syst Ecol 30: 1109–1111.
  • Calixto JB, Campos MM, Otuki MF, Santos ARS (2004): Anti-inflammatory compounds of plant origin. Part II. Modulation of pro-inflammatory cytokines, chemokines, adhesion molecules. Planta Med 70: 93–103.
  • Clark A (2000): Post-transcriptional regulation of pro-inflammatory gene expression. Arthritis Res 2: 172–174.
  • Clement M, Ponton A, Pervaiz S (1998): Apoptosis induced by hydrogen peroxide is mediated by decreased superoxide anion concentration and reduction of intracellular milieu. Febs Letters 440: 13–18.
  • Cook CN, Samman S (1996): Flavonoids – Chemistry, metabolism, cardioprotective effects and dietary sources. J Nutr Biochem 7: 66–76.
  • D’Alessandro T, Prasain J, Benton MR, Botting N, Moore R, Darley-Usmar V, Patel R, Barnes S (2003): Polyphenols, inflammatory response, and cancer prevention: Chlorination of isoflavones by human neutrophils. J Nutr 133: S3773–3777.
  • Di Stasi LC, Oliveira GP, Carvalhaes MA, Queiroz Junior M, Tien OS, Kakinami SH, Reis MS (2002): Medicinal plants popularly used in the Brazilian Tropical Atlantic Forest. Fitoterapia 73: 69–91.
  • Dirsch VM, Kiemer AK, Wagner H, Vollmar AM (1998): Effect of allicin and ajoene, two compounds of garlic, on inducible nitric oxide synthase. Atherosclerosis 139: 333–339.
  • Dunstan CA, Noreen Y, Serrano G, Cox PA, Perera P, Bohlin L (1997): Evaluation of some Samoan and Peruvian medicinal plants by prostaglandin biosysthesis and rat ear oedema assays. J Ethnopharmacol 57: 35–56.
  • Durigan G, Bacic MC, Franco GADC, Siqueira MF (1999): Inventário Florístico do Cerrado na Estação Ecológica de Assis, SP. Hoehnea 26: 149–172.
  • Eigler A, Sinha B, Hartmann G, Endres S (1997): Taming TNF: Strategies to restrain this proinflamatory cytokine. Immunol Today 18: 487–492.
  • Elisabetsky E, Wannmacher L (1993): The status of ethnopharmacology in Brazil. J Ethnopharmacol 38: 137–143.
  • Forman HJ, Torres M (2001): Redox signaling in macrophages. Mol Aspects Med 22: 189–216.
  • Goldsby RA, Kindt TJ, Osborne BA (2000): Kuby Immunology. New York, W.H. Freeman.
  • Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR (1982): Analysis of nitrate, nitrite, and [15N] nitrate in biological fluids. Anal Biochem 126: 131–138.
  • Guzik TJ, Korbut R, Adamek-Guzik T (2003): Nitric oxide and superoxide in inflammation and immune regulation. J Physiol Pharmacol 54: 469–487.
  • Halliwell B (1987): Oxidants and human disease: Some new concepts. FASEB J 1: 358–364.
  • Hobbs AJ, Higgs A, Moncada S (1999): Inhibition of nitric oxide synthase as a potential therapeutic target. Ann Rev Pharmacol Toxicol 39: 191–220.
  • Holetz FB, Pessini GL, Sanches NR, Cortez DA, Nakamura CV, Filho BP (2002): Screening of some plants used in the Brazilian folk medicine for the treatment of infectious diseases. Mem Inst Oswaldo Cruz 97: 1027–1031.
  • Kobuchi H, Droy-Lefaix MT, Christen Y, Packer L (1997): Ginkgo biloba extract (EGb 761): Inhibitory effect on nitric oxide production in the macrophage cell line RAW 264.7. Biochem Pharmacol 53: 897–903.
  • Kong JM, Goh NK, Chia LS, Chia TF (2003): Recent advances in traditional plant drugs and orchids. Acta Pharmacol Sin 24: 7–21.
  • Lee HS, Kim BS, Kim MK (2002): Suppression effect of Cinnamomum cassia bark-derived component on nitric oxide synthase. J Agric Food Chem 50: 7700–7703.
  • Lima ZP, Calvo TR, Silva EF, Pellizzon CH, Vilegas W, Brito AR, Bauab TM, Hiruma-Lima CA (2008): Brazilian medicinal plant acts on prostaglandin level and Helicobacter pylori. J Med Food 11: 701–708.
  • Lopes FC, Calvo TR, Vilegas W, Carlos IZ (2005): Inhibition of hydrogen peroxide, nitric oxide and TNF-alpha production in peritoneal macrophages by ethyl acetate fraction from Alchornea glandulosa. Biol Pharm Bull 28: 1726–1730.
  • Manga HM, Brkic D, Marie DEP, Quetin-Leclercq J (2004): In vivo anti-inflammatory activity of Alchornea cordifolia (Schumach. & Thonn.) Müll. Arg. (Euphorbiaceae). J Ethnopharmacol 92: 209–214.
  • Mosmann T (1983): Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65: 55–63.
  • Moss ML, White JM, Lambert MH, Andrews RC (2001): TACE and other ADAM proteases as targets for drug discovery. Drug Discov Today 6: 417–426.
  • Osadebe PO, Okoye FB (2003): Anti-inflammatory effects of crude methanolic extract and fractions of Alchornea cordifolia leaves. J Ethnopharmacol 89: 19–24.
  • Palladino MA, Bahjat FR, Theodorakis EA, Moldawer LL (2003): Anti-TNF-α therapies: The next generation. Nat Rev Drug Discov 2: 736–746.
  • Pick E, Keisari Y (1980): A simple colorimetric method for the measurement of hydrogen peroxide produced by cells in culture. J Immunol Methods 38: 161–170.
  • Pick E, Mizel DJ (1981): Rapid microassays for the measurement of superoxide and hydrogen peroxide production by macrophages in culture using an automatic enzyme immunoassay reader. J Immunol Methods 46: 211–226.
  • Ramasarma T (1990): H2O2 has a role in cellular regulation. Indian J Biochem Biophys 27: 269–274.
  • Robak J, Gryglewski RJ (1996): Bioactivity of flavonoids. Pol J Pharmacol 48: 555–564.
  • Schulz V, Hänsel R, Tyler VE (2002): Fitoterapia Racional: Um Guia de Fitoterapia para as Ciências da Saúde. Barueri, Brazil, Manole.
  • Secco RS (2004): Alchorneae (Euphorbiaceae: Alchornea, Aparisthmium e Conceveiba). Flora Neotropica 93: 1–195.
  • Seo WG, Pae HO, Oh GS, Chai KY, Yun YG, Kwon TO, Chung HT (2001): Inhibitory effect of ethyl acetate fraction from Cudrania tricuspidata on the expression of nitric oxide synthase gene in RAW 264.7 macrophages stimulated with interferon-γ and lipopolysaccharide. Gen Pharmacol 35: 21–28.
  • Setzer WN, Shen X, Bates RB, Burns JR, Mcclure KJ, Zhang P, Moriarity DM, Lawton RO (2000): A phytochemical investigation of Alchornea latifolia. Fitoterapia 71: 195–198.
  • Shen SC, Lee WR, Lin HY, Huang HC, Ko CH, Yang LL, Chen YC (2002): In vitro and in vivo inhibitory activities of rutin, wogonin, and quercetin on lipopolysaccharide-induced nitric oxide and prostaglandin E2 production. Eur J Pharmacol 446: 187–194.
  • Silva EM, Hiruma-Lima CA, Lólis SF (2000): Etnobotânica no município de Porto Nacional [abstract]. In: Symposium of Brazilian Medicinal Plants, Cuiabá, Federal University of Mato Grosso (UFMT), p.106.
  • Silva FC, Marconi LP (1990): Fitossociologia de uma floresta com araucária em Colombo-PR. Boletim de Pesquisa Florestal 20: 23–38.
  • Siqueira MF (1994): Análise florística e ordenação de espécies arbóreas da Mata Atlântica através de dados binaries. MSc thesis, Unicamp, Campinas, Brazil.
  • Southan GJ, Szabo C (1996): Selective pharmacological inhibition of distinct nitric oxide synthase isoforms. Biochem Pharmacol 51: 383–394.
  • Stannard BL (1995): Flora of the Pico das Almas, Chapada Diamantina −Bahia, Brazil. London, Royal Botanic Gardens, Kew.
  • Trotter RT, Logan MH, Rocha JM, Boneta JL (1982): Ethnography and bioassay: Combined method for a preliminary screen of home remedies for potential pharmacological activity. J Ethnopharmacol 8: 113–119.
  • Vaccaro S, Longhi SJ, Brena DA (1999): Aspectos da composição florística e categorias sucessionais do estrato arbóreo de três subseres de uma floresta estacional decidual, no Município de Santa Tereza - RS. Ciência Florestal 9: 1–18.
  • Wagner HM, Bladt S, Zgainski EM (1986): Plant Drug Analysis. Berlin, Germany: Springer.
  • Williams JE (2001): Review of antiviral and immunomodulating properties of plants of the Peruvian rainforest with a particular emphasis on Una de Gato and Sangre de Grado. Altern Med Rev 6: 567–579.
  • Yunes RA, Calixto JB (2001): Plantas Medicinais sob a Ótica da Química Medicinal Moderna. Chapecó, Brazil: Argos.

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