Antimalarial natural products drug discovery in Panama

References

• Abiodun OO, Gbotosho GO, Ajaiyeoba EO, Happi CT, Hofer S, Wittlin S, Sowunmi A, Brun R, Oduola AM. (2010). Comparison of SYBR Green I-, PicoGreen-, and [3H]-hypoxanthine-based assays for in vitro antimalarial screening of plants from Nigerian ethnomedicine. Parasitol Res, 106, 933–939.
   PubMed Web of Science ®Google Scholar
• Adebajo AC, Olawode EO, Omobuwajo OR, Adesanya SA, Begrow F, Elkhawad A, Akanmu MA, Edrada R, Proksch P, Schmidt TJ, Klaes M, Verspohl EJ. (2007). Hypoglycaemic constituents of Stachytarpheta cayennensis leaf. Planta Med, 73, 241–250.
   PubMed Web of Science ®Google Scholar
• Baniecki ML, Wirth DF, Clardy J. (2007). High-throughput Plasmodium falciparum growth assay for malaria drug discovery. Antimicrob Agents Chemother, 51, 716–723.
   PubMed Web of Science ®Google Scholar
• Berenbaum MC. (1978). A method for testing for synergy with any number of agents. j Infect Dis, 137, 122–130.
   PubMed Web of Science ®Google Scholar
• Bero J, Quetin-Leclercq J. (2011). Natural products published in 2009 from plants traditionally used to treat malaria. Planta Med, 77, 631–640.
   PubMed Web of Science ®Google Scholar
• Calderón AI, Romero LI, Ortega-Barría E, Brun R, Correa MD, Gupta MP. (2006). Evaluation of larvicida land in vitro antiparasitic activities of plants in a biodiversity plot in the Altos de Campana National Park, Panama. Pharm Biol, 44, 487–498.
   Web of Science ®Google Scholar
• Calderón AI, Romero LI, Ortega-Barría E, Solís PN, Zacchino S, Gimenez A, Pinzón R, Cáceres A, Tamayo G, Guerra C, Espinosa A, Correa M, Gupta MP. (2010). Screening of Latin American plants for antiparasitic activities against malaria, Chagas disease, and leishmaniasis. Pharm Biol, 48, 545–553.
   PubMed Web of Science ®Google Scholar
• Canfield CJ, Pudney M, Gutteridge WE. (1995). Interactions of atovaquone with other antimalarial drugs against Plasmodium falciparum in vitro. Exp Parasitol, 80, 373–381.
   PubMed Web of Science ®Google Scholar
• Corbett Y, Herrera L, Gonzalez J, Cubilla L, Capson TL, Coley PD, Kursar TA, Romero LI, Ortega-Barria E. (2004). A novel DNA-based microfluorimetric method to evaluate antimalarial drug activity. Am j Trop Med Hyg, 70, 119–124.
   PubMed Web of Science ®Google Scholar
• Correa MD, Galdames C, Stapf de Maria S. (2004). Catálogo de plantas vasculares de Panamá. Editora Novo Art, SA, Panama. Available at: http://herbario.up.ac.pa. Accessed on 5 May 2011.
   Google Scholar
• Correa M. Director of the Herbarium of University of Panama, personal communication based on her updated checklist dated 5 May 2011. [email protected].
   Google Scholar
• Desjardins RE. (1984). In vitro techniques for antimalarial development and evaluation. In: Peters W and Richards WH, ed. Handbook of Experimental Pharmacology. Germany: Springer-Verlag, 179–200.
   Google Scholar
• Desjardins RE, Canfield CJ, Haynes JD, Chulay JD. (1979). Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique. Antimicrob Agents Chemother, 16, 710–718.
   PubMed Web of Science ®Google Scholar
• Sahal D, Kannan R, Chauhan VS. (2003). Applying malaria parasite’s heme detoxification system for screening potential antimalarial drugs. Anal Biochem, 312, 258–260.
   PubMed Web of Science ®Google Scholar
• Fidock DA, Rosenthal PJ, Croft SL, Brun R, Nwaka S. (2004). Antimalarial drug discovery: efficacy models for compound screening. Nat Rev Drug Discov, 3, 509–520.
   PubMed Web of Science ®Google Scholar
• Froelich S, Gupta MP, Siems K, Jenett-Siems K. (2008). Phenylethanoid glycosides from Stachytarphetacayennensis (Rich.) Vahl, Verbenaceae, a traditional antimalarial medicinal plant. Rev Bras Farmacogn, 18, 517–520.
   Google Scholar
• Gupta MP, Correa MD, Solís PN, Jones A, Galdames C, Guionneau-Sinclair F. (1993). Medicinal plant inventory of Kuna Indians: Part 1. j Ethnopharmacol, 40, 77–109.
   PubMed Web of Science ®Google Scholar
• Gupta MP, Solís PN, Calderón AI, Guionneau-Sinclair F, Guinneau-Sinclair F, Correa M, Galdames C, Guerra C, Espinosa A, Alvenda GI, Robles G, Ocampo R. (2005). Medical ethnobotany of the Teribes of Bocas del Toro, Panama. j Ethnopharmacol, 96, 389–401.
   PubMed Web of Science ®Google Scholar
• Hussein AA, Bozzi B, Correa M, Capson TL, Kursar TA, Coley PD, Solis PN, Gupta MP. (2003). Bioactive constituents from three Vismia species. j Nat Prod, 66, 858–860.
   PubMed Web of Science ®Google Scholar
• Jenett-Siems K, Köhler I, Kraft C, Siems K, Solis PN, Gupta MP, Bienzle U. (2003). Cornutins C-L, neo-clerodane-type diterpenoids from Cornutia grandifolia var. intermedia. Phytochemistry, 64, 797–804.
   PubMed Web of Science ®Google Scholar
• Jenett-Siems K, Kraft C, Siems K, Jakupovic J, Solis PN, Gupta MP, Bienzle U. (2003). Sipaucins A-C, sesquiterpenoids from Siparuna pauciflora. Phytochemistry, 63, 377–381.
   PubMed Web of Science ®Google Scholar
• Jenett-Siems K, Siems K, Jakupovic J, Solis PN, Gupta MP, Mockenhaupt FP, Bienzle U, Eich E. (2000). Sipandinolide: a butenolide including a novel type of carbon skeleton from Siparuna andina. Planta Med, 66, 384–385.
   PubMed Web of Science ®Google Scholar
• Joly LG, Guerra S, Séptimo R, Solís PN, Correa M, Gupta M, Levy S, Sandberg F. (1987). Ethnobotanical inventory of medicinal plants used by the Guaymi Indians in western Panama. Part I. j Ethnopharmacol, 20, 145–171.
   PubMed Web of Science ®Google Scholar
• Joly LG, Guerra S, Séptimo R, Solís PN, Correa MD, Gupta MP, Levy S, Sandberg F, Perera P. (1990). Ethnobotanical inventory of medicinal plants used by the Guaymi Indians in western Panama. Part II. j Ethnopharmacol, 28, 191–206.
   PubMed Web of Science ®Google Scholar
• Kalra BS, Chawla S, Gupta P, Valecha N. (2006). Screening of antimalarial drugs: An overview. Indian J Pharmacol, 38, 5–12.
   Google Scholar
• Kaur K, Jain M, Kaur T, Jain R. (2009). Antimalarials from nature. Bioorg Med Chem, 17, 3229–3256.
   PubMed Web of Science ®Google Scholar
• Kraft C, Jenett-Siems K, Siems K, Gupta MP, Bienzle U, Eich E. (2000). Antiplasmodial activity of isoflavones from Andira inermis. j Ethnopharmacol, 73, 131–135.
   PubMed Web of Science ®Google Scholar
• Kraft C, Jenett-Siems K, Siems K, Solis PN, Gupta MP, Bienzle U, Eich E. (2001). Andinermals A-C, antiplasmodial constituents from Andira inermis. Phytochemistry, 58, 769–774.
   PubMed Web of Science ®Google Scholar
• Kvist LP, Christensen SB, Rasmussen HB, Mejia K, Gonzalez A. (2006). Identification and evaluation of Peruvian plants used to treat malaria and leishmaniasis. j Ethnopharmacol, 106, 390–402.
   PubMed Web of Science ®Google Scholar
• Makler MT, Hinrichs DJ. (1993). Measurement of the lactate dehydrogenase activity of Plasmodium falciparum as an assessment of parasitemia. Am j Trop Med Hyg, 48, 205–210.
   PubMed Web of Science ®Google Scholar
• Martin F, Hay AE, Cressend D, Reist M, Vivas L, Gupta MP, Carrupt PA, Hostettmann K. (2008). Antioxidant C-Glucosylxanthones from the Leaves of Arrabidaea patellifera. j Nat Prod, 71, 1887–1890.
   PubMed Web of Science ®Google Scholar
• Molinar-Toribio E, González J, Ortega-Barría E, Capson TL, Coley PD, Kursar TA, McPhail KL, Cubilla-Rios L. (2006). Antiprotozoal activity against Plasmodium falciparum and Trypanosomacruzi of xanthones isolated from Chrysochlamystenuis. Pharm Biol, 44, 550–553.
   Web of Science ®Google Scholar
• Montenegro H, González J, Ortega-Barría E, Cubilla-Rios L. (2007). Antiprotozoal activity of flavonoid glycosides isolated from Climediasericea and Mosquitoxylonjamaicense. Pharm Biol, 45, 376–380.
   Web of Science ®Google Scholar
• Mulabagal V, Calderón AI. (2010). Development of binding assays to screen ligands for Plasmodium falciparum thioredoxin and glutathione reductases by ultrafiltration and liquid chromatography/mass spectrometry. j Chromatogr b Analyt Technol Biomed Life Sci, 878, 987–993.
   PubMed Web of Science ®Google Scholar
• Munigunti R, Nelson N, Mulabagal V, Gupta MP, Brun R, Calderón AI. (2011). Identification of oleamide in Guatteriare curvisepala by LC-MS based Plasmodium falciparum thioredoxinreductase ligand binding method. DOI: http://dx.doi.org/10.1055/s-0030–1271080.
   Google Scholar
• Muthaura CN, Keriko JM, Derese S, Yenesew A, Rukunga GM. (2011). Investigation of some medicinal plants traditionally used for treatment of malaria in Kenya as potential sources of antimalarial drugs. Exp Parasitol, 127, 609–626.
   PubMed Web of Science ®Google Scholar
• Ncokazi KK, Egan TJ. (2005). A colorimetric high-throughput β-hematin inhibition screening assay for use in the search for antimalarial compounds. Anal Biochem, 338, 306–319.
   PubMed Web of Science ®Google Scholar
• O’Neill MJ, Bray DH, Boardman P, Wright CW, Phillipson JD, Warhurst DC, Gupta MP, Correya M, Solis P. (1988). Plants as sources of antimalarial drugs, Part 6: Activities of Simarouba amara fruits. j Ethnopharmacol, 22, 183–190.
   PubMed Web of Science ®Google Scholar
• Ohrt C, Willingmyre GD, Lee P, Knirsch C, Milhous W. (2002). Assessment of azithromycin in combination with other antimalarial drugs against Plasmodium falciparum in vitro. Antimicrob Agents Chemother, 46, 2518–2524.
   PubMed Web of Science ®Google Scholar
• Ovenden SP, Cao S, Leong C, Flotow H, Gupta MP, Buss AD, Butler MS. (2002). Spermine alkaloids from Albizia adinocephala with activity against Plasmodium falciparum plasmepsin II. Phytochemistry, 60, 175–177.
   PubMed Web of Science ®Google Scholar
• Plowe CV, Djimde A, Bouare M, Doumbo O, Wellems TE. (1995). Pyrimethamine and proguanil resistance-conferring mutations in Plasmodium falciparum dihydrofolate reductase: polymerase chain reaction methods for surveillance in Africa. Am j Trop Med Hyg, 52, 565–568.
   PubMed Web of Science ®Google Scholar
• Plowe CV, Djimde A, Wellems TE, Diop S, Kouriba B, Doumbo OK. (1996). Community pyrimethamine-sulfadoxine use and prevalence of resistant Plasmodium falciparum genotypes in Mali: a model for deterring resistance. Am j Trop Med Hyg, 55, 467–471.
   PubMed Web of Science ®Google Scholar
• Pohlit AM, Rezende AR, Lopes Baldin EL, Lopes NP, Neto VF. (2011). Plant extracts, isolated phytochemicals, and plant-derived agents which are lethal to arthropod vectors of human tropical diseases–a review. Planta Med, 77, 618–630.
   PubMed Web of Science ®Google Scholar
• Singer VL, Jones LJ, Yue ST, Haugland RP. (1997). Characterization of PicoGreen reagent and development of a fluorescence-based solution assay for double-stranded DNA quantitation. Anal Biochem, 249, 228–238.
   PubMed Web of Science ®Google Scholar
• Smilkstein M, Sriwilaijaroen N, Kelly JX, Wilairat P, Riscoe M. (2004). Simple and inexpensive fluorescence-based technique for high-throughput antimalarial drug screening. Antimicrob Agents Chemother, 48, 1803–1806.
   PubMed Web of Science ®Google Scholar
• Solis PN, Lang’at C, Gupta MP, Kirby GC, Warhusrst DC, Phillipson JD. (1995). Bio-active compounds from Psychotria camponutans. Planta Med, 61, 62–65.
   PubMed Web of Science ®Google Scholar
• Solís PN, Olmedo D, Nakamura N, Calderón AI, Hattori M, Gupta MP. (2005). A new larvicidallignan from Piper fimbriulatum. Pharm Biol, 43, 378–381.
   PubMed Web of Science ®Google Scholar
• Sturm N, Hu Y, Zimmermann H, Fritz-Wolf K, Wittlin S, Rahlfs S, Becker K. (2009). Compounds structurally related to ellagic acid show improved antiplasmodial activity. Antimicrob Agents Chemother, 53, 622–630.
   PubMed Web of Science ®Google Scholar
• SYBR Safe® Case Study. (2006). MIT Green Chemistry Case Study Substitution of Ethidium Bromide with SYBR Safe®. Available at: http://web.mit.edu/environment/pdf/SYBR.pdf. Accessed 10 Jan 2009.
   Google Scholar
• Taylor S, Berridge V. (2006). Medicinal plants and Malaria: an historical case study of research at the London School of Hygiene and Tropical Medicine in the twentieth century. Trans r Soc Trop Med Hyg, 100, 707–714.
   PubMed Web of Science ®Google Scholar
• Torres-Mendoza D, González J, Ortega-Barría E, Heller MV, Capson TL, McPhail K, Gerwick WH, Cubilla-Rios L. (2006). Weakly antimalarial flavonol arabinofuranosides from Calycolpus warszewiczianus. j Nat Prod, 69, 826–828.
   PubMed Web of Science ®Google Scholar
• Tripathi AK, Khan SI, Walker LA, Tekwani BL. (2004). Spectrophotometric determination of de novo hemozoin/β-hematin formation in an in vitro assay. Anal Biochem, 325, 85–91.
   PubMed Web of Science ®Google Scholar
• Valdés BA. (2005). “Estudio fitoquímicobiodirigido de Socratea exorrhiza (Mart.) Wendl.” BS thesis, University of Panama.
   Google Scholar
• van der Heyde HC, Elloso MM, vande Waa J, Schell K, Weidanz WP. (1995). Use of hydroethidine and flow cytometry to assess the effects of leukocytes on the malarial parasite Plasmodium falciparum. Clin Diagn Lab Immunol, 2, 417–425.
   PubMedGoogle Scholar
• Willcox M. (2011). Improved traditional phytomedicines in current use for the clinical treatment of malaria. Planta Med, 77, 662–671.
   PubMed Web of Science ®Google Scholar
• Wilson DW, Crabb BS, Beeson JG. (2010). Development of fluorescent Plasmodium falciparum for in vitro growth inhibition assays. Malar j, 9, 152.
   PubMed Web of Science ®Google Scholar
• World Health Organization. (2004). Position of WHO’s Roll Back Malaria Department on Malaria Treatment Policy. Available at: http://www.who.int/malaria/resistance. Accessed 6 May 2005.
   Google Scholar