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Review Article

Polydatin: A review of pharmacology and pharmacokinetics

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Pages 1347-1354 | Received 14 Jan 2013, Accepted 27 Mar 2013, Published online: 18 Jul 2013

References

  • Balasubramanian S, Neidle S. (2009). G-Quadruplex nucleic acids as therapeutic targets. Curr Opin Chem Biol 13:345–53
  • Ban SH, Kwona YR, Pandit S, et al. (2010). Effects of a bio-assay guided fraction from Polygonum cuspidatum root on the viability, acid production and glucosyltranferase of mutans streptococci. Fitoterapia 81:30–4
  • Bian HN, Sun CW, Chen HD, et al. (2012). Effects of polydatin on the biological features of cultured fibroblasts. Chin J Tissue Eng Res 16:6111–15
  • Briviba K, Abrahamse SL, Pool-Zobel BL, et al. (2001). Neurotensin- and EGF-induced metabolic activation of colon carcinoma cells is diminished by dietary flavonoid cyanidin but not by its glycosides. Nutr Cancer 41:172–9
  • Chen L, Lan Z, Lin Q, et al. (2013). Polydatin ameliorates renal injury by attenuating oxidative stress-related inflammatory responses in fructose-induced urate nephropathic mice. Food Chem Toxicol 52:28–35
  • Chen P, Hu XL, Lei WY, et al. (2006a). Effects of polydatin on thrombosis and interactions of platelets to neutrophils. J Yunnan Univ (Natural Sci) 28:364–8
  • Chen P, Yang LC, Hu XL, et al. (2006b). Investigation of polydatin on antithrombotic effects and plasma levels of TXB2 and 6-keto-PGF1α. Nat Prod Res Dev 18:398–400, 404
  • Cheng Y, Zhang HT, Sun L, et al. (2006c). Involvement of cell adhesion molecules in polydatin protection of brain tissues from ischemia–reperfusion injury. Brain Res 1110:193–200
  • Deng J, Liu W, Wang Y, et al. (2012). Polydatin modulates Ca2+ handling, excitation–contraction coupling and β-adrenergic signaling in rat ventricular myocytes. J Mole Cell Card 53:646–56
  • Deng YH, Alex D, Huang HQ, et al. (2011). Inhibition of TNF-α-mediated endothelial cell-monocyte cell adhesion and adhesion molecules expression by the resveratrol derivative, trans-3,5,4′-trimethoxystilbene. Phytother Res 25:451–7
  • Du J, Sun LN, Xing WW, et al. (2009). Lipid-lowering effects of polydatin from Polygonum cuspidatum in hyperlipidemic hamsters. Phytomedicine 16:652–8
  • Fabris S, Momo F, Ravagnan G, et al. (2008). Antioxidant properties of resveratrol and piceid on lipid peroxidation in micelles and monolamellar liposomes. Biophys Chem 135:76–83
  • Fei J, Xie K, Tao FS. (2009). Effects of polydatin on expressions of NF-κB and MPO during renal ischemia–reperfusion injury. J Clin Anesthesiol 25:511–13
  • Gao JP, Chen CX, Gu WL, et al. (2010). Effects of polydatin on attenuating ventricular remodeling in isoproterenol-induced mouse and pressure-overload rat models. Fitoterapia 81:953–60
  • Gao S, Fan G, Hong Z, et al. (2006). HPLC determination of polydatin in rat biological matrices: Application to pharmacokinetic studies. J Pharmaceut Biomed 41:240–5
  • He H, Zhao Y, Chen X, et al. (2007). Quantitative determination of trans-polydatin, a natural strong antioxidative compound, in rat plasma and cellular environment of a human colon adenocarcinoma cell line for pharmacokinetic studies. J Chromatogr B 855:145–51
  • He YD, Liu YT, Lin QX, et al. (2012). Polydatin suppresses ultraviolet B-induced cyclooxygenase-2 expression in vitro and in vivo via reduced production of reactive oxygen species. Br J Dermatol 167:941–4
  • Henry C, Vitrac X, Decendit A, et al. (2005). Cellular uptake and efflux of trans-piceid and its aglycone trans-resveratrol on the apical membrane of human intestinal Caco-2 cells. J Agric Food Chem 53:798–803
  • Henry-Vitrac C, Desmoulière A, Girard D, et al. (2006). Transport, deglycosylation, and metabolism of trans-piceid by small intestinal epithelial cells. Eur J Nutr 45:376–82
  • Hollman PC. (1997). Bioavailability of flavonoids. Eur J Clin Nutr 51:S66–9
  • Hollman PC, de Vries JH, van Leeuwen SD, et al. (1995). Absorption of dietary quercetin glycosides and quercetin in healthy ileostomy volunteers. Am J Clin Nutr 62:1276–82
  • Huang ZS, Wang ZW, Liu MP, et al. (1999). Protective effects of polydatin against CCl4-induced injury to primarily cultured rat hepatocytes. World J Gastroenterol 5:41–4
  • Jeong ET, Jin MH, Kim MS, et al. (2010). Inhibition of melanogenesis by piceid isolated from Polygonum cuspidatum. Arch Pharm Res 33:1331–8
  • Ji H, Zhang X, Du Y, et al. (2012). Polydatin modulates inflammation by decreasing NF-κB activation and oxidative stress by increasing Gli1, Ptch1, SOD1 expression and ameliorates blood-brain barrier permeability for its neuroprotective effect in pMCAO rat brain. Brain Res Bulletin 87:50–9
  • Jin XF, Xu ZJ, Wang WT, et al. (2009). The regulative effects of polydatin on toll-like receptor 4 signal transduction pathway in lung ischemia/reperfusion injury in rabbits. Chin J Appl Physial 25:41–4
  • Kennedy S, Bergqvist A, Chapron C, et al. (2005). ESHRE guideline for the diagnosis and treatment of endometriosis. Hum Reprod 20:2698–704
  • Kim YM, Yun J, Lee CK, et al. (2002). Oxyresveratrol and hydroxystilbene compounds. Inhibitory effect on tyrosinase and mechanism of action. J Biol Chem 227:16340–4
  • Kimura Y, Okuda H. (2000). Effects of naturally occurring stilbene glucosides from medicinal plants and wine, on tumour growth and lung metastasis in Lewis lung carcinoma-bearing mice. J Pharm Pharmacol 52:1287–95
  • Kwon YR, Son KJ, Pandit S, et al. (2010). Bioactivity-guided separation of anti-acidogenic substances against Streptococcus mutans UA 159 from Polygonum cuspidatum. Oral Diseases 16:204–9
  • Lanzilli G, Cottarelli A, Nicotera G, et al. (2012). Anti-inflammatory effect of resveratrol and polydatin by in vitro IL-17 modulation. Inflammation 35:240–8
  • Li H, Yuan G. (2010). Electrospray ionization mass spectrometry probing of formation and recognition of the G-quadruplex in the proximal promoter of the human vascular endothelial growth factor gene. Rapid Commun Mass Sp 24:2030–4
  • Li RP, Wang ZZ, Sun MX, et al. (2012). Polydatin protects learning and memory impairments in a rat model of vascular dementia. Phytomedicine 19:677–81
  • Liu H, Zhang G, Bie X, et al. (2010). Effect of polydatin on dynamic changes of excitatory amino acids in cerebrospinal fluid of cerebral hemorrhage rats. China J Chin Mate Med 35:3038–42
  • Liu H, Zhao S, Zhang Y, et al. (2011). Reactive oxygen species-mediated endoplasmic reticulum stress and mitochondrial dysfunction contribute to polydatin-induced apoptosis in human nasopharyngeal carcinoma CNE cells. J Cell Biochem 112:3695–703
  • Luo SF, Yu CL, Zhang PW. (1990). Influences of 3,4′,5-trihydroxystibene 3-beta-mono-d-glucoside on beat rate and injury of cultured newborn rat myocardial cells. Acta Pharmacol Sin 11:147–50
  • Lv C, Zhang L, Wang Q, et al. (2006). Determination of piceid in rat plasma and tissues by high-performance liquid chromatographic method with UV detection. Biomed Chromatogr 20:1260–6
  • Lv G, Lou Z, Chen S, et al. (2011). Pharmacokinetics and tissue distribution of 2,3,5,4′-tetrahydroxystilbene-2-O-β-d-glucoside from traditional Chinese medicine Polygonum multiflorum following oral administration to rats. J Ethnopharmacol 137:449–56
  • Medina I, Alcántara D, González MJ, et al. (2010). Antioxidant activity of resveratrol in several fish lipid matrices: Effect of acylation and glucosylation. J Agric Food Chem 58:9778–86
  • Miao Q, Shi XP, Ye MX, et al. (2012). Polydatin attenuates hypoxic pulmonary hypertension and reverses remodeling through protein kinase C mechanisms. Int J Mol Sci 13:7776–87
  • Miao Q, Wang S, Miao S, et al. (2011). Cardioprotective effect of polydatin against ischemia/reperfusion injury: Roles of protein kinase C and mito KATP activation. Phytomedicine 19:8–12
  • Mikulski D, Molski M. (2010). Quantitative structure-antioxidant activity relationship of trans-resveratrol oligomers, trans-4,4′-dihydroxystilbene dimer, trans-resveratrol-3-O-glucuronide, glucosides: Trans-piceid, cis-piceid, trans-astringin and trans-resveratrol-4′-O-β-d-glucopyranoside. Eur J Med Chem 45:2366–80
  • Mo ZX, Shao HX, Zheng YS. (1999). Protective effects of polydatin on hepatocyte injury induced by pyrogallic acid in mice. Pharm Clin Chin Mater Med 15:6–8
  • Pastore S, Lulli D, Fidanza P, et al. (2012). Plant polyphenols regulate chemokine expression and tissue repair in human keratinocytes through interaction with cytoplasmic and nuclear components of epidermal growth factor receptor system. Antioxid Redox Sign 16:314–28
  • Potapovich AI, Lulli D, Fidanza P, et al. (2011). Plant polyphenols differentially modulate inflammatory responses of human keratinocytes by interfering with activation of transcription factors NF-κB and AhR and EGFR-ERK pathway. Toxicol Appl Pharm 255:138–49
  • Qin J, Chen YZ, Zhou QX, et al. (2004). Effect of polydatin on endothelial function in aorta vascular strips of healthy rabbits treated with ADMA. Chin Tradit Herbal Drugs 35:535–8
  • Ravagnan G, De Filippis A, Cartenì M, et al. (2013). Polydatin, a natural precursor of resveratrol, induces β-defensin production and reduces inflammatory response. Inflammation 36:26–34
  • Ren X, Ouyang H, Wang G, et al. (2010). Study on excretion of stilbene glycoside (THSG) and its beta-cyclodextrin inclusion. China J Chin Mater Med 35:2620–3
  • Reqev-Shoshani G, Shoseyov O, Bilkis I, et al. (2003). Glycosylation of resveratrol protects it from enzymic oxidation. Biochem J 374:157–63
  • Richard T, Vitrac X, Merillon JM, et al. (2005). Role of peptide primary sequence in polyphenol-protein recognition: An example with neurotensin. Biochim Biophys Acta 1726:238–43
  • Rivière C, Papastamoulis Y, Fortin PY, et al. (2010). New stilbene dimers against amyloid fibril formation. Bioorg Med Chem Lett 20:3441–3
  • Rivière C, Richard T, Quentin L, et al. (2007). Inhibitory activity of stilbenes on Alzheimer’s β-amyloid fibrils in vitro. Bioorg Med Chem Lett 15:1160–7
  • Rivière C, Delaunay JC, Immel F, et al. (2009). The polyphenol piceid destabilizes preformed amyloid fibrils and oligomers in vitro: Hypothesis on possible molecular mechanisms. Neurochem Res 34:1120–8
  • Shan CW, Yang SQ, He HD, et al. (1990). Influence of 3,4′,5-trihydroxystibene-3-β-mono-d-glucoskle on rabbits' platelet aggregation and thromboxane B2 production in vitro. Acta Pharmacol Sin 11:527–30
  • Sheng C, Yu YH, Zhao KS, et al. (2011). Hypotensive resuscitation combined with polydatin improve microcirculation and survival in a rabbit model of uncontrolled hemorrhagic shock in pregnancy. J Surg Res 168:103–10
  • Shi YW, Wang CP, Liu L, et al. (2012). Antihyperuricemic and nephroprotective effects of resveratrol and its analogues in hyperuricemic mice. Mol Nutr Food Res 56:1433–44
  • Shu SY, Ling ZY, Wang XY, et al. (2004). Effect of polydatin on phospholipase A2 in lung tissues in rats with endotoxic shock. Chin J Traumatol 7:239–43
  • Shu SY, Ling ZY, Ye M, et al. (2011). Polydatin up-regulates Clara cell secretory protein to suppress phospholipase A2 of lung induced by LPS in vivo and in vitro. BMC Cell Biol 12:31
  • Su D, Zhang BL, Huan ML, et al. (2010). Comparison of resveratrol and polydatin on antioxidative activities. Chin Pharma 13:471–3
  • Sun D, Guo K, Rusche JJ, et al. (2005). Facilitation of a structural transition in the polypurine/polypyrimidine tract within the proximal promoter region of the human VEGF gene by the presence of potassium and G-quadruplex-interactive agents. Nucleic Acids Res 33:6070–80
  • Sun J, Qu XY, He HM, et al. (2012). Effects of polydatin on expression of BDNF in cortex of neonatal rats with hypoxic-ischemic brain damage. Chin J Public Health 28:783–5
  • Tian JW, Yang JX. (2001). In vitro antioxidative effect of polydatin. Chin Trad Herb Drugs 32:918–20
  • Waffo-Téquo P, Hawthorne ME, Cuendet M, et al. (2001). Potential cancer-chemopreventive activities of wine stilbenoids and flavans extracted from grape (Vitis vinifera) cell cultures. Nutr Cancer 40:173–9
  • Wang D, Zhang Z, Ju J, et al. (2011). Investigation of piceid metabolites in rat by liquid chromatography tandem mass spectrometry. J Chromatogr B 879:69–74
  • Wang FY, Xu ZJ, Zhang XL, et al. (2008). Protective effects of polydatin against lung ischemia/reperfusion injury and the initial exploration for its mechanism. Chin J Appl physiol 24:62–5
  • Wang M, Li ZC, Wang JB. (2001). Protective effect of polydatin on hypoxia-induced injury in rat pulmonary microvascular endothelial cells. Northwest Pharmaceut J 26:185–9
  • Wang X, Song R, Bian HN, et al. (2012). Polydatin, a natural polyphenol, protects arterial smooth muscle cells against mitochondrial dysfunction and lysosomal destabilization following hemorrhagic shock. Am J Physiol Regul Integr Comp Physiol 302:R805–14
  • Wang X, Song R, Chen Y, et al. (2013). Polydatin – A new mitochondria protector for acute severe hemorrhagic shock treatment. Expert Opin Investig Drugs 22:169–79
  • Wang Y, Xue J, Sun XD, et al. (2004). Study on decreasing effects of polydatin on blood viscosity in the rat model of acute blood stasis. China Pharm 15:275–7
  • Wen H, Shi W, Qin J. (2012). Multiparameter evaluation of the longevity in C. elegans under stress using an integrated microfluidic device. Biomed Microdevices 14:721–8
  • Wu MJ, Gong X, Jiang R, et al. (2012). Polydatin protects against lipopolysaccharide-induced fulminant hepatic failure in d-galactosamine-sensitized mice. Int J Immunopathol Pharmacol 25:923–34
  • Xie X, Peng J, Huang K, et al. (2012). Polydatin ameliorates experimental diabetes-induced fibronectin through inhibiting the activation of NF-κB signaling pathway in rat glomerular mesangial cells. Mole Cell Endocrinol 362:183–93
  • Xing WW, Wu JZ, Jia M, Du J, Zhang H, Qin LP. (2009). Effects of polydatin from Polygonum cuspidatum on lipid profile in hyperlipidemic rabbits. Biomed Pharmacother 63:457–62
  • Xu B, Lin HB, Zhou H, et al. (2010). Protective effect of polydatin on a PC12 cell model of oxygen-glucose deprivation. J South Med Univ 30:1041–3
  • Xu CY, Li S, Hao W, et al. (2011). Effect of polydatin on learning and memory and expression of NR2B in the prefrontal cortex of rats with chronic alcoholism. Chin J Appl Physiol 27:213–14, 220, 235
  • Xu CY, Li S, Hao W, et al. (2012). Effect of polydatin on expression of cdk5 in the prefrontal cortex of rats with chronic alcoholism. Chin J Appl Physiol 28:158–9, 188
  • Xue X, Jin CH, Li L, et al. (2008). Influence of polydatin on myocardial function and ultrastructure of LPS infected rats. Chin Practical Med 3:3–4
  • Yao J, Wang JY, Liu L, et al. (2011). Polydatin ameliorates DSS-induced colitis in mice through inhibition of nuclear factor-kappaB activation. Planta Med 77:421–7
  • Yee S. (1997). In vitro permeability across Caco-2 cells (colonic) can predict in vivo (small intestinal) absorption in man-fact or myth. Pharm Res 14:763–6
  • Yuan M, Li J, Lv J, et al. (2012). Polydatin (PD) inhibits IgE-mediated passive cutaneous anaphylaxis in mice by stabilizing mast cells through modulating Ca2+ mobilization. Toxicol Appl Pharmacol 264:462–9
  • Zhang DQ, Sun LS, Xu JP. (2006). Effect of piceid on the dog with an acute myocardial infarction model. Herald Med 25:510–13
  • Zhang H, Yu CH, Jiang YP, et al. (2012a). Protective effects of polydatin from Polygonum cuspidatum against carbon tetrachloride-induced liver injury in mice. Plos One 7:e46574
  • Zhang J, Tan Y, Yao F, et al. (2012b). Polydatin alleviates non-alcoholic fatty liver disease in rats by inhibiting the expression of TNF-α and SREBP-1c. Mol Med Report 6:815–20
  • Zhang L, Lv ZP. (2010). Effect of polydatin on nonalcoholic fatty liver disease and the TNF-α level in serum. LiShizhen Med Mater Med Res 21:1007–8
  • Zhang LP, Ma HJ, Bu HM, et al. (2009). Polydatin attenuates ischemia/reperfusion-induced apoptosis in myocardium of the rat. Acta Physiol Sin 61:367–72
  • Zhang LP, Wei Y, Song SL, et al. (2011a). Effect of polydatin on action potential in ventricular papillary muscle of rat and the underlying ionic mechanism. Acta Physiol Sin 63:48–54
  • Zhang LP, Yang CY, Wang YP, et al. (2008a). Protective effect of polydatin against ischemia/reperfusion injury in rat heart. Acta Physiol Sin 60:161–8
  • Zhang W, Li Q, Zhu M, et al. (2008b). Direct determination of polydatin and its metabolite in rat excrement samples by high-performance liquid chromatography. Chem Pharm Bull 56:1592–5
  • Zhang Y, Chen LY, Liang B. (2011b). Effects of polydatin on bleomycin-induced pulmonary fibrosis in rats. China J Chin Materia Med 24:3528–34
  • Zhao J, Li HY, Wang ZH, et al. (2010). Effect of polydatin on ultrastructure of cardiac myocytes in rats with adriamycininduced myocardial damage. Acta Acad Med CPAPF 19:629–30, 634
  • Zhao KS, Jin C, Huang X, et al. (2003). The mechanism of polydatin in shock treatment. Clin Hemorheol Microcirc 29:211–17
  • Zhao Q, Huang HX, Jin CH. (2004). The regulation and its mechanism of polydatin on the β-adrenoreceptor in cardiac myocytes stimulated by lipopolysaccharide. Chin Pharm Bull 20:769–72
  • Zhou MJ, Chen XY, Zhong DF. (2007). Metabolism of trans-resveratrol-3-O-glucoside in vitro in rat tissues. Acta Pharm Sin 42:520–4
  • Zhou S, Yang R, Teng Z, et al. (2009). Dose-dependent absorption and metabolism of trans-polydatin in rats. J Agric Food Chem 57:4572–9
  • Zhu LX, Jin ZY. (2005). Effects of piceid on blood lipid metabolism, nitric oxide and nitricoxide synthase in experimental hyperlipidemia rats. Pharm Clin Chin Materia Med 21:16–18
  • Zhu LX, Jin ZY. (2006). Effect of polydatin on metabolism of blood lipid of hyperlipidemia rats and its antioxidation. Chin Trad Patent Med 28:260–1

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