Antiulcer activity of Muntingia calabura leaves involves the modulation of endogenous nitric oxide and nonprotein sulfhydryl compounds

References

• Abdelwahab SI, Mohan S, Abdulla MA, et al. (2011). The methanolic extract of Boesenbergia rotunda (L.) Mansf. and its major compound pinostrobin induces anti-ulcerogenic property in vivo: Possible involvement of indirect antioxidant action. J Ethnopharmacol 137:963–70
   PubMed Web of Science ®Google Scholar
• Allen A, Flemström G. (2005). Gastroduodenal mucus bicarbonate barrier: Protection against acid and pepsin. Am J Physiol Cell Physiol 288:C1–19
   PubMed Web of Science ®Google Scholar
• Andreo MA, Ballesteros KV, Hiruma-Lima CA, et al. (2006). Effect of Mouriri pusa extracts on experimentally induced gastric lesions in rodents: Role of endogenous sulfhydryls compounds and nitric oxide in gastroprotection. J Ethnopharmacol 107:431–41
   PubMed Web of Science ®Google Scholar
• Avila JR, de la Lastra CA, Martin MJ, et al. (2005). Roll of endogenous sulphydryls and neutrophil infiltration in the pathogenesis of gastric mucosal injury induced by piroxicam in rats. Inflamm Res 45:83–8
   Google Scholar
• Bagchi D, Carryl OR, Tran MX, et al. (1998). Stress, diet and alcohol induced oxidative gastrointestinal mucosal injury in rats and protection by bismuth subsalicylate. J Appl Toxicol 18:3–13
   PubMed Web of Science ®Google Scholar
• Barocelli E, Chiavarini M, Ballabeni V, et al. (1997). Study of the antisecretory and antiulcer mechanism of a new indenopirydazinone derivative in rats. Pharmacol Res 35:487–92
   PubMed Web of Science ®Google Scholar
• Beck PL, Xavier R, Lu N, et al. (2000). Mechanism of NSAID induced gastrointestinal injury defined using mutant mice. Gastroenterology 119:699–705
   PubMed Web of Science ®Google Scholar
• Bodhankar SL, Jain BB, Ahire BP, et al. (2006). The effect of rabeprazole and its isomers on aspirin and histamine-induced ulcers in rats. Indian J Pharmacol 38:357–8
   Google Scholar
• Borelli F, Izzo AA. (2000). The plant kingdom as a source of anti-ulcer remedies. Phytother Res 14:581–91
   PubMed Web of Science ®Google Scholar
• Brzozowski T, Konturek PC, Sliwowski Z, et al. (2006). Interaction of nonsteroidal anti-inflammatory drugs (NSAID) with Helicobacter pylori in the stomach of humans and experimental animals. J Physiol Pharmacol 57:67–79
   PubMed Web of Science ®Google Scholar
• Chandranath SI, Bastaki SM, Singh J. (2002). A comparative study on the activity of lansoprazole, omeprazole and PD-136450 on acidified ethanol- and indomethacin-induced gastric lesions in the rat. Clin Exp Pharmacol Physiol 29:173–80
   Google Scholar
• Chaturvedi A, Kumar MM, Bhawani G, et al. (2007). Effect of ethanolic extract of Eugenia jambolana seeds on gastric ulceration and secretion in rats. Indian J Physiol Pharmacol 51:131–40
   PubMedGoogle Scholar
• Chávez-Piña AE, Tapia-Álvarez GR, Reyes-Ramínrez A, Navarrete A. (2011). Carbenoxolone gastroprotective mechanism: Participation of nitric oxide/cGMP/KATP pathway in ethanol-induced gastric injury in the rat. Fund Clin Pharmacol 25:717–22
   Google Scholar
• Chin WY. (1989). A Guide to the Wayside Trees of Singapore. Singapore: BP Singapore Science Centre
   Google Scholar
• Czinner E, Hagymási K, Blázovics A, et al. (2001). The in vitro effect of Helichysi flos on microsomal lipd peroxidation. J Ethnopharmacol 77:31–5
   PubMed Web of Science ®Google Scholar
• de-Faria FM, Almeida AC, Luiz-Ferreira A, et al. (2012). Mechanisms of action underlying the gastric antiulcer activity of the Rhizophora mangle L. J Ethnopharmacol 139:234–43
   PubMed Web of Science ®Google Scholar
• Galani VJ, Goswami SS, Shah MB. (2010). Antiulcer activity of Trichosanthes cucumerina linn. against experimental gastro-duodenal ulcers in rats. Orient Pharm Exp Med 10:222–30
   Google Scholar
• Gilman AG, Hardman JG, Limbard LE. (2001). The Pharmacological Basis of Therapeutics. 10th ed. New York: McGraw Hill
   Google Scholar
• Hatler F, Schmassmann A, Peskar BM. (2001). Cyclooxygenase 2-implications on maintenance of gastric mucosal integrity and ulcer healing: Controversial issues and perspectives. Gut 49:443–53
   Google Scholar
• Hayllar J, Bjarnason L. (1995). NSAIDs, Cox2 inhibitors and the gut. Lancet 346:521–2
   PubMed Web of Science ®Google Scholar
• Hoogerwerf WA, Pasricha J. (2006). Pharmacotherapy of gastric acidity, peptic ulcers and gastroesophageal reflux disease. In: Brunton LL, Lazo JS, Parker MDK, et al., eds. The Pharmacological Basis of Therapeutics. 11th ed. New York: McGrawHill Companies, 967–81
   Google Scholar
• Jamal A, Javed K, Aslam M, Jafri M. (2006). Gastroprotective effect of cardamom, Elettaria cardamomum Maton. fruits in rats. J Ethnopharmacol 103:149–53
   PubMed Web of Science ®Google Scholar
• Jensen M. (1999). Trees Commonly Cultivated in Southeast Asia: An Illustrated Field Guide. 2nd ed. (FAO Corporate Document Repository). Bangkok: Craftsman Press
   Google Scholar
• John TA, Onabanjo AO. (1990). Gastroprotective effect of an aqueous extract of Entandrophragma utile bark in experimental ethanol-induced peptic ulceration in mice and rats. J Ethnopharmacol 29:87–93
   PubMedGoogle Scholar
• Kaneda N, Pezzuto JM, Soejarto DD, et al. (1991). Plant anticancer agents, XLVII. New cytotoxic flavonoids from Muntingia calabura roots. J Nat Prod 54:196–206
   PubMed Web of Science ®Google Scholar
• Kinoshita M, Noto T, Tamaki H. (1995). Effect of a combination of ecabet sodium and cimetidine on experimentally induced gastric lesions and gastric mucosal resistance to ulcerogenic agents in rats. Biol Pharm Bull 18:223–6
   Google Scholar
• Kumar A, Singh V, Chaudhary AK. (2011). Gastric antisecretory and antiulcer activities of Cedrus deodara (Roxb.) Loud. in Wistar rats. J Ethnopharmacol 134:294–7
   PubMed Web of Science ®Google Scholar
• La Casa C, Villegas I, Alarcón de la Lastra C, et al. (2000). Evidence for protective and antioxidant properties of rutin, a natural flavones against ethanol induced gastric lesions. J Ethnopharmacol 71:45–53
   PubMed Web of Science ®Google Scholar
• Lemos LM, Martins TB, Tanajura GH, et al. (2012). Evaluation of antiulcer activity of chromanone fraction from Calophyllum brasiliesnse Camb. J Ethnopharmacol 141:432–9
   PubMed Web of Science ®Google Scholar
• Mohd. Sani MH, Zakaria ZA, Balan T, et al. (2012). Antinociceptive activity of methanol extract of Muntingia calabura leaves and the mechanisms of action involved. Evid Based Complement Alternat Med. Available from: http://www.hindawi.com/journals/ecam/2012/890361/ [last accessed 15 Sep 2012]
   Google Scholar
• Morton JF. (1987). Jamaica cherry. In: Morton JF, ed. Fruits of Warm Climates. Miami, Florida: Julia F. Morton, 65–9
   Google Scholar
• Navarette A, Arrieta J, Terrones L, et al. (2005). Gastroprotective effect of Astragaloside IV: Role of prostaglandins, sulfhydryls and nitric oxide. J Pharm Pharmacol 57:1059–64
   Google Scholar
• Noor SM, Mahmood AA, Salmah I, Philip K. (2006). Prevention of acute gastric mucosal lesions by R. hasseltii in rats. J Anim Vet Adv 5:161–4
   Google Scholar
• Nshimo CM, Pezzuto JM, Kinghorn AD, Farnsworth NR. (1993). Cytotoxic constituents of Muntingia calabura leaves and stems collected in Thailand. Int J Pharmacol 31:77–81
   Google Scholar
• Nwafor PA, Effraim KD, Jacks TW. (1996). Gastroprotective effect of aqueous extract of Khaya senegalensis bark on indomethacin-induced ulceration in rats. West African J Pharmacol Drug Res 12:46–50
   Google Scholar
• Nwafor PA, Okwuasaba FB, Bind LG. (2000). Antidiarrhoeal and antiulcerogenic effects of methanolic extract of Asparagus pubescens root in rats. J Ethnopharmacol 72:421–7
   PubMed Web of Science ®Google Scholar
• OECD. (2002). Test No. 420: Acute Oral Toxicity – Fixed Dose Procedure, OECD Guidelines for the Testing of Chemicals, Section 4. Paris, France: OECD Publishing
   Google Scholar
• Rachchh MA, Jain SM. (2008). Gastroprotective effect of Benincasa hispida fruit extract. Indian J Pharmacol 40:271–5
   PubMed Web of Science ®Google Scholar
• Repetto MG, Llesuy SF. (2002). Antioxidant properties of natural compounds used in popular medicine for gastric ulcers. Braz J Med Biol Res 35:523–34
   PubMed Web of Science ®Google Scholar
• Sikirić P, Seiwerth S, Grabarević Z, et al. (1997). The influence of a novel pentadecapeptide, BPC 157, on N-G-nitroarginine methylester and l-arginine effects on stomach mucosa integrity and blood pressure. Eur J Pharmacol 332:23–33
   PubMed Web of Science ®Google Scholar
• Su BN, Jung Park E, Vigo JS, et al. (2003). Activity-guided isolation of the chemical constituents of Muntingia calabura using a quinone reductase induction assay. Phytochemistry 63:335–41
   PubMed Web of Science ®Google Scholar
• Szabo S. (1987). Mechanisms of mucosal injury in the stomach and duodenum: Time sequence analysis of morphologic, functional, biochemical and histochemical studies. Scand J Gastroenterol Suppl 22:21–8
   Google Scholar
• Szabo S, Vattay P. (1990). Experimental gastric and duodenal ulcers. Advances in pathogenesis. Gastroenterol Clin North Am 19:67–85
   PubMed Web of Science ®Google Scholar
• Takahashi S, Shigeta J, Inoue H, et al. (1998). Localization of cyclooxygenase2 and regulation of its mRNA expression in gastric ulcers in rats. Am J Physiol 275:G1137–45
   Google Scholar
• Trivedi NP, Rawal UM. (2001). Hepatoprotective and antioxidant property of Andrographis paniculata (Nees) in BHC induced liver damage in mice. Indian J Exp Biol 39:41–6
   PubMedGoogle Scholar
• Verheij EWM, Coronel RE. (1992). Plant Resources of South East Asia (PROSEA): No. 2: Edible Fruits and Nuts. Wageningen, The Netherlands: Pudoc Scientific Publishers
   Google Scholar
• Wallace JL. (2001). Mechanisms of protection and healing: Current knowledge and future research. Am J Med 110:19S–22S
   Google Scholar
• Zakaria ZA, Fatimah CA, Mat Jais AM, et al. (2006b). The in vitro antibacterial activity of Muntingia calabura extracts. Int J Pharmacol 2:290–3
   Google Scholar
• Zakaria ZA, Hassan MH, Nurul Aqmar MNH, et al. (2007a). Effects of various nonopioid receptor antagonists on the antinociceptive activity of Muntingia calabura extracts in mice. Methods Find Exp Clin Pharmacol 29:515–20
   PubMedGoogle Scholar
• Zakaria ZA, Mohamed AM, Jamil NS, et al. (2011). In vitro antiproliferative and antioxidant activities of the extracts of Muntingia calabura leaves. Am J Chin Med 39:183–200
   PubMed Web of Science ®Google Scholar
• Zakaria ZA, Mustapha S, Sulaiman MR, et al. (2007b). The antinociceptive action of aqueous extract from Muntingia calabura leaves: The role of opioid receptors. Med Princ Pract 16:130–6
   PubMed Web of Science ®Google Scholar
• Zakaria ZA, Nor Hazalin N, Zaid S, et al. (2007c). Antinociceptive, anti-inflammatory and antipyretic effects of Muntingia calabura aqueous extract in animal models. J Nat Med 61:443–8
   Web of Science ®Google Scholar
• Zakaria ZA, Sulaiman MR, Jais AM, et al. (2006a). The antinociceptive activity of Muntingia calabura aqueous extract and the involvement of l-arginine/nitric oxide/cyclic guanosine monophosphate pathway in its observed activity in mice. Fundam Clin Pharmacol 20:365–72
   PubMed Web of Science ®Google Scholar