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Research Article

Alteration of the ERK5 pathway by hydroxysafflor yellow A blocks expression of MEF2C in activated hepatic stellate cells in vitro: Potential treatment for hepatic fibrogenesis

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Pages 435-443 | Received 30 Apr 2013, Accepted 01 Sep 2013, Published online: 05 Nov 2013

References

  • Abergel A, Sapin V, Dif N, et al. (2006). Growth arrest and decrease of alpha-SMA and type I collagen expression by palmitic acid in the rat hepatic stellate cell line PAV-1. Dig Dis Sci 51:986–95
  • Bie XD, Han J, Dai HB. (2010). Effects of hydroxysafflor yellow A on the experimental traumatic brain injury in rats. J Asian Nat Prod Res 12:239–47
  • Black BL, Olson EN. (1998). Transcriptional control of muscle development by myocyte enhancer factor-2 (MEF2) proteins. Annu Rev Cell Dev Biol 14:167–96
  • Che J, Chan ES, Cronstein BN. (2007). Adenosine A2A receptor occupancy stimulates collagen expression by hepatic stellate cells via pathways involving protein kinase A, Src, and extracellular signal-regulated kinases 1/2 signaling cascade or p38 mitogen-activated protein kinase signaling pathway. Mol Pharmacol 72:1626–36
  • Cho MK, Lee GH, Park EY, Kim SG. (2004). Hyaluronic acid inhibits adhesion of hepatic stellate cells in spite of its stimulation of DNA synthesis. Tissue Cell 36:293–305
  • Clark PR, Jensen TJ, Kluger MS, et al. (2011). MEK5 is activated by shear stress, activates ERK5 and induces KLF4 to modulate TNF responses in human dermal microvascular endothelial cells. Microcirculation 18:102–17
  • Debernardi-Venon W, Martini S, Biasi F, et al. (2007). AT1 receptor antagonist Candesartan in selected cirrhotic patients: Effect on portal pressure and liver fibrosis markers. J Hepatol 46:1026–33
  • Di Pascoli M, Diví M, Rodríguez-Vilarrupla A, et al. (2013). Resveratrol improves intrahepatic endothelial dysfunction and reduces hepatic fibrosis and portal pressure in cirrhotic rats. J Hepatol 58:904–10
  • Drew BA, Burow ME, Beckman BS. (2011). MEK5/ERK5 pathway: The first fifteen years. Biochim Biophys Acta 1825:37–48
  • Fu R, Wu J, Ding J, et al. (2011). Targeting transforming growth factor βRII expression inhibits the activation of hepatic stellate cells and reduces collagen synthesis. Exp Biol Med 236:291–7
  • Herrmann J, Gressner AM, Weiskirchen R. (2007). Immortal hepatic stellate cell lines: Useful tools to study hepatic stellate cell biology and function? J Cell Mol Med 11:704–22.
  • Iñesta-Vaquera FA, Campbell DG, Tournier C, et al. (2010). Alternative ERK5 regulation by phosphorylation during the cell cycle. Cell Signal 22:1829–37
  • Katsarou K, Tsitoura P, Georgopoulou U. (2011). MEK5/ERK5/mef2: A novel signaling pathway affected by hepatitis C virus non-enveloped capsid-like particles. Biochim Biophys Acta 1813:1854–62
  • Kimura TE, Jin J, Zi M, et al. (2010). Targeted deletion of the extracellular signal-regulated protein kinase 5 attenuates hypertrophic response and promotes pressure overload-induced apoptosis in the heart. Circ Res 106:961–70
  • Konno T, Chen D, Wang L, et al. (2010). Heterogeneous myocyte enhancer factor-2 (Mef2) activation in myocytes predicts focal scarring in hypertrophic cardiomyopathy. Proc Natl Acad Sci USA 107:18097–102
  • Lee KH. (2000). Research and future trends in the pharmaceutical development of medicinal herbs from Chinese medicine. Public Health Nutr 3:515–22
  • Liu L, Cavanaugh JE, Wang Y, et al. (2003). ERK5 activation of MEF2-mediated gene expression plays a critical role in BDNF-promoted survival of developing but not mature cortical neurons. Proc Natl Acad Sci USA 100:8532–7
  • Livak KJ, Schmittgen TD. (2001). Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta CT) method. Methods 25:402–8
  • Lv LZ, Tong CQ, Lv Q, et al. (2012). Enhanced absorption of hydroxysafflor yellow A using a self-double-emulsifying drug delivery system: In vitro and in vivo studies. Int J Nanomedicine 7:4099–107
  • Mee CJ, Farquhar MJ, Harris HJ, et al. (2010). Hepatitis C virus infection reduces hepatocellular polarity in a vascular endothelial growth factor-dependent manner. Gastroenterology 138:1134–42
  • Mishra BB, Tiwari VK. (2011). Natural products: An evolving role in future drug discovery. Eur J Med Chem 46:4769–807
  • Parsons CJ, Bradford BU, Pan CQ, et al. (2004). Antifibrotic effects of a tissue inhibitor of metalloproteinase-1 antibody on established liver fibrosis in rats. Hepatology 40:1106–15
  • Potthoff MJ, Olson EN. (2007). MEF2: A central regulator of diverse developmental programs. Development 134:4131–40
  • Pradeep Kumar S, Medhi S, Asim M, et al. (2011). Evaluation of adefovir & lamivudine in chronic hepatitis B: Correlation with HBV viral kinetic, hepatic-necro inflammation & fibrosis. Indian J Med Res 133:50–6
  • Purohit V, Russo D, Coates PM. (2004). Role of fatty liver, dietary fatty acid supplements, and obesity in the progression of alcoholic liver disease: Introduction and summary of the symposium. Alcohol 34:3–8
  • Rovida E, Navari N, Caligiuri A, et al. (2008). ERK5 differentially regulates PDGF-induced proliferation and migration of hepatic stellate cells. J Hepatol 48:107–15
  • Trebicka J, Hennenberg M, Odenthal M, et al. (2010). Atorvastatin attenuates hepatic fibrosis in rats after bile duct ligation via decreased turnover of hepatic stellate cells. J Hepatol 53:702–12
  • Vaillant B, Chiaramonte MG, Cheever AW, et al. (2001). Regulation of hepatic fibrosis and extracellular matrix genes by the th response: New insight into the role of tissue inhibitors of matrix metalloproteinases. J Immunol 167:7017–26
  • Wang ME, Chen YC, Chen IS, et al. (2012). Curcumin protects against thioacetamide-induced hepatic fibrosis by attenuating the inflammatory response and inducing apoptosis of damaged hepatocytes. J Nutr Biochem 23:1352–66
  • Wang RM, Zhang QG, Li J, et al. (2009). The ERK5-MEF2C transcription factor pathway contributes to antiapoptotic effect of cerebral ischemia preconditioning in the hippocampal CA1 region of rats. Brain Res 1255:32–41
  • Wang X, Tang X, Gong X, et al. (2004). Regulation of hepatic stellate cell activation and growth by transcription factor myocyte enhancer factor 2. Gastroenterology 127:1174–88
  • Weiskirchen R, Gressner AM. (2005). Isolation and culture of hepatic stellate cells. Methods Mol Med 117:99–113
  • Xu J, Gong NL, Bodi I, et al. (2006). Myocyte enhancer factors 2A and 2C induce dilated cardiomyopathy in transgenic mice. J Biol Chem 281:9152–62
  • Yang Q, Deng X, Lu B, et al. (2010). Pharmacological inhibition of BMK1 suppresses tumor growth through promyelocytic leukemia protein. Cancer Cell 18:258–67
  • Yang Z, Yang J, Jia Y, et al. (2009). Pharmacokinetic properties of hydroxysafflor yellow A in healthy Chinese female volunteers. J Ethnopharmacol 124:635–8
  • Yoshiji H, Noguchi R, Ikenaka Y, et al. (2011). Cocktail therapy with a combination of interferon, ribavirin and angiotensin-II type 1 receptor blocker attenuates murine liver fibrosis development. Int J Mol Med 28:81–8
  • Zhang YB, Dong HY, Zhao XM, et al. (2012). Hydroxysafflor yellow A attenuates carbon tetrachloride-induced hepatic fibrosis in rats by inhibiting ERK5 signaling. Am J Chin Med 40:481–94
  • Zhang Y, Guo J, Dong H, et al. (2011). Hydroxysafflor yellow A protects against chronic carbon tetrachloride-induced liver fibrosis. Eur J Pharmacol 660:438–44
  • Zhen MC, Wang Q, Huang XH, et al. (2007). Green tea polyphenol epigallocatechin-3-gallate inhibits oxidative damage and preventive effects on carbon tetrachloride-induced hepatic fibrosis. J Nutr Biochem 18:795–805
  • Zheng S, Yumei F, Chen A. (2007). De novo synthesis of glutathione is a prerequisite for curcumin to inhibit hepatic stellate cell (HSC) activation. Free Radic Biol Med 43:444–53

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