Hesperidin, a flavanoglycone attenuates experimental diabetic neuropathy via modulation of cellular and biochemical marker to improve nerve functions

References

• Akiyama S, Katsumata S-I, Suzuki K, et al. (2010). Dietary hesperidin exerts hypoglycemic and hypolipidemic effects in streptozotocin-induced marginal type 1 diabetic rats. J Clin Biochem Nutr 46:87–92
   PubMed Web of Science ®Google Scholar
• Ar'rajab A, Ahrén B. (1993). Long-term diabetogenic effect of streptozotocin in rats. Pancreas 8:50–7
   PubMed Web of Science ®Google Scholar
• Arai K, Maguchi S, Fujii S, et al. (1987). Glycation and inactivation of human Cu–Zn–superoxide dismutase. Identification of the in vitro glycated sites. J Biol Chem 262:16969–72
   PubMed Web of Science ®Google Scholar
• Baydas G, Sonkaya E, Tuzcu M, et al. (2005). Novel role for gabapentin in neuroprotection of central nervous system in streptozotocine‐induced diabetic rats 1. Acta Pharmacol Sin 26:417–22
   PubMedGoogle Scholar
• Bhatt L, Veeranjaneyulu A. (2010). Minocycline with aspirin: A therapeutic approach in the treatment of diabetic neuropathy. Neurolog Sci 31:705–16
   PubMed Web of Science ®Google Scholar
• Bhattacharya G. (1955). On the protection against alloxan ciabetes by hexoses. Science (New York, NY) 121:427
   Google Scholar
• Bonting S. (1970). Presence of Enzyme System in Mammalian Tissues. Membrane and Ion Transport. London: Wiley Inter Science, 257--63
   Google Scholar
• Brecher P. (1983). The interaction of long-chain acyl CoA with membranes. Mol Cell Biochem 57:3–15
   PubMedGoogle Scholar
• Calcutt N, Freshwater J, Mizisin A. (2004). Prevention of sensory disorders in diabetic Sprague–Dawley rats by aldose reductase inhibition or treatment with ciliary neurotrophic factor. Diabetologia 47:718–24
   PubMed Web of Science ®Google Scholar
• Callaghan MJ, Ceradini DJ, Gurtner GC. (2005). Hyperglycemia-induced reactive oxygen species and impaired endothelial progenitor cell function. Antioxid Redox Signal 7:1476–82
   PubMed Web of Science ®Google Scholar
• Cameron NE, Cotter MA, Robertson S. (1991). Essential fatty acid diet supplementation. Effects on peripheral nerve and skeletal muscle function and capillarization in streptozocin-induced diabetic rats. Diabetes 40:532–9
   PubMedGoogle Scholar
• Chaplan S, Bach F, Pogrel J, et al. (1994). Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Meth 53:55–63
   PubMed Web of Science ®Google Scholar
• Cook N, Samman S. (1996). Flavonoids—Chemistry, metabolism, cardioprotective effects, and dietary sources. J Nutr Biochem 7:66–76
   Web of Science ®Google Scholar
• Coppey LJ, Gellett JS, Davidson EP, et al. (2001). Effect of M40403 treatment of diabetic rats on endoneurial blood flow, motor nerve conduction velocity and vascular function of epineurial arterioles of the sciatic nerve. Br J Pharmacol 134:21–9
   PubMed Web of Science ®Google Scholar
• Courteix C, Eschalier A, Lavarenne J. (1993). Streptozocin-induced diabetic rats: Behavioural evidence for a model of chronic pain. Pain 53:81–8
   PubMed Web of Science ®Google Scholar
• Davidson JA. (2004). Treatment of the patient with diabetes: Importance of maintaining target HbA1c levels. Curr Med Res Opin 20:1919–27
   PubMed Web of Science ®Google Scholar
• Dinarello CA. (2009). Immunological and inflammatory functions of the interleukin-1 family. Ann Rev Immunol 27:519–50
   PubMed Web of Science ®Google Scholar
• Ditzel J, Dyerberg J. (1977). Hyperlipoproteinemia, diabetes, and oxygen affinity of hemoglobin. Metabolism 26:141–50
   PubMedGoogle Scholar
• Dobretsov M, Romanovsky D, Stimers JR. (2007). Early diabetic neuropathy: Triggers and mechanisms. World J Gastroenterol (WJG) 13:175–91
   PubMed Web of Science ®Google Scholar
• Dyck PJ, Zimmerman BR, Vilen TH, et al. (1988). Nerve glucose, fructose, sorbitol, myo-inositol, and fiber degeneration and regeneration in diabetic neuropathy. New Engl J Med 319:542–8
   PubMed Web of Science ®Google Scholar
• Emim JA, Oliveira AB, Lapa AJ. (1994). Pharmacological evaluation of the anti-inflammatory activity of a citrus bioflavonoid, hesperidin, and the isoflavonoids, duartin and claussequinone, in rats and mice. J Pharm Pharmacol 46:118–22
   PubMed Web of Science ®Google Scholar
• Friedmann N, Gellhorn A, Benjamin W. (1966). Synthesis of arachidonic acid from linoleic acid in vivo in diabetic rats. Israel J Med Sci 2:677–82
   PubMedGoogle Scholar
• Gabay C, Lamacchia C, Palmer G. (2010). IL-1 pathways in inflammation and human diseases. Nat Rev Rheumatol 6:232–41
   PubMed Web of Science ®Google Scholar
• Garner MH, Spector A. (1987). Direct stimulation of Na+–K+–ATPase and its glucosylated derivative by aldose reductase inhibitor. Diabetes 36:716–20
   PubMedGoogle Scholar
• Ghosh P, Kandhare AD, Raygude KS, et al. (2012). Determination of the long term diabetes related complications and cardiovascular events using UKPDS risk engine and UKPDS outcomes model in a representative western Indian population. Asian Pac J Trop Dis 2:S642–S50
   Google Scholar
• Gidal B, Billington R. (2006). New and emerging treatment options for neuropathic pain. Am J Manag Care 12:S269–78
   PubMed Web of Science ®Google Scholar
• Gosavi T, Ghosh P, Kandhare A, Bodhankar S. (2011). Unwrapping homeopathic principles in the wake of research: Serendipity, placebo or true therapeutic milestones. Pharmacologyonline 1:894–906
   Google Scholar
• Gosavi TP, Kandhare AD, Ghosh P, Bodhankar SL. (2012). Anticonvulsant activity of Argentum metallicum, a homeopathic preparation. Der Pharmacia Lett 4:626–37
   Google Scholar
• Goto Y, Hotta N, Shigeta Y, et al. (1995). Effects of an aldose reductase inhibitor, epalrestat, on diabetic neuropathy. Clinical benefit and indication for the drug assessed from the results of a placebo-controlled double-blind study. Biomed Pharmacother 49:269–77
   PubMed Web of Science ®Google Scholar
• Greene DA, Sima AA, Stevens MJ, et al. (1992). Complications: Neuropathy, pathogenetic considerations. Diabetes Care 15:1902–25
   PubMed Web of Science ®Google Scholar
• Group DR. (1994). Effect of intensive diabetes treatment on the development and progression of long-term complications in adolescents with insulin-dependent diabetes mellitus: Diabetes control and complications trial. J Pediatr 125:177–88
   PubMedGoogle Scholar
• Guneli E, Kazikdas KC, Kolatan E. (2007). Ghrelin may attenuate proinflammatory cytokine-mediated neuropathic pain. Med Hypotheses 69:356–60
   PubMedGoogle Scholar
• Gustafson-Vickers SL, Lu VB, Lai AY, et al. (2008). Long-term actions of interleukin-1beta on delay and tonic firing neurons in rat superficial dorsal horn and their relevance to central sensitization. Mol Pain 4:63–73
   PubMedGoogle Scholar
• Halliwell B. (1991). Drug antioxidant effects. A basis for drug selection? Drugs 42:569–605.
   PubMed Web of Science ®Google Scholar
• Hargreaves K, Dubner R, Brown F, et al. (1988). A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain 32:77–88
   PubMed Web of Science ®Google Scholar
• Head KA. (2006). Peripheral neuropathy: Pathogenic mechanisms and alternative therapies. Alternat Med Rev 11:294–329
   PubMed Web of Science ®Google Scholar
• Hirata Y, Okada K. (1990). Relation of Na+, K(+)-ATPase to delayed motor nerve conduction velocity: Effect of aldose reductase inhibitor, ADN-138, on Na+, K(+)-ATPase activity. Metabolism 39:563--7
   Google Scholar
• Huang H-Y, Appel LJ. (2003). Supplementation of diets with α-tocopherol reduces serum concentrations of γ-and δ-tocopherol in humans. J Nutr 133:3137–40
   PubMed Web of Science ®Google Scholar
• Ibrahim SS. (2008). Protective effect of hesperidin, a citrus bioflavonoid, on diabetes-induced brain damage in rats. J Appl Sci Res 4:84–95
   Google Scholar
• Jean T, Bodinier M. (1994). Mediators involved in inflammation: Effects of Daflon 500 mg on their release. Angiology 45:554–9
   PubMed Web of Science ®Google Scholar
• Jensen TS, Baron R. (2003). Translation of symptoms and signs into mechanisms in neuropathic pain. Pain 102:1–8
   PubMed Web of Science ®Google Scholar
• Jin YR, Han XH, Zhang YH, et al. (2008). Hesperetin, a bioflavonoid, inhibits rat aortic vascular smooth muscle cells proliferation by arresting cell cycle. J Cell Biochem 104:1–14
   PubMed Web of Science ®Google Scholar
• Jung UJ, Lee M-K, Jeong K-S, Choi M-S. (2004). The hypoglycemic effects of hesperidin and naringin are partly mediated by hepatic glucose-regulating enzymes in C57BL/KsJ-db/db mice. J Nutr 134:2499–503
   PubMed Web of Science ®Google Scholar
• Kandhare A, Raygude K, Ghosh P, Bodhankar S. (2011a). The ameliorative effect of fisetin, a bioflavonoid, on ethanol-induced and pylorus ligation-induced gastric ulcer in rats. Int J Green Pharmacy 5:236–43
   Google Scholar
• Kandhare AD, Raygude KS, Ghosh P, et al. (2011b). Patentability of animal models: India and the globe. Intl J PharmBiol Arch 2:1024–32
   Google Scholar
• Kandhare AD, Kumar VS, Adil M, et al. (2012a). Investigation of gastro protective activity of Xanthium strumarium L. by modulation of cellular and biochemical marker. Orient Pharm Exp Med 12:287–99
   Google Scholar
• Kandhare AD, Raygude KS, Ghosh P, et al. (2012b). Neuroprotective effect of naringin by modulation of endogenous biomarkers in streptozotocin induced painful diabetic neuropathy. Fitoterapia 83:650–9
   PubMed Web of Science ®Google Scholar
• Kandhare AD, Raygude KS, Ghosh P, et al. (2012c). Therapeutic role of curcumin in prevention of biochemical and behavioral aberration induced by alcoholic neuropathy in laboratory animals. Neurosci Lett 511:18–22
   PubMed Web of Science ®Google Scholar
• Kandhare AD, Raygude KS, Ghosh P, et al. (2012d). Effect of hydroalcoholic extract of Hibiscus rosa sinensis Linn. leaves in experimental colitis in rats. Asian Pac J Trop Biomed 5:337–44
   Google Scholar
• Kandhare AD, Raygude KS, Shiva Kumar V, et al. (2012e). Ameliorative effects quercetin against impaired motor nerve function, inflammatory mediators and apoptosis in neonatal streptozotocin-induced diabetic neuropathy in rats. Biomed Aging Pathol 2:173–86
   Google Scholar
• Kandhare AD, Ghosh P, Ghule AE, Bodhankar SL. (2013a). Elucidation of molecular mechanism involved in neuroprotective effect of Coenzyme Q10 in alcohol induced neuropathic pain. Fundam Clin Pharmacol 27:603--22
   Google Scholar
• Kandhare AD, Ghosh P, Ghule AE, et al. (2013b). Protective effect of Phyllanthus amarus by modulation of endogenous biomarkers and DNA damage in acetic acid induced ulcerative colitis: Role of phyllanthin and hypophyllanthin. Apollo Med 10:87–97
   Google Scholar
• Kapur D. (2003). Neuropathic pain and diabetes. Diabetes/Metab Res Rev 19:S9–15
   PubMed Web of Science ®Google Scholar
• Kaur G, Tirkey N, Chopra K. (2006). Beneficial effect of hesperidin on lipopolysaccharide-induced hepatotoxicity. Toxicology 226:152–60
   PubMed Web of Science ®Google Scholar
• Kawaguchi K, Mizuno T, Aida K, Uchino K. (1997). Hesperidin as an inhibitor of lipases from porcine pancreas and Pseudomonas. Biosci Biotechnol Biochem 61:102–4
   PubMed Web of Science ®Google Scholar
• Kim SY, Lee JH, Yang ES, et al. (2003). Human sensitive to apoptosis gene protein inhibits peroxynitrite-induced DNA damage. Biochem Biophys Res Commun 301:671–4
   PubMed Web of Science ®Google Scholar
• Kishi Y, Nickander KK, Schmelzer JD, Low PA. (2000). Gene expression of antioxidant enzymes in experimental diabetic neuropathy. J Peripher Nerv Syst 5:11–18
   PubMedGoogle Scholar
• Kuhad A, Chopra K. (2009). Tocotrienol attenuates oxidative–nitrosative stress and inflammatory cascade in experimental model of diabetic neuropathy. Neuropharmacology 57:456–62
   PubMedGoogle Scholar
• Kumar A, Kaundal RK, Iyer S, Sharma SS. (2007). Effects of resveratrol on nerve functions, oxidative stress and DNA fragmentation in experimental diabetic neuropathy. Life Sci 80:1236–44
   PubMed Web of Science ®Google Scholar
• Lee N-K, Choi S-H, Park S-H, et al. (2004). Antiallergic activity of hesperidin is activated by intestinal microflora. Pharmacology 71:174–80
   PubMed Web of Science ®Google Scholar
• Lonchampt M, Guardiola B, Sicot N, et al. (1989). Protective effect of a purified flavonoid fraction against reactive oxygen radicals. In vivo and in vitro study. Arzneimittel-Forschung 39:882–5
   PubMedGoogle Scholar
• Low PA, Nickander KK. (1991). Oxygen free radical effects in sciatic nerve in experimental diabetes. Diabetes 40:873–7
   PubMed Web of Science ®Google Scholar
• Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. (1951). Protein measurement with the Folin phenol reagent. J Biol Chem 193:265–75
   PubMed Web of Science ®Google Scholar
• Matkovics B, Kotorman M, Varga IS, et al. (1997). Oxidative stress in experimental diabetes induced by streptozotocin. Acta Physiol Hungarica 85:29–38
   PubMedGoogle Scholar
• Matrisian LM. (2005). The matrix‐degrading metalloproteinases. Bioassays 14:455–63
   Google Scholar
• Milenkovic D, Deval C, Dubray C, et al. (2011). Hesperidin displays relevant role in the nutrigenomic effect of orange juice on blood leukocytes in human volunteers: A randomized controlled cross-over study. PloS One 6:e26669
   PubMed Web of Science ®Google Scholar
• Miranda KM, Espey MG, Wink DA. (2001). A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite. Nitric Oxide: Biol Chem/Official J Nitric Oxide Soc 5:62–71
   PubMed Web of Science ®Google Scholar
• Misra HP, Fridovich I. (1972). The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. J Biol Chem 247:3170–5
   PubMed Web of Science ®Google Scholar
• Moron MS, Depierre JW, Mannervik B. (1979). Levels of glutathione, glutathione reductase and glutathione-S-transferase activities in rat lung and liver. Biochim Biophys Acta (BBA)-Gen Subj 582:67–78
   PubMed Web of Science ®Google Scholar
• Nagamatsu M, Nickander KK, Schmelzer JD, et al. (1995). Lipoic acid improves nerve blood flow, reduces oxidative stress, and improves distal nerve conduction in experimental diabetic neuropathy. Diabetes Care 18:1160–7
   PubMed Web of Science ®Google Scholar
• Nandakumar N, Jayaprakash R, Rengarajan T, et al. (2011). Hesperidin, a natural citrus flavonoglycoside, normalizes lipid peroxidation and membrane bound marker enzymes in 7, 12-dimethylbenz (a) anthracene induced experimental breast cancer rats. Biomed Prev Nutr 1:255–62
   Google Scholar
• Necker R, Hellon R. (1978). Noxious thermal input from the rat tail: Modulation by descending inhibitory influences. Pain 4:231–42
   PubMed Web of Science ®Google Scholar
• Newby AC. (2005). Dual role of matrix metalloproteinases (matrixins) in intimal thickening and atherosclerotic plaque rupture. Physiol Rev 85:1–31
   PubMed Web of Science ®Google Scholar
• Niedowicz DM, Daleke DL. (2005). The role of oxidative stress in diabetic complications. Cell Biochem Biophys 43:289–330
   PubMed Web of Science ®Google Scholar
• Nishikawa T, Edelstein D, Du XL, et al. (2000). Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature 404:787–90
   PubMed Web of Science ®Google Scholar
• Obrosova IG, Drel VR, Pacher P, et al. (2005). Oxidative-nitrosative stress and poly (ADP-ribose) polymerase (PARP) activation in experimental diabetic neuropathy the telation is revisited. Diabetes 54:3435–41
   PubMed Web of Science ®Google Scholar
• Opara E. (2002). Oxidative stress, micronutrients, diabetes mellitus and its complications. J R Soc Promot Health 122:28–34
   PubMedGoogle Scholar
• Pabbidi RM, Yu S-Q, Peng S, et al. (2008). Influence of TRPV1 on diabetes-induced alterations in thermal pain sensitivity. Mol Pain 4:9
   PubMedGoogle Scholar
• Patil M, Kandhare A, Bhise S. (2012a). Anti-inflammatory effect of Daucus carota root on experimental colitis in rats. Int J Pharm Pharm Sci 4:337–43
   Google Scholar
• Patil MVK, Kandhare AD, Bhise SD. (2012b). Anti-arthritic and anti-inflammatory activity of Xanthium strumarium L. ethanolic extract in Freund's complete adjuvant induced arthritis. Biomed Aging Pathol 2:6–15
   Google Scholar
• Patil MVK, Kandhare AD, Bhise SD. (2012c). Effect of aqueous extract of Cucumis sativus Linn. fruit in ulcerative colitis in laboratory animals. Asian Pac J Trop Biomed 2:S962–9
   Google Scholar
• Patil MVK, Kandhare AD, Ghosh P, Bhise SD. (2012d). Determination of role of GABA and nitric oxide in anticonvulsant activity of Fragaria vesca L. ethanolic extract in chemically induced epilepsy in laboratory animals. Oriental Pharm Exp Med 12:255–64
   Google Scholar
• Perkins N, Tracey D. (2000). Hyperalgesia due to nerve injury: Role of neutrophils. Neuroscience 101:745–57
   PubMedGoogle Scholar
• Pires Das Neves RN, Carvalho F, Carvalho M, et al. (2004). Protective activity of hesperidin and lipoic acid against sodium arsenite acute toxicity in mice. Toxicol Pathol 32:527–35
   PubMedGoogle Scholar
• Quattrini C, Tesfaye S. (2003). Understanding the impact of painful diabetic neuropathy. Diabetes/Metab Res Rev 19:S2–8
   Web of Science ®Google Scholar
• Randall LO, Selitto JJ. (1957). A method for measurement of analgesic activity on inflamed tissue. Arch Int Pharmacodyn Ther 111:409–19
   PubMedGoogle Scholar
• Raygude KS, Kandhare AD, Ghosh P, Bodhankar SL. (2012a). Anticonvulsant effect of fisetin by modulation of endogenous biomarkers. Biomed Prev Nutr 2:215–22
   Google Scholar
• Raygude KS, Kandhare AD, Ghosh P, et al. (2012b). Evaluation of ameliorative effect of quercetin in experimental model of alcoholic neuropathy in rats. Inflammopharmacology 20:331–41
   PubMedGoogle Scholar
• Rice-Evans C, Miller N, Paganga G. (1997). Antioxidant properties of phenolic compounds. Trends Plant Sci 2:152–9
   Web of Science ®Google Scholar
• Rizza S, Muniyappa R, Iantorno M, et al. (2011). Citrus polyphenol hesperidin stimulates production of nitric oxide in endothelial cells while improving endothelial function and reducing inflammatory markers in patients with metabolic syndrome. J Clin Endocrinol Metab 96:E782–92
   PubMed Web of Science ®Google Scholar
• Rossetti L, Giaccari A, Defronzo RA. (1990). Glucose toxicity. Diabetes Care 13:610–30
   PubMed Web of Science ®Google Scholar
• Said G. (2007). Diabetic neuropathy—A review. Nat Clin Pract Neurol 3:331–40
   PubMedGoogle Scholar
• Samad TA, Moore KA, Sapirstein A, et al. (2001). Interleukin-1β-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity. Nature 410:471–5
   PubMed Web of Science ®Google Scholar
• Sayyed SG, Kumar A, Sharma SS. (2006). Effects of U83836E on nerve functions, hyperalgesia and oxidative stress in experimental diabetic neuropathy. Life Sci 79:777–83
   PubMedGoogle Scholar
• Scholz J, Woolf CJ. (2007). The neuropathic pain triad: Neurons, immune cells and glia. Nat Neurosci 10:1361–8
   PubMed Web of Science ®Google Scholar
• Serpell M. (2006). Anatomy, physiology and pharmacology of pain. Surgery (Oxford) 24:350–3
   Google Scholar
• Severenghaus J, Ferrebee J. (1950). Calcium determination by flame photometry; methods for serum, urine, and other fluids. J Biol Chem 187:621–30
   PubMedGoogle Scholar
• Shah JK, Patel N. (2010). Effect of hesperidin on renal complication in experimentally induced renal damage in diabetic Sprague–Dawley rats. J Ecobiotechnol 2:35--40
   Google Scholar
• Sharma A, Thomas P, De Molina A. (1977). Peripheral nerve fiber size in experimental diabetes. Diabetes 26:689–92
   PubMedGoogle Scholar
• Shi X, Liao S, Mi H, et al. (2012). Hesperidin prevents retinal and plasma abnormalities in streptozotocin-induced diabetic rats. Molecules 17:12868–81
   PubMed Web of Science ®Google Scholar
• Sima A. (2006). Pathological mechanisms involved in diabetic neuropathy: Can we slow the process? Curr Opin Invest Drugs 7:324–37
   PubMedGoogle Scholar
• Slater T, Sawyer B. (1971). The stimulatory effects of carbon tetrachloride and other halogenoalkanes on peroxidative reactions in rat liver fractions in vitro. General features of the systems used. Biochem J 123:805–14
   PubMed Web of Science ®Google Scholar
• Soriano FG, Pacher P, Mabley J, et al. (2001). Rapid reversal of the diabetic endothelial dysfunction by pharmacological inhibition of poly (ADP-ribose) polymerase. Circ Res 89:684–91
   PubMed Web of Science ®Google Scholar
• Sorkin LS, Doom CM. (2001). Epineurial application of TNF elicits an acute mechanical hyperalgesia in the awake rat. J Peripher Nerv Syst 5:96–100
   Google Scholar
• Stevens MJ, Obrosova I, Cao X, et al. (2000). Effects of dl-alpha-lipoic acid on peripheral nerve conduction, blood flow, energy metabolism, and oxidative stress in experimental diabetic neuropathy. Diabetes 49:1006–15
   PubMed Web of Science ®Google Scholar
• Sudoh Y, Desai SP, Haderer AE, et al. (2004). Neurologic and histopathologic evaluation after high-volume intrathecal amitriptyline. Reg Anesth Pain Med 29:434–40
   PubMed Web of Science ®Google Scholar
• Valensi P, Le Devehat C, Richard J-L, et al. (2005). A multicenter, double-blind, safety study of QR-333 for the treatment of symptomatic diabetic peripheral neuropathy: A preliminary report. J Diabetes Compl 19:247–53
   PubMed Web of Science ®Google Scholar
• Verri W Jr, Cunha TM, Parada CA, et al. (2006). Hypernociceptive role of cytokines and chemokines: Targets for analgesic drug development? Pharmacol Therapeut 112:116–38
   PubMed Web of Science ®Google Scholar
• Vincent AM, Russell JW, Low P, Feldman EL. (2004). Oxidative stress in the pathogenesis of diabetic neuropathy. Endocrine Rev 25:612–28
   PubMed Web of Science ®Google Scholar
• Visnagri A, Kandhare AD, Shiva Kumar V, et al. (2012). Elucidation of ameliorative effect of co-enzyme Q10 in streptozotocin-induced diabetic neuropathic perturbation by modulation of electrophysiological, biochemical and behavioral markers. Biomed Aging Pathol 2:157–72
   Google Scholar
• Wild S, Roglic G, Green A, et al. (2004). Global prevalence of diabetes estimates for the year 2000 and projections for 2030. Diabetes Care 27:1047–53
   PubMed Web of Science ®Google Scholar
• Wuarin-Bierman L, Zahnd G, Kaufmann F, et al. (1987). Hyperalgesia in spontaneous and experimental animal models of diabetic neuropathy. Diabetologia 30:653–8
   PubMedGoogle Scholar
• Yoon SL, Horne CH, Adams C. (2004). Herbal product use by African American older women. Clin Nurs Res 13:271–88
   PubMedGoogle Scholar
• Yurchenco PD, Schittny JC. (1990). Molecular architecture of basement membranes. FASEB J 4:1577–90
   PubMed Web of Science ®Google Scholar
• Ziegler D, Hanefeld M, Ruhnau KJ, et al. (1999). Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: A 7-month multicenter randomized controlled trial (ALADIN III Study). ALADIN III study group. Alpha-lipoic acid in diabetic neuropathy. Diabetes Care 22:1296–301
   PubMed Web of Science ®Google Scholar
• Zochodne D, Levy D. (2005). Nitric oxide in damage, disease and repair of the peripheral nervous system. Cell Mol Biol (Noisy-le-Grand, France) 51:255–67
   PubMed Web of Science ®Google Scholar