2,302
Views
6
CrossRef citations to date
0
Altmetric
Research Article

Effects of l-arginine and creatine administration on spatial memory in rats subjected to a chronic variable stress model

, , , , , & show all
Pages 1033-1038 | Received 30 Jul 2013, Accepted 31 Oct 2013, Published online: 12 Mar 2014

References

  • Benton D, Donohoe R. (2011). The influence of creatine supplementation on the cognitive functioning of vegetarians and omnivores. Br J Nutr 105:1100–5
  • Chrousos GP. (2009). Stress and disorders of the stress system. Nat Rev Endocrinol 5:374–81
  • Cymeryng CB, Dada LA, Colonna C. (1999). Effects of l-arginine in rat adrenal cells: Involvement of nitric oxide synthase. Endocrinology 140:2962–7
  • Derave W, Marescau B, Vanden Eede E, et al. (2004). Plasma guanidino compounds are altered by oral creatine supplementation in healthy humans. J Appl Physiol 97:852–7
  • Esplugues JV. (2002). NO as a signaling molecule in the nervous system. Br J Pharmacol 135:1079–95
  • Guerra GP, Mello CF, Sauzem PD, et al. (2006). Nitric oxide is involved in the memory facilitation induced by spermidine in rats. Psychopharmacology (Berl) 186:150–8
  • Heinzen EL, Pollack GM. (2003). Pharmacokinetics and pharmacodynamics of l-arginine in rats: A model of stimulated neuronal nitric oxide synthesis. Brain Res 989:67–75
  • Huynh NN, Chin-Dusting J. (2006). Amino acids, arginase and nitric oxide in vascular health. Clin Exp Pharmacol Physiol 33:1–8
  • Jahangir E, Vita JA, Handy D, et al. (2009). The effect of l-arginine and creatine on vascular function and homocysteine metabolism. Vasc Med 14:239–48
  • Kleen JK, Sitomer MT, Killeen PR, Conrad CD. (2006). Chronic stress impairs spatial memory and motivation for reward without disrupting motor ability and motivation to explore. Behav Neurosci 120:842–51
  • Klein AM, Ferrante RJ. (2007). The neuroprotective role of creatine. Subcell Biochem 46:205–43
  • Koga Y, Takahashi H, Oikawa D, et al. (2005). Brain creatine functions to attenuate acute stress responses through GABAnergic system in chicks. Neuroscience 132:65–71
  • Kronon MT, Allen BS, Halldorsson A. (1999). l-Arginine, prostaglandin, and white cell filtration equally improve myocardial protection in stressed neonatal hearts. J Thorac Cardiovasc Surg 118:665–72
  • Lawler JM, Barnes WS, Wu G, et al. (2002). Direct antioxidant properties of creatine. Biochem Biophys Res Commun 290:47–52
  • Little JP, Forbes SC, Candow DG, et al. (2008). Creatine, arginine alpha-ketoglutarate, amino acids, and medium-chain triglycerides and endurance and performance. Int J Sport Nutr Exerc Metab 18:493–508
  • Magni DV, Oliveira MS, Furian AF, et al. (2007). Creatine decreases convulsions and neurochemical alterations induced by glutaric acid in rats. Brain Res 1185:336–45
  • Mclay RN, Freeman SM, Zadina JE. (1998). Chronic corticosterone impairs memory performance in the Barnes maze. Physiol Behav 63:933–7
  • McMorris T, Harris RC, Swain J, et al. (2006). Effect of creatine supplementation and sleep deprivation, with mild exercise, on cognitive and psychomotor performance, mood state, and plasma concentrations of catecholamines and cortisol. Psychopharmacology (Berl) 185:93–103
  • McMorris T, Harris RC, Howard AN, et al. (2007a). Creatine supplementation, sleep deprivation, cortisol, melatonin and behavior. Physiol Behav 90:21–8
  • McMorris T, Mielcarz G, Harris RC, et al. (2007b). Creatine supplementation and cognitive performance in elderly individuals. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 14:517–28
  • Morris R. (1984). Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci Methods 11:47–60
  • Mungrue IN, Gros R, You X, et al. (2002). Cardiomyocyte over expression of iNOS in mice results in peroxynitrite generation, heart block, and sudden death. J Clin Invest 109:735–43
  • Netto CA, Hodges H, Sinden JD, et al. (1993). Effects of fetal hippocampal field grafts on ischemic-induced deficits in spatial navigation in the water maze. Neuroscience 54:69–92
  • Oliveira MS, Furian AF, Fighera MR, et al. (2008). The involvement of the polyamines binding sites at the NMDA receptor in creatine-induced spatial learning enhancement. Behav Brain Res 187:200–4
  • Paul V, Ekambaram P. (2011). Involvement of nitric oxide in learning & memory processes. Indian J Med Res 133:471–8
  • Rae C, Digney AL, McEwan SR, Bates TC. (2003). Oral creatine monohydrate supplementation improves brain performance: A double-blind, placebo controlled, cross-over trial. Proc Biol Sci 270:2147–50
  • Saraiva AL, Ferreira AP, Silva LF, et al. (2012). Creatine reduces oxidative stress markers but does not protect against seizure susceptibility after severe traumatic brain injury. Brain Res Bull 87:180–6
  • Tagliari B, Noschang CG, Ferreira AG, et al. (2010). Chronic variable stress impairs energy metabolism in prefrontal cortex and hippocampus of rats: Prevention by chronic antioxidant treatment. Metab Brain Dis 25:169–76
  • Ulrich-Lai YM, Herman JP. (2009). Neural regulation of endocrine and autonomic stress responses. Nat Rev Neurosci 10:397–409
  • Valenzuela MJ, Jones M, Wen W, et al. Memory training alters hippocampal neurochemistry in healthy elderly. (2003). Neuroreport 14:1333–7
  • Vasconcellos AP, Zugno AI, Santos AH, et al. (2005). Na+, K+-ATPase activity is reduced in hippocampus of rats submitted to an experimental model of depression: Effect of chronic lithium treatment and possible involvement in learning deficits. Neurobiol Learn Mem 84:102–10
  • Wallen WJ, Cserti C, Belanger MP, Wittnich C. (2000). Gender-differences in myocardial adaptation to afterload in normotensive and hypertensive rats. Hypertension 36:774–9

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.