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Review Article

Pharmaceutical properties of calycosin, the major bioactive isoflavonoid in the dry root extract of Radix astragali

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Pages 1217-1222 | Received 05 Aug 2013, Accepted 23 Dec 2013, Published online: 17 Mar 2014

References

  • Bitto A, Polito F, Squadrito F, et al. (2010). Aglycone: A dual mode of action antiosteoporotic soy isoflavone rebalancing bone turnover towards bone formation. Curr Med Chem 17:3007–18
  • Burz C, Berindan-Neagoe I, Balacescu O, Irimie A. (2009). Apoptosis in cancer: Key molecular signaling pathways and therapy targets. Acta Oncol 48:811–21
  • Chan JY, Lam FC, Leung PC, et al. (2009). Antihyperglycemic and antioxidative effects of a herbal formulation of Radix astragali, Radix codonopsis and Cortex lycii in a mouse model of type 2 diabetes mellitus. Phytother Res 23:658–65
  • Chen CY, Zu YG, Fu YJ, et al. (2011a). Preparation and antioxidant activity of Radix astragali residues extracts rich in calycosin and formononetin. Biochem Eng J 56:84–93
  • Chen J, Liu LT, Hou R, et al. (2011b). Calycosin promotes proliferation of estrogen receptor-positive cells via estrogen receptors and ERK1/2 activation in vitro and in vivo. Cancer Lett 308:144–51
  • Chen HQ, Wang XJ, Jin ZY, et al. (2008). Protective effect of isoflavones from Trifolium pratense on dopaminergic neurons. Neurosci Res 62:123–30
  • Chen J, Xiong WB, Xiong Y, et al. (2011c). Calycosin stimulates proliferation of estrogen receptor-positive human breast cancer cells through downregulation of Bax Gene expression and upregulation of Bcl-2 gene expression at low concentrations. JPEN J Parenter Enteral Nutr 35:763–9
  • Cheng CC, Chen YH, Chang WL, et al. (2010). Phytoestrogen bavachin mediates anti-inflammation targeting Ikappa B kinase-I kappaB alpha-NF-kappaB signaling pathway in chondrocytes in vitro. Eur J Pharmacol 636:181–8
  • Chopra M, Thurnham DI. (1999). Clinical nutrition and metabolism group symposium on “nutrition and antioxidants”: Antioxidants and lipoprotein metabolism. Proc Nutr Soc 58:663–71
  • Christiansen T, Richelsen B, Bruun JM. (2005). Monocyte chemoattractant protein-1 is produced in isolated adipocytes, associated with adiposity and reduced after weight loss in morbid obese subjects. Int J Obes 29:146–50
  • Cindric M, Cipak A, Zapletal E, et al. (2012). Stobadine attenuates impairment of an intestinal barrier model caused by 4-hydroxynonenal. Toxicol In Vitro 27:426–32
  • Davids MS, Letai A. (2012). Targeting the B-cell lymphoma/leukemia 2 family in cancer. J Clin Oncol 30:3127–35
  • Eaton P, Li JM, Hearse DJ, Shattock MJ. (1999). Formation of 4-hydroxy-2-nonenal-modified proteins in ischemic rat heart. Am J Physiol Heart Circ Physiol 276:H935–43
  • Emerit J, Edeas M, Bricaire K. (2004). Neurodegenerative disease and oxidative stress. Biomed Pharmacother 58:39–46
  • Fan Y, Wu DZ, Gong YQ, et al. (2003). Effects of calycosin on the impairment of barrier function induced by hypoxia in human umbilical vein endothelial cells. Eur J Pharmacol 481:33–40
  • Figarola JL, Shanmugam N, Natarajan R, Rahbar S. (2007). Anti-inflammatory effects of the advanced glycation end product inhibitor LR-90 in human monocytes. Diabetes 56:647–55
  • Gui SY, Wei W, Wang H, et al. (2006). Effects and mechanisms of crude astragalosides fraction on liver fibrosis in rats. J Ethnopharmacol 103:154–9
  • Guo C, Tong L, Xi M, et al. (2012). Neuroprotective effect of calycosin on cerebral ischemia and reperfusion injury in rats. J Ethnopharmacol 144:768–74
  • Guo Q, Rimbach G, Monini H, et al. (2002). ESR and cell culture studies on free radical-scavenging and antioxidant activities of isoflavonoids. Toxicology 179:171–80
  • Goldin A, Beckman JA, Schmidt AM, Creager MA. (2006). Advanced glycation end products: Sparking the development of diabetic vascular injury. Circulation 114:597–605
  • Hoo RLC, Wong JYL, Qiao CF, et al. (2010). The effective fraction isolated from Radix astragali alleviates glucose intolerance, insulin resistance and hypertriglyceridemia in db/db diabetic mice through its anti-inflammatory activity. Nutr Metab 7:67–79
  • Hong-Fen L, Waisman T, Maimon Y, et al. (2001). The effects of a Chinese herb formula, anti-cancer number one (ACNO), on NK cell activity and tumor metastasis in rats. Int Immunopharmacol 1:1947–56
  • Hotamisligil GS, Shargill NS, Spiegelman BM. (1993). Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance. Science 259:87–91
  • Hu G, Siu SO, Li S, et al. (2012). Metabolism of calycosin, an isoflavone from Astragali Radix, in zebrafish larvae. Xenobiotica 42:294–303
  • Jin S, Zhang QY, Kang XM, et al. (2010). Daidzein induces MCF-7 breast cancer cell apoptosis via the mitochondrial pathway. Ann Oncol 21:263–8
  • Kanda H, Tateya S, Tamori Y, et al. (2006). MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J Clin Invest 116:1494–505
  • Kang MH, Reynolds CP. (2009). Bcl-2 inhibitors: Targeting mitochondrial apoptotic pathways in cancer therapy. Clin Cancer Res 15:1126–32
  • Kim JW, Jin YC, Kim YM, et al. (2009). Daidzein administration in vivo reduces myocardial injury in a rat ischemia/reperfusion model by inhibiting NF-kappaB activation. Life Sci 84:227–34
  • Leung PC, Wong MW, Wong WC. (2008). Limb salvage in extensive diabetic foot ulceration: An extended study using a herbal supplement. HK Med J 14:29–33
  • Li S, Lou S, Lei BUW, et al. (2011). Transcriptional profiling of angiogenesis activities of calycosin in zebrafish. Mol BioSyst 7:3112–21
  • Lin L, Park S, Lakatta EG. (2009). RAGE signaling in inflammation and arterial aging. Front Biosci 14:1403–13
  • Liu CY, Gu ZL, Han R, et al. (2005). Protective effect of Astragalus complanatus flavonoid on liver fibrosis induced by CCl4 and CalN in mice and hepatocellular primary culture. Chin Tradit Herb Drugs 36:1838–41
  • Liu CY, Gu ZL, Han R, et al. (2007). Screening of antineoplasmic active component of flavonoids of Astragalus complanatus in vivo and vitro. Chin Tradit Herb Drugs 38:1052–4
  • Mahajan SK, Kashyap R, Sood BR, et al. (2004). Stroke at moderate altitude. J Assoc Physicians India 52:699–702
  • Neeper M, Schmidt AM, Brett J, et al. (1992). Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins. J Biol Chem 267:14998–5004
  • Orasanu G, Plutzky J. (2009). The pathologic continuum of diabetic vascular disease. J Am Coll Cardiol 53:S35–42
  • Pilšáková L, Riečanský I, Jagla F. (2010). The physiological actions of isoflavone phytoestrogens. Physiol Res 59:651–64
  • Qi L, Liu CY, Wu WQ, et al. (2011). Protective effect of flavonoids from Astragalus complanatus on radiation induced damages in mice. Fitoterapia 82:383–92
  • Qi LW, Cao J, Li P, et al. (2008). Qualitative and quantitative analysis of Radix Astragali products by fast high-performance liquid chromatography-diode array detection coupled with time-of-flight mass spectrometry through dynamic adjustment of fragmentor voltage. J Chromatogr A 1203:27–35
  • Romagnolo DF, Selmin OI. (2012). Flavonoids and cancer prevention: A review of the evidence. J Nutr Gerontol Geriatr 31:206–38
  • Rice-Evans CA, Miller NJ, Bolwell PG, et al. (1995). The relative antioxidant activities of plant-derived polyphenolic flavonoids. Free Radic Res 22:375–83
  • Ryu M, Kim EH, Chun M, et al. (2008). Astragali Radix elicits anti-inflammation via activation of MKP-1, concomitant with attenuation of p38 and Erk. J Ethnopharmacol 115:184–93
  • Sakaguchi T, Yan SF, Yan SD, et al. (2003). Central role of RAGE-dependent neointimal expansion in arterial restenosis. J Clin Invest 111:959–72
  • Sato Y, Itagaki S, Oikawa S, et al. (2011). Protective effect of soy isoflavone genistein on ischemia-reperfusion in the rat small intestine. Biol Pharm Bull 34:1448–54
  • Schmidt AM, Yan SD, Yan SF, Stern DM. (2001). The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses. J Clin Invest 108:949–55
  • Shirataki Y, Takao M, Yoshida S, Toda S. (1997). Antioxidative components isolated from the roots of Astragalus membranaceus Bunge (Astragali Radix). Phytother Res 11:603–5
  • Silvestrelli G, Corea F, Paciaroni M, et al. (2002). The Perugia hospital-based stroke registry: Report of the 2nd year. Clin Exp Hypertens 24:485–91
  • Sohal RS, Mockett RJ, Orr WC. (2002). Mechanisms of aging: An appraisal of the oxidative stress hypothesis. Free Radic Biol Med 33:575–86
  • Tang JY, Li S, Li ZH, et al. (2010). Calycosin promotes angiogenesis involving estrogen receptor and mitogen-activated protein kinase (MAPK) signaling pathway in zebrafish and HUVEC. PLoS One 5:e11822 (1–14)
  • Tang LL, Sheng JF, Xu CH, Liu KZ. (2009). Clinical and experimental effectiveness of Astragali compound in the treatment of chronic viral hepatitis B. J Int Med Res 37:662–7
  • Tian J, Duan YX, Bei CY, Chen J. (2013). Calycosin induces apoptosis by upregulation of RASD1 in human breast cancer cells MCF-7. Horm Metab Res 45:593–8
  • Uysal KT, Wiesbrock SM, Marino MW, Hotamisligil GS. (1997). Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature 389:610–14
  • Wang DQ, Li Y, Tian YP. (2005). Inhibition effects of total flavonids of Astragalus on BEL-7402 cell in vitro. Acad J PLA Postgraduate Med School 26:331–3
  • Wang D, Zhuang Y, Tian Y, et al. (2012). Study of the effects of total flavonoids of Astragalus on atherosclerosis formation and potential mechanisms. Oxid Med Cell Longev 2012:282383 (1–10)
  • Watanabe M, de Moura NL, Da CSC, et al. (2007). Isoflavone and the heme oxygenase system in ischemic acute kidney injury in rats. Food Chem Toxicol 45:2366–71
  • Weisberg SP, Hunter D, Huber R, et al. (2006). CCR2 modulates inflammatory and metabolic effects of high-fat feeding. J Clin Invest 116:115–24
  • Weisberg SP, McCann D, Desai M, et al. (2003). Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 112:1796–808
  • Wu XL, Wang YY, Cheng J, Zhao YY. (2006). Calcium channel blocking activity of calycosin, a major active component of Astragali Radix, on rat aorta. Acta Pharmacol Sin 27:1007–12
  • Xiao WH, Han LJ, Shi B. (2009). Isolation and purification of flavonoid glucosides from Radix Astragali by high-speed counter-current chromatography. J Chromatogr B 877:697–702
  • Xu A, Wang Y, Keshaw H, et al. (2003). The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. J Clin Invest 112:91–100
  • Xu YH, Feng L, Wang SS, et al. (2011). Calycosin protects HUVECs from advanced glycation end products-induced macrophage infiltration. J Ethnopharmacol 137:359–70
  • Yu DH, Bao YM, An LJ, Yang M. (2009). Protection of PC12 cells against superoxide-induced damage by isoflavonoids from Astragalus mongholicus. Biomed Environ Sci 22:50–4
  • Yu DH, Duan YL, Bao YM, et al. (2005). Isoflavonoids from Astragalus mongholicus protect PC12 cells from toxicity induced by l-glutamate. J Ethnopharmacol 98:89–94
  • Zeng GX, Ou HY, Ning ZX. (2012). The antioxidative activity and the fingerprint by HPLC of the flavonoids of Astragalus mongholicus. Adv Mat Res 550–3:1637–42
  • Zhang D, Zhuang Y, Pan J, et al. (2012). Investigation of effects and mechanisms of total flavonoids of Astragalus and calycosin on human erythroleukemia cells. Oxid Med Cell Longev 2012:209843 (1–5)
  • Zhang JQ, Xie XS, Li C, Fu P. (2009). Systematic review of the renal protective effect of Astragalus membranaceus (root) on diabetic nephropathy in animal models. J Ethnopharmacol 126:189–96
  • Zhang Y, Shi S, Guo J, et al. (2013). On-line surface plasmon resonance-high performance liquid chromatography–tandem mass spectrometry for analysis of human serum albumin binders from Radix Astragali. J Chromatogr A 1293:92–9
  • Zhao BS, Fu YJ, Wang W, et al. (2011). Enhanced extraction of isoflavonoids from Radix Astragali by incubation pretreatment combined with negative pressure cavitation and its antioxidant activity. Innov Food Sci Emerg Technol 12:577–85
  • Zhou XQ, Zeng XN, Kong H, Sun XL. (2008). Neuroprotective effects of berberine on stroke models in vitro and in vivo. Neurosci Lett 447:31–6
  • Zhou Z, Wang K, Penn MS, et al. (2003). Receptor for AGE (RAGE) mediates neointimal formation in response to arterial injury. Circulation 107:2238–43
  • Zhu X, Raina AK, Lee H, et al. (2004). Oxidative stress signaling in Alzheimer’s disease. Brain Res 1000:32–9

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