1,616
Views
14
CrossRef citations to date
0
Altmetric
Research Article

In vitro cytotoxic and anticlastogenic activities of saxifragifolin B and cyclamin isolated from Cyclamen persicum and Cyclamen libanoticum

, , , , , , , , & show all
Pages 1134-1140 | Received 03 Sep 2013, Accepted 26 Dec 2013, Published online: 20 Mar 2014

References

  • Arslan S, Ozgun O. (2012). Cyclamen trochopteranthum: Cytotoxic activity and possible adverse interactions including drugs and carcinogens. Chin J Integr Med 23. doi: 10.1007/s11655-012-1253-1
  • Çaliş T, Satana ME, Yürüker A, et al. (1997). Triterpene saponins from Cyclamen mirabile and their biological activities. J Nat Prod 60:315–18
  • Cragg GM, Newman DJ, Snader KM. (1997). Natural products in drug discovery and development. J Nat Prod 60:52–60
  • Dall'Acqua S, Castagliuolo I, Brun P, et al. (2010). Triterpene glycosides with in vitro anti-inflammatory activity from Cyclamen repandum tubers. Carbohydr Res 345:709–14
  • Hofheinz RD, Beyer U, Al-Batran SE, Hartmann JT. (2008). Mitomycin C in the treatment of gastrointestinal tumours: Recent data and perspectives. Onkologie 31:271–81
  • Hu JL, Nie SP, Huang DF, et al. (2012). Extraction of saponin from Camellia oleifera cake and evaluation of its antioxidant activity. Int J Food Sci Technol 47:1676–87
  • Huang WY, Cai YZ, Zhang Y. (2010). Natural phenolic compounds from medicinal herbs and dietary plants: Potential use for cancer prevention. Nutr Cancer 62:1–20
  • Imanshahidi M, Hosseinzadeh H. (2008). Pharmacological and therapeutic effects of Berberis vulgaris and its active constituent, berberine. Phytother Res 22:999–1012
  • Kahmann L, Beyer U, Mehlhorn G, et al. (2010). Mitomycin C in patients with gynecological malignancies. Onkologie 33:547–57
  • Kirsch-Volders M, Sofuni T, Aardema M, et al. (2003). Report from the in vitro micronucleus assay working group. Mutat Res 540:153–63
  • Krishna G, Kropko ML, Theiss JC. (1989). Use of the cytokinesis-block method for the analysis of micronuclei in V79 Chinese hamster lung cells: Results with mitomycin C and cyclophosphamide. Mutat Res 222:63–9
  • Kupchan SM, Hemingway RJ, Knox JR, et al. (1967). Tumor inhibitors XXI. Active principles of Acer negundo and Cyclamen persicum. J Pharm Sci 56:603–8
  • Levin DE, Marnett LJ, Ames BN. (1984). Genetics spontaneous and mutagen-induced deletions: Mechanistic studies in Salmonella tester strain TA102 (single-strand breaks/mutagenic gyrase inhibitors/DNA repair/multicopy plasmid). Proc Natl Acad Sci USA 81:4457–61
  • Lim YY, Lim TT, Tee JJ. (2007). Antioxidant properties of several tropical fruits: A comparative study. Food Chem 103:1003–8
  • Mahasneh AM, El-Oqlah AA. (1999). Antimicrobial activity of extracts of herbal plants used in the traditional medicine of Jordan. J Ethnopharmacol 64:271–6
  • Matsunaga T, Tsuji Y, Kaai K, et al. (2010). Toxicity against gastric cancer cells by combined treatment with 5-fluorouracil and mitomycin C: Implication in oxidative stress. Cancer Chemother Pharmacol 66:517–26
  • Mihci-Gaidi G, Ozbey S, Orhan I, et al. (2010). Triterpene saponins from Cyclamen trocopteranthum. Planta Med 76:818–21
  • Park JH, Kwak JH, Khoo JH, et al. (2010). Cytotoxic effects of triterpenoid saponins from Androsace umbellata against multidrug resistance (MDR) and non-MDR cells. Arch Pharm Res 33:1175–80
  • Primorac M, Sekulović D, Antonić S. (1985). In vitro determination of the spermicidal activity of plant saponins. Pharmazie 40:585–94
  • Reznicek G, Jurenitsc, J, Robien W, Kubelka W. (1989). Saponins in Cyclamen species: Configuration of cyclamiretin C and structure of isocyclamin. Phytochemistry 28:825–8
  • Santoso J, Yoshie-Stark Y, Suzuki T. (2004). Anti-oxidant activity of methanol extracts from Indonesian seaweeds in an oil emulsion model. Fisheries Sci 70:183–8
  • Sasaki M, Okamura M, Ideo A, et al. (2006). Re-evaluation of tumor-specific cytotoxicity of mitomycin C, bleomycin and peplomycin. Anticancer Res 26:3373–80
  • Schwartsmann G, Ratain MJ, Cragg GM, et al. (2002). Anticancer drug discovery and development throughout the world. J Clin Oncol 20:47–59
  • Sedej IJ, Sakac MB, Misan AC, Mandic AI. (2010). Antioxidant activity of wheat and buckwheat flours. Proc Nat Sci 118:59–68
  • Song L. (1998). Chinese Bencao. Vol. 6. Shanghai: Shanghai Science and Technology Press
  • Speroni E, Cervellati R, Costa S, et al. (2007). Analgesic and antiinflammatory activity of Cyclamen repandum S. et S. Phytother Res 21:684–9
  • Volpe A, Racioppi M, D’Agostino D, et al. (2010). Mitomycin C for the treatment of bladder cancer. Minerva Urol Nefrol 6:133–44
  • Wall ME. (1992). Antimutagenic agents from natural products. J Nat Prod 55:1561–8
  • Waltho J, Williams DH, Mahato SB, et al. (1986). Structure elucidation of two triterpenoid tetrasaccharides from Androsace saxifragifolia. J Chem Soc Perkin Trans 18:1527–31
  • Yan GC, Chen HY. (1995). Antioxidant activity of various tea extracts in relation to their antimutagenecity. J Agric Food Chem 43:27–37
  • Zhang DM, Wang Y, Tang MK, et al. (2007). Saxifragifolin B from Androsace umbellata induced apoptosis on human hepatoma cells. Biochem Biophys Res Commun 362:759–65
  • Ziech D, Franco R, Pappa A, Panayiotidis MI. (2011). Reactive oxygen species (ROS)-induced genetic and epigenetic alterations in human carcinogenesis. Mutat Res 711:167–73

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.