1,731
Views
31
CrossRef citations to date
0
Altmetric
Original Article

An ethanol extract of Origanum vulgare attenuates cyclophosphamide-induced pulmonary injury and oxidative lung damage in mice

, , , , , & show all
Pages 1229-1236 | Received 21 Oct 2013, Accepted 27 Dec 2013, Published online: 19 Mar 2014

References

  • Ahmadi A, Ebrahimzadeh MA, Ahmad-Ashrafi S, et al. (2011). Hepatoprotective, antinociceptive and antioxidant activities of cimetidine, ranitidine and famotidine as histamine H2 receptor antagonists. Fundam Clin Pharmacol 25:72–9
  • Ahmadi A, Hosseinimehr SJ, Naghshvar F, et al. (2008). Chemoprotective effects of hesperidin against genotoxicity induced by cyclophosphamide in mice bone marrow cells. Arch Pharm Res 31:794–7
  • Arami S, Ahmadi A, Haeri SA. (2013). The radioprotective effects of Origanum vulgare extract against genotoxicity induced by (131)I in human blood lymphocyte. Cancer Biother Radiopharm 28:201–6
  • Azadbakht M, Hosseinimehr S, Shokrzadeh M, et al. (2011). Diospyros lotus L. fruit extract protects G6PD-deficient erythrocytes from hemolytic injury in vitro and in vivo: Prevention of favism disorder. Eur Rev Med Pharmacol Sci 15:1270–81
  • Bukowski RM. (1996). The need for cytoprotection. Eur J Cancer 32A (Suppl 4):S2–4
  • Bunn PA, Carney DN. (1997). Overview of chemotherapy for small cell lung cancer. Semin Oncol 24: S7-69-74
  • Ceker S, Agar G, Nardemir G, et al. (2012). Investigation of anti-oxidative and anti-genotoxic effects of Origanum vulgare L. essential oil on human lymphocytes in vitro. J Essent Oil Bear Pl 15:997–1005
  • Cervato G, Carabelli M, Gervasio S, et al. (2000). Antioxbdant properties of oregano (Origanum vulgare) leaf extracts. J Food Biochem 24:453–65
  • Chabra A, Shokrzadeh M, Naghshvar F, et al. (2014). Melatonin ameliorates oxidative stress and reproductive toxicity induced by cyclophosphamide in male mice. Hum Exp Toxicol. 33:185–95
  • Chum S, Vattem D, Lin Y, Shetty K. (2005). Phenolic antioxidants from clonal oregano (Origanum vulgare) with antimicrobial activity against Helicobacter pylori. Process Biochem 40:809–16
  • Cooper JA, White DA, Matthay RA. (1986). Drug-induced pulmonary disease. Part 1: Cytotoxic drugs. Am Rev Respir Dis 133:321–40
  • Daba MH, Abdel-Aziz AA, Moustafa AM, et al. (2002). Effects of l-carnitine and Ginkgo biloba extract (EG b 761) in experimental bleomycin-induced lung fibrosis. Pharmacol Res 45:461–7
  • Das UB, Mallick M, Debnath JM, Ghosh D. (2002). Protective effect of ascorbic acid on cyclophosphamide-induced testicular gametogenic and androgenic disorders in male rats. Asian J Androl 4:201–7
  • Di Sotto A, Mazzanti G, Carbone F, et al. (2010). Inhibition by beta-caryophyllene of ethyl methanesulfonate-induced clastogenicity in cultured human lymphocytes. Mutat Res 699:23–8
  • Doelman CJ, Bast A. (1990). Oxygen radicals in lung pathology. Free Radic Biol Med 9:381–400
  • Ellman GL. (1959). Tissue sulfhydryl groups. Arch Biochem Biophys 82:70–7
  • Fraiser LH, Kanekal S, Kehrer JP. (1991). Cyclophosphamide toxicity. Characterising and avoiding the problem. Drugs 42:781–95
  • Gebicki S, Gebicki JM. (1993). Formation of peroxides in amino acids and proteins exposed to oxygen free radicals. Biochem J 289:743–9
  • Ghosh D, Das UB, Ghosh S, et al. (2002). Testicular gametogenic and steroidogenic activities in cyclophosphamide treated rat: A correlative study with testicular oxidative stress. Drug Chem Toxicol 25:281–92
  • Gould VE, Miller J. (1975). Sclerosing alveolitis induced by cyclophosphamide. Ultrastructural observations on alveolar injury and repair. Am J Pathol 81:513–30
  • Haenen GR, Vermeulen NP, Tai Tin Tsoi JN, et al. (1988). Activation of the microsomal glutathione-S-transferase and reduction of the glutathione dependent protection against lipid peroxidation by acrolein. Biochem Pharmacol 37:1933–8
  • Halici M, Odabasoglu F, Suleyman H, et al. (2005). Effects of water extract of Usnea longissima on antioxidant enzyme activity and mucosal damage caused by indomethacin in rats. Phytomedicine 12:656–62
  • Hosseinimehr SJ, Ahmadashrafi S, Naghshvar F, et al. (2010). Chemoprotective effects of Zataria multiflora against genotoxicity induced by cyclophosphamide in mice bone marrow cells. Integr Cancer Ther 9:219–23
  • Hosseinimehr SJ, Mahmoudzadeh A, Ahmadi A, et al. (2011). The radioprotective effect of Zataria multiflora against genotoxicity induced by gamma irradiation in human blood lymphocytes. Cancer Biother Radiopharm 26:325–9
  • Karimian A, Shokrzadeh M, Ahmadi A. (2013). The potential chemoprotective effects of melatonin against genotoxicity induced by diazinon in human peripheral blood lymphocytes. Toxicol Ind Health. [Epub ahead of print]. doi:10.1177/0748233713500824
  • Jadhav SJ, Nimbalkar SS, Kulkarni AD, Madhavi DL. (1995). Lipid oxidation in biological and food systems. In: Madhavi DL, Deshpande SS, Salunkhe DK, ed. Food Antioxidants: Technological, Toxicological and Health Perspectives. Vol. 1. New York: Marcel Dekker Inc., 159–265
  • Kim S, Tannock I, Sridhar S, et al. (2012). Chemotherapy-induced infiltrative pneumonitis cases in breast cancer patients. J Oncol Pharm Pract 18:311–15
  • Kulisic T, Krisko A, Dragovic-Uzelac V, et al. (2007). The effects of essential oils and aqueous tea infusions of oregano (Origanum vulgare L. spp. hirtum), thyme (Thymus vulgaris L.) and wild thyme (Thymus serpyllum L.) on the copper-induced oxidation of human low-density lipoproteins. Int J Food Sci Nutr 58:87–93
  • Lambert RJ, Skandamis PN, Coote PJ, Nychas GJ. (2001). A study of the minimum inhibitory concentration and mode of action of oregano essential oil, thymol and carvacrol. J Appl Microbiol 91:453–62
  • Malik SW, Myers JL, DeRemee RA, Specks U. (1996). Lung toxicity associated with cyclophosphamide use. Two distinct patterns. Am J Respir Crit Care Med 154:1851–6
  • Manda K, Bhatia AL. (2003). Prophylactic action of melatonin against cyclophosphamide-induced oxidative stress in mice. Cell Biol Toxicol 19:367–72
  • Marklund SL. (1985). Superoxide dismutase isoenzymes in tissues and plasma from New Zealand black mice, nude mice and normal BALB/c mice. Mutat Res 148:129–34
  • Matsuura H, Chiji H, Asakawa C, et al. (2003). DPPH radical scavengers from dried leaves of oregano (Origanum vulgare). Biosci Biotechnol Biochem 67:2311–16
  • Miguel MG, Figueiredo AC, Costa MM, et al. (2003). Effect of the volatile constituents isolated from Thymus albicans, Th. mastichina, Th. carnosus and Thymbra capitata in sunflower oil. Nahrung 47:397–402
  • Navarova J, Ujhazy E, Dubovicky M. (1999). Protective effect of the antioxidant stobadine against cyclophosphamide and irradiation induced oxidative stress. Gen Physiol Biophys 18:112–19
  • Newman DJ, Cragg GM. (2007). Natural products as sources of new drugs over the last 25 years. J Nat Prod 70:461–77
  • Odabasoglu F, Aslan A, Cakir A, et al. (2004). Comparison of antioxidant activity and phenolic content of three lichen species. Phytother Res 18:938–41
  • Ohkawa H, Ohishi N, Yagi K. (1979). Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95:351–8
  • Parejo I, Viladomat F, Bastida J, et al. (2002). Comparison between the radical scavenging activity and antioxidant activity of six distilled and nondistilled Mediterranean herbs and aromatic plants. J Agric Food Chem 50:6882–90
  • Patel JM. (1987). Stimulation of cyclophosphamide-induced pulmonary microsomal lipid peroxidation by oxygen. Toxicology 45:79–91
  • Patel JM. (1990). Metabolism and pulmonary toxicity of cyclophosphamide. Pharmacol Ther 47:137–46
  • Patel JM, Block ER. (1985). Cyclophosphamide-induced depression of the antioxidant defense mechanisms of the lung. Exp Lung Res 8:153–65
  • Pratheeshkumar P, Kuttan G. (2010). Ameliorative action of Vernonia cinerea L. on cyclophosphamide-induced immunosuppression and oxidative stress in mice. Inflammopharmacology 18:197–207
  • Roofchaee A, Irani M, Ebrahimzadeh MA, Akbari MR. (2011). Effect of dietary oregano (Origanum vulgare) essential oil on growth performance, cecal microflora and serum antioxidant activity of broiler chickens. Afr J Biotechnol 10:6177–83
  • Russo A, Bonina F, Acquaviva R, et al. (2002). Red Orange extract: Effect on DNA cleavage. J Food Sci 67:2814–18
  • Selvakumar E, Prahalathan C, Mythili Y, Varalakshmi P. (2005). Mitigation of oxidative stress in cyclophosphamide-challenged hepatic tissue by dl-α-lipoic acid. Mol Cell Biochem 272:179–85
  • Sheibani V, Afarinesh M, Hajializadeh Z. (2011). Evaluation of Origanum vulgare L. ssp. Viridis leaves extract effect on discrimination learning and LTP induction in the CA1 region of the rat hippocampus. Iran J Basic Med Sci 14:177–84
  • Sladek NE. (1971). Metabolism of cyclophosphamide by rat hepatic microsomes. Cancer Res 31:901–8
  • Stankiewicz A, Skrzydlewska E, Makiela M. (2002). Effects of amifostine on liver oxidative stress caused by cyclophosphamide administration to rats. Drug Metabol Drug Interact 19:67–82
  • Suddek GM, Ashry NA, Gameil NM. (2012). Thymoquinone attenuates cyclophosphamide-induced pulmonary injury in rats. Inflammopharmacology 21:427–35
  • Sulkowska M, Skrzydlewska E, Sobaniec-Lotowska M, et al. (2002). Effect of cyclophosphamide-induced generation reactive oxygen forms on ultrastructure of the liver and lung. Bull Vet Inst IN Pulway 46:239–46
  • Tannehill SP, Mehta MP. (1996). Amifostine and radiation therapy: Past, present, and future. Semin Oncol 23:69–77
  • Tiwari AK. (2001). Imbalance in antioxidant defence and human diseases: Multiple approach of natural antioxidants therapy. Curr Sci Banglore 81:1179–87
  • Venkatesan N, Chandrakasan G. (1995). Modulation of cyclophosphamide-induced early lung injury by curcumin, an anti-inflammatory antioxidant. Mol Cell Biochem 142:79–87
  • Vouldoukis I, Lacan D, Kamate C, et al. (2004). Antioxidant and anti-inflammatory properties of a Cucumis melo LC. extract rich in superoxide dismutase activity. J Ethnopharmacol 94:67–75
  • Yoshino K, Higashi N, Koga K. (2006). Antioxidant and antiinflammatory activities of oregano extract. J Health Sci 52:169–73

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.