Silymarin alleviates bleomycin-induced pulmonary toxicity and lipid peroxidation in mice

References

• Bayer RA, Gaynor ER, Fisher RI. (1992). Bleomycin in non-Hodgkin’s lymphoma. Semin Oncol 19:46–52
   PubMed Web of Science ®Google Scholar
• Buege JA, Aust SD. (1978). Microsomal lipid peroxidation. Methods Enzymol 52:302–10
   PubMedGoogle Scholar
• Burger RM, Peisach J, Horwitz SB. (1981). Activated bleomycin. A transient complex of drug, iron, and oxygen that degrades DNA. J Biol Chem 256:11636–44
   PubMed Web of Science ®Google Scholar
• Chen CH, Huang TS, Wong CH, et al. (2009). Synergistic anticancer effect of baicalein and silymarin on human hepatoma HepG2 Cells. Food Chem Toxicol 47:638–44
   PubMed Web of Science ®Google Scholar
• Chen K, Wei Y, Sharp GC, Braley-Mullen H. (2007). Decreasing TNF-α results in less fibrosis and earlier resolution of granulomatous experimental autoimmune thyroiditis. J Leukoc Biol 81:306–14
   PubMed Web of Science ®Google Scholar
• Cheresh P, Kim SJ, Tulasiram S, Kamp DW. (2012). Oxidative stress and pulmonary fibrosis. Biochim Biophys Acta 1832:1028–40
   PubMed Web of Science ®Google Scholar
• Day BJ. (2008). Antioxidants as potential therapeutics for lung fibrosis. Antioxid Redox Signal 10:355–70
   PubMed Web of Science ®Google Scholar
• Faner R, Rojas M, Macnee W, Agusti A. (2012). Abnormal lung aging in chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 186:306–13
   PubMed Web of Science ®Google Scholar
• Gazak R, Walterova D, Kren V. (2007). Silybin and silymarin – New and emerging applications in medicine. Curr Med Chem 14:315–38
   PubMed Web of Science ®Google Scholar
• Habig WH, Jakoby WB. (1981). Assays for differentiation of glutathione S-transferases. Methods Enzymol 77:398–405
   PubMedGoogle Scholar
• Hogan FS, Krishnegowda NK, Mikhailova M, Kahlenberg MS. (2007). Flavonoid, silibinin, inhibits proliferation and promotes cell-cycle arrest of human colon cancer. J Surg Res 143:58–65
   PubMed Web of Science ®Google Scholar
• Janero DR. (1990). Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury. Free Radic Biol Med 9:515–40
   PubMed Web of Science ®Google Scholar
• Jones DP. (2006). Extracellular redox state: Refining the definition of oxidative stress in aging. Rejuvenation Res 9:169–81
   PubMed Web of Science ®Google Scholar
• Kara H, Karatas F, Tug T, et al. (2010). Protective effect of octreotide on intra-tracheal bleomycin-induced oxidative damage in rats. Exp Toxicol Pathol 62:235–41
   PubMed Web of Science ®Google Scholar
• Kettle AJ, Van Dalen CJ, Winterbourn CC. (1997). Peroxynitrite and myeloperoxidase leave the same footprint in protein nitration. Redox Rep 3:257–8
   PubMed Web of Science ®Google Scholar
• Khan SM. (2006). Protective effect of black tea extract on the levels of lipid peroxidation and antioxidant enzymes in liver of mice with pesticideinduced liver injury. Cell Biochem Funct 24:327–32
   PubMed Web of Science ®Google Scholar
• Kiruthiga PV, Shafreen RB, Pandian SK, et al. (2007). Protective effect of silymarin on erythrocyte hemolysate against benzo(a)pyrene and exogenous reactive oxygen species (HO) induced oxidative stress. Chemosphere 68:1511–18
   PubMed Web of Science ®Google Scholar
• Kliment CR, Oury TD. (2010). Oxidative stress, extracellular matrix targets, and idiopathic pulmonary fibrosis. Free Radic Biol Med 49:707–17
   PubMed Web of Science ®Google Scholar
• Larki-Harchegani A, Hemmati AA, Arzi A, et al. (2013). Evaluation of the effects of caffeic acid phenethyl ester on prostaglandin E2 and two key cytokines involved in bleomycin-induced pulmonary fibrosis. Iran J Basic Med Sci 16:850–7
   PubMed Web of Science ®Google Scholar
• Levi JA, Raghavan D, Harvey V, et al. (1993). The importance of bleomycin in combination chemotherapy for good-prognosis germ cell carcinoma. Australasian germ cell trial group. J Clin Oncol 11:1300–5
   PubMed Web of Science ®Google Scholar
• Marnett LJ. (1999). Lipid peroxidation-DNA damage by malondialdehyde. Mutat Res 424:83–95
   PubMed Web of Science ®Google Scholar
• Martin WG, Ristow KM, Habermann TM, et al. (2005). Bleomycin pulmonary toxicity has a negative impact on the outcome of patients with Hodgkin’s lymphoma. J Clin Oncol 23:7614–20
   PubMed Web of Science ®Google Scholar
• Mata M, Ruız A, Cerda M, et al. (2003). Oral N-acetylcysteine reduces bleomycin-induced lung damage and mucin Muc5ac expression in rats. Eur Respir J 22:900–5
   PubMed Web of Science ®Google Scholar
• Meeran SM, Katiyar S, Elmets CA, Katiyar SK. (2006). Silymarin inhibits UV radiation-induced immunosuppression through augmentation of interleukin-12 in mice. Mol Cancer Ther 5:1660–8
   PubMed Web of Science ®Google Scholar
• Mukarram Shah SM, Khan FA, Hassan Shah SM, et al. (2011). Evaluation of phytochemicals and antimicrobial activity of white and blue capitulum and whole plant of Silybum Marianum. World Appl Sci J 12:1139–44
   Google Scholar
• Murthy S, Adamcakova-Dodd A, Perry SS, et al. (2009). Modulation of reactive oxygen species by Rac1 or catalase prevents asbestos-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol 297:846–55
   PubMed Web of Science ®Google Scholar
• Nazemian F, Karimi G, Moatamedi M, et al. (2010). Effect of silymarin administration on TNF-α serum concentration in peritoneal dialysis patients. Phytother Res 24:1654–7
   PubMed Web of Science ®Google Scholar
• Oliveira C, Lopasso FP, Laurindo F, et al. (2001). Protection against liver ischemiareperfusion injury in rats by silymarin or verapamil. Transplant Proc 33:3010–14
   PubMed Web of Science ®Google Scholar
• Pandey G, Sahni YP. (2011). A review on hepatoprotective activity of silymarin. IJRAP 2:75–9
   Google Scholar
• Piguet PF, Collart MA, Grau GE, et al. (1989). Tumor necrosis factor/cachectin plays a key role in bleomycin-induced pneumopathy and fibrosis. J Exp Med 170:655–63
   PubMed Web of Science ®Google Scholar
• Pradeep K, Mohan CVR, Gobianand K, Karthikeyan S. (2007). Silymarin modulates the oxidant–antioxidant imbalance during diethylnitrosamine induced oxidative stress in rats. Eur J Pharmacol 560:110–16
   PubMed Web of Science ®Google Scholar
• Quinlan T, Spivack S, Mossman BT. (1994). Regulation of antioxidant enzymes in lung after oxidant injury. Environ Health Perspect 2:79–87
   Google Scholar
• Schumann J, Prockl J, Kiemer AK, et al. (2003). Silibinin protects mice from T cell-dependent liver injury. J Hepatol 39:333–40
   PubMed Web of Science ®Google Scholar
• Sedlak J, Lindsay RH. (1968). Estimation of total protein bound and non-protein sulfhydryl groups in tissue with Ellman’s reagent. Anal Biochem 25:192–205
   PubMed Web of Science ®Google Scholar
• Sener G, Topaloglu N, Sehirli AO, et al. (2007). Resveratrol alleviates bleomycin-induced lung injury in rats. Pulm Pharmacol Ther 20:642–9
   PubMed Web of Science ®Google Scholar
• Singh RP, Agarwal R. (2004). Prostate cancer prevention by silibinin. Curr Cancer Drug Targets 4:1–11
   PubMed Web of Science ®Google Scholar
• Soto C, Recoba R, Barron H, et al. (2003). Silymarin increases antioxidant enzymes in alloxan-induced diabetes in rat pancreas. Comp Biochem Physiol C Toxicol Pharmacol 136:205–12
   PubMed Web of Science ®Google Scholar
• Tobwala S, Fan W, Stoeger T, Ercal N. (2013). N-Acetylcysteine amide, a thiol antioxidant, prevents bleomycin-induced toxicity in human alveolar basal epithelial cells (A549). Free Radic Res 47:740–9
   Google Scholar
• Townsend, DM, Tew KD, Tapiero H. (2003). The importance of glutathione in human disease. Biomed Pharmacother 57:145–55
   PubMed Web of Science ®Google Scholar
• Wei H, Frenkel K. (1993). Relationship of oxidative events and DNA oxidation in Sencar mice to in vivo promoting activity of phorbol ester-type tumor promoters. Carcinogenesis 14:1195–201
   PubMed Web of Science ®Google Scholar
• Yang SH, Lin JK, Chen WS, Chiu JH. (2003). Antiangiogenic effect of silymarin on colon cancer LoVo cell line. J Surg Res 113:133–8
   PubMed Web of Science ®Google Scholar
• Yildirim Z, Kotuk M, Iraz M, et al. (2005). Attenuation of bleomycin-induced lung fibrosis by oral sulfhydryl containing antioxidants in rats: Erdosteine and N-acetylcysteine. Pulm Pharmacol Ther 18:367–73
   PubMed Web of Science ®Google Scholar