1,908
Views
22
CrossRef citations to date
0
Altmetric
Research Article

Interactions of the active components of Punica granatum (pomegranate) with the essential renal and hepatic human Solute Carrier transporters

, , , , , & show all
Pages 1510-1517 | Received 02 Sep 2013, Accepted 24 Feb 2014, Published online: 15 Jul 2014

References

  • Amphoux A, Millan MJ, Cordi A, et al. (2010). Inhibitory and facilitory actions of isocyanine derivatives at human and rat organic cation transporters 1, 2 and 3: A comparison to human α1- and α2-adrenoceptor subtypes. Eur J Pharmacol 634:1–9
  • American Diabetes Association. (2012). Diagnosis and classification of diabetes mellitus. Diabet Care 35:S64–71
  • Ban JY, Nguyen HTT, Lee HJ, et al. (2008). Neuroprotective properties of gallic acid from Sanguisorbae radix on amyloid beta protein (25–35)-induced toxicity in cultured rat cortical neurons. Biol Pharm Bull 31:149–53
  • Basu S, Jana S, Patel VB, Patel H. (2012). Effects of piperine, cinnamic acid and gallic acid on rosuvastatin pharmacokinetics in rats. Phytother Res 27:1548–56
  • Chang C, Pang KS, Swaan PW, Ekins S. (2005). Comparative pharmacophore modeling of organic anion transporting polypeptides: A meta-analysis of rat oatp1a1 and human OATP1B1. J Pharmacol Exp Ther 314:533–41
  • De Bruyn T, Van Westen GJP, Ijzerman AP, et al. (2013). Structure-based identification of OATP1B1/3 inhibitors. Mol Pharmacol 83:1257–67
  • Degorter MK, Xia CQ, Yang JJ, Kim RB. (2012). Drug transporters in drug efficacy and toxicity. Annu Rev Pharmacol Toxicol 52:249–73
  • Esmaillzadeh A, Tahbaz F, Gaieni I, et al. (2004). Concentrated pomegranate juice improves lipid profiles in diabetic patients with hyperlipidemia. J Med Food 7:305–8
  • Faria A, Calhau C. (2011). The bioactivity of pomegranate: Impact on health and disease. Crit Rev Food Sci Nutr 51:626–34
  • Gründemann D, Harlfinger S, Golz S, et al. (2005). Discovery of the ergothioneine transporter. Proc Natl Acad Sci USA 102:5256–61
  • Gui C, Obaidat A, Chaguturu R, Hagenbuch B. (2010). Development of a cell-based high-throughput assay to screen for inhibitors of organic anion transporting polypeptides 1B1 and 1B3. Curr Chem Genomics 4:1–8
  • Hirano M, Maeda K, Shitara Y, Sugiyama Y. (2004). Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans. J Pharmacol Exp Ther 311:139–46
  • Ho RH, Tirona RG, Leake BF, et al. (2006). Drug and bile acid transporters in rosuvastatin hepatic uptake: Function, expression, and pharmacogenetics. Gastroenterology 130:1793–806
  • Hong S, Jeong W, Jun M. (2012). Protective effects of the key compounds isolated from Corni fructus against β-amyloid-induced neurotoxicity in PC12 Cells. Molecules 17:10831–45
  • Hsu JH, Wu YC, Liu IM, Cheng JT. (2006). Release of acetylcholine to raise insulin secretion in Wistar rats by oleanolic acid, one of the active principles contained in Cornus officinalis. Neurosci Lett 404:112–16
  • Huang THW, Peng G, Kota BP, et al. (2005a). Pomegranate flower improves cardiac lipid metabolism in a diabetic rat model: Role of lowering circulating lipids. Br J Pharmacol 145:767–74
  • Huang THW, Peng G, Kota BP, et al. (2005b). Anti-diabetic action of Punica granatum flower extract: Activation of PPAR-γ and identification of an active component. Toxicol Appl Pharmacol 207:160–9
  • Jain V, Viswanatha GL, Manohar D, Shivaprasad HN. (2012). Isolation of antidiabetic principle from fruit rinds of Punica granatum. Evid Based Complement Alternat Med 2012:147202
  • Jang SM, Kim MJ, Choi MS, et al. (2010). Inhibitory effects of ursolic acid on hepatic polyol pathway and glucose production in streptozotocin-induced diabetic mice. Metabolism 59:512–19
  • Jang SM, Yee ST, Choi J, et al. (2009). Ursolic acid enhances the cellular immune system and pancreatic β-cell function in streptozotocin-induced diabetic mice fed a high-fat diet. Int Immunopharmacol 9:113–19
  • Jayprakasam B, Olson LK, Schutzki RE, et al. (2005). Amelioration of obesity and glucose intolerance in high-fat-fed C57BL/6 mice by anthocyanins and ursolic acid in Cornelian cherry (Cornus mas). J Agri Food Chem 54:243–8
  • Jung SH, Ha YJ, Shim EK, et al. (2007). Insulin-mimetic and insulin-sensitizing activities of a pentacyclic triterpenoid insulin receptor activator. Biochem J 403:243–50
  • Karlgren M. (2012). Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): Influence of protein expression on drug-drug interactions. J Med Chem 55:4740–63
  • Katz SR, Newman RA, Lansky EP. (2007). Punica granatum: Heuristic treatment for diabetes mellitus. J Med Food 10:213–17
  • Kim DO, Lee KW, Lee HJ, Lee CY. (2002). Vitamin C equivalent antioxidant capacity (VCEAC) of phenolic phytochemicals. J Agric Food Chem 50:3713–17
  • Kindla J, Müller F, Mieth M, et al. (2011). Influence of non-steroidal anti-inflammatory drugs on organic anion transporting polypeptide (OATP) 1B1- and OATP1B3-mediated drug transport. Drug Metab Dispos 39:1047–53
  • Kitamura S, Maeda K, Wang Y, Sugiyama Y. (2008). Involvement of multiple transporters in the hepatobiliary transport of rosuvastatin. Drug Metab Dispos 36:2014–23
  • Kroes BH, Van Den Berg AJJ, Quarles van Ufford HC, et al. (1992). Anti-inflammatory activity of gallic acid. Planta Med 58:499–504
  • Lei F, Zhang XN, Wang W, et al. (2007). Evidence of anti-obesity effects of the pomegranate leaf extract in high-fat diet induced obese mice. Int J Obes 31:1023–9
  • Li Y, Qi Y, Huang THW, et al. (2008). Pomegranate flower: A unique traditional antidiabetic medicine with dual PPAR-α/-γ activator properties. Diabetes Obes Metab 10:10–17
  • Li Y, Wen S, Kota BP, et al. (2005). Punica granatum flower extract, a potent α-glucosidase inhibitor, improves postprandial hyperglycemia in Zucker diabetic fatty rats. J Ethnopharmacol 99:239–44
  • Liu J. (1995). Pharmacology of oleanolic acid and ursolic acid. J Ethnopharmacol 49:57–68
  • Makihara H, Shimada T, Machida E, et al. (2012). Preventive effect of Terminalia bellirica on obesity and metabolic disorders in spontaneously obese type 2 diabetic model mice. J Nat Med 66:459–67
  • Manach C, Williamson G, Morand C, et al. (2005). Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am J Clin Nutr 81:230S–42S
  • Mondal A, Maity TK, Pal D. (2012). Hypoglycaemic effect of Melothria heterophylla in streptozotocin-induced diabetic rats. Pharm Biol 50:1151–6
  • Nabavi S, Habtemariam S, Nabavi S, et al. (2013). Protective effect of gallic acid isolated from Peltiphyllum peltatum against sodium fluoride-induced oxidative stress in rat's kidney. Mol Cell Biochem 372:233–9
  • Noé J, Portmann R, Brun ME, Funk C. (2007). Substrate-dependent drug-drug interactions between gemfibrozil, fluvastatin and other organic anion-transporting peptide (OATP) substrates on OATP1B1, OATP2B1, and OATP1B3. Drug Metab Dispos 35:1308–14
  • Pai PG, Chamari Nawarathna S, Kulkarni A, et al. (2012). Nephroprotective effect of ursolic acid in a murine model of gentamicin-induced renal damage. ISRN Pharmacol 2012:410902
  • Parmar HS, Kar A. (2007). Antidiabetic potential of Citrus sinensis and Punica granatum peel extracts in alloxan treated male mice. BioFactors 31:17–24
  • Pedersen JM, Matsson P, Bergström CAS, et al. (2008). Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). J Med Chem 51:3275–87
  • Punithavathi VR, Stanely Mainzen Prince P, Kumar MR, Selvakumari CJ. (2011). Protective effects of gallic acid on hepatic lipid peroxide metabolism, glycoprotein components and lipids in streptozotocin-induced type II diabetic Wistar rats. J Biochem Mol Toxicol 25:68–76
  • Race JE, Grassl SM, Williams WJ, Holtzman EJ. (1999). Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3). Biochem Biophys Res Commun 255:508–14
  • Rao AR, Veeresham C, Asres K. (2012). In vitro and in vivo inhibitory activities of four Indian medicinal plant extracts and their major components on rat aldose reductase and generation of advanced glycation endproducts. Phytother Res 27:753–60
  • Roth M, Araya JJ, Timmermann BN, Hagenbuch B. (2011). Isolation of modulators of the liver-specific organic anion-transporting polypeptides (OATPs) 1B1 and 1B3 from Rollinia emarginata Schlecht (Annonaceae). J Pharmacol Exp Ther 339:624–32
  • Roth M, Obaidat A, Hagenbuch B. (2012). OATPs, OATs and OCTs: The organic anion and cation transporters of the SLCO and SLC22A gene superfamilies. Br J Pharmacol 165:1260–87
  • Sato H, Genet C, Strehle A, et al. (2007). Anti-hyperglycemic activity of a TGR5 agonist isolated from Olea europaea. Biochem Biophys Res Commun 362:793–8
  • Shahrzad S, Aoyagi K, Winter A, et al. (2001). Pharmacokinetics of gallic acid and its relative bioavailability from tea in healthy humans. J Nutr 131:1207–10
  • Song M, Hang TJ, Wang Y, et al. (2006). Determination of oleanolic acid in human plasma and study of its pharmacokinetics in Chinese healthy male volunteers by HPLC tandem mass spectrometry. J Pharm Biomed Anal 23:190–6
  • Tamai I, Ohashi R, Nezu JI, et al. (1998). Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2. J Biol Chem 273:20378–82
  • Teodoro T, Zhang L, Alexander T, et al. (2008). Oleanolic acid enhances insulin secretion in pancreatic β-cells. FEBS Lett 582:1375–80
  • Toh DSL, Murray M, Pern Tan K, et al. (2011). Functional analysis of pharmacogenetic variants of human organic cation/carnitine transporter 2 (hOCTN2) identified in Singaporean populations. Biochem Pharmacol 82:1692–9
  • Ueo H, Motohashi H, Katsura T, Inui KI. (2005). Human organic anion transporter hOAT3 is a potent transporter of cephalosporin antibiotics, in comparison with hOAT1. Biochem Pharmacol 70:1104–13
  • Ugele B, Bahn A, Rex-Haffner M. (2008). Functional differences in steroid sulfate uptake of organic anion transporter 4 (OAT4) and organic anion transporting polypeptide 2B1 (OATP2B1) in human placenta. J Steroid Biochem Mol Biol 111:1–6
  • Viuda-Martos M, Fernández-López J, Pérez-Álvarez JA. (2010). Pomegranate and its many functional components as related to human health: A review. Compr Rev Food Sci Food Saf 9:635–54
  • Wang L, Sweet DH. (2012). Potential for food–drug interactions by dietary phenolic acids on human organic anion transporters 1 (SLC22A6), 3 (SLC22A8), and 4 (SLC22A11). Biochem Pharmacol 84:1088–95
  • Wen JH, Xiong YQ. (2011). The effect of herbal medicine danshensu and ursolic acid on pharmacokinetics of rosuvastatin in rats. Eur J Drug Metab Pharmacokinet 36:205–11
  • Wu LX, Guo CX, Qu Q, et al. (2012). Effects of natural products on the function of human organic anion transporting polypeptide 1B1. Xenobiotica 42:339–48
  • Xu F, Li Z, Zheng J, et al. (2013a). The inhibitory effects of the bioactive components isolated from Scutellaria baicalensis on the cellular uptake mediated by the essential solute carrier transporters. J Pharm Sci 102:4205–11
  • Xu GL, Li HL, He JC, et al. (2013b). Comparative pharmacokinetics of swertiamarin in rats after oral administration of swertiamarin alone, Qing Ye Dan tablets and co-administration of swertiamarin and oleanolic acid. J Ethnopharmacol 149:49–54
  • Zhang L, Ma WF, Li J, et al. (2013). Influence of processing on pharmacokinetic of typical constituents in radix polygoni multiflori after oral administration by LC–ESI–MS/MS. J Ethnopharmacol 148:246–53
  • Zhang Y, Jayaprakasam B, Seeram NP, et al. (2003). Insulin secretion and cyclooxygenase enzyme inhibition by cabernet sauvignon grape skin compounds. J Agric Food Chem 52:228–33
  • Zhao D, Gao ZD, Han DE, et al. (2012). Influence of fifampicin on the pharmacokinetics of salvianolic acid B may involve inhibition of organic anion transporting polypeptide (Oatp) mediated influx. Phytother Res 26:118–21
  • Zhou F, Lee AC, Krafczyk K, et al. (2011). Protein kinase C regulates the internalization and function of the human organic anion transporting polypeptide 1A2. Br J Pharmacol 162:1380–8
  • Zhou F, Zhu L, Cui P, et al. (2010). Functional characterization of nonsynonymous single nucleotide polymorphisms in the human organic anion transporter 4 (hOAT4). Br J Pharmacol 159:419–27
  • Zhou S, Lim LY, Chowbay B. (2004). Herbal modulation of P-glycoprotein. Drug Metab Rev 36:57–104
  • Zhu Z, Qian Z, Yan Z, et al. (2013). A phase I pharmacokinetic study of ursolic acid nanoliposomes in healthy volunteers and patients with advanced solid tumors. Int J Nanomedicine 8:129–36

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.