Investigation on the toxic potential of Tribulus terrestris in vitro

References

• Adaikan PG, Gauthaman K, Prasad RN, Ng SC. (2000). Proerectile pharmacological effects of Tribulus terrestris on the rabbit corpus cavernosum. Ann Acad Med Singapore 29:22–6
   PubMedGoogle Scholar
• Adimoelja A, Adaikan PG. (1997). Protodioscin from herbal plant Tribulus terrestris L. improves male sexual functions possibly via DHEA. Int J Impotence Res 9:64–9
   Google Scholar
• Ali NAA, Julich WD, Kusnick C, Lindequist U. (2001). Screening of Yemeni medicinal plants for antibacterial and cytotoxic activities. J Ethnopharmacol 74:173–9
   PubMed Web of Science ®Google Scholar
• Alley MC, Scudiero DA, Monks A, et al. (1988). Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay. Cancer Res 48:589–601
   PubMed Web of Science ®Google Scholar
• Angelova S, Gospodinova Z, Krasteva M, et al. (2013). Antitumor activity of Bulgarian herb Tribulus terrestris L. on human breast cancer cells. J BioSci Biotech 2:25–32
   Google Scholar
• Antonio J, Uelmen J, Rodriguez R, Earnest C. (2000). The effects of Tribulus terrestris on body composition and exercise performance in resistance-trained males. Int J Sport Nutr Exerc Metab 10:208–15
   PubMedGoogle Scholar
• Arcasoy HB, Erenmemisoglu A, Tekol Y, et al. (1998). Effect of Tribulus terrestris L. saponin mixture on some smooth muscle preparations: A preliminary study. Boll Chim Farm 137:473–5
   PubMedGoogle Scholar
• Bowen DE, Whitwell JH, Lillford L, et al. (2011). Evaluation of a multi-endpoint assay in rats, combining the bone-marrow micronucleus test, the Comet assay and the flow-cytometric peripheral blood micronucleus test. Mutat Res 722:7–19
   PubMed Web of Science ®Google Scholar
• Cai L, Wu Y, Zhang J, et al. (2001). Steroidal saponins from Tribulus terrestris. Planta Med 67:196–8
   PubMed Web of Science ®Google Scholar
• De Sá Ferreira ICF, Vargas VMF. (1999). Mutagenicity of medicinal plant extracts in Salmonella/microsome assay. Phytotherapy Res 13:397–400
   PubMed Web of Science ®Google Scholar
• Déciga-Campos M, Rivero-Cruz I, Arriaga-Alba M, et al. (2007). Acute toxicity and mutagenic activity of Mexican plants used in traditional medicine. J Ethnopharmacol 110:334–42
   PubMed Web of Science ®Google Scholar
• Elgorashi EE, Taylor JLS, Maes A, et al. (2003). Screening of medicinal plants used in South African traditional medicine for genotoxic effects. Toxicol Lett 143:195–207
   PubMed Web of Science ®Google Scholar
• Flückiger-Isler S, Kamber M. (2006). The Ames MPF™ 98/100 Assay: Novel Mutagenicity Testing in Liquid Microplate Format Using S. typhimurium TA98 and TA100. Prague: EEMS
   Google Scholar
• Gauthaman K, Adaikan PG, Prasad RNV. (2002). Aphrodisiac properties of Tribulus terrestris extract (Protodioscin) in normal and castrated rats. Life Sci 71:1385–96
   PubMed Web of Science ®Google Scholar
• Gauthaman K, Ganesan AP, Prasad RN. (2003). Sexual effects of puncture vine (Tribulus terrestris) extract (protodioscin): An evaluation using a rat model. J Altern Complement Med 9:257–65
   PubMed Web of Science ®Google Scholar
• Hussain AA, Abbas AM, Heba HI, Amir HA. (2009). Study the biological activities of Tribulus terrestris extracts. WASET 57:433–5
   Google Scholar
• Kim HJ, Kim JC, Min JS, et al. (2011). Aqueous extract of Tribulus terrestris Linn induces cell growth arrest and apoptosis by down regulating NF-κB signaling in liver cancer cells. J Ethnopharmacol 136:197–203
   PubMed Web of Science ®Google Scholar
• Kostova I, Dinchev D. (2005). Saponins in Tribulus terrestris – Chemistry and bioactivity. Phytochem Rev 4:111–37
   Google Scholar
• Maron DM, Ames BN. (1983). Revised methods for the Salmonella mutagenicity test. Mutation Res 113:173–215
   PubMed Web of Science ®Google Scholar
• Mortelmans K, Zeiger E. (2000). The Ames Salmonella/microsome mutagenicity assay. Mutation Res 455:29–60
   PubMed Web of Science ®Google Scholar
• Mulinacci N, Vignolini P, La Marca G, et al. (2003). Food supplements of Tribulus terrestris L. Chromatographia 57:581–92
   Web of Science ®Google Scholar
• Neychev VK, Nicolova E, Zhelev N, Mitev VI. (2007). Saponins from Tribulus terrestris L. are less toxic for normal human fibroblasts than for many cancer lines: Influence on apoptosis and proliferation. Exp Biol Med 232:126–33
   PubMed Web of Science ®Google Scholar
• Razak MFA, Aidoo KE, Candlish AGG. (2007). Mutagenic and cytotoxic properties of three herbal plants from Southeast Asia. Trop Biomed 24:49–59
   PubMed Web of Science ®Google Scholar
• Rogerson S, Riches CJ, Jennings C, et al. (2007). The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in Elite Rugby League Players. J Strength Cond Res 21:348–53
   PubMed Web of Science ®Google Scholar
• Rojas E, Lopez MC, Valverde M. (1999). Single cell gel electrophoresis assay: Methodology and applications. J Chromat B 722:225–54
   PubMed Web of Science ®Google Scholar
• Routledge EJ, Sumpter JP. (1996). Estrogenic activity of surfactants and some of their degradation products assessed using a recombinant yeast screen. Environ Toxicol Chem 15:241–8
   Web of Science ®Google Scholar
• Sebata A, Ngongoni NT, Mupangwa JF, et al. (2005). Effects of supplementing native pasture hay with puncture vine Tribullus terrestris on the intake, weight change, nitrogen balance and excretion of purine derivatives of sheep. Trop Subtrop Agroecosyst 5:123–8
   Google Scholar
• Sohoni P, Sumpter JP. (1998). Several environmental oestrogens are also anti-androgens. J Endocrinol 158:327–39
   PubMed Web of Science ®Google Scholar
• Speit G, Hartmann A. (1999). The comet assay (single-cell gel test): A sensitive genotoxicity test for the detection of DNA damage and repair. DNA Repair Protocols 113:203–12
   Google Scholar
• Sun B, Qu WJ, Zhang XL. (2004). Ivestigation on inhibitory and apoptosis-inducing effects of saponins from Tribulus terrestris on hepatoma cell line BEL-7402. Zhongguo Zhong Yao Za Zhi 29:681–4
   PubMedGoogle Scholar
• Sun WJ, Gao J, Tu GZ, et al. (2002). A new steroidal saponin from Tribulus terrestris Linn. Nat Prod Lett 16:243–7
   PubMed Web of Science ®Google Scholar
• Sun B, Qu W, Bai Z. (2003). The inhibitory effect of saponins from Tribulus terrestris on Bcap-37 breast cancer cell line in vitro. Zhong Yao Cai 26:104–6
   PubMedGoogle Scholar
• Tomova M, Gyulemetova R, Zarkova S. (1978). An agent for stimulation of sexual function. Bulg Patent (11) 27584, A61K35/1978
   Google Scholar
• Tomova M, Gyulemetova R, Zarkova S, et al. (1981). Steroidal saponins from Tribulus terrestris L. with a stimulating action on the sexual functions. In: Proceedings of the First International Conference on Chemistry and. Biotechnology of Biological Active Natural Products, Varna, September 3:289–91
   Google Scholar
• Trouillas P, Corbière C, Liagre B, et al. (2005). Structure–function relationship for saponin effects on cell cycle arrest and apoptosis in the human 1547 osteosarcoma cells: A molecular modelling approach of natural molecules structurally close to diosgenin. Bioorg Med Chem 13:1141–9
   PubMed Web of Science ®Google Scholar
• Umbuzeiro GDA, Rech CM, Correia S, et al. (2010). Comparison of the Salmonella/microsome microsuspension assay with the new microplate fluctuation (MPF) protocol for testing the mutagenicity of environmental samples. Environ Mol Mutagen 51:31–8
   PubMed Web of Science ®Google Scholar
• Van Meerloo J, Kaspers GJ, Cloos J. (2011). Cell sensitivity assays: The MTT assay. Methods Mol Biol 731:237–45
   PubMedGoogle Scholar
• Wang J, Zu X, Jiang Y. (2009). Five furostanol saponins from fruits of Tribulus terrestris and their cytotoxic activities. Nat Prod Res 23:1436–44
   PubMed Web of Science ®Google Scholar
• Wu G, Jiang S, Jiang F, et al. (1996). Steroidal glycosides from Tribulus terrestris. Phytochemistry 42:1677–81
   PubMed Web of Science ®Google Scholar
• Xu YX, Chen HS, Liang HQ, et al. (2000). Three new saponins from Tribulus terrestris. Planta Med 66:545–50
   PubMed Web of Science ®Google Scholar