Mangiferin activates the Nrf2-ARE pathway and reduces etoposide-induced DNA damage in human umbilical cord mononuclear blood cells

References

• Adilakshmi T, Laine RO. (2002). Ribosomal protein S25 mRNA partners with MTF-1 and La to provide a p53-mediated mechanism for survival or death. J Biol Chem 277:4147–51
   PubMed Web of Science ®Google Scholar
• Andreu GL, Delgado R, Velho JA, et al. (2005). Mangiferin, a natural occurring glucosyl xanthone, increases susceptibility of rat liver mitochondria to calcium-induced permeability transition. Arch Biochem Biophys 439:184–93
   PubMed Web of Science ®Google Scholar
• Balasubramanyam A, Sailaja N, Mahboob M, et al. (2009). In vivo genotoxicity assessment of aluminium oxide nanomaterials in rat peripheral blood cells using the comet assay and micronucleus test. Mutagenesis 24:245–51
   PubMed Web of Science ®Google Scholar
• Bauer AK, Faiola B, Abernethy DJ, et al. (2003). Genetic susceptibility to benzene-induced toxicity: Role of NADPH: Quinone oxidoreductase-1. Cancer Res 63:929–35
   PubMed Web of Science ®Google Scholar
• Bryce SM, Bemis JC, Avlasevich SL, Dertinger SD. (2007). In vitro micronucleus assay scored by flow cytometry provides a comprehensive evaluation of cytogenetic damage and cytotoxicity. Mutat Res 630:78–91
   PubMed Web of Science ®Google Scholar
• Eggler AL, Gay KA, Mesecar AD. (2008). Molecular mechanisms of natural products in chemoprevention: Induction of cytoprotective enzymes by Nrf2. Mol Nutr Food Res 52:S84–94
   PubMed Web of Science ®Google Scholar
• Escobar PA, Smith MT, Vasishta A, et al. (2007). Leukaemia-specific chromosome damage detected by comet with fluorescence in situ hybridization (comet-FISH). Mutagenesis 22:321–7
   PubMed Web of Science ®Google Scholar
• Felix CA. (2001). Leukemias related to treatment with DNA topoisomerase II inhibitors. Med Pediatr Oncol 36:525–35
   PubMedGoogle Scholar
• Felix CA, Kolaris CP, Osheroff N. (2006). Topoisomerase II and the etiology of chromosomal translocations. DNA Repair (Amst) 5:1093–108
   PubMed Web of Science ®Google Scholar
• Hayes JD, McMahon M, Chowdhry S, Dinkova-Kostova AT. (2010). Cancer chemoprevention mechanisms mediated through the Keap1-Nrf2 pathway. Antioxid Redox Signal 13:1713–48
   PubMed Web of Science ®Google Scholar
• Irigaray P, Belpomme D. (2010). Basic properties and molecular mechanisms of exogenous chemical carcinogens. Carcinogenesis 31:135–48
   PubMed Web of Science ®Google Scholar
• Iskander K, Jaiswal AK. (2005). Quinone oxidoreductases in protection against myelogenous hyperplasia and benzene toxicity. Chem Biol Interact 153 and 154:147–57
   Web of Science ®Google Scholar
• Jaramillo MC, Zhang DD. (2013). The emerging role of the Nrf2-Keap1 signaling pathway in cancer. Genes Dev 27:2179–91
   PubMed Web of Science ®Google Scholar
• Kim YJ, Ahn JY, Liang P, et al. (2007). Human prx1 gene is a target of Nrf2 and is up-regulated by hypoxia/reoxygenation: Implication to tumor biology. Cancer Res 67:546–54
   PubMed Web of Science ®Google Scholar
• Kim SB, Pandita RK, Eskiocak U, et al. (2012). Targeting of Nrf2 induces DNA damage signaling and protects colonic epithelial cells from ionizing radiation. Proc Natl Acad Sci USA 109:2949–55
   Google Scholar
• Kumar S, Sun X, Wedgwood S, Black SM. (2008). Hydrogen peroxide decreases endothelial nitric oxide synthase promoter activity through the inhibition of AP-1 activity. Am J Physiol Lung Cell Mol Physiol 292:L370–7
   Google Scholar
• Kundu JK, Surh YJ. (2010). Nrf2-Keap1 signaling as a potential target for chemoprevention of inflammation-associated carcinogenesis. Pharm Res 27:999–1013
   PubMed Web of Science ®Google Scholar
• Kwak MK, Kensler TW. (2010). Targeting NRF2 signaling for cancer chemoprevention. Toxicol Appl Pharmacol 244:66–76
   PubMed Web of Science ®Google Scholar
• Li W, Kong AN. (2009). Molecular mechanisms of Nrf2-mediated antioxidant response. Mol Carcinog 48:91–104
   PubMed Web of Science ®Google Scholar
• Libura J, Slater Dj, Felix Ca, Richardson C. (2005). Therapy-related acute myeloid leukemia-like MLL rearrangements are induced by etoposide in primary human CD34 + cells and remain stable after clonal expansion. Blood 105:2124–31
   PubMed Web of Science ®Google Scholar
• Malik E, Cohen SB, Sahar D, et al. (2006). The frequencies of NAD(P)H quinone oxidoreductase (NQO1) variant allele in Israeli ethnic groups and the relationship of NQO1*2 to adult acute myeloid leukemia in Israeli patients. Haematologica 91:956–9
   PubMed Web of Science ®Google Scholar
• McMahon M, Itoch K, Yamamoto M, et al. (2001). The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes. Cancer Res 61:3299–307
   PubMed Web of Science ®Google Scholar
• Montecucco A, Biamonti G. (2007). Cellular response to etoposide treatment. Cancer Lett 252:9–18
   PubMed Web of Science ®Google Scholar
• Muruganandan S, Gupta S, Kataria M, et al. (2002). Mangiferin protects the streptozotocin-induced oxidative damage to cardiac and renal tissues in rats. Toxicology 176:165–73
   PubMed Web of Science ®Google Scholar
• Newcomb M, Chen CY, Wu JH. (2007). Induction of the celC operon of Clostridium thermocellum by laminaribiose. Proc Natl Acad Sci USA 104:3747–52
   PubMed Web of Science ®Google Scholar
• Nguyen T. (2005). Nrf2 controls constitutive and inducible expression of ARE-driven genes through a dynamic pathway involving nucleocytoplasmic shuttling by Keap1. J Biol Chem 280:32485–92
   PubMed Web of Science ®Google Scholar
• Nguyen T, Nioi P, Pickett CB. (2009). The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress. J Biol Chem 284:13291–5
   PubMed Web of Science ®Google Scholar
• Niture SK, Jaiswal AK. (2012). Nrf2 protein up-regulates antiapoptotic protein Bcl-2 and prevents cellular apoptosis. J Biol Chem 287:9873–86
   PubMed Web of Science ®Google Scholar
• Percival SS, Talcott ST, Chin ST, et al. (2006). Neoplastic transformation of BALB/3T3 cells and cell cycle of HL-60 cells are inhibited by mango (Mangifera indica L.) juice and mango juice extracts. J Nutr 136:1300–4
   PubMed Web of Science ®Google Scholar
• Rajendran P, Ekambaram G, Sakthisekaran D. (2008). Protective role of mangiferin against benzo(a)pyrene induced lung carcinogenesis in experimental animals. Biol Pharm Bull 31:1053–8
   PubMed Web of Science ®Google Scholar
• Ross D. (2005). Functions and distribution of NQO1 in human bone marrow: Potential clues to benzene toxicity. Chem Biol Interact 153 and 154:137–46
   Web of Science ®Google Scholar
• Shoji K, Tsubaki M, Yamazoe Y, et al. (2011). Mangiferin induces apoptosis by suppressing Bcl-xL and XIAP expressions and nuclear entry of NF-kappaB in HL-60 cells. Arch Pharm Res 34:469–75
   PubMed Web of Science ®Google Scholar
• Shu L, Cheung KL, Khor TO, et al. (2010). Phytochemicals: Cancer chemoprevention and suppression of tumor onset and metastasis. Cancer Metastasis Rev 29:483–502
   PubMed Web of Science ®Google Scholar
• Sporn MB, Liby KT. (2012). NRF2 and cancer: The good, the bad and the importance of context. Nat Rev Cancer 12:564–71
   PubMed Web of Science ®Google Scholar
• Stewart D, Killeen E, Naquin R, et al. (2003). Degradation of transcription factor Nrf2 via the ubiquitin-proteasome pathway and stabilization by cadmium. J Biol Chem 278:2396–402
   PubMed Web of Science ®Google Scholar
• Sun Z, Zhang S, Chan JY, Zhang DD. (2007). Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2. Mol Cell Biol 27:6334–49
   PubMed Web of Science ®Google Scholar
• Trotter KW, Archer TK. (2004). Reconstitution of glucocorticoid receptor-dependent transcription in vivo. Mol Cell Biol 24:3347–58
   PubMed Web of Science ®Google Scholar
• Velichkova M, Hasson T. (2005). Keap1 regulates the oxidation-sensitive shuttling of Nrf2 into and out of the nucleus via a Crm1-dependent nuclear export mechanism. Mol Cell Biol 25:4501–13
   PubMed Web of Science ®Google Scholar
• Vlasova II, Feng WH, Goff JP, et al. (2011). Myeloperoxidase-dependent oxidation of etoposide in human myeloid progenitor CD34 + cells. Mol Pharmacol 79:479–87
   PubMed Web of Science ®Google Scholar
• Wozniak AJ, Ross WE. (1983). DNA damage as a basis for 4′-demethylepipodophyllotoxin-9-(4,6-O-ethylidene-beta-d-glucopyranoside) (etoposide) cytotoxicity. Cancer Res 43:120–4
   PubMed Web of Science ®Google Scholar
• Yamada NA, Castro A, Farber RA. (2003). Variation in the extent of microsatellite instability in human cell lines with defects in different mismatch repair genes. Mutagenesis 18:277–82
   PubMed Web of Science ®Google Scholar
• Yates MS. (2006). Potent protection against aflatoxin-induced tumorigenesis through induction of Nrf2-regulated pathways by the triterpenoid 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole. Cancer Res 66:2488–94
   PubMed Web of Science ®Google Scholar
• Yates MS, Kensler TW. (2007). Chemopreventive promise of targeting the Nrf2 pathway. Drug News Perspect 20:109–17
   PubMedGoogle Scholar
• Yates MS, Tran QT, Dolan PM, et al. (2009). Genetic versus chemoprotective activation of Nrf2 signaling: Overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice. Carcinogenesis 30:1024–31
   PubMed Web of Science ®Google Scholar
• Yoshimi N, Matsunaga K, Katayama M, et al. (2001). The inhibitory effects of mangiferin, a naturally occurring glucosylxanthone, in bowel carcinogenesis of male F344 rats. Cancer Lett 163:163–70
   PubMed Web of Science ®Google Scholar
• Zhang BP, Zhao J, Li SS, et al. (2013). Mangiferin activates Nrf2-antioxidant response element signaling without reducing the sensitivity to etoposide of human myeloid leukemia cells in vitro: A novel Nrf2 activator without a “dark side”. Acta Pharmacol Sin 35:257–66
   PubMed Web of Science ®Google Scholar
• Zhao F, Chen Y, Li R, et al. (2010). Triptolide alters histone H3K9 and H3K27 methylation state and induces G0/G1 arrest and caspase-dependent apoptosis in multiple myeloma in vitro. Toxicology 267:70–9
   PubMed Web of Science ®Google Scholar
• Zhou FL, Zhang WG, Wei YC, et al. (2010). Involvement of oxidative stress in the relapse of acute myeloid leukemia. J Biol Chem 285:15010–15
   PubMed Web of Science ®Google Scholar