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Original Article

Cardiovascular effects of a labdenic diterpene isolated from Moldenhawera nutans in conscious, spontaneously hypertensive rats

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Pages 582-587 | Received 18 Feb 2014, Accepted 04 Jun 2014, Published online: 09 Dec 2014

References

  • Bruneton J. (1995). Pharmacognosy, Phytochemistry, Medicinal Plants. London, England: Lavoisier Technique & Documentation
  • David JP, David JM, Yang SW, Cordell GA. (1998). A bis-labdenic diterpene from Moldenhawera nutans. Phytochemistry 50:443–7
  • David JP, Ferrari J, David JM, et al. (2007). New triterpene and antibacterial labdenoic acid derivatives from Moldenhawere nutans. J Braz Chem Soc 18:1585–9
  • de Oliveira AP, Furtado FF, da Silva MS, et al. (2006). Calcium channel blockade as a target for the cardiovascular effects induced by the 8 (17), 12E, 14-labdatrien-18-oic acid (labdane-302). Vascul Pharmacol 44:338–44
  • de Siqueira RJ, Rodrigues KM, da Silva MT, et al. (2014). Linalool-rich rosewood oil induces vago-vagal bradycardic and depressor reflex in rats. Phytother Res 28:42–8
  • Dubey MP, Srimal RC, Nityanand S, Dhawan BN. (1981). Pharmacological studies on coleonol, a hypotensive diterpene from Coleus forskohlii. J Ethnopharmacol 3:1–13
  • El-Bardai S, Wibo M, Hamaide MC, et al. (2003). Characterisation of marrubenol, a diterpene extracted from Marrubium vulgare, as an l-type calcium channel blocker. Br J Pharmacol 140:1211–16
  • Interaminense LF, dos Ramos-Alves FE, de Siqueira RJ, et al. (2013). Vasorelaxant effects of 1-nitro-2-phenylethane, the main constituent of the essential oil of Aniba canelilla, in superior mesenteric arteries from spontaneously hypertensive rats. Eur J Pharm Sci 48:709–16
  • Judy WV, Watanabe AM, Henry DP, et al. (1976). Sympathetic nerve activity: Role in regulation of blood pressure in the spontaneously hypertensive rat. Circ Res 38:21–9
  • Lahlou S, de Barros Correia CA Jr, Vasconcelos dos Santos M, et al. (2007). Mechanisms underlying the cardiovascular effects of a labdenic diterpene isolated from Moldenhawera nutans in normotensive rats. Vascul Pharmacol 46:60–6
  • Lindner E, Dohadwalla AN, Bhattacharya BK. (1978). Positive inotropic and blood pressure lowering activity of a diterpene derivative isolated from Coleus forskohli: Forskolin. Arzneimittelforschung 28:284–9
  • Lüscher TF, Vanhoutte PM. (1986). Endothelium-dependent contractions to acetylcholine in the aorta of the spontaneously hypertensive rat. Hypertension 8:344–8
  • Pertino MW, Theoduloz C, Bastías M, Schmeda-Hirschmann G. (2013). Dimeric labdane diterpenes: Synthesis and antiproliferative effects. Molecules 18:5936–53
  • Queiroz LP, Lewis GP, Allkin R. (1999). A revision of the genus Moldenhawera Schrad. (Leguminosae-Caesalpinioideae). Kew Bull 54:817–52
  • Simplicio JA, Pernomian L, Simão MR, et al. (2014). Mechanisms underlying the vascular and hypotensive actions of the labdane ent-3-acetoxy-labda-8(17),13-dien-15-oic acid. Eur J Pharmacol 726C:66–76
  • Sonoki H, Uchida Y, Masuo M, et al. (1986). Effects of forskolin on canine congestive heart failure. Nihon Yakurigaku Zasshi 88:389–94
  • Tesmafariam B, Halpern W. (1988). Endothelium-dependent and endothelium-independent vasodilators in resistance arteries from hypertensive rats. Hypertension 11:440–4
  • Viana BF, da Silva FO, Kleinert AMP. (2006). The bee flora of the sea coastal and dunes of Abaeté, Salvador, Bahia State, Brazil. Braz J Bot 29:13–25

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