Protection by genistein on cortical neurons against oxidative stress injury via inhibition of NF-kappaB, JNK and ERK signaling pathway

References

• Aoki M, Nata T, Morishita R, et al. (2001). Endothelial apoptosis induced by oxidative stress through activation of NF-kappaB: Antiapoptotic effect of antioxidant agents on endothelial cells. Hypertension 38:48–55
   PubMed Web of Science ®Google Scholar
• Bortner CD, Cidlowski JA. (2002). Cellular mechanisms for the repression of apoptosis. Annu Rev Pharmacol Toxicol 42:259–81
   PubMed Web of Science ®Google Scholar
• Bradford MM. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248–54
   PubMed Web of Science ®Google Scholar
• Chandra D, Liu JW, Tang DG. (2002). Early mitochondrial activation and cytochrome c up-regulation during apoptosis. J Biol Chem 277:50842–54
   PubMed Web of Science ®Google Scholar
• Chao DT, Korsmeyer SJ. (1998). BCL-2 family: Regulators of cell death. Annu Rev Immunol 16:395–419
   PubMed Web of Science ®Google Scholar
• Chinopoulos C, Adam-Vizi V. (2006). Calcium, mitochondria and oxidative stress in neuronal pathology. Novel aspects of an enduring theme. FEBS J 273:433–50
   PubMed Web of Science ®Google Scholar
• Clark WM, Rinker LG, Lessov NS, et al. (2001). Efficacy of antioxidant therapies in transient focal ischemia in mice. Stroke 32:1000–4
   PubMed Web of Science ®Google Scholar
• Clemens JA. (2000). Cerebral ischemia: Gene activation, neuronal injury, and the protective role of antioxidants. Free Radic Biol Med 28:1526–31
   PubMedGoogle Scholar
• Crack PJ, Taylor JM. (2005). Reactive oxygen species and the modulation of stroke. Free Radic Biol Med 38:1433–44
   PubMed Web of Science ®Google Scholar
• Dalton TP, Shertzer HG, Puga A. (1999). Regulation of gene expression by reactive oxygen. Annu Rev Pharmacol Toxicol 39:67–101
   PubMed Web of Science ®Google Scholar
• Del Rio MJ, Velez-Pardo C. (2002). Monoamine neurotoxins-induced apoptosis in lymphocytes by a common oxidative stress mechanism: Involvement of hydrogen peroxide (H(2)O(2)), caspase-3, and nuclear factor kappa-B (NF-kappaB), p53, c-Jun transcription factors. Biochem Pharmacol 63:677–88
   PubMedGoogle Scholar
• Doyle KP, Simon RP, Stenzel-Poore MP. (2008). Mechanisms of ischemic brain damage. Neuropharmacology 55:310–18
   PubMed Web of Science ®Google Scholar
• Gasparova Z, Janega P, Babal P, et al. (2009). Effect of the new pyridoindole antioxidant SMe1EC2 on functional deficits and oedema formation in rat hippocampus exposed to ischaemia in vitro. Neuro Endocrinol Lett 30:574–81
   PubMed Web of Science ®Google Scholar
• Graham D, Huynh NN, Hamilton CA, et al. (2009). Mitochondria-targeted antioxidant MitoQ10 improves endothelial function and attenuates cardiac hypertrophy. Hypertension 54:322–8
   PubMed Web of Science ®Google Scholar
• Green DR, Reed JC. (1998). Mitochondria and apoptosis. Science 281:1309–12
   PubMed Web of Science ®Google Scholar
• Henderson VW, St John JA, Hodis HN, et al. (2012). Long-term soy isoflavone supplementation and cognition in women: A randomized, controlled trial. Neurology 78:1841–8
   PubMed Web of Science ®Google Scholar
• Hodnick WF, Kung FS, Roettger WJ, et al. (1986). Inhibition of mitochondrial respiration and production of toxic oxygen radicals by flavonoids. A structure–activity study. Biochem Pharmacol 35:2345–57
   PubMed Web of Science ®Google Scholar
• Hsieh HM, Wu WM, Hu ML. (2011). Genistein attenuates d-galactose-induced oxidative damage through decreased reactive oxygen species and NF-kappaB binding activity in neuronal PC12 cells. Life Sci 88:82–8
   PubMed Web of Science ®Google Scholar
• Hussain A, Harish G, Prabhu SA, et al. (2012). Inhibitory effect of genistein on the invasive potential of human cervical cancer cells via modulation of matrix metalloproteinase-9 and tissue inhibitors of matrix metalloproteinase-1 expression. Cancer Epidemiol 36:e387–93
   PubMed Web of Science ®Google Scholar
• Jiang X, Nie B, Fu S, et al. (2009). EGb761 protects hydrogen peroxide-induced death of spinal cord neurons through inhibition of intracellular ROS production and modulation of apoptotic regulating genes. J Mol Neurosci 38:103–13
   PubMed Web of Science ®Google Scholar
• Korsmeyer SJ. (1995). Regulators of cell death. Trends Genet 11:101–5
   PubMed Web of Science ®Google Scholar
• Li J, Xie ZZ, Tang YB. (2010). Genistein prevents myocardial hypertrophy in 2-kidney 1-clip renal hypertensive rats by restoring eNOS pathway. Pharmacology 86:240–8
   PubMedGoogle Scholar
• Liu CS, Chen NH, Zhang JT. (2007). Protection of PC12 cells from hydrogen peroxide-induced cytotoxicity by salvianolic acid B, a new compound isolated from Radix Salviae miltiorrhizae. Phytomedicine 14:492–7
   PubMed Web of Science ®Google Scholar
• Lopez-Neblina F, Toledo-Pereyra LH. (2006). Phosphoregulation of signal transduction pathways in ischemia and reperfusion. J Surg Res 134:292–9
   PubMed Web of Science ®Google Scholar
• Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. (1951). Protein measurement with the Folin phenol reagent. J Biol Chem 193:265–75
   PubMed Web of Science ®Google Scholar
• Matsura T, Kai M, Fujii Y, et al. (1999). Hydrogen peroxide-induced apoptosis in HL-60 cells requires caspase-3 activation. Free Radic Res 30:73–83
   PubMed Web of Science ®Google Scholar
• Peng Y, Kwok KH, Yang PH, et al. (2005). Ascorbic acid inhibits ROS production, NF-kappa B activation and prevents ethanol-induced growth retardation and microencephaly. Neuropharmacology 48:426–34
   PubMedGoogle Scholar
• Peters O, Back T, Lindauer U, et al. (1998). Increased formation of reactive oxygen species after permanent and reversible middle cerebral artery occlusion in the rat. J Cereb Blood Flow Metab 18:196–205
   PubMed Web of Science ®Google Scholar
• Qian Y, Guan T, Huang M, et al. (2012). Neuroprotection by the soy isoflavone, genistein, via inhibition of mitochondria-dependent apoptosis pathways and reactive oxygen induced-NF-kappaB activation in a cerebral ischemia mouse model. Neurochem Int 60:759–67
   PubMed Web of Science ®Google Scholar
• Ratan RR, Murphy TH, Baraban JM. (1994). Oxidative stress induces apoptosis in embryonic cortical neurons. J Neurochem 62:376–9
   PubMed Web of Science ®Google Scholar
• Ravindran J, Gupta N, Agrawal M, et al. (2011). Modulation of ROS/MAPK signaling pathways by okadaic acid leads to cell death via, mitochondrial mediated caspase-dependent mechanism. Apoptosis 16:145–61
   PubMed Web of Science ®Google Scholar
• Satoh T, Nakatsuka D, Watanabe Y, et al. (2000). Neuroprotection by MAPK/ERK kinase inhibition with U0126 against oxidative stress in a mouse neuronal cell line and rat primary cultured cortical neurons. Neurosci Lett 288:163–6
   PubMed Web of Science ®Google Scholar
• Setchell KD. (2001). Soy isoflavones – benefits and risks from nature's selective estrogen receptor modulators (SERMs). J Am Coll Nutr 20:354S–6S; discussion 381S–3S
   PubMed Web of Science ®Google Scholar
• Slemmer JE, Shacka JJ, Sweeney MI, Weber JT. (2008). Antioxidants and free radical scavengers for the treatment of stroke, traumatic brain injury and aging. Curr Med Chem 15:404–14
   PubMed Web of Science ®Google Scholar
• Sugawara T, Fujimura M, Noshita N, et al. (2004). Neuronal death/survival signaling pathways in cerebral ischemia. NeuroRx 1:17–25
   PubMedGoogle Scholar
• Tarabin V, Schwaninger M. (2004). The role of NF-kappaB in 6-hydroxydopamine- and TNFalpha-induced apoptosis of PC12 cells. Naunyn Schmiedebergs Arch Pharmacol 369:563–9
   PubMedGoogle Scholar
• Torres M. (2003). Mitogen-activated protein kinase pathways in redox signaling. Front Biosci 8:d369–91
   PubMed Web of Science ®Google Scholar
• Velez-Pardo C, Ospina GG, Jimenez del Rio M. (2002). Abeta[25-35] peptide and iron promote apoptosis in lymphocytes by an oxidative stress mechanism: Involvement of H2O2, caspase-3, NF-kappaB, p53 and c-Jun. Neurotoxicology 23:351–65
   PubMed Web of Science ®Google Scholar
• Wada T, Penninger JM. (2004). Mitogen-activated protein kinases in apoptosis regulation. Oncogene 23:2838–49
   PubMed Web of Science ®Google Scholar
• Wang T, Gu J, Wu PF, et al. (2009). Protection by tetrahydroxystilbene glucoside against cerebral ischemia: Involvement of JNK, SIRT1, and NF-kappaB pathways and inhibition of intracellular ROS/RNS generation. Free Radic Biol Med 47:229–40
   PubMed Web of Science ®Google Scholar
• Wang Z, Liu T, Gan L, et al. (2010). Shikonin protects mouse brain against cerebral ischemia/reperfusion injury through its antioxidant activity. Eur J Pharmacol 643:211–17
   PubMed Web of Science ®Google Scholar
• Xiong ZG, Zhu XM, Chu XP, et al. (2004). Neuroprotection in ischemia: Blocking calcium-permeable acid-sensing ion channels. Cell 118:687–98
   PubMed Web of Science ®Google Scholar
• Zamzami N, Marchetti P, Castedo M, et al. (1995). Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death. J Exp Med 182:367–77
   PubMed Web of Science ®Google Scholar
• Zhou Y, Wang Q, Evers BM, Chung DH. (2005). Signal transduction pathways involved in oxidative stress-induced intestinal epithelial cell apoptosis. Pediatr Res 58:1192–7
   PubMed Web of Science ®Google Scholar