Genistein induces activation of the mitochondrial apoptosis pathway by inhibiting phosphorylation of Akt in colorectal cancer cells

References

• Akiyama T, Ishida J, Nakagawa S, et al. (1987). Genistein, a specific inhibitor of tyrosine-specific protein kinases. J Biol Chem 262:5592–5
   PubMed Web of Science ®Google Scholar
• Arai N, Ström A, Rafter JJ, et al. (2000). Estrogen receptor beta mRNA in colon cancer cells: Growth effects of estrogen and genistein. Biochem Biophys Res Commun 270:425–31
   PubMed Web of Science ®Google Scholar
• Baba Y, Nosho K, Shima K, et al. (2011). Phosphorylated AKT expression is associated with PIK3CA mutation, low stage, and favorable outcome in 717 colorectal cancers. Cancer 117:1399–408
   PubMed Web of Science ®Google Scholar
• Bellacosa A, Testa JR, Moore R, et al. (2004). A portrait of AKT kinases: Human cancer and animal models depict a family with strong individualities. Cancer Biol Ther 3:268–75
   PubMed Web of Science ®Google Scholar
• Caiazza F, Galluzzo P, Lorenzetti S, et al. (2007). 17Beta-estradiol induces ERbeta up-regulation via p38/MAPK activation in colon cancer cells. Biochem Biophys Res Commun 359:102–7
   PubMed Web of Science ®Google Scholar
• Campbell-Thompson M, Lynch IJ, Bhardwaj B. (2001). Expression of estrogen receptor (ER) subtypes and ERbeta isoforms in colon cancer. Cancer Res 61:632–40
   PubMed Web of Science ®Google Scholar
• Chang TS. (2014). Isolation, bioactivity, and production of ortho-hydroxydaidzein and ortho-hydroxygenistein. Int J Mol Sci 15:5699–716
   PubMed Web of Science ®Google Scholar
• Chen J, Hou R, Zhang X, et al. (2014). Calycosin suppresses breast cancer cell growth via ERβ-dependent regulation of IGF-1R, p38 MAPK and PI3K/Akt pathways. PLoS One 9:e91245
   PubMed Web of Science ®Google Scholar
• Chiyomaru T, Yamamura S, Zaman MS, et al. (2012). Genistein suppresses prostate cancer growth through inhibition of oncogenic microRNA-151. PLoS One 7:e43812
   PubMed Web of Science ®Google Scholar
• Fan YZ, Li GH, Wang YH, et al. (2010). Effects of genistein on colon cancer cells in vitro and in vivo and its mechanism of action. Zhonghua Zhong Liu Za Zhi 32:4–9
   PubMedGoogle Scholar
• Fernandez E, La Vecchia C, Braga C, et al. (1998). Hormone replacement therapy and risk of colon and rectal cancer. Cancer Epidemiol Biomarkers Prev 7:329–33
   PubMed Web of Science ®Google Scholar
• Gu S, Papadopoulou N, Nasir O, et al. (2011). Activation of membrane androgen receptors in colon cancer inhibits the prosurvival signals Akt/bad in vitro and in vivo and blocks migration via vinculin/actin signaling. Mol Med 17:48–58
   PubMed Web of Science ®Google Scholar
• Gu Y, Liu SL, Ju WZ, et al. (2013). Analgesic-antitumor peptide induces apoptosis and inhibits the proliferation of SW480 human colon cancer cells. Oncol Lett 5:483–8
   PubMed Web of Science ®Google Scholar
• Han J, Kurita Y, Isoda H. (2013). Genistein-induced G2/M cell cycle arrest of human intestinal colon cancer Caco-2 cells is associated with Cyclin B1 and Chk2 down-regulation. Cytotechnology 65:973–8
   PubMed Web of Science ®Google Scholar
• Huang WJ, Bi LY, Li ZZ, et al. (2014). Formononetin induces the mitochondrial apoptosis pathway in prostate cancer cells via downregulation of the IGF-1/IGF-1R signaling pathway. Pharm Biol 52:466–70
   Web of Science ®Google Scholar
• Huang Z, Li S, Song W, et al. (2013). Lysine-specific demethylase 1 (LSD1/KDM1A) contributes to colorectal tumorigenesis via activation of the Wnt/β-catenin pathway by down-regulating Dickkopf-1 (DKK1). PLoS One 8:e70077
   Google Scholar
• Jemal A, Bray F, Center MM, et al. (2011). Global cancer statistics. CA Cancer J Clin 61:69–90
   PubMed Web of Science ®Google Scholar
• Klaus A, Birchmeier W. (2008). Wnt signalling and its impact on development and cancer. Nat Rev Cancer 8:387–98
   PubMed Web of Science ®Google Scholar
• Li Y, Chen H, Hardy TM, et al. (2013). Epigenetic regulation of multiple tumor-related genes leads to suppression of breast tumorigenesis by dietary genistein. PLoS One 8:e54369
   PubMed Web of Science ®Google Scholar
• Manning BD, Cantley LC. (2007). AKT/PKB signaling: Navigating downstream. Cell 129:1261–74
   PubMed Web of Science ®Google Scholar
• Pampaloni B, Palmini G, Mavilia C, et al. (2014). In vitro effects of polyphenols on colorectal cancer cells. World J Gastrointest Oncol 6:289–300
   PubMedGoogle Scholar
• Park JW, Kim SC, Kim WK, et al. (2014). Expression of phosphoenolpyruvate carboxykinase linked to chemoradiation susceptibility of human colon cancer cells. BMC Cancer 14:160
   PubMed Web of Science ®Google Scholar
• Qi W, Weber CR, Wasland K, et al. (2011). Genistein inhibits proliferation of colon cancer cells by attenuating a negative effect of epidermal growth factor on tumor suppressor FOXO3 activity. BMC Cancer 11:219
   PubMed Web of Science ®Google Scholar
• Ramadas A, Kandiah M. (2009). Food intake and colorectal adenomas: A case–control study in Malaysia. Asian Pac J Cancer Prev 10:925–32
   PubMed Web of Science ®Google Scholar
• Rudolph A, Toth C, Hoffmeister M, et al. (2013). Colorectal cancer risk associated with hormone use varies by expression of estrogen receptor-β. Cancer Res 73:3306–15
   PubMed Web of Science ®Google Scholar
• Tadaishi M, Nishide Y, Tousen Y, et al. (2014). Cooperative effects of soy isoflavones and carotenoids on osteoclast formation. J Clin Biochem Nutr 54:109–15
   PubMed Web of Science ®Google Scholar
• Wang H, Li Q, Chen H. (2012). Genistein affects histone modifications on Dickkopf-related protein 1 (DKK1) gene in SW480 human colon cancer cell line. PLoS One 7:e40955
   PubMed Web of Science ®Google Scholar
• Wang L, Li CL, Wang L, et al. (2011). Influence of CXCR4/SDF-1 axis on E-cadherin/β-catenin complex expression in HT29 colon cancer cells. World J Gastroenterol 17:625–32
   PubMed Web of Science ®Google Scholar
• Yang G, Shu XO, Li H, et al. (2009). Prospective cohort study of soy food intake and colorectal cancer risk in women. Am J Clin Nutr 89:577–83
   PubMed Web of Science ®Google Scholar
• Yang WL, Wu CY, Wu J, et al. (2010). Regulation of Akt signaling activation by ubiquitination. Cell Cycle 9:487–97
   PubMed Web of Science ®Google Scholar
• Yu Q, Yang L, Ding Y, et al. (2013). Expression of Dickkopf-1 in human colon carcinoma cell lines. Nan Fang Yi Ke Da Xue Xue Bao 33:923–5, 933
   PubMedGoogle Scholar