Increased frequency of circulating follicular helper T cells in patients with ankylosing spondylitis

References

• Szántó S, Aleksza M, Mihály E, Lakos G, Szabó Z, Végvári A, et al. Intracytoplasmic cytokine expression and T cell subset distribution in the peripheral blood of patients with ankylosing spondylitis. J Rheumatol. 2008;35:2372–5.
   PubMed Web of Science ®Google Scholar
• Appel H, Kuhne M, Spiekermann S, Ebhardt H, Grozdanovic Z, Köhler D, et al. Immunohistologic analysis of zygapophyseal joints in patients with ankylosing spondylitis. Arthritis Rheum. 2006; 54:2845–51.
   PubMed Web of Science ®Google Scholar
• Appel H, Loddenkemper C, Grozdanovic Z, Ebhardt H, Dreimann M, Hempfing A, et al. Correlation of histopathological findings and magnetic resonance imaging in the spine of patients with ankylosing spondylitis. Arthritis Res Ther. 2006;8:R143.
   PubMed Web of Science ®Google Scholar
• Wright C, Sibani S, Trudgian D, Fischer R, Kessler B, LaBaer J, et al. Detection of multiple autoantibodies in patients with ankylosing spondylitis using nucleic acid programmable protein arrays. Mol Cell Proteomics. 2012; 11:M9.00384.
   Web of Science ®Google Scholar
• Lin Q, Gu JR, Li TW, Zhang FC, Lin ZM, Liao ZT, et al. Value of the peripheral blood B-cells subsets in patients with ankylosing spondylitis. Chin Med J (Engl). 2009;122:1784–9.
   PubMed Web of Science ®Google Scholar
• Schmidlin H, Diehl SA, Blom B. New insights into the regulation of human B-cell differentiation. Trends Immunol. 2009;30:277–85.
   PubMed Web of Science ®Google Scholar
• King C. New insights into the differentiation and function of T follicular helper cells. Nat Rev Immunol. 2009;9:757–66.
   PubMed Web of Science ®Google Scholar
• Chen M, Guo Z, Ju W, Ryffel B, He X, Zheng SG. The development and function of follicular helper T cells in immune responses. Cell Mol Immunol. 2012;9:375–9.
   PubMed Web of Science ®Google Scholar
• Andersen T, Rasmussen TK, Hvid M, Holm CK, Madsen KJ, Jurik AG, et al. Increased plasma levels of IL-21 and IL-23 in spondyloarthritis are not associated with clinical and MRI findings. Rheumatol Int. 2012;32:387–93.
   PubMed Web of Science ®Google Scholar
• Ma J, Zhu C, Ma B, Tian J, Baidoo SE, Mao C, et al. Increased frequency of circulating follicular helper T cells in patients with rheumatoid arthritis. Clin Dev Immunol. 2012;2012:827480.
   PubMedGoogle Scholar
• Dong W, Zhu P, Wang Y, Wang Z. Follicular helper T cells in systemic lupus erythematosus: a potential therapeutic target. Autoimmun Rev. 2011;10:299–304.
   PubMed Web of Science ®Google Scholar
• Szabo K, Papp G, Barath S, Gyimesi E, Szanto A, Zeher M. Follicular helper T cells may play an important role in the severity of primary Sjögren's syndrome. Clin Immunol. 2013;147:95–104.
   PubMed Web of Science ®Google Scholar
• Fazilleau N, Mark L, McHeyzer-Williams LJ, McHeyzer-Williams MG. Follicular helper T cells: lineage and location. Immunity. 2009;30:324–35.
   PubMed Web of Science ®Google Scholar
• Morita R, Schmitt N, Bentebibel SE, Ranganathan R, Bourdery L, Zurawski G, et al. Human blood CXCR5(+)CD4(+) T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion. Immunity. 2011;34:108–21.
   PubMed Web of Science ®Google Scholar
• Li Q, Liu Z, Dang E, Jin L, He Z, Yang L, et al. Follicular helper T Cells (Tfh) and IL-21 involvement in the pathogenesis of bullous pemphigoid. PLoS One. 2013;8:e68145.
   PubMed Web of Science ®Google Scholar
• Simpson N, Gatenby PA, Wilson A, Malik S, Fulcher DA, Tangye SG, et al. Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus. Arthritis Rheum. 2010;62:234–44.
   PubMed Web of Science ®Google Scholar
• Van der Linden S, Valkenburg HA, Cats A. Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria.Arthritis Rheum. 1984;27:361–8.
   PubMed Web of Science ®Google Scholar
• Garrett S, Jenkinson T, Kennedy LG, Whitelock H, Gaisford P, Calin A. A new approach to defining disease status in ankylosing spondylitis: the Bath Ankylosing Spondylitis Disease Activity Index. J Rheumatol. 1994;21:2286–91.
   PubMed Web of Science ®Google Scholar
• Xiao F, Zhang HY, Liu YJ, Zhao D, Shan YX, Jiang YF. Higher frequency of peripheral blood interleukin 21 positive follicular helper T cells in patients with ankylosing spondylitis. J Rheumatol. 2013:40:2029–37.
   PubMed Web of Science ®Google Scholar
• Li XY, Wu ZB, Ding J, Zheng ZH, Li XY, Chen LN, et al. Role of the frequency of blood CD4(+)CXCR5(+)CCR6(+) T cells in autoimmunity in patients with Sjögren's syndrome. Biochem Biophys Res Commun. 2012;422:238–44.
   PubMed Web of Science ®Google Scholar
• Zhu C, Ma J, Liu Y, Tong J, Tian J, Chen J, et al. Increased frequency of follicular helper T cells in patients with autoimmune thyroid disease. J Clin Endocrinol Metab. 2012;97:943–50.
   PubMed Web of Science ®Google Scholar
• Zotos D, Coquet JM, Zhang Y, Light A, D’Costa K, Kallies A, et al. IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism. J Exp Med. 2010;207:365–78.
   PubMed Web of Science ®Google Scholar
• Platt AM, Gibson VB, Patakas A, Benson RA, Nadler SG, Brewer JM, et al. Abatacept limits breach of self-tolerance in a murine model of arthritis via effects on the generation of T follicular helper cells. J Immunol. 2010; 185:1558–67.
   PubMed Web of Science ®Google Scholar
• Bryant VL, Ma CS, Avery DT, Li Y, Good KL, Corcoran LM, et al. Cytokine-mediated regulation of human B cell differentiation into Ig-secreting cells: predominant role of IL-21 produced by CXCR5 + T follicular helper cells. J Immunol. 2007;179:8180–90.
   PubMed Web of Science ®Google Scholar
• Shilling RA, Wilkes DS. Role of Th17 cells and IL-17 in lung transplant rejection. Semin Immunopathol. 2011; 33:129–34.
   PubMed Web of Science ®Google Scholar
• Dienz O, Eaton SM, Bond JP, Neveu W, Moquin D, Noubade R, et al. The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4 + T cells. J Exp Med. 2009;206:69–78.
   PubMed Web of Science ®Google Scholar
• Karnowski A, Chevrier S, Belz GT, Mount A, Emslie D, D’Costa K, et al. B and T cells collaborate in antiviral responses via IL-6, IL-21, and transcriptional activator and coactivator, Oct2 and OBF-1. J Exp Med. 2012;209:2049–64.
   PubMed Web of Science ®Google Scholar