Possible participation of IgG4 in the activation of complement in IgG4-related disease with hypocomplementemia

References

• Isenman DE, Dorrington KJ, Painter RH. The structure and function of immunoglobulin domains. II. The importance of interchain disulfide bonds and the possible role of molecular flexibility in the interaction between immunoglobulin G and complement. J Immunol. 1975;114:1726–9.
   PubMed Web of Science ®Google Scholar
• Bruggemann M, Williams GT, Bindon CI, Clark MR, Walker MR, Jefferis R, et al. Comparison of the effector functions of human immunoglobulins using a matched set of chimeric antibodies. J Exp Med. 1987;166:1351–61.
   PubMed Web of Science ®Google Scholar
• Dangl JL, Wensel TG, Morrison SL, Stryer L, Herzenberg LA, Oi VT. Segmental flexibility and complement fixation of genetically engineered chimeric human, rabbit and mouse antibodies. EMBO J. 1988;7:1989–94.
   PubMed Web of Science ®Google Scholar
• Tao MH, Smith RI, Morrison SL. Structural features of human immunoglobulin G that determine isotype-specific differences in complement activation. J Exp Med. 1993;178:661–7.
   PubMed Web of Science ®Google Scholar
• Canfield SM, Morrison SL. The binding affinity of human IgG for its high affinity Fc receptor is determined by multiple amino acids in the CH2 domain and is modulated by the hinge region. J Exp Med. 1991;173:1483–91.
   PubMed Web of Science ®Google Scholar
• van der Neut Kolfschoten M, Schuurman J, Losen M, Bleeker WK, Martinez-Martinez P, Vermeulen E, et al. Anti-inflammatory activity of human IgG4 antibodies by dynamic Fab arm exchange. Science. 2007;317:1554–7.
   PubMed Web of Science ®Google Scholar
• Umehara H, Okazaki K, Masaki Y, Kawano M, Yamamoto M, Saeki T, et al. Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011. Mod Rheumatol. 2012;22:21–30.
   PubMed Web of Science ®Google Scholar
• Stone JH, Zen Y, Deshpande V. IgG4-related disease [review]. N Engl J Med. 2012;366:539–51.
   PubMed Web of Science ®Google Scholar
• Yamamoto M, Ohara M, Suzuki C, Naishiro Y, Yamamoto H, Takahashi H, et al. Elevated IgG4 concentrations in serum of patients with Mikulicz's disease. Scand J Rheumatol. 2004;33:432–3.
   PubMed Web of Science ®Google Scholar
• Masaki Y, Dong L, Kurose N, Kitagawa K, Morikawa Y, Yamamoto M, et al. Proposal for a new clinical entity, IgG4-positive multiorgan lymphoproliferative syndrome: analysis of 64 cases of IgG4-related disorders. Ann Rheum Dis. 2009;68:1310–15.
   PubMed Web of Science ®Google Scholar
• Hamano H, Kawa S, Horiuchi A, Unno H, Furuya N, Akamatsu T, et al. High serum IgG4 concentrations in patients with sclerosing pancreatitis. N Engl J Med. 2001;344:732–8.
   PubMed Web of Science ®Google Scholar
• Okazaki K, Uchida K, Koyabu M, Miyoshi H, Takaoka M. Recent advances in the concept and diagnosis of autoimmune pancreatitis and IgG4-related disease [review]. J Gastroenterol. 2011;46:277–88.
   PubMed Web of Science ®Google Scholar
• Hamano H, Kawa S, Ochi Y, Unno H, Shiba N, Wajiki M, et al. Hydronephrosis associated with retroperitoneal fibrosis and sclerosing pancreatitis. Lancet. 2002;359:1403–4.
   PubMed Web of Science ®Google Scholar
• Zen Y, Onodera M, Inoue D, Kitao A, Matsui O, Nohara T, et al. Retroperitoneal fibrosis: a clinicopathologic study with respect to immunoglobulin G4. Am J Surg Pathol. 2009;33:1833–9.
   PubMed Web of Science ®Google Scholar
• Uchiyama-Tanaka Y, Mori Y, Kimura T, Sonomura K, Umemura S, Kishimoto N, et al. Acute tubulointerstitial nephritis associated with autoimmune-related pancreatitis. Am J Kidney Dis. 2004;43:e18–25.
   PubMed Web of Science ®Google Scholar
• Takeda S, Haratake J, Kasai T, Takaeda C, Takazakura E. IgG4-associated idiopathic tubulointerstitial nephritis complicating autoimmune pancreatitis. Nephrol Dial Transplant. 2004;19:474–6.
   PubMed Web of Science ®Google Scholar
• Kawano M, Saeki T, Nakashima H, Nishi S, Yamaguchi Y, Hisano S, et al. Proposal for diagnostic criteria for IgG4-related kidney disease. Clin Exp Nephrol. 2011;15:615–26.
   PubMed Web of Science ®Google Scholar
• Dahlgren M, Khosroshahi A, Nielsen GP, Deshpande V, Stone JH. Riedel's thyroiditis and multifocal fibrosclerosis are part of the IgG4-related systemic disease spectrum. Arthritis Care Res. (Hoboken) 2010;62:1312–18.
   PubMed Web of Science ®Google Scholar
• Muraki T, Hamano H, Ochi Y, Komatsu K, Komiyama Y, Arakura N, et al. Autoimmune pancreatitis and complement activation system. Pancreas. 2006;32:16–21.
   PubMed Web of Science ®Google Scholar
• Deshpande V, Chicano S, Finkelberg D, Selig MK, Mino-Kenudson M, Brugge WR, et al. Autoimmune pancreatitis: a systemic immune complex mediated disease. Am J Surg Pathol. 2006;30:1537–45.
   PubMed Web of Science ®Google Scholar
• Cornell LD, Chicano SL, Deshpande V, Collins AB, Selig MK, Lauwers GY, et al. Pseudotumors due to IgG4 immune-complex tubulointerstitial nephritis associated with autoimmune pancreatocentric disease. Am J Surg Pathol. 2007;31:1586–97.
   PubMed Web of Science ®Google Scholar
• Kohro-Kawata J, Wener MH, Mannik M. The effect of high salt concentration on detection of serum immune complexes and autoantibodies to C1q in patients with systemic lupus erythematosus. J Rheumatol. 2002;29:84–9.
   PubMed Web of Science ®Google Scholar
• Harkiss GD, Brown DL. Detection of immune complexes by a new assay, the polyethylene glycol precipitation-complement consumption test (PEG-CC). Clin Exp Immunol. 1979;36:117–29.
   PubMed Web of Science ®Google Scholar
• Wener MH, Uwatoko S, Mannik M. Antibodies to the collagen-like region of C1q in sera of patients with autoimmune rheumatic diseases. Arthritis Rheum. 1989;32:544–51.
   PubMed Web of Science ®Google Scholar
• Malhotra R, Wormald MR, Rudd PM, Fischer PB, Dwek RA, Sim RB. Glycosylation changes of IgG associated with rheumatoid arthritis can activate complement via the mannose-binding protein. Nat Med. 1995;1:237–43.
   PubMed Web of Science ®Google Scholar
• Arnold JN, Wormald MR, Suter DM, Radcliffe CM, Harvey DJ, Dwek RA, et al. Human serum IgM glycosylation: identification of glycoforms that can bind to mannan-binding lectin. J Biol Chem. 2005;280:29080–7.
   PubMed Web of Science ®Google Scholar
• Terai I, Kobayashi K, Vaerman JP, Mafune N. Degalactosylated and/or denatured IgA, but not native IgA in any form, bind to mannose-binding lectin. J Immunol. 2006;177:1737–45.
   PubMed Web of Science ®Google Scholar
• Ma H, Sandor DG, Beck LH. Jr. The role of complement in membranous nephropathy. Semin Nephrol. 2013;33:531–42.
   PubMed Web of Science ®Google Scholar
• Suzuki S, Kida S, Ohira Y, Ohba T, Miyata M, Nishimaki T, et al. A case of Sjogren's syndrome accompanied by lymphadenopathy and IgG4 hypergammaglobulinemia. Ryumachi. 1993;33:249–54. (Japanese)
   PubMedGoogle Scholar
• Klein M, Haeffner-Cavaillon N, Isenman DE, Rivat C, Navia MA, Davies DR, et al. Expression of biological effector functions by immunoglobulin G molecules lacking the hinge region. Proc Natl Acad Sci U S A. 1981;78:524–8.
   PubMed Web of Science ®Google Scholar
• Norderhaug L, Brekke OH, Bremnes B, Sandin R, Aase A, Michaelsen TE, et al. Chimeric mouse human IgG3 antibodies with an IgG4-like hinge region induce complement-mediated lysis more efficiently than IgG3 with normal hinge. Eur J Immunol. 1991;21:2379–84.
   PubMed Web of Science ®Google Scholar
• Xu Y, Oomen R, Klein MH. Residue at position 331 in the IgG1 and IgG4 CH2 domains contributes to their differential ability to bind and activate complement. J Biol Chem. 1994;269:3469–74.
   PubMed Web of Science ®Google Scholar