Association of antibodies to the NR1 subunit of N-methyl-D-aspartate receptors with neuropsychiatric systemic lupus erythematosus

References

• Bluestein HG, Williams GW, Steinberg AD. Cerebrospinal fluid antibodies to neuronal cells: association with neuropsychiatric manifestations of systemic lupus erythematosus. Am J Med. 1981;70:240–6.
   PubMed Web of Science ®Google Scholar
• Isshi K, Hirohata S. Differential roles of the anti-ribosomal P antibody and antineuronal antibody in the pathogenesis of central nervous system involvement in systemic lupus erythematosus. Arthritis Rheum. 1998;41:1819–27.
   PubMed Web of Science ®Google Scholar
• DeGiorgio LA, Konstantinov KN, Lee SC, Hardin JA, Volpe BT, Diamond B. A subset of lupus anti-DNA antibodies cross-reacts with the NR2 glutamate receptor in systemic lupus erythematosus. Nat Med. 2001;7:1189–93.
   PubMed Web of Science ®Google Scholar
• Morris RG, Anderson E, Lynch GS, Baudry M. Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5. Nature. 1986;319:774–6.
   PubMed Web of Science ®Google Scholar
• Choi DW, Rothman SM. The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death. Annu Rev Neurosci. 1990;13:71–82.
   Google Scholar
• Mattson MP, LaFerla FM, Chan SL, Leissring MA, Shepel PN, Geiger JD. Calcium signaling in the ER: its role in neuronal plasticity and neurodegenerative disorders. Trends Neurosci. 2000;23:222–9.
   PubMed Web of Science ®Google Scholar
• Dingledine R, Borges K, Bowie D, Traynelis SF. The glutamate receptor ion channels. Pharmacol Rev. 1999;51;7–61.
   PubMed Web of Science ®Google Scholar
• Flores-Soto ME, Chaparro-Huerta V, Escoto-Delgadillo M, Vazquez-Valls E, González-Castañeda RE, Beas-Zarate C. Structure and function of NMDA-type glutamate receptor subunits. Neurologia. 2012;27:301–10.
   PubMed Web of Science ®Google Scholar
• Schorge S, Colquhoun D. Studies of NMDA receptor function and stoichiometry with truncated and tándem subunits. J Neurosci. 2003;23:1151–8.
   PubMed Web of Science ®Google Scholar
• Papadakis M, Hawkins LM, Stephenson FA. Appropriate NR1-NR1 disulfide-linked homodimer formation is requisite for efficient expression of functional, cell surface N-methyl-d-aspartate NR1/NR2 receptors. J Biol Chem. 2004;279:14703–12.
   PubMed Web of Science ®Google Scholar
• Schüler T, Mesic I, Madry C, Bartholomäus I, Laube B. Formation of NR1/NR2 and NR1/NR3 heterodimers constitutes the initial step in N-methyl-d-aspartate receptor assembly. J Biol Chem. 2008; 283: 37–46.
   PubMed Web of Science ®Google Scholar
• Furukawa H, Singh SK, Mancusso R, Gouaux E. Subunit arrangement and function in NMDA receptors. Nature. 2005;438:185–92.
   PubMed Web of Science ®Google Scholar
• Chen PE, Wyllie DJ. Pharmacological insights obtained from structure-function studies of ionotropic glutamate receptors. Br J Pharmacol. 2006;147:839–53.
   PubMed Web of Science ®Google Scholar
• Perez IO, Schulteis CT, Contractor A. Assembly with the NR1 subunit is required for surface expression of NR3A-containing NMDA receptors. J Neurosci. 2001;1:1228–37.
   Google Scholar
• Watanabe K, Kanno T, Oshima T, Miwa H, Tashiro C, Nishizaki T. Vagotomy upregulates expression of the N-methyl-D-aspartate receptor NR2D subunit in the stomach. J Gastroenterol. 2008;43:322–6.
   PubMed Web of Science ®Google Scholar
• Arinuma Y, Yanagida T, Hirohata S. Association of cerebrospinal fluid anti-NR2 glutamate receptor antibodies with diffuse neuropsychiatric systemic lupus erythematosus. Arthritis Rheum. 2008;58:1130–5.
   PubMed Web of Science ®Google Scholar
• Tan EM, Cohen AS, Fries JF, Masi AT, McShane DJ, Rothfield NF, et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1982;25:1271–7.
   PubMed Web of Science ®Google Scholar
• Hochberg MC. Updating the American college of rheumatology revised criteria for the classification of systemic lupus erythematosus (letter). Arthritis Rheum. 1997;40:1725.
   PubMed Web of Science ®Google Scholar
• ACR Ad Hoc Committee on Neuropsychiatric Lupus Nomenclature. The American college of rheumatology nomenclature and case definitions for neuropsychiatric lupus syndromes. Arthritis Rheum. 1999;42:599–608.
   PubMed Web of Science ®Google Scholar
• Planells-Cases R, Sun W, Ferrer-Montiel AV, Montal M. Molecular cloning, functional expression, and pharmacological characterization of an N-methyl-D-aspartate receptor subunit from human brain. Proc Natl Acad Sci USA. 1993;90:5057–61.
   PubMed Web of Science ®Google Scholar
• Hirohata S, Arinuma Y, Yanagida T, Yoshio T. Blood-brain barrier damages and intrathecal synthesis of anti-N-methyl-D-aspartate receptor NR2 antibodies in diffuse psychiatric/neuropsychological syndromes in systemic lupus erythematosus. Arthritis Res Ther. 2014;16:R77.
   PubMed Web of Science ®Google Scholar
• Kowal C, DeGiorgio LA, Nakaoka T, Hetherington H, Huerta PT, Diamond B, Volpe BT. Cognition and immunity; antibody impairs memory. Immunity. 2004;21:179–88.
   PubMed Web of Science ®Google Scholar
• Wahlestedt C, Golanov E, Yamamoto S, Yee F, Ericson H, Yoo H, et al. Antisense oligodeoxynucleotides to NMDA-R1 receptor channel protect cortical neurons from excitotoxicity and reduce focal ischaemic infarctions. Nature. 1993;363:260–3.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Su P, Liang P, Liu T, Liu X, Liu XY, et al. The DREAM protein negatively regulates the NMDA receptor through interaction with the NR1 subunit. J Neurosci. 2010;30:7575–86.
   PubMed Web of Science ®Google Scholar
• Wesseling H, Guest PC, Lee CM, Wong EH, Rahmoune H, Bahn S. Integrative proteomic analysis of the NMDA NR1 knockdown mouse model reveals effects on central and peripheral pathways associated with schizophrenia and autism spectrum disorders. Mol Autism. 2014;5:38.
   PubMed Web of Science ®Google Scholar
• Burgoyne RD. Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling. Nat Rev Neurosci. 2007;8:182–93.
   PubMed Web of Science ®Google Scholar
• Yoshio T, Okamoto H, Hirohata S, Minota S. IgG anti-NR2 glutamate receptor autoantibodies from patients with systemic lupus erythematosus activate endothelial cells. Arthritis Rheum. 2013;65:457–63.
   PubMed Web of Science ®Google Scholar
• Carrión AM, Link WA, Ledo F, Mellström B, Naranjo JR. DREAM is a Ca2+-regulated transcriptional repressor. Nature. 1999;398:80–4.
   PubMed Web of Science ®Google Scholar
• Link H, Tibbling G. Principles of albumin and IgG analyses in neurological disorders. III. Evaluation of IgG synthesis within the central nervous system in multiple sclerosis. Scand J Clin Lab Invest. 1977;37: 397–401.
   PubMed Web of Science ®Google Scholar
• Reiber H, Peter JB. Cerebrospinal fluid analysis: disease-related data patterns and evaluation programs. J Neurol Sci. 2001; 184:101–22.
   PubMed Web of Science ®Google Scholar
• Mia Levite, Yonatan Ganor. Autoantibodies to glutamate receptors can damage the brain in epilepsy, systemic lupus erythematosus and encephalitis. Expert Rev Neurother. 2008;8:1141–60.
   PubMedGoogle Scholar
• Hirohata S, Sakuma Y, Yanagida T, Yoshio T. Association of cerebrospinal fluid anti-Sm antibodies with acute confusional state in systemic lupus erythematosus. Arthritis Res Ther. 2014;16:450.
   PubMed Web of Science ®Google Scholar