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Human Fertility
an international, multidisciplinary journal dedicated to furthering research and promoting good practice
Volume 13, 2010 - Issue 3
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Blastomere Multinucleation

Blastomere multinucleation: Contributing factors and effects on embryo development and clinical outcome

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Pages 143-150 | Published online: 17 Sep 2010

References

  • Agerholm, I. E., Hnida, C., Cruger, D. G., Berg, C., Bruun-Petersen, G., Kølvraa, S., et al (2008). Nuclei size in relation to nuclear status and aneuploidy rate for 13 chromosomes in donated four cells embryos. Journal of Assisted Reproduction and Genetics, 25, 95–102.
  • Alberts, B., Bray, D., Lewis, J., Raff, M., Roberts, K., Watson, J.D. (1994). Molecular biology of the cell. New York: Garland Publishing.
  • Asch, R., Simerly, C., Ord, T., Ord, V. A., Schatten, G.(1995). The stages at which human fertilization arrests: microtubule and chromosome configurations in inseminated oocytes which failed to complete fertilization and development in humans. Human Reproduction, 10, 1897–1906.
  • Baart, E. B., Martini, E., Eijkemans, M. J., Van Opstal, D., Beckers, N.G., Verhoeff, A., et al (2007). Milder ovarian stimulation for in-vitro fertilization reduces aneuploidy in the human preimplantation embryo: a randomized controlled trial. Human Reproduction, 22, 980–988.
  • Balaban, B., Urman, B. (2006). Effect of oocyte morphology on embryo development and implantation. Reproductive Biomedicine Online, 12, 608–615.
  • Balakier, H., Cadesky, K. (1997). The frequency and developmental capability of human embryos containing multinucleated blastomeres. Human Reproduction, 12, 800–804.
  • Ebner, T., Moser, M., Sommergruber, M., Tews, G. (2003). Selection based on morphological assessment of oocytes and embryos at different stages of preimplantation development: a review. Human Reproduction Update, 9, 251–262.
  • Eldar-Geva, T., B. Brooks, E. J. Margalioth, Zylber-Haran, E., Gal, M., Silber, S.J. (2003). Successful pregnancy and delivery after calcium ionophore oocyte activation in a normozoospermic patient with previous repeated failed fertilization after intracytoplasmic sperm injection. Fertility and Sterility, 79 (Suppl 3), 1656–1658.
  • Fauser, B. C., Devroey, P., Macklon, N. S. (2005). Multiple birth resulting from ovarian stimulation for subfertility treatment. Lancet, 365, 1807–1816.
  • Gomez, E., Perez-Cano, I., Amorocho, B., Landeras, J., Ballesteros, A., Pellicer, A. (2000). Effect of injected spermatozoa morphology on the outcome of intracytoplasmic sperm injection in humans. Fertility and Sterility, 74, 842–843.
  • Greco, E., Litwicka, K., Ferrero, S., Baroni, E., Sapienza, F., Rienzi, L., et al (2007). GnRH antagonists in ovarian stimulation for ICSI with oocyte restriction: a matched, controlled study. Reproductive Biomedicine Online, 14, 572–578.
  • Haaf, T., Hahn, A., Lambrecht, A., Grossmann, B., Schwaab, E., Khanaga, O., et al (2008). A high oocyte yield for intracytoplasmic sperm injection treatment is associated with an increased chromosome error rate. Fertility and Sterility, 91, 733–738.
  • Hardy, K., Winston, R. M., Handyside, A. H. (1993). Binucleate blastomeres in preimplantation human embryos in vitro: failure of cytokinesis during early cleavage. Journal of Reproduction Fertility, 98, 549–558.
  • Jackson, K. V., Ginsburg, E. S., Hornstein, M. D., Rein, M.S., Clarke, R.N. (1998). Multinucleation in normally fertilized embryos is associated with an accelerated ovulation induction response and lower implantation and pregnancy rates in in vitro fertilization-embryo transfer cycles. Fertility and Sterility, 70, 60–66.
  • Kligman, I., Benadiva, C., Alikani, M., Munné, S. (1996). The presence of multinucleated blastomeres in human embryos is correlated with chromosomal abnormalities. Human Reproduction, 11, 1492–1498.
  • Macklon, N. S., Stouffer, R. L., Giudice, L. C., Fauser, B.C. (2006). The science behind 25 years of ovarian stimulation for in vitro fertilization. Endocrine Reviews, 27, 170–207.
  • Manandhar, G., Schatten, H., Sutovsky, P. (2005). Centrosome reduction during gametogenesis and its significance. Biology of Reproduction, 72, 2–13.
  • Meriano, J., Clark, C., Cadesky, K., Laskin, C.A. (2004). Binucleated and micronucleated blastomeres in embryos derived from human assisted reproduction cycles. Reproductive Biomedicine Online, 9, 511–520.
  • Nicopoullos, J. D., Gilling-Smith, C., Almeida, P. A., Norman-Taylor, J., Grace, I., Ramsay, J.W. (2004). Use of surgical sperm retrieval in azoospermic men: a meta-analysis. Fertility and Sterility, 82, 691–701.
  • Ohsugi, M., Adachi, K., Horai, R., Kakuta, S., Sudo, K., Kotaki, H., et al (2008). “Kid-mediated chromosome compaction ensures proper nuclear envelope formation. Cell, 132, 771–782.
  • Pelinck, M. J., De Vos, M., Dekens, M., Van der Elst, J., De Sutter, P., Dhont, M. (1998). Embryos cultured in vitro with multinucleated blastomeres have poor implantation potential in human in-vitro fertilization and intracytoplasmic sperm injection. Human Reproduction, 13, 960–963.
  • Pickering, S. J., Taylor, A., Johnson, M. H., Braude, P.R. (1995). An analysis of multinucleated blastomere formation in human embryos. Human Reproduction, 10, 1912–1922.
  • Romanova, L., Korobova, F., Noniashvilli, E., Dyban, A., Zatsepina, O. (2006). High resolution mapping of ribosomal DNA in early mouse embryos by fluorescence in situ hybridization. Biology of Reproduction, 74, 807–815.
  • Rout, U. K., Krawetz, S. A., Armant, D. R. (1997). Ethanol-induced intracellular calcium mobilization rapidly alters gene expression in the mouse blastocyst. Cell Calcium, 22, 463–474.
  • Sadowy, S., Tomkin, G., Munne, S., Ferrara-Congedo, T., Cohen, J. (1998). Impaired development of zygotes with uneven pronuclear size. Zygote, 6, 137–141.
  • Salumets, A., Hyden-Granskog, C., Suikkari, A. M., Tiitinen, A., Tuuri, T. (2001). The predictive value of pronuclear morphology of zygotes in the assessment of human embryo quality. Human Reproduction, 16, 2177–2181.
  • Schatten, G. (1994). The centrosome and its mode of inheritance: the reduction of the centrosome during gametogenesis and its restoration during fertilization. Developmental Biology, 165, 299–335.
  • Scott, L., Alvero, R., Leondires, M., Miller, B. (2000). The morphology of human pronuclear embryos is positively related to blastocyst development and implantation. Human Reproduction, 15, 2394–2403.
  • Staessen, C., Van Steirteghem, A. (1998). The genetic constitution of multinuclear blastomeres and their derivative daughter blastomeres. Human Reproduction, 13, 1625–1631.
  • Tesarik, J., Kopecny, V., Plachot, M., Mandelbaum, J. (1987). Ultrastructural and autoradiographic observations on multinucleated blastomeres of human cleaving embryos obtained by in-vitro fertilization. Human Reproduction, 2, 127–136.
  • Van Royen, E., Mangelschots, K., Vercruyssen, M., De Neubourg, D., Valkenburg, M., Ryckaert, G., Gerris, J. (2003). Multinucleation in cleavage stage embryos. Human Reproduction, 18, 1062–1069.
  • Veeck, L. L. (1991). Atlas of the human ocyte and early conceptus. Baltimore: William and Wilkins.
  • Verza, S., Jr., Esteves, S. C. (2008). Sperm defect severity rather than sperm source is associated with lower fertilization rates after intracytoplasmic sperm injection. International Brazilian Journal of Urology, 34, 49–56.
  • Winston, N. J., Braude, P. R., Pickering, S. J., George, M.A., Cant, A., Currie, J., et al (1991). The incidence of abnormal morphology and nucleocytoplasmic ratios in 2-, 3- and 5-day human pre-embryos. Human Reproduction, 6, 17–24.

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