Efficient expansion of mesenchymal stromal cells from umbilical cord under low serum conditions

References

• Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, . Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 2006;8:315–17.
   PubMed Web of Science ®Google Scholar
• Arthur A, Zannettino A, Gronthos S. The therapeutic applications of multipotential mesenchymal/stromal stem cells in skeletal tissue repair. J Cell Physiol 2009;218:237–45.
   PubMed Web of Science ®Google Scholar
• Korda M, Blunn G, Goodship A, Hua J. Use of mesenchymal stem cells to enhance bone formation around revision hip replacements. J Orthop Res 2008;26:880–5.
   PubMed Web of Science ®Google Scholar
• Au P, Tam J, Fukumura D, Jain RK. Bone marrow-derived mesenchymal stem cells facilitate engineering of long-lasting functional vasculature. Blood 2008;111:4551–8.
   PubMed Web of Science ®Google Scholar
• Falanga V, Iwamoto S, Chartier M, Yufit T, Butmarc J, Kouttab N, . Autologous bone marrow-derived cultured mesenchymal stem cells delivered in a fibrin spray accelerate healing in murine and human cutaneous wounds. Tissue Eng 2007;13:1299–312.
   PubMedGoogle Scholar
• Phinney DG, Prockop DJ. Concise review: mesenchymal stem/multipotent stromal cells. The state of transdifferentiation and modes of tissue repair: current views. Stem Cells 2007;25:2896–902.
   PubMed Web of Science ®Google Scholar
• Fox JM, Chamberlain G, Ashton BA, Middleton J. Recent advances into the understanding of mesenchymal stem cell trafficking. Br J Haematol 2007;137:491–502.
   PubMed Web of Science ®Google Scholar
• Caplan AI, Dennis JE. Mesenchymal stem cells as trophic mediators. J Cell Biochem 2006;98:1076–84.
   PubMed Web of Science ®Google Scholar
• Zwart I, Hill AJ, Girdlestone J, Manca MF, Navarrete R, Navarrete C, . Analysis of neural potential of human umbilical cord blood-derived multipotent mesenchymal stem cells in response to a range of neurogenic stimuli. J Neurosci Res 2008;86:1902–25.
   PubMed Web of Science ®Google Scholar
• Martin-Rendon E, Sweeney D, Lu F, Girdlestone J, Navarrete C, Watt SM. 5-Azacytidine-treated human mesenchymal stem/progenitor cells derived from umbilical cord, cord blood and bone marrow do not generate cardiomyocytes in vitro at high frequencies. Vox Sang 2008;95:137–48.
   PubMed Web of Science ®Google Scholar
• Le Blanc K, Ringden O. Immunomodulation by mesenchymal stem cells and clinical experience. J Intern Med 2007;262:509–25.
   PubMed Web of Science ®Google Scholar
• Nauta AJ, Kruisselbrink AB, Lurvink E, Willemze R, Fibbe WE. Mesenchymal stem cells inhibit generation and function of both CD34+-derived and monocyte-derived dendritic cells. J Immunol 2006;177:2080–7.
   PubMed Web of Science ®Google Scholar
• Nauta AJ, Fibbe WE. Immunomodulatory properties of mesenchymal stromal cells. Blood 2007;110:3499–506.
   PubMed Web of Science ®Google Scholar
• Le Blanc K, Rasmusson I, Sundberg B, Gotherstrom C, Hassan M, Uzunel M, . Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells. Lancet 2004;363:1439–41.
   PubMed Web of Science ®Google Scholar
• Le Blanc K, Frassoni F, Ball L, Locatelli F, Roelofs H, Lewis I, . Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study. Lancet 2008;371:1579–86.
   PubMed Web of Science ®Google Scholar
• Ball LM, Bernardo ME, Roelofs H, Lankester A, Cometa A, Egeler RM, . Cotransplantation of ex vivo expanded mesenchymal stem cells accelerates lymphocyte recovery and may reduce the risk of graft failure in haploidentical hematopoietic stem-cell transplantation. Blood 2007;110:2764–7.
   PubMed Web of Science ®Google Scholar
• Kern S, Eichler H, Stoeve J, Kluter H, Bieback K. Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue. Stem Cells 2006;24:1294–301.
   PubMed Web of Science ®Google Scholar
• Guillot PV, De Bari C, Dell'accio F, Kurata H, Polak J, Fisk NM. Comparative osteogenic transcription profiling of various fetal and adult mesenchymal stem cell sources. Differentiation 2008;76:946–57.
   PubMed Web of Science ®Google Scholar
• Manca MF, Zwart I, Beo J, Palasingham R, Jen LS, Navarrete R, . Characterization of mesenchymal stromal cells derived from full-term umbilical cord blood. Cytotherapy 2008;10:54–68.
   PubMed Web of Science ®Google Scholar
• Zhang ZY, Teoh SH, Chong MS, Schantz JT, Fisk NM, Choolani MA, . Superior osteogenic capacity for bone tissue engineering of fetal compared to perinatal and adult mesenchymal stem cells. Stem Cells (in press)
   Google Scholar
• Doucet C, Ernou I, Zhang Y, Llense JR, Begot L, Holy X, . Platelet lysates promote mesenchymal stem cell expansion: a safety substitute for animal serum in cell-based therapy applications. J Cell Physiol 2005;205:228–36.
   PubMed Web of Science ®Google Scholar
• Yokoyama M, Miwa H, Maeda S, Wakitani S, Takagi M. Influence of fetal calf serum on differentiation of mesenchymal stem cells to chondrocytes during expansion. J Biosci Bioeng 2008;106:46–50.
   PubMed Web of Science ®Google Scholar
• Romanov YA, Svintsitskaya VA, Smirnov VN. Searching for alternative sources of postnatal human mesenchymal stem cells: candidate MSC-like cells from umbilical cord. Stem Cells 2003;21:105–10.
   PubMed Web of Science ®Google Scholar
• Sarugaser R, Lickorish D, Baksh D, Hosseini MM, Davies JE. Human umbilical cord perivascular (HUCPV) cells: a source of mesenchymal progenitors. Stem Cells 2005;23:220–9.
   PubMed Web of Science ®Google Scholar
• Troyer DL, Weiss ML. Wharton's jelly-derived cells are a primitive stromal cell population. Stem Cells 2008;26:591–9.
   PubMed Web of Science ®Google Scholar
• Jiang Y, Vaessen B, Lenvik T, Blackstad M, Reyes M, Verfaillie CM. Multipotent progenitor cells can be isolated from postnatal murine bone marrow, muscle, and brain. Exp Hematol 2002;30:896–904.
   PubMed Web of Science ®Google Scholar
• Rebelatto CK, Aguiar AM, Moretao MP, Senegaglia AC, Hansen P, Barchiki F, . Dissimilar differentiation of mesenchymal stem cells from bone marrow, umbilical cord blood, and adipose tissue. Exp Biol Med (Maywood) 2008;233:901–13.
   PubMed Web of Science ®Google Scholar
• Le Blanc K, Tammik L, Sundberg B, Haynesworth SE, Ringden O. Mesenchymal stem cells inhibit and stimulate mixed lymphocyte cultures and mitogenic responses independently of the major histocompatibility complex. Scand J Immunol 2003;57:11–20.
   PubMed Web of Science ®Google Scholar
• Covas DT, Panepucci RA, Fontes AM, Silva WA Jr, Orellana MD, Freitas MC, . Multipotent mesenchymal stromal cells obtained from diverse human tissues share functional properties and gene-expression profile with CD146+ perivascular cells and fibroblasts. Exp Hematol 2008;36:642–54.
   PubMed Web of Science ®Google Scholar
• Le Blanc K, Frassoni F, Ball L, Locatelli F, Roelofs H, Lewis I, . Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study. Lancet 2008;371:1579–86.
   PubMed Web of Science ®Google Scholar
• Evangelista M, Soncini M, Parolini O. Placenta-derived stem cells: new hope for cell therapy? Cytotechnology 2008;58:33–42.
   PubMed Web of Science ®Google Scholar
• Wang HS, Hung SC, Peng ST, Huang CC, Wei HM, Guo YJ, . Mesenchymal stem cells in the Wharton's jelly of the human umbilical cord. Stem Cells 2004;22:1330–7.
   PubMed Web of Science ®Google Scholar
• Crisan M, Yap S, Casteilla L, Chen CW, Corselli M, Park TS, . A perivascular origin for mesenchymal stem cells in multiple human organs. Cell Stem Cell 2008;3:301–13.
   PubMed Web of Science ®Google Scholar
• Schwab KE, Gargett CE. Co-expression of two perivascular cell markers isolates mesenchymal stem-like cells from human endometrium. Hum Reprod 2007;22:2903–11.
   PubMed Web of Science ®Google Scholar
• Sacchetti B, Funari A, Michienzi S, Di Cesare S, Piersanti S, Saggio I, . Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment. Cell 2007;131:324–36.
   PubMed Web of Science ®Google Scholar
• Jiang Y, Jahagirdar BN, Reinhardt RL, Schwartz RE, Keene CD, Ortiz-Gonzalez XR, . Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 2002;418:41–9.
   PubMed Web of Science ®Google Scholar
• Sobolewski K, Malkowski A, Bankowski E, Jaworski S. Wharton's jelly as a reservoir of peptide growth factors. Placenta 2005;26:747–52.
   PubMed Web of Science ®Google Scholar
• Croft AP, Przyborski SA. Generation of neuroprogenitor-like cells from adult mammalian bone marrow stromal cells in vitro. Stem Cells Devel 2004;13:409–20.
   PubMedGoogle Scholar
• Amoh Y, Yang M, Li L, Reynoso J, Bouvet M, Moossa AR, . Nestin-linked green fluorescent protein transgenic nude mouse for imaging human tumor angiogenesis. Cancer Res 2005;65:5352–7.
   PubMed Web of Science ®Google Scholar
• Ulloa-Montoya F, Kidder BL, Pauwelyn KA, Chase LG, Luttun A, Crabbe A, . Comparative transcriptome analysis of embryonic and adult stem cells with extended and limited differentiation capacity. Genome Biol 2007;8:R163.
   Google Scholar
• Liu TM, Martina M, Hutmacher DW, Hui JH, Lee EH, Lim B. Identification of common pathways mediating differentiation of bone marrow-and adipose tissue-derived human mesenchymal stem cells into three mesenchymal lineages. Stem Cells 2007;25:750–60.
   PubMed Web of Science ®Google Scholar
• Phinney DG. Biochemical heterogeneity of mesenchymal stem cell populations: clues to their therapeutic efficacy. Cell Cycle 2007;6:2884–9.
   PubMed Web of Science ®Google Scholar
• Ackema KB, Charite J. Mesenchymal stem cells from different organs are characterized by distinct topographic Hox codes. Stem Cells Dev 2008;17:979–91.
   PubMed Web of Science ®Google Scholar
• Shahnazari M, Yao W, Corr M, Lane NE. Targeting the Wnt signaling pathway to augment bone formation. Curr Osteoporos Rep 2008;6:142–8.
   PubMedGoogle Scholar
• Kim YJ, Kim JT, Bae YC, Suh KT, Jung JS. ICAT participates in proliferation and osteogenic differentiation of human adipose tissue-derived mesenchymal stem cell. Life Sci 2008;83:851–8.
   PubMed Web of Science ®Google Scholar
• Bernardo ME, Avanzini MA, Perotti C, Cometa AM, Moretta A, Lenta E, . Optimization of in vitro expansion of human multipotent mesenchymal stromal cells for cell-therapy approaches: further insights in the search for a fetal calf serum substitute. J Cell Physiol 2007;211:121–30.
   PubMed Web of Science ®Google Scholar
• Haniffa MA, Wang XN, Holtick U, Rae M, Isaacs JD, Dickinson AM, Hilkens CM, Collin MP. Adult human fibroblasts are potent immunoregulatory cells and functionally equivalent to mesenchymal stem cells. J Immunol 2007;179:1595–604.
   PubMed Web of Science ®Google Scholar
• Jones S, Horwood N, Cope A, Dazzi F. The antiproliferative effect of mesenchymal stem cells is a fundamental property shared by all stromal cells. J Immunol 2007;179:2824–31.
   Google Scholar
• Ennis J, Gotherstrom C, Le Blanc K, Davies JE. In vitro immunologic properties of human umbilical cord perivascular cells. Cytotherapy 2008;10:174–81.
   PubMed Web of Science ®Google Scholar
• Weiss ML, Anderson C, Medicetty S, Seshareddy KB, Weiss RJ, VanderWerff I, . Immune properties of human umbilical cord Wharton's jelly-derived cells. Stem Cells 2008;26:2865–74.
   PubMed Web of Science ®Google Scholar
• Le Blanc K, Frassoni F, Ball L, Locatelli F, Roelofs H, Lewis I, . Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study. Lancet 2008;371:1579–86.
   PubMed Web of Science ®Google Scholar
• Nemeth K, Leelahavanichkul A, Yuen PS, Mayer B, Parmelee A, Doi K, . Bone marrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming of host macrophages to increase their interleukin-10 production. Nat Med 2008;15:42–9.
   PubMed Web of Science ®Google Scholar
• Karlsson H, Samarasinghe S, Ball LM, Sundberg B, Lankester AC, Dazzi F, . Mesenchymal stem cells exert differential effects on alloantigen and virus-specific T-cell responses. Blood 2008;112:532–41.
   PubMed Web of Science ®Google Scholar
• Ning H, Yang F, Jiang M, Hu L, Feng K, Zhang J, . The correlation between cotransplantation of mesenchymal stem cells and higher recurrence rate in hematologic malignancy patients: outcome of a pilot clinical study. Leukemia 2008;22:593–9.
   PubMed Web of Science ®Google Scholar