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Research Article

Telomerase activity and expression in adult human mesenchymal stem cells derived from amyotrophic lateral sclerosis individuals

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Pages 837-848 | Published online: 10 Nov 2009

References

  • Collins K, Mitchell JR. Telomerase in the human organism. Oncogene 2002;21:564–79.
  • Smogorzewska A, de Lange T. Regulation of telomerase by telomeric proteins. Annu Rev Biochem 2004;73:177–208.
  • Urquidi V, Tarin D, Goodison S. Role of telomerase in cell senescence and oncogenesis. Annu Rev Med 2000;51:65–79.
  • Cong Y, Shay J. Actions of human telomerase beyond telomeres. Cell Res 2008;18:725–32.
  • Swiggers S, Nibbeling H, Zeilemaker A, . Telomerase activity level, but not hTERT mRNA and hTR level, regulates telomere length in telomerase-reconstituted primary fibroblasts. Exp Cell Res 2004;297:434–43.
  • Masutomi K, Yu EY, Khurts S, . Telomerase maintains telomere structure in normal human cells. Cell 2003;114:241–53.
  • Stocum DL, Zupanc GK. Stretching the limits: stem cells in regeneration science. Dev Dyn 2008;237:3648–71.
  • Flores I, Benetti R, Blasco MA. Telomerase regulation and stem cell behavior. Curr Opin Cell Biol 2006;18:254–60.
  • Simonsen J, Rosada C, Serakinci N, . Telomerase expression extends the proliferative life-span and maintains the osteogenic potential of human bone marrow stromal cells. Nature Biotechnol 2002;20:592–6.
  • Zimmermann S, Voss M, Kaiser S, . Lack of telomerase activity in human mesenchymal stem cells. Leukemia 2003;17:1146–9.
  • Zimmermann S, Martens U. Telomeres, senescence, and hematopoietic stem cells. Cell Tissue Res 2008;331:79–90.
  • Zhao Y, Li J, Lan J, . Cell cycle dependent telomere regulation by telomerase in human bone marrow mesenchymal stem cells. Biochem Biophys Res Commun 2008;369:1114–9.
  • Hamada H, Kobune M, Nakamura K, . Mesenchymal stem cells (MSC) as therapeutic cytoreagents for gene therapy. Cancer Sci 2005;96:149–56.
  • Dominici M, Le Blanc K, Mueller I, . Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 2006;8:315–7.
  • Baxter MA, Wynn R, Jowitt S, . Study of telomere length reveals rapid aging of human marrow stromal cells following in vitro expansion. Stem Cells 2004;22:675–82.
  • Bocker W, Yin Z, Drosse I, . Introducing a single-cell-derived human mesenchymal stem cell line expressing hTERT after lentiviral gene transfer. J Cell Mol Med 2008;12:1347–59.
  • Deda H, Inci MC, Kurekci AE, . Treatment of amyotrophic lateral sclerosis patients by autologous bone marrow-derived hematopoietic stem cell transplantation: a 1-year follow-up. Cytotherapy 2009;11:18–25.
  • Mazzini L, Mareschi K, Ferrero I, . Stem cell treatment in amyotrophic lateral sclerosis. J Neurol Sci 2008;265:78–83.
  • Slavin S, Kurkalli B, Karussis D. The potential use of adult stem cells for the treatment of multiple sclerosis and other neurodegenerative disorders. Clin Neur Nerurosurg 2008;110:943–6.
  • Ferrero I, Mazzini L, Rustichelli D, . Bone marrow mesenchymal stem cells from healthy donors and sporadic amyotrophic lateral sclerosis patients. Cell Transplant 2008;17:255–66.
  • Li DC, Zhang WY, Li HL, . Mesenchymal stem cells derived from human placenta suppress allogeneic umbilical cord blood lymphocyte proliferation. Cell Res 2005;15:539–47.
  • Maxson S, Burg KJL. Conditioned media cause increases in select osteogenic and adipogenic differentiation markers in mesenchymal stem cell cultures. J Tissue Eng Regen Med 2008;2:147–54.
  • Auer B, Vosberg H, Buhre U, . Intracellular distribution of DNA topoisomerase I in fibroblast from patient with Fanconi's anemia. Hum Genet 1982;61:369–71.
  • Bendetz-Nezer S, Gazit A, Priel E. DNA topoisomerase I as one of the cellular targets of certain tyrphostin derivatives. Mol Pharmacol 2004;66:627–34.
  • Zehorai E, Eitan E, Hershfinkel M, . Glutamate regulates the activity of topoisomerase I in mouse cerebellum. Mol Neurobiol 2008;38:242–52.
  • Tirosh A, Potashnik R, Bashan N, . Oxidative stress disrupts insulin-induced cellular redistribution of insulin receptor substrate-1 and phosphatidylinositol 3-kinase in 3T3-L1 adipocytes. A putative cellular mechanism for impaired protein kinase B activation and GLUT4 translocation. J Biol Chem 1999;274:10595–602.
  • Kovsan J, Osnis A, Maissel A, . Depot-specific adipocyte cell lines reveal differential drug-induced responses of white adipocytes: relevance for partial lipodystrophy. Am J Physiol Endocrinol Metab 2009;296:E315–22.
  • Sambrook J, Fritch E, Maniatis T. Molecular cloning: A laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, 1989.
  • Kaufmann S, Svingen P. Immunoblot analysis and band depletion assays in DNA topoisomerase protocols, Vol. 1. Totowa, NJ: Humana Press Inc, 1999.
  • Fiaccavento R, Carotenuto F, Minieri M, . Stem cell activation sustains hereditary hypertrophy in hamster cardiomyopathy. J Pathol 2005;205:397–407.
  • Ishigami M, Swertfeger DK, Norman A, . Apolipoprotein E inhibits platelet-derived growth factor-induced vascular smooth muscle cell migration and proliferation by suppressing signal transduction and preventing cell entry to G1 phase. FEBS Lett 1996;273:20156–61.
  • Konnikova L, Simeone M, Kruger M, . Signal transducer and activator of transcription 3 (STAT3) regulates human telomerase reverse transcriptase (hTERT) expression in human cancer and primary cells. Cancer Res 2005;65:6516–20.
  • Chin R, Zhu M, Christiansen P, . Lymphotoxin pathway: directed, autoimmune regulator-independent central tolerance to arthritogenic collagen. J Immunol 2006;177:290–7.
  • Kim N, Piatyszek M, Prowse K, . Specific association of human telomerase activity with immortal cells and cancer. Science 1994;266:2011–5.
  • Pittenger M, Mackay A, Beck S, . Multilineage potential of adult human mesenchymal stem cells. Science 1999;284:143–7.
  • Horwitz E, Le Blanc K, Dominici M, . Clarification of the nomenclature for MSC: the International Society for Cellular Therapy position statement. Cytotherapy 2005;7:393–5.
  • Mariotti E, Mirabelli P, Abate G, . Comparative characteristics of mesenchymal stem cells from human bone marrow and placenta: CD10, CD49d, and CD56 make a difference. Stem Cells Dev 2008;17:1039–41.
  • Wagner W, Wein F, Seckinger A, . Comparative characteristics of mesenchymal stem cells from human bone marrow, adipose tissue, and umbilical cord blood. Exp Hematol 2005;33:1402–16.
  • Kastrinaki MC, Andreakou I, Charbord P, . Isolation of human bone marrow mesenchymal stem cells using different membrane markers: comparison of colony/cloning efficiency, differentiation potential, and molecular profile. Tissue Eng Part C Methods 2008;14:333–9.
  • Jiang XX, Zhang Y, Liu B, . Human mesenchymal stem cells inhibit differentiation and function of monocyte-derived dendritic cells. Blood 2005;105:4120–6.
  • Komata T, Kanzawa T, Kondo Y, . Telomerase as a therapeutic target for malignant gliomas. Oncogene 2002;21:656–63.
  • Kondo Y, Kondo S, Tanaka Y, . Inhibition of telomerase increases the susceptibility of human malignant glioblastoma cells to cisplatin-induced apoptosis. Oncogene 1998;16:2243–8.
  • Wu Y, Dudognon C, Nguyen E, . Immunodetection of human telomerase reverse-transcriptase (hTERT) re-appraised: nucleolin and telomerase cross paths. J Cell Sci 2006;119:2797–806.
  • Saeboe-Larssen S, Fossberg E, Gaudernack G. Characterization of novel alternative splicing sites in human telomerase reverse transcriptase (hTERT): analysis of expression and mutual correlation in mRNA isoforms from normal and tumour tissues. BMC Mol Biol 2006;7:26–35.
  • Reynoso R, Minces L, Salomon H, . HIV-1 infection downregulates nuclear telomerase activity on lymphoblastoic cells without affecting the enzymatic components at the transcriptional level. AIDS Res Hum Retroviruses 2006;22:425–9.
  • Bermundez Y, Erasso D, Johnson N, . Telomerase confers resistance to caspase-mediated apoptosis. Clin Interv Aging 2006;1:155–67.
  • Santos J, Meyer J, Van Houten B. Mitochondrial localization of telomerase as a determinant for hydrogen peroxide-induced mitochondrial DNA damage and apoptosis. Hum Mol Genet 2006;15:1757–68.doi:10.1093/hmg/ddl098
  • Sung Y, Choi Y, Cheong C, . The pleiotropy of telomerase against cell death. Mol Cells 2005;19:303–9.
  • Zhao C, Zhang C, Zhou S, . Human mesenchymal stromal cells ameliorate the phenotype of SOD1-G93A ALS mice. Cytotherapy 2007;9:414–26.
  • Passos J, Saretzki G, Von Zglinicki T. DNA damage in telomeres and mitochondria during cellular senescence: is there a connection?. Nucleic Acids Res 2007;35:7505–13.
  • Nergadze S, Santagostino M, Salzano A, . Contribution of telomerase RNA retrotranscription to DNA doublestrand break repair during mammalian genome evolution. Genome Biol 2007;8:R260–R260.13..
  • Lee J, Sung YH, Cheong C, . TERT promotes cellular and organismal survival independently of telomerase activity. Oncogene 2008;27:3754–60.

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