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Research Article

Ex vivo-expanded autologous bone marrow-derived mesenchymal stromal cells in human spinal cord injury/paraplegia: a pilot clinical study

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Pages 897-911 | Published online: 10 Nov 2009

References

  • Singh R, Sharma SC, Mittal R, Sharma A. Traumatic spinal cord injuries in Haryana: an epidemiological study. Indian J Comm Med 2003;XXV111:184–6.
  • Morrison SJ, Uchida N, Weissman IL. The biology of hematopoietic stem cells. Ann Rev Cell Dev Biol 1995;11:35–71.
  • Deans RJ, Moseley AM. Mesenchymal stem cells: biology and potential clinical uses. Exp Hematol 2000;28:875–84.
  • Bianco P, Riminucci M, Gronthos S, Robey PG. Bone marrow stromal stem cells: nature, biology and potential applications. Stem Cells 2001;19:180–92.
  • Hofstetter CP, Scharwz EJ, Hess D, Widenfalk JEL, Manira A, Prockop DJ, Olson L. Marrow stromal cells form guiding strands in the injured spinal cord and promote recovery. Proc Natl Acad Sci USA 2002;99:2199–204.
  • Qian L, Saltzman WM. Improving the expansion and neuronal differentiation of mesenchymal stem cells through culture surface modification. Biomaterials 2004;25:1331–7.
  • Dezawa M, Kanno H, Hoshino M, Cho H, Matsumoto N, Itokazu Y, . Specific induction of neuronal cells from bone marrow stromal cells and application for autologous transplantation. J Clin Invest 2004;113:1701–10.
  • Meirelles L, Da S, Caplan AI, Nardi NB. In search of the in vivo identity of mesenchymal stem cells. Stem Cells 2008;26:2287–99.
  • Satake K, Lou J, Lenke LG. Migration of mesenchymal stem cells through cerebrospinal fluid into injured spinal cord tissue. Spine 2004;29:1971–9.
  • Schultz SS. Adult stem cell application in spinal cord injury. Curr Drug Targets 2005;6:63–73.
  • Callera F, Nascimento RX. Delivery of autologous bone marrow precursor cells into the spinal cord via lumbar puncture technique in patients with spinal cord injury: a preliminary safety study. Exp Hematol 2006;34:130–1.
  • Kang KS, Kim SW, Oh YH, Yu JW, Kim KY, Park HK, . A 37-year-old spinal cord-injured female patient transplanted of multipotent stem cells from human UC blood, with improved sensory perception and mobility, both functionally and morphologically: a case study. Cytotherapy 2005;7:368–73.
  • Pal R, Hanwate M, Jan M, Totey S. Phenotypic and functional comparison of optimum culture conditions for upscaling of bone marrow-derived mesenchymal stem cells. J Tissue Eng Regen Med 2009;3:163–74.
  • Liu XZ, Xu XM, Hu R, Du C, Zhang SX, McDonald JW, . Neuronal and glial apoptosis after traumatic spinal cord injury. J Neurosci 1997;17:5395–406.
  • Sattler R, Xiong Z, Lu W, MacDonald JF, Tymianski M. Distinct role of synaptic and extrasynaptic NMDA receptors in excitotoxicity. J Neurosci 2000;20:22–33.
  • Fitch MT, Doller, C, Combs CK, Landreth GE, Silver J. Cellular and molecular mechanism of glial scarring and progressive cavitations: in vivo and in vitro analysis of inflammation-induced secondary injury after CNS trauma. J Neurosci 1999;19:8182–98.
  • Murphy JM, Dixon K, Beck S, Fabian D, Feldman A, Barry F. Reduced chondrogenic and adipogenic activity of mesenchymal stem cells from patients with advanced osteoarthritis. Arthritis Rheum 2002;46:704–13.
  • Callera F, de Melo CMTP. Magnetic resonance tracing of magnetically labeled autologous bone marrow CD34 (+) cells transplanted into the spinal cord via lumbar puncture technique in patients with chronic spinal cord injury: CD34 (+) cell migration into the injured site. Stem Cell Dev 2007;16:461–4.
  • Garcı'a R, Aguiar J, Alberti E, de la Cue'tara K, Pavo'n N. Bone marrow stromal cells produce nerve growth factor and glial cell line-derived neurotrophic factors. Biochem Biophys Res Commun 2004;316:753–4.
  • Deda H, Inci MC, Kürekçi AE, Kayihan K, Ozgün E, Ustünsoy GE, Kocabay S. Treatment of chronic spinal cord injured patients with autologous bone marrow-derived hematopoietic stem cell transplantation: 1-year follow-up. Cytotherapy 2008;10:565–74.
  • Rismanchi N, Floyd CL, Berman RF, Lyeth BG. Cell death and long-term maintenance of neuron-like state after differentiation of rat bone marrow stromal cells: a comparison of protocols. Brain Res 2003;991:46–55.
  • Naghdi M, Tiraihi T, Namin SAM, Arabkheradmand J. Transdifferentiation of bone marrow stromal cells into cholinergic neuronal phenotype: a potential source for cell therapy in spinal cord injury. Cytotherapy 2009;11:137–52.
  • Thompson FJ, Reier PJ, Uthman B, Mott S, Fessler RG, Behrman A, Trimble Mark, Anderson Douglas K, Wirth Edward D, . Neurophysiological assessment of the feasibility and safety of neural tissue transplantation in patients with syringomyelia. J Neurotrauma 2001;18:931–45.
  • Jones DG, Anderson ER, Galvin KA. Spinal cord regeneration: moving tentatively towards new perspectives. NeuroRehabilitation 2003;18:339–51.
  • Knoller N, Auerbach G, Fulga V, Zelig G, Attias J, Bakimer R, . Clinical experience using incubated autologous macrophages as a treatment for complete spinal cord injury: phase I study results. J Neurosurg Spine 2005;3:173–81.
  • Syková E, Jendelová P. Magnetic resonance tracking of implanted adult and embryonic stem cells in injured brain and spinal cord. Ann NY Acad Sci 2005;1049:146–60.
  • Deng YB, Liu Y, Zhu WB, Bi XB, Wang YZ, Ye MH, . The co-transplantation of human bone marrow stromal cells and embryo olfactory ensheathing cells as a new approach to treat spinal cord injury in a rat model. Cytotherapy 2008;106:551–64.
  • Bonilla S, Silva A, Valdés L, Geijo E, García-Verdugo JM, Martínez S. Functional neural stem cells derived from adult bone marrow. Neuroscience 2005;133:85–95.
  • Zurita M, Vaquero J, Oya S, Miguel M. Schwann cells induce neuronal differentiation of bone marrow stromal cells. Neuro-report 2005;16:505–8.
  • Qu Y, Vadivelu S, Choi L, Liu S, Lu A, Lewis B, . Neurons derived from embryonic stem (ES) cells resemble normal neurons in their vulnerability to excitotoxic death. Exp Neurol 2003;184:326–36.
  • Woodbury D, Schwarz EJ, Prockop DJ, Black IB. Adult rat and human bone marrow stromal cells differentiate into neurons. J Neurosci Res 2000;61:364–70.
  • Sanchez-Ramos J, Song S, Cardozo-Pelaez F, Hazzi C, Stedeford T, Willing A, . Adult bone marrow stromal cells differentiate into neural cells in vitro. Exp Neurol 2000;164:247–56.
  • Munoz-Elıas G, Woodbury D, Black IB. Marrow stromal cells, mitosis, and neuronal differentiation: stem cell and precursor functions. Stem Cells 2003;21:437–48.
  • Mackay-Sim F, Féron J, Cochrane L, Bassingthwaighte C, Bayliss W, Davies W, . Autologous olfactory ensheathing cell transplantation in human paraplegia: a 3-year clinical trial. Brain 2008;131:2376–86.
  • Ponomaryov T, Peled A, Petit I, Taichman RS, Habler L, Sandbank J, Arenzana-Seisdedos F, Magerus A, Caruz A, Fujii N, Nagler A, Lahav M, Szyper-Kravitz M, Zipori D, Lapidot T, . Induction of the chemokine stromal-derived factor-I following DNA damage improves human stem cell function. J Clin Invest 2000;106:1331–9.
  • Crigler L, Robey RC, Asawachaicharn A, Gaupp D, Phinney DG, . Human mesenchymal stem cell subpopulations express a variety of neuroregulatory molecules and promote neuronal cell survival and neuritogenesis. Exp Neurol 2006;198:54–64.
  • Horwitz EM, Dominici M. How do mesenchymal stromal cells exert their therapeutic benefit?. Cytotherapy 2008;10:771–4.

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