BMP12 and BMP13 gene transfer induce ligamentogenic differentiation in mesenchymal progenitor and anterior cruciate ligament cells

References

• Schoderbek RJ Jr, Treme GP, Miller MD. Bone-patella tendon-bone autograft anterior cruciate ligament reconstruction. Clin Sports Med. 2007;26:525–47.
   PubMedGoogle Scholar
• Lawhorn KW, Howell SM. Principles for using hamstring tendons for anterior cruciate ligament reconstruction. Clin Sports Med. 2007;26:567–85.
   PubMed Web of Science ®Google Scholar
• Anderson AF. Transepiphyseal replacement of the anterior cruciate ligament using quadruple hamstring grafts in skeletally immature patients. J Bone Joint Surg Am. 2004;86A (Suppl 1):201–9.
   Google Scholar
• Cooper JA Jr, Bailey LO, Carter JN, Castiglioni CE, Kofron MD, Ko FK, . Evaluation of the anterior cruciate ligament, medial collateral ligament, Achilles tendon and patellar tendon as cell sources for tissue-engineered ligament. Biomaterials. 2006;27:2747–54.
   PubMed Web of Science ®Google Scholar
• Gentleman E, Livesay GA, Dee KC, Nauman EA. Development of ligament-like structural organization and properties in cell-seeded collagen scaffolds in vitro. Ann Biomed Eng. 2006;34:726–36.
   PubMedGoogle Scholar
• Hairfield-Stein M, England C, Paek HJ, Gilbraith KB, Dennis R, Boland E, . Development of self-assembled, tissue-engineered ligament from bone marrow stromal cells. Tissue Eng. 2007;13:703–10.
   PubMedGoogle Scholar
• Heckmann L, Fiedler J, Mattes T, Brenner RE. Mesenchymal progenitor cells communicate via alpha and beta integrins with a three-dimensional collagen type I matrix. Cells Tissues Organs. 2006;182:143–54.
   PubMed Web of Science ®Google Scholar
• Laurencin CT, Freeman JW. Ligament tissue engineering: an evolutionary materials science approach. Biomaterials. 2005;26:7530–6.
   PubMed Web of Science ®Google Scholar
• Liu H, Fan H, Toh SL, Goh JC. A comparison of rabbit mesenchymal stem cells and anterior cruciate ligament fibroblasts responses on combined silk scaffolds. Biomaterials. 2008;29:1443–53.
   PubMed Web of Science ®Google Scholar
• Noth U, Schupp K, Heymer A, Kall S, Jakob F, Schutze N, . Anterior cruciate ligament constructs fabricated from human mesenchymal stem cells in a collagen type I hydrogel. Cytotherapy. 2005;7:447–55.
   PubMed Web of Science ®Google Scholar
• Murray MM, Forsythe B, Chen F, Lee SJ, Yoo JJ, Atala A, . The effect of thrombin on ACL fibroblast interactions with collagen hydrogels. J Orthop Res. 2006;24:508–15.
   PubMed Web of Science ®Google Scholar
• Kuo CK, Tuan RS. Mechanoactive tenogenic differentiation of human mesenchymal stem cells. Tissue Eng Part A. 2008; 14:1615–27.
   PubMed Web of Science ®Google Scholar
• Altman GH, Horan RL, Martin I, Farhadi J, Stark PR, Volloch V, . Cell differentiation by mechanical stress. FASEB J. 2002;16:270–2.
   PubMed Web of Science ®Google Scholar
• Redden RA, Doolin EJ. Collagen crosslinking and cell density have distinct effects on fibroblast-mediated contraction of collagen gels. Skin Res Technol. 2003;9:290–3.
   PubMedGoogle Scholar
• Evans CH. Cytokines and the role they play in the healing of ligaments and tendons. Sports Med. 1999;28:71–6.
   PubMed Web of Science ®Google Scholar
• Fu SC, Wong YP, Chan BP, Pau HM, Cheuk YC, Lee KM, . The roles of bone morphogenetic protein (BMP) 12 in stimulating the proliferation and matrix production of human patellar tendon fibroblasts. Life Sci. 2003;72:2965–74.
   PubMed Web of Science ®Google Scholar
• Heckmann L, Schlenker HJ, Fiedler J, Brenner R, Dauner M, Bergenthal G, . Human mesenchymal progenitor cell responses to a novel textured poly(L-lactide) scaffold for ligament tissue engineering. J Biomed Mater Res B Appl Biomater. 2007;81:82–90.
   PubMedGoogle Scholar
• Jenner JM, van Eijk F, Saris DB, Willems WJ, Dhert WJ, Creemers LB. Effect of transforming growth factor-beta and growth differentiation factor-5 on proliferation and matrix production by human bone marrow stromal cells cultured on braided poly lactic-co-glycolic acid scaffolds for ligament tissue engineering. Tissue Eng. 2007;13:1573–82.
   PubMedGoogle Scholar
• Molloy T, Wang Y, Murrell G. The roles of growth factors in tendon and ligament healing. Sports Med. 2003;33:381–94.
   PubMed Web of Science ®Google Scholar
• Tsai AD, Yeh LC, Lee JC. Effects of osteogenic protein-1 (OP-1, BMP-7) on gene expression in cultured medial collateral ligament cells. J Cell Biochem. 2003;90:777–91.
   PubMedGoogle Scholar
• Helm GA, Li JZ, Alden TD, Hudson SB, Beres EJ, Cunningham M, . A light and electron microscopic study of ectopic tendon and ligament formation induced by bone morphogenetic protein-13 adenoviral gene therapy. J Neurosurg. 2001;95:298–307.
   PubMed Web of Science ®Google Scholar
• Wolfman NM, Hattersley G, Cox K, Celeste AJ, Nelson R, Yamaji N, . Ectopic induction of tendon and ligament in rats by growth and differentiation factors 5, 6, and 7, members of the TGF-beta gene family. J Clin Invest. 1997; 100:321–30.
   PubMed Web of Science ®Google Scholar
• Aspenberg P, Forslund C. Enhanced tendon healing with GDF 5 and 6. Acta Orthop Scand. 1999;70:51–4.
   PubMed Web of Science ®Google Scholar
• Lou J, Tu Y, Burns M, Silva MJ, Manske P. BMP-12 gene transfer augmentation of lacerated tendon repair. J Orthop Res. 2001;19:1199–202.
   PubMed Web of Science ®Google Scholar
• Rickert M, Jung M, Adiyaman M, Richter W, Simank HG. A growth and differentiation factor-5 (GDF-5)-coated suture stimulates tendon healing in an Achilles tendon model in rats. Growth Factors. 2001;19:115–26.
   PubMed Web of Science ®Google Scholar
• Majewski M, Betz O, Ochsner PE, Liu F, Porter RM, Evans CH. Ex vivo adenoviral transfer of bone morphogenetic protein 12 (BMP-12) cDNA improves Achilles tendon healing in a rat model. Gene Ther. 2008;15:1139–46.
   PubMed Web of Science ®Google Scholar
• Palmer G, Gouze E, Gouze JN, Betz O, Evans CH, Ghivizzani SC. Gene transfer to articular chondrocytes with recombinant adenovirus. Methods Mol Biol. 2003;215: 235–46.
   PubMedGoogle Scholar
• Haynesworth SE, Goshima J, Goldberg VM, Caplan AI. Characterization of cells with osteogenic potential from human marrow. Bone. 1992;13:81–8.
   PubMed Web of Science ®Google Scholar
• Noth U, Osyczka AM, Tuli R, Hickok NJ, Danielson KG, Tuan RS. Multilineage mesenchymal differentiation potential of human trabecular bone-derived cells. J Orthop Res. 2002;20:1060–9.
   PubMed Web of Science ®Google Scholar
• Chen G, Sato T, Sakane M, Ohgushi H, Ushida T, Tanaka J, . Application of PLGA-collagen hybrid mesh for three-dimensional culture of canine anterior cruciate ligament cells. Mat Sci Engineer C. 2004;24:861–6.
   Web of Science ®Google Scholar
• Steinert AF, Weber M, Kunz M, Palmer GD, Noth U, Evans CH, . In situ IGF-1 gene delivery to cells emerging from the injured anterior cruciate ligament. Biomaterials. 2008; 29:904–16.
   PubMedGoogle Scholar
• Martin SJ, Reutelingsperger CP, McGahon AJ, Rader JA, van Schie RC, LaFace DM, . Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl. J Exp Med. 1995;182:1545–56.
   PubMed Web of Science ®Google Scholar
• Pascher A, Steinert AF, Palmer GD, Betz O, Gouze JN, Gouze E, . Enhanced repair of the anterior cruciate ligament by in situ gene transfer: evaluation in an in vitro model. Mol Ther. 2004;10:327–36.
   PubMed Web of Science ®Google Scholar
• Murray MM, Spindler KP, Ballard P, Welch TP, Zurakowski D, Nanney LB. Enhanced histologic repair in a central wound in the anterior cruciate ligament with a collagen-platelet-rich plasma scaffold. J Orthop Res. 2007;25:1007–17.
   PubMed Web of Science ®Google Scholar
• Heckmann L, Fiedler J, Mattes T, Dauner M, Brenner RE. Interactive effects of growth factors and three-dimensional scaffolds on multipotent mesenchymal stromal cells. Biotechnol Appl Biochem. 2008;49:185–94.
   PubMedGoogle Scholar
• Forslund C, Aspenberg P. Tendon healing stimulated by injected CDMP-2. Med Sci Sports Exerc. 2001;33:685–7.
   PubMed Web of Science ®Google Scholar
• Hoffmann A, Gross G. Tendon and ligament engineering: from cell biology to in vivo application. Regen Med. 2006; 1:563–74.
   PubMedGoogle Scholar
• Hoffmann A, Pelled G, Turgeman G, Eberle P, Zilberman Y, Shinar H, . Neotendon formation induced by manipulation of the Smad8 signalling pathway in mesenchymal stem cells. J Clin Invest. 2006;116:940–52.
   PubMed Web of Science ®Google Scholar
• Murchison ND, Price BA, Conner DA, Keene DR, Olson EN, Tabin CJ, . Regulation of tendon differentiation by scleraxis distinguishes force-transmitting tendons from muscle-anchoring tendons. Development. 2007;134:2697–708.
   PubMed Web of Science ®Google Scholar
• Schweitzer R, Chyung JH, Murtaugh LC, Brent AE, Rosen V, Olson EN, . Analysis of the tendon cell fate using Scleraxis, a specific marker for tendons and ligaments. Development. 2001;128:3855–66.
   PubMed Web of Science ®Google Scholar
• Docheva D, Hunziker EB, Fassler R, Brandau O. Tenomodulin is necessary for tenocyte proliferation and tendon maturation. Mol Cell Biol. 2005;25:699–705.
   PubMed Web of Science ®Google Scholar