Human bone marrow-derived mesenchymal cells differentiate and mature into endocrine pancreatic lineage in vivo

References

• Dy EC, Harlan DM, Rother KI. Assessment of islet function following islet and pancreas transplantation. Curr Diab Rep. 2006 Aug;6(4):316–22.
   PubMedGoogle Scholar
• Matsumoto S, Okitsu T, Iwanaga Y, Noguchi H, Nagata H, Yonekawa Y, . Insulin independence after living-donor distal pancreatectomy and islet allotransplantation. Lancet. 2005 May 7–13;365(9471):1642–4.
   PubMedGoogle Scholar
• Harlan DM, Rother KI. Islet transplantation as a treatment for diabetes. N Engl J Med. 2004 May 13;350(20):2104; author reply
   PubMedGoogle Scholar
• Shapiro J, Ryan E, Warnock GL, Kneteman NM, Lakey J, Korbutt GS, . Could fewer islet cells be transplanted in type 1 diabetes? Insulin independence should be dominant force in islet transplantation. BMJ. 2001 Apr 7;322(7290):861.
   PubMedGoogle Scholar
• Gershengorn MC, Hardikar AA, Wei C, Geras-Raaka E, Marcus-Samuels B, Raaka BM. Epithelial- to-mesenchymal transition generates proliferative human islet precursor cells. Science. 2004 Dec 24;306(5705):2261–4.
   PubMedGoogle Scholar
• Joglekar MV, Joglekar VM, Joglekar SV, Hardikar AA. Human fetal pancreatic insulin-producing cells proliferate in vitro. J Endocrinol. 2009 Apr;201(1):27–36.
   PubMedGoogle Scholar
• Russ HA, Bar Y, Ravassard P, Efrat S. In vitro proliferation of cells derived from adult human beta-cells revealed by cell-lineage tracing. Diabetes. 2008 Jun;57(6):1575–83.
   PubMedGoogle Scholar
• D'Amour KA, Bang AG, Eliazer S, Kelly OG, Agulnick AD, Smart NG, . Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. Nat Biotechnol. 2006 Nov;24(11):1392–401.
   PubMed Web of Science ®Google Scholar
• Jiang W, Shi Y, Zhao D, Chen S, Yong J, Zhang J, . In vitro derivation of functional insulin-producing cells from human embryonic stem cells. Cell Res. 2007 Apr;17(4):333–44.
   PubMed Web of Science ®Google Scholar
• Kroon E, Martinson LA, Kadoya K, Bang AG, Kelly OG, Eliazer S, . Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo. Nat Biotechnol. 2008 Apr;26(4): 443–52.
   PubMed Web of Science ®Google Scholar
• Ianus A, Holz GG, Theise ND, Hussain MA. In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion. J Clin Invest. 2003 Mar;111(6):843–50.
   PubMed Web of Science ®Google Scholar
• Moriscot C, de Fraipont F, Richard MJ, Marchand M, Savatier P, Bosco D, . Human bone marrow mesenchymal stem cells can express insulin and key transcription factors of the endocrine pancreas developmental pathway upon genetic and/or microenvironmental manipulation in vitro. Stem Cells. 2005 Apr;23(4):594–603.
   PubMedGoogle Scholar
• Sapir T, Shternhall K, Meivar-Levy I, Blumenfeld T, Cohen H, Skutelsky E, . Cell-replacement therapy for diabetes: Generating functional insulin-producing tissue from adult human liver cells. Proc Natl Acad Sci USA. 2005 May 31; 102(22):7964–9.
   PubMedGoogle Scholar
• Zalzman M, Anker-Kitai L, Efrat S. Differentiation of human liver-derived, insulin-producing cells toward the beta-cell phenotype. Diabetes. 2005 Sep;54(9):2568–75.
   PubMed Web of Science ®Google Scholar
• Chandra V, Swetha G, Phadnis S, Nair PD, Bhonde RR. Generation of pancreatic hormone-expressing islet-like cell aggregates from murine adipose tissue-derived stem cells. Stem Cells. 2009 Aug;27(8):1941–53.
   PubMed Web of Science ®Google Scholar
• Bonner-Weir S, Taneja M, Weir GC, Tatarkiewicz K, Song KH, Sharma A, . In vitro cultivation of human islets from expanded ductal tissue. Proc Natl Acad Sci USA. 2000 Jul 5;97(14):7999–8004.
   PubMedGoogle Scholar
• Parekh VS, Joglekar MV, Hardikar AA. Differentiation of human umbilical cord blood-derived mononuclear cells to endocrine pancreatic lineage. Differentiation. 2009 Nov;78(4): 232–40.
   PubMedGoogle Scholar
• Choi JB, Uchino H, Azuma K, Iwashita N, Tanaka Y, Mochizuki H, . Little evidence of transdifferentiation of bone marrow-derived cells into pancreatic beta cells. Diabetologia. 2003 Oct;46(10):1366–74.
   PubMedGoogle Scholar
• Hasegawa Y, Ogihara T, Yamada T, Ishigaki Y, Imai J, Uno K, . Bone marrow (BM) transplantation promotes beta-cell regeneration after acute injury through BM cell mobilization. Endocrinology. 2007 May;148(5):2006–15.
   PubMedGoogle Scholar
• Kojima H, Fujimiya M, Matsumura K, Nakahara T, Hara M, Chan L. Extrapancreatic insulin- producing cells in multiple organs in diabetes. Proc Natl Acad Sci USA. 2004 Feb 24;101(8):2458–63.
   PubMedGoogle Scholar
• Lechner A, Yang YG, Blacken RA, Wang L, Nolan AL, Habener JF. No evidence for significant transdifferentiation of bone marrow into pancreatic beta-cells in vivo. Diabetes. 2004 Mar;53(3):616–23.
   PubMedGoogle Scholar
• Mathews V, Hanson PT, Ford E, Fujita J, Polonsky KS, Graubert TA. Recruitment of bone marrow- derived endothelial cells to sites of pancreatic beta-cell injury. Diabetes. 2004 Jan;53(1): 91–8.
   PubMedGoogle Scholar
• Ai C, Todorov I, Slovak ML, Digiusto D, Forman SJ, Shih CC. Human marrow-derived mesodermal progenitor cells generate insulin-secreting islet-like clusters in vivo. Stem Cells Dev. 2007 Oct;16(5):757–70.
   PubMedGoogle Scholar
• Lee RH, Seo MJ, Reger RL, Spees JL, Pulin AA, Olson SD, . Multipotent stromal cells from human marrow home to and promote repair of pancreatic islets and renal glomeruli in diabetic NOD/scid mice. Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17438–43.
   PubMed Web of Science ®Google Scholar
• Hess D, Li L, Martin M, Sakano S, Hill D, Strutt B, . Bone marrow-derived stem cells initiate pancreatic regeneration. Nat Biotechnol. 2003 Jul;21(7):763–70.
   PubMed Web of Science ®Google Scholar
• Ende N, Chen R, Reddi AS. Transplantation of human umbilical cord blood cells improves glycemia and glomerular hypertrophy in type 2 diabetic mice. Biochem Biophys Res Commun. 2004 Aug 13;321(1):168–71.
   PubMedGoogle Scholar
• Banerjee M, Kumar A, Bhonde RR. Reversal of experimental diabetes by multiple bone marrow transplantation. Biochem Biophys Res Commun. 2005 Mar 4;328(1):318–25.
   PubMedGoogle Scholar
• Li Y, Zhang R, Qiao H, Zhang H, Wang Y, Yuan H, . Generation of insulin-producing cells from PDX-1 gene-modified human mesenchymal stem cells. J Cell Physiol. 2007 Apr;211(1):36–44.
   PubMed Web of Science ®Google Scholar
• Karnieli O, Izhar-Prato Y, Bulvik S, Efrat S. Generation of insulin-producing cells from human bone marrow mesenchymal stem cells by genetic manipulation. Stem Cells. 2007 Nov;25(11):2837–44.
   PubMed Web of Science ®Google Scholar
• Tang DQ, Cao LZ, Burkhardt BR, Xia CQ, Litherland SA, Atkinson MA, . In vivo and in vitro characterization of insulin-producing cells obtained from murine bone marrow. Diabetes. 2004 Jul;53(7):1721–32.
   PubMedGoogle Scholar
• Chen LB, Jiang XB, Yang L. Differentiation of rat marrow mesenchymal stem cells into pancreatic islet beta-cells. World J Gastroenterol. 2004 Oct 15;10(20):3016–20.
   PubMedGoogle Scholar
• D'Ippolito G, Diabira S, Howard GA, Menei P, Roos BA, Schiller PC. Marrow-isolated adult multilineage inducible (MIAMI) cells, a unique population of postnatal young and old human cells with extensive expansion and differentiation potential. J Cell Sci. 2004 Jun 15;117(Pt 14):2971–81.
   PubMedGoogle Scholar
• Sun Y, Chen L, Hou XG, Hou WK, Dong JJ, Sun L, . Differentiation of bone marrow-derived mesenchymal stem cells from diabetic patients into insulin-producing cells in vitro. Chin Med J (Engl). 2007 May 5;120(9):771–6.
   PubMedGoogle Scholar
• Choi KS, Shin JS, Lee JJ, Kim YS, Kim SB, Kim CW. In vitro trans-differentiation of rat mesenchymal cells into insulin-producing cells by rat pancreatic extract. Biochem Biophys Res Commun. 2005 May 20;330(4):1299–305.
   PubMedGoogle Scholar
• Phadnis SM, Joglekar MV, Venkateshan V, Ghaskadbi SM, Hardikar AA, Bhonde RR. Human umbilical cord blood serum promotes growth, proliferation, as well as differentiation of human bone marrow-derived progenitor cells. In Vitro Cell Dev Biol Anim. 2006 Nov-Dec;42(10):283–6.
   PubMedGoogle Scholar
• Hardikar AA, Karandikar MS, Bhonde RR. Effect of partial pancreatectomy on diabetic status in BALB/c mice. J Endocrinol. 1999 Aug;162(2):189–95.
   PubMedGoogle Scholar
• Nair PD, inventor. India patent Indian Patent No 230740 2009.
   Google Scholar
• George S, Nair PD, Risbud MV, Bhonde RR. Nonporous polyurethane membranes as islet immunoisolation matrices—biocompatibility studies. J Biomater Appl. 2002 Apr;16(4):327–40.
   PubMedGoogle Scholar
• Kadam SS, Sudhakar M, Nair PD, Bhonde RR. Reversal of experimental diabetes in mice by transplantation of neo-islets generated from human amnion-derived mesenchymal stromal cells using immuno-isolatory macrocapsules. Cytotherapy. 2010 Aug 31.
   PubMedGoogle Scholar
• Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, . Multilineage potential of adult human mesenchymal stem cells. Science. 1999 Apr 2;284(5411):143–7.
   PubMed Web of Science ®Google Scholar
• Wen JH, Chen YY, Song SJ, Ding J, Gao Y, Hu QK, . Paired box 6 (PAX6) regulates glucose metabolism via proinsulin processing mediated by prohormone convertase 1/3 (PC1/3). Diabetologia. 2009 Mar;52(3):504–13.
   PubMedGoogle Scholar
• Drucker DJ, Jin T, Asa SL, Young TA, Brubaker PL. Activation of proglucagon gene transcription by protein kinase-A in a novel mouse enteroendocrine cell line. Mol Endocrinol. 1994 Dec;8(12):1646–55.
   PubMedGoogle Scholar
• Wideman RD, Covey SD, Webb GC, Drucker DJ, Kieffer TJ. A switch from prohormone convertase (PC)-2 to PC1/3 expression in transplanted alpha-cells is accompanied by differential processing of proglucagon and improved glucose homeostasis in mice. Diabetes. 2007 Nov;56(11):2744–52.
   PubMed Web of Science ®Google Scholar
• Ritz-Laser B, Mamin A, Brun T, Avril I, Schwitzgebel VM, Philippe J. The zinc finger-containing transcription factor Gata-4 is expressed in the developing endocrine pancreas and activates glucagon gene expression. Mol Endocrinol. 2005 Mar;19(3):759–70.
   PubMedGoogle Scholar
• Decker K, Goldman DC, Grasch CL, Sussel L. Gata6 is an important regulator of mouse pancreas development. Dev Biol. 2006 Oct 15;298(2):415–29.
   PubMedGoogle Scholar
• Sordi V, Malosio ML, Marchesi F, Mercalli A, Melzi R, Giordano T, . Bone marrow mesenchymal stem cells express a restricted set of functionally active chemokine receptors capable of promoting migration to pancreatic islets. Blood. 2005 Jul 15;106(2):419–27.
   PubMed Web of Science ®Google Scholar
• Hardikar AA, Marcus-Samuels B, Geras-Raaka E, Raaka BM, Gershengorn MC. Human pancreatic precursor cells secrete FGF2 to stimulate clustering into hormone-expressing islet-like cell aggregates. Proc Natl Acad Sci USA. 2003 Jun 10;100(12):7117–22.
   PubMedGoogle Scholar
• Draberova E, del Valle L, Gordon J, Markova V, Smejkalova B, Bertrand L, . Class III beta- tubulin is constitutively coexpressed with glial fibrillary acidic protein and nestin in midgestational human fetal astrocytes: implications for phenotypic identity. J Neuropathol Exp Neurol. 2008 Apr;67(4):341–54.
   PubMedGoogle Scholar
• Joglekar MV, Patil D, Joglekar VM, Rao GV, Reddy DN, Sasikala M, . The miR-30 Family microRNAs Confer Epithelial Phenotype to Human Pancreatic Cells. Islets. 2009; 1(2):1–11.
   PubMedGoogle Scholar
• Davani B, Ikonomou L, Raaka BM, Geras-Raaka E, Morton RA, Marcus-Samuels B, . Human islet-derived precursor cells are mesenchymal stromal cells that differentiate and mature to hormone-expressing cells in vivo. Stem Cells. 2007 Dec;25(12):3215–22.
   PubMedGoogle Scholar
• Hardikar AA, Wang XY, Williams LJ, Kwok J, Wong R, Yao M, . Functional maturation of fetal porcine beta-cells by glucagon-like peptide 1 and cholecystokinin. Endocrinology. 2002 Sep;143(9):3505–14.
   PubMedGoogle Scholar
• Hardikar AA, Bhonde RR. Modulating experimental diabetes by treatment with cytosolic extract from the regenerating pancreas. Diabetes Res Clin Pract. 1999 Dec;46(3):203–11.
   PubMedGoogle Scholar
• Elsner M, Tiedge M, Lenzen S. Mechanism underlying resistance of human pancreatic beta cells against toxicity of streptozotocin and alloxan. Diabetologia. 2003 Dec;46(12):1713–4.
   PubMedGoogle Scholar
• Yang H, Wright JR, Jr. Human beta cells are exceedingly resistant to streptozotocin in vivo. Endocrinology. 2002 Jul;143(7):2491–5.
   PubMedGoogle Scholar
• Rajagopal J, Anderson WJ, Kume S, Martinez OI, Melton DA. Insulin staining of ES cell progeny from insulin uptake. Science. 2003 Jan 17;299(5605):363.
   PubMed Web of Science ®Google Scholar
• Liu WD, Wang HW, Muguira M, Breslin MB, Lan MS. INSM1 functions as a transcriptional repressor of the neuroD/beta2 gene through the recruitment of cyclin D1 and histone deacetylases. Biochem J. 2006 Jul 1;397(1):169–77.
   PubMedGoogle Scholar
• Phadnis SM, Ghaskadbi SM, Hardikar AA, Bhonde RR. Mesenchymal stem cells derived from bone marrow of diabetic patients portrait unique markers influenced by the diabetic microenvironment. Rev Diabet Stud. 2009 Winter;6(4):260–70.
   PubMedGoogle Scholar
• Zhao M, Amiel SA, Ajami S, Jiang J, Rela M, Heaton N, . Amelioration of streptozotocin- induced diabetes in mice with cells derived from human marrow stromal cells. PLoS One. 2008;3(7):e2666.
   Google Scholar
• Haumaitre C, Lenoir O, Scharfmann R. Histone deacetylase inhibitors modify pancreatic cell fate determination and amplify endocrine progenitors. Mol Cell Biol. 2008 Oct;28(20):6373–83.
   PubMedGoogle Scholar