Initial phase I safety of retrovirally transduced human chondrocytes expressing transforming growth factor-beta-1 in degenerative arthritis patients

References

• Murray CJL, Lopez AD. The Global Burden of Disease: A Comprehensive Assessment of Mortality and Disability from Disease, Injury and Risk Factors in 1990 and Projected to 2020. World Health Organization. Cambridge, MA: Harvard University Press; 1996.
   Google Scholar
• Mankin HJ. The response of articular cartilage to mechanical injury. J Bone Joint Surg Am. 1982;64:460–6.
   PubMed Web of Science ®Google Scholar
• Zegzula HD, Buck DC, Brekke J, Wozney JM, Hollinger, JO. Bone formation with use of rhBMP-2 (recombinant human bone morphogenetic protein-2). J Bone Joint Surg Am. 1997; 79:1778–90.
   PubMed Web of Science ®Google Scholar
• Louwerse RT, Heyleger IC, Klein-Nulend J, Sugihara S, van Kampen GP, Semeins CM, . Use of recombinant human osteogenic protein-1 for the repair of subchondral defects in articular cartilage in goats. J Biomed Mater Res. 2000;49: 506–16.
   PubMedGoogle Scholar
• Sellers RS, Zhang R, Glasson SS, Kim HD, Peluso D, D'Augusta DA, . Repair of articular cartilage defects one year after treatment with recombinant human bone morphogenetic protein-2 (rhBMP-2). J Bone Joint Surg Am. 2000;82: 151–60.
   PubMedGoogle Scholar
• Sporn MB, Roberts AB. Peptide growth factors are multifunctional. Nature 1988;332:217–9.
   PubMed Web of Science ®Google Scholar
• Joyce ME, Roberts AB, Sporn MD, Bolander ME. Transforming growth factor-β and the initiation of chondrogenesis and osteogenesis in the rat femur. J Cell Biol 1990;110: 2195–207.
   PubMed Web of Science ®Google Scholar
• van Beuningen HM, van der Kraan PM, Arntz OJ, van den Berg WB. Transforming growth factor-β1 stimulates articular chondrocyte proteoglycan synthesis and induces osteophyte formation in the murine knee joint. Lab Invest. 1994;71: 279–90.
   PubMed Web of Science ®Google Scholar
• van Osch GJ, van der Veen SW, Buma P, Verwoerd-Verhoef HL. Effect of transforming growth factor-β on proteoglycan synthesis by chondrocytes in relation to differentiation stage and the presence of pericellular matrix. Matrix Biol. 1998;17: 413–24.
   PubMed Web of Science ®Google Scholar
• Yonekura A, Osaki M, Hirota Y, Tsukazaki T, Miyazaki Y, Matsumoto T, . Transforming growth factor-β stimulates articular chondrocyte cell growth through p44/42 MAP kinase (ERK) activation. Endocr J. 1999;46:545–53.
   PubMed Web of Science ®Google Scholar
• Morales TI, Roberts AB. Transforming growth factor β regulates the metabolism of proteoglycans in bovine cartilage organ cultures. J Biol Chem. 1988;263:12828–31.
   PubMed Web of Science ®Google Scholar
• Redini F, Daireaux M, Mauviel A, Galera P, Loyau G, Pujol JP. Characterization of proteoglycans synthesized by rabbit articular chondrocytes in response to transforming growth factor-beta (TGF-β). Biochim Biophys Acta. 1991; 1093:196–206.
   PubMedGoogle Scholar
• Roberts AB, Sporn MB. Physiological actions and clinical applications of transforming growth factor-beta (TGF- β). Growth Factors. 1993;8:1–9.
   PubMed Web of Science ®Google Scholar
• Lind M, Schumacker B, Soballe K, Keller J, Melsen F, Bunger C. Transforming growth factor-β enhances fracture healing in rabbit tibiae. Acta Orthop Scand. 1993;64:553–6.
   PubMed Web of Science ®Google Scholar
• Critchlow MA, Bland YS, Ashhurst DE. The effect of exogenous transforming growth factor-β2 on healing fractures in the rabbit. Bone. 1995;16:521–7.
   PubMed Web of Science ®Google Scholar
• Ripamonti U, Duneas N, van den Heever B, Bosch C, Crooks J. Recombinant transforming growth factor-β1 induces endochondral bone in the baboon and synergizes with recombinant osteogenic protein-1 (bone morphogenetic protein-7) to initiate rapid bone formation. J Bone Miner Res. 1997;12: 1584–95.
   PubMed Web of Science ®Google Scholar
• Glansbeek HL, van Beuningen HM, Vitters EL, van der Kraan PM, van den Berg WB. Stimulation of articular cartilage repair in established arthritis by administration of transforming growth factor-β into murine knee joints. Lab Invest. 1998;78:133–42.
   PubMed Web of Science ®Google Scholar
• Lee KH, Song SU, Hwang TS, Yi Y, Oh IS, Lee JY, . Regeneration of hyaline cartilage by cell-mediated gene therapy using transforming growth factor β1-producing fibroblasts. Hum Gene Ther. 2001;12:1805–13.
   PubMed Web of Science ®Google Scholar
• Lee DK, Choi KB, Oh IS, Song SU, Hwang S, Lim CL, . Continuous transforming growth factor beta1 secretion by cell-mediated gene therapy maintains chondrocyte redifferentiation. Tissue Eng. 2005;11:310–8.
   PubMedGoogle Scholar
• Song SU, Cha YD, Han JU, Oh IS, Choi KB, Yi Y, . Hyaline cartilage regeneration using mixed human chondrocytes and transforming growth factor-β1-producing chondrocytes. Tissue Eng. 2005;11:1516–26.
   PubMedGoogle Scholar
• Kellgren JH, Lawrence JS. Radiological assessment of osteoarthritis. Ann Rheum Dis. 1957;16:494–501.
   PubMed Web of Science ®Google Scholar
• Brittberg M, Winalski CS. Evaluation of cartilage injuries and repairs. J Bone Joint Surg Am. 2003;85:58–69.
   PubMed Web of Science ®Google Scholar
• Insall JN, Dorr LD, Scott RD, Scott WN. Rationale of the knee society clinical rating system. Clin Orthop. 1989;248:13–14.
   PubMed Web of Science ®Google Scholar
• Brittberg M, Lindahl A, Nilsson A, Ohlsson C, Isaksson O, Peterson L. Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N Engl J Med. 1994;331:889–95.
   PubMed Web of Science ®Google Scholar
• Peterson L, Brittberg M, Kiviranta I, Akerlund EL, Lindahl A. Autologous chondrocyte transplantation. Biomechanics and long-term durability. Am J Sports Med. 2002:30:2–12.
   PubMed Web of Science ®Google Scholar