Cell-based therapy for epithelial wounds

References

• D'Ippolito G, Diabira S, Howard GA, Roos BA, Schiller PC. Low oxygen tension inhibits osteogenic differentiation and enhances stemness of human MIAMI cells. Bone. 2006;39:513–22.
   PubMed Web of Science ®Google Scholar
• Grayson WL, Zhao F, Bunnell B, Ma T. Hypoxia enhances proliferation and tissue formation of human mesenchymal stem cells. Biochem Biophys Res Commun. 2007;358:948–53.
   PubMed Web of Science ®Google Scholar
• Grayson WL, Zhao F, Izadpanah R, Bunnell B, Ma T. Effects of hypoxia on human mesenchymal stem cell expansion and plasticity in 3D constructs. J Cell Physiol. 2006;207:331–9.
   PubMed Web of Science ®Google Scholar
• Ma T, Grayson WL, Frohlich M, Vunjak-Novakovic G. Hypoxia and stem cell-based engineering of mesenchymal tissues. Biotechnol Prog. 2009;25:32–42.
   PubMed Web of Science ®Google Scholar
• Santos FD, Andrade PZ, Boura JS, Abecasis MM, Silva CLD, Cabral JMS. Ex vivo expansion of human mesenchymal stem cells: a more effective cell proliferation kinetics and metabolism under hypoxia. J Cell Physiol. 2010;223:27–35.
   PubMedGoogle Scholar
• Simon MC, Keith B. The role of oxygen availability in embryonic development and stem cell function. Nat Rev Mol Cell Biol. 2008;9:285–96.
   PubMed Web of Science ®Google Scholar
• Fehrer C, Brunauer R, Laschober G, Unterluggauer H, Reitinger S, Kloss F, . Reduced oxygen tension attenuates differentiation capacity of human mesenchymal stem cells and prolongs their lifespan. Aging Cell. 2007;6:745–57.
   PubMed Web of Science ®Google Scholar
• Chow DC, Wenning LA, Miller WM, Papoutsakis ET. Modeling pO(2) distributions in the bone marrow hematopoietic compartment. II. Modified Kroghian models. Biophys J. 2001;81:685–96.
   PubMed Web of Science ®Google Scholar
• Lin Q, Kim Y, Alarcon RM, Yun Z. Oxygen and cell fate decisions. Gene Regul Syst Bio. 2008;2:43–51.
   Google Scholar
• Ohnishi S, Yasuda T, Kitamura S, Nagaya N. Effect of hypoxia on gene expression of bone marrow-derived mesenchymal stem cells and mononuclear cells. Stem Cells. 2007;25:1166–77.
   PubMed Web of Science ®Google Scholar
• Rosova I, Dao M, Capoccia B, Link D, Nolta JA. Hypoxic preconditioning results in increased motility and improved therapeutic potential of human mesenchymal stem cells. Stem Cells. 2008;26:2173–82.
   PubMed Web of Science ®Google Scholar
• Buravkova LB, Grinakovskaia OS, Andreeva EP, Zhambalova AP, Kozionova MP. [Characteristics of human lipoaspirate-isolated mesenchymal stromal cells cultivated under a lower oxygen tension]. Tsitologiia. 2009;51:5–11.
   PubMedGoogle Scholar
• Chung HM, Won CH, Sung JH. Responses of adipose-derived stem cells during hypoxia: enhanced skin-regenerative potential. Expert Opin Biol Ther. 2009;9:1499–508.
   PubMed Web of Science ®Google Scholar
• Kluth SM, Buchheiser A, Houben AP, Geyh S, Krenz T, Radke TF, . DLK-1 as a marker to distinguish unrestricted somatic stem cells and mesenchymal stromal cells in cord blood. Stem Cells Dev. 2010;19:1471–1483.
   PubMedGoogle Scholar
• Liedtke S, Buchheiser A, Bosch J, Bosse F, Kruse F, Zhao X, . The HOX code as a ‘biological fingerprint’ to distinguish functionally distinct stem cell populations derived from cord blood. Stem Cell Res. 2010;5:40–50.
   PubMedGoogle Scholar
• Aktas M, Buchheiser A, Houben A, Reimann V, Radke T, Jeltsch K, . Good manufacturing practice-grade production of unrestricted somatic stem cell from fresh cord blood. Cytotherapy. 2010;12:338–48.
   PubMed Web of Science ®Google Scholar
• Morgan R. Hox genes: a continuation of embryonic patterning? Trends Genet. 2006;22:67–9.
   PubMedGoogle Scholar
• Krumlauf R. Hox genes in vertebrate development. Cell. 1994;78:191–201.
   PubMed Web of Science ®Google Scholar
• Lengerke C, McKinney-Freeman S, Naveiras O, Yates F, Wang Y, Bansal D, . The cdx-hox pathway in hematopoietic stem cell formation from embryonic stem cells. Ann NY Acad Sci. 2007;1106:197–208.
   PubMedGoogle Scholar
• Lengerke C, Schmitt S, Bowman TV, Jang IH, Maouche-Chretien L, McKinney-Freeman S, . BMP and Wnt specify hematopoietic fate by activation of the Cdx-Hox pathway. Cell Stem Cell. 2008;2:72–82.
   PubMed Web of Science ®Google Scholar
• Blickstein I, Green T. Umbilical cord blood gases. Clin Perinatol. 2007;34:451–9.
   PubMed Web of Science ®Google Scholar
• Lin Q, Lee YJ, Yun Z. Differentiation arrest by hypoxia. J Biol Chem. 2006;281:30678–83.
   PubMed Web of Science ®Google Scholar
• Leucht P, Kim JB, Amasha R, James AW, Girod S, Helms JA. Embryonic origin and Hox status determine progenitor cell fate during adult bone regeneration. Development. 2008;135:2845–54.
   PubMed Web of Science ®Google Scholar
• Takahashi Y, Hamada J, Murakawa K, Takada M, Tada M, Nogami I, . Expression profiles of 39 HOX genes in normal human adult organs and anaplastic thyroid cancer cell lines by quantitative real-time RT-PCR system. Exp Cell Res. 2004;293:144–53.
   PubMed Web of Science ®Google Scholar
• Church V, Nohno T, Linker C, Marcelle C, Francis-West P. Wnt regulation of chondrocyte differentiation. J Cell Sci. 2002;115:4809–18.
   PubMed Web of Science ®Google Scholar
• Church VL, Francis-West P. Wnt signalling during limb development. Int J Dev Biol. 2002;46:927–36.
   PubMed Web of Science ®Google Scholar
• Hu H, Hilton MJ, Tu X, Yu K, Ornitz DM, Long F. Sequential roles of Hedgehog and Wnt signaling in osteoblast development. Development. 2005;132:49–60.
   PubMed Web of Science ®Google Scholar
• Surmann-Schmitt C, Widmann N, Dietz U, Saeger B, Eitzinger N, Nakamura Y, . Wif-1 is expressed at cartilage-mesenchyme interfaces and impedes Wnt3a-mediated inhibition of chondrogenesis. J Cell Sci. 2009;122:3627–37.
   PubMed Web of Science ®Google Scholar
• Witte F, Dokas J, Neuendorf F, Mundlos S, Stricker S. Comprehensive expression analysis of all Wnt genes and their major secreted antagonists during mouse limb development and cartilage differentiation. Gene Expression Patterns. 2009; 9:215–23.
   PubMedGoogle Scholar
• Glass D, Karsenty G. Molecular bases of the regulation of bone remodeling by the canonical Wnt signaling pathway. Curr Top Dev Biol. 2006;73:43–84.
   PubMed Web of Science ®Google Scholar
• Glass DA II, Karsenty G. In vivo analysis of Wnt signaling in bone. Endocrinology. 2007;148:2630–4.
   PubMedGoogle Scholar